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GSE58827: Dynamics of the Mouse Liver

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Results for Mecom

Z-value: 0.79

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Transcription factors associated with Mecom

Gene Symbol Gene ID Gene Info
Mecom
ENSMUSG00000027684.10 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mecommm10_v2_chr3_-_30509462_30509514-0.363.1e-02Click!

Activity profile of Mecom motif

Sorted Z-values of Mecom motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_62087261 10.72 ENSMUST00000107488.3
ENSMUST00000107472.1
ENSMUST00000084531.4
Mup3
major urinary protein 3
chr4_-_61303802 10.29 ENSMUST00000125461.1
Mup14
major urinary protein 14
chr1_+_152399824 6.18 ENSMUST00000044311.8
Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr4_+_60003438 3.83 ENSMUST00000107517.1
ENSMUST00000107520.1
Mup6
major urinary protein 6
chr13_+_89540636 2.70 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chr3_-_56890593 2.37 ENSMUST00000099093.3
F830104G03Rik
RIKEN cDNA F830104G03 gene
chr6_+_138140298 2.03 ENSMUST00000008684.4
Mgst1
microsomal glutathione S-transferase 1
chr8_+_12385769 1.70 ENSMUST00000080795.8
Gm5607
predicted gene 5607
chr1_+_185454803 1.68 ENSMUST00000061093.6
Slc30a10
solute carrier family 30, member 10
chr5_-_66080971 1.62 ENSMUST00000127275.1
ENSMUST00000113724.1
Rbm47
RNA binding motif protein 47
chr9_-_104337700 1.34 ENSMUST00000112590.2
ENSMUST00000062723.6
Acpp
acid phosphatase, prostate
chr6_-_34910869 1.20 ENSMUST00000081214.5
Wdr91
WD repeat domain 91
chr14_-_56211407 1.16 ENSMUST00000022757.3
Gzmf
granzyme F
chr1_-_162984519 1.06 ENSMUST00000028010.7
Fmo3
flavin containing monooxygenase 3
chrX_+_21714896 0.94 ENSMUST00000033414.7
Slc6a14
solute carrier family 6 (neurotransmitter transporter), member 14
chr2_+_34874396 0.89 ENSMUST00000113068.2
ENSMUST00000047447.8
Cutal
cutA divalent cation tolerance homolog-like
chr8_-_36953139 0.84 ENSMUST00000179501.1
Dlc1
deleted in liver cancer 1
chrX_-_113185485 0.84 ENSMUST00000026607.8
ENSMUST00000113388.2
Chm
choroidermia
chr3_+_41742615 0.83 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
D3Ertd751e
DNA segment, Chr 3, ERATO Doi 751, expressed
chr11_-_50953745 0.82 ENSMUST00000162420.1
ENSMUST00000051159.2
Prop1
paired like homeodomain factor 1
chr2_+_34874486 0.81 ENSMUST00000028228.3
Cutal
cutA divalent cation tolerance homolog-like
chrX_+_98149666 0.80 ENSMUST00000052837.7
Ar
androgen receptor
chrX_+_140381971 0.76 ENSMUST00000044702.6
Frmpd3
FERM and PDZ domain containing 3
chr9_+_64235201 0.75 ENSMUST00000039011.3
Uchl4
ubiquitin carboxyl-terminal esterase L4
chrY_+_897782 0.72 ENSMUST00000055032.7
Kdm5d
lysine (K)-specific demethylase 5D
chrX_+_9350599 0.71 ENSMUST00000073949.2
Gm14501
predicted gene 14501
chr4_+_133039482 0.68 ENSMUST00000105914.1
Ahdc1
AT hook, DNA binding motif, containing 1
chrX_+_9885622 0.65 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5
synaptotagmin-like 5
chrX_+_11302432 0.65 ENSMUST00000179428.1
Gm14474
predicted gene 14474
chr10_-_68278713 0.62 ENSMUST00000020106.7
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr17_+_33432890 0.61 ENSMUST00000174088.2
Actl9
actin-like 9
chr19_-_37176055 0.60 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3
cytoplasmic polyadenylation element binding protein 3
chrX_+_11311934 0.59 ENSMUST00000178979.1
Gm14484
predicted gene 14484
chrX_+_9283764 0.59 ENSMUST00000177926.1
1700012L04Rik
RIKEN cDNA 1700012L04 gene
chr14_+_87416610 0.56 ENSMUST00000168275.1
ENSMUST00000169504.1
ENSMUST00000170865.1
Tdrd3
tudor domain containing 3
chr5_+_65131184 0.55 ENSMUST00000031089.5
ENSMUST00000101191.3
Klhl5
kelch-like 5
chr16_+_56477838 0.55 ENSMUST00000048471.7
ENSMUST00000096013.3
ENSMUST00000096012.3
ENSMUST00000171000.1
Abi3bp
ABI gene family, member 3 (NESH) binding protein
chr9_+_59589288 0.54 ENSMUST00000121266.1
ENSMUST00000118164.1
Celf6
CUGBP, Elav-like family member 6
chr18_-_43477764 0.54 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chrX_+_11324659 0.53 ENSMUST00000164729.2
Gm14475
predicted gene 14475
chrX_+_11308824 0.52 ENSMUST00000178595.1
Gm14476
predicted gene 14476
chr5_+_66259890 0.50 ENSMUST00000065530.6
Nsun7
NOL1/NOP2/Sun domain family, member 7
chr13_+_109260481 0.50 ENSMUST00000153234.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr10_+_61648552 0.48 ENSMUST00000020286.6
Ppa1
pyrophosphatase (inorganic) 1
chr2_+_18672384 0.46 ENSMUST00000171845.1
ENSMUST00000061158.4
Commd3
COMM domain containing 3
chrX_+_11321423 0.45 ENSMUST00000178196.1
Gm14478
predicted gene 14478
chrX_+_11305655 0.45 ENSMUST00000178806.1
Gm14477
predicted gene 14477
chrX_+_11299257 0.44 ENSMUST00000178729.1
Gm14483
predicted gene 14483
chr4_+_128846163 0.43 ENSMUST00000138291.1
Gm12968
predicted gene 12968
chrX_+_11315158 0.42 ENSMUST00000179004.1
Gm14479
predicted gene 14479
