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GSE58827: Dynamics of the Mouse Liver
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Results for Mecp2
Z-value: 1.65
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Transcription factors associated with Mecp2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mecp2 | mm10_v2_chrX_-_74085656_74085690 | -0.37 | 2.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mecp2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 10.9 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.2 | 8.6 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.3 | 8.2 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.2 | 7.9 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.1 | 7.7 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.2 | 6.9 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 6.7 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.7 | 6.5 | GO:0015691 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.6 | 6.5 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) |
| 1.0 | 6.0 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 60.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 22.4 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 19.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 16.9 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 15.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 13.7 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 12.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.8 | 10.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.3 | 8.8 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 8.6 | GO:0043296 | apical junction complex(GO:0043296) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.8 | 10.9 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.2 | 10.1 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.2 | 9.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 1.7 | 8.6 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 0.2 | 8.0 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.2 | 7.3 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.2 | 7.0 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 6.4 | GO:0030170 | pyridoxal phosphate binding(GO:0030170) |
| 0.1 | 6.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 13.1 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.3 | 8.9 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.2 | 8.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 8.0 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 7.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 7.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 5.0 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 5.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 4.5 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 10.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 9.8 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.5 | 9.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 8.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 7.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 7.5 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.3 | 6.8 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 6.6 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.