chrX_+_11318256 0.41 ENSMUST00000179859.1
Gm14482
predicted gene 14482
chrX_+_76264281 0.40 ENSMUST00000096389.4
Gm4937
predicted gene 4937
chr2_-_45110241 0.34 ENSMUST00000177302.1
Zeb2
zinc finger E-box binding homeobox 2
chr5_+_34525797 0.33 ENSMUST00000125817.1
ENSMUST00000067638.7
Sh3bp2
SH3-domain binding protein 2
chrX_-_37110257 0.33 ENSMUST00000076265.6
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr9_-_13245741 0.32 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr15_-_36140393 0.31 ENSMUST00000172831.1
Rgs22
regulator of G-protein signalling 22
chrX_-_21221564 0.30 ENSMUST00000155208.1
ENSMUST00000125569.1
4930453H23Rik
RIKEN cDNA 4930453H23 gene
chrX_-_89409689 0.30 ENSMUST00000113959.1
ENSMUST00000113960.2
Pet2
plasmacytoma expressed transcript 2
chr3_+_36552600 0.29 ENSMUST00000029269.5
ENSMUST00000136890.1
Exosc9
exosome component 9
chr1_-_189343342 0.29 ENSMUST00000079451.6
Kcnk2
potassium channel, subfamily K, member 2
chr16_-_48771956 0.29 ENSMUST00000170861.1
Trat1
T cell receptor associated transmembrane adaptor 1
chr3_+_106034661 0.28 ENSMUST00000170669.2
Gm4540
predicted gene 4540
chr7_+_6222278 0.26 ENSMUST00000072662.5
ENSMUST00000155314.1
Zscan5b
zinc finger and SCAN domain containing 5B
chr12_-_11208948 0.25 ENSMUST00000049877.1
Msgn1
mesogenin 1
chr11_-_83020722 0.25 ENSMUST00000108152.2
Slfn8
schlafen 8
chrX_+_14211148 0.25 ENSMUST00000079952.2
Gm5382
predicted gene 5382
chr18_+_4994600 0.24 ENSMUST00000140448.1
Svil
supervillin
chr9_+_105053239 0.24 ENSMUST00000035177.8
ENSMUST00000149243.1
Mrpl3
mitochondrial ribosomal protein L3
chr9_-_117252111 0.22 ENSMUST00000111772.3
Rbms3
RNA binding motif, single stranded interacting protein
chr7_+_140690884 0.22 ENSMUST00000084454.3
Olfr45
olfactory receptor 45
chr11_-_115367667 0.21 ENSMUST00000123428.1
ENSMUST00000044152.6
ENSMUST00000106542.2
Hid1
HID1 domain containing
chr10_+_3740348 0.20 ENSMUST00000120274.1
Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr11_-_83020788 0.20 ENSMUST00000038141.8
ENSMUST00000092838.4
Slfn8
schlafen 8
chr13_-_27513206 0.20 ENSMUST00000018389.3
ENSMUST00000110350.1
Prl8a8
prolactin family 8, subfamily a, member 81
chr2_-_45110336 0.19 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2
zinc finger E-box binding homeobox 2
chr6_+_96113146 0.19 ENSMUST00000122120.1
Fam19a1
family with sequence similarity 19, member A1
chr2_+_97467657 0.18 ENSMUST00000059049.7
Lrrc4c
leucine rich repeat containing 4C
chr16_+_94425083 0.17 ENSMUST00000141176.1
Ttc3
tetratricopeptide repeat domain 3
chr8_+_46490968 0.16 ENSMUST00000110372.1
ENSMUST00000130563.1
Acsl1
acyl-CoA synthetase long-chain family member 1
chr9_+_115937142 0.16 ENSMUST00000121770.1
Gadl1
glutamate decarboxylase-like 1
chrX_-_155128409 0.15 ENSMUST00000076671.3
1700042B14Rik
RIKEN cDNA 1700042B14 gene
chr11_+_96302595 0.15 ENSMUST00000049272.3
Hoxb5
homeobox B5
chr7_+_82337218 0.14 ENSMUST00000173828.1
Adamtsl3
ADAMTS-like 3
chr6_-_99435345 0.13 ENSMUST00000113322.2
ENSMUST00000176850.1
ENSMUST00000176632.1
Foxp1
forkhead box P1
chr14_-_124677089 0.13 ENSMUST00000095529.3
Fgf14
fibroblast growth factor 14
chr14_+_115042752 0.12 ENSMUST00000134140.2
Mir17hg
Mir17 host gene 1 (non-protein coding)
chr13_+_21495218 0.12 ENSMUST00000104942.1
AK157302
cDNA sequence AK157302
chr6_-_29609607 0.11 ENSMUST00000115251.1
Tnpo3
transportin 3
chr6_+_30401866 0.10 ENSMUST00000068240.6
ENSMUST00000068259.6
Klhdc10
kelch domain containing 10
chr11_-_88718078 0.10 ENSMUST00000092794.5
Msi2
musashi RNA-binding protein 2
chr3_+_87357874 0.10 ENSMUST00000015998.6
Cd5l
CD5 antigen-like
chr9_-_117251801 0.07 ENSMUST00000172564.1
Rbms3
RNA binding motif, single stranded interacting protein
chr14_+_61599493 0.06 ENSMUST00000039562.6
Trim13
tripartite motif-containing 13
chr3_-_123236134 0.06 ENSMUST00000106427.1
ENSMUST00000106426.1
ENSMUST00000051443.5
Synpo2
synaptopodin 2
chr16_-_29541483 0.06 ENSMUST00000057018.8
ENSMUST00000182627.1
Atp13a4
ATPase type 13A4
chr8_-_43306991 0.05 ENSMUST00000082120.3
Zfp42
zinc finger protein 42
chr5_-_136198908 0.05 ENSMUST00000149151.1
ENSMUST00000151786.1
Prkrip1
Prkr interacting protein 1 (IL11 inducible)
chr4_-_110292719 0.05 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_-_152830266 0.04 ENSMUST00000140436.1
Bcl2l1
BCL2-like 1
chr4_+_11704439 0.04 ENSMUST00000108304.2
Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr5_+_129715488 0.03 ENSMUST00000119576.1
ENSMUST00000042191.5
ENSMUST00000118420.1
ENSMUST00000154358.1
ENSMUST00000121339.1
ENSMUST00000119604.1
ENSMUST00000136108.1
ENSMUST00000121813.1
ENSMUST00000119985.1
ENSMUST00000138812.1
Mrps17
mitochondrial ribosomal protein S17
chr16_-_38713235 0.01 ENSMUST00000023487.4
Arhgap31
Rho GTPase activating protein 31
chr5_-_120467296 0.01 ENSMUST00000132916.1
Sdsl
serine dehydratase-like
chr6_-_29609811 0.01 ENSMUST00000012679.8
Tnpo3
transportin 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecom

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.5 2.0 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.4 1.3 GO:0006772 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.4 0.8 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.4 10.7 GO:0035634 response to stilbenoid(GO:0035634)
0.3 0.8 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.2 0.6 GO:1900248 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.2 1.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.3 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1 0.3 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.1 0.8 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.5 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.6 GO:0060613 fat pad development(GO:0060613)
0.1 0.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.8 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.5 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.1 GO:0017144 drug metabolic process(GO:0017144)
0.0 0.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 1.2 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 0.5 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.0 GO:0019050 suppression by virus of host apoptotic process(GO:0019050) modulation by virus of host apoptotic process(GO:0039526) response to cycloheximide(GO:0046898)
0.0 0.3 GO:0007379 segment specification(GO:0007379)
0.0 0.0 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.3 GO:0044305 calyx of Held(GO:0044305)
0.0 0.2 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 1.3 GO:0005771 multivesicular body(GO:0005771)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 2.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.7 GO:0055037 recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.7 GO:0005550 pheromone binding(GO:0005550)
0.2 6.2 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.2 1.3 GO:0033265 choline binding(GO:0033265)
0.2 0.9 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.5 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 2.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.7 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 2.0 GO:0043295 glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.0 0.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 1.7 GO:0005507 copper ion binding(GO:0005507)
0.0 0.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.0 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.3 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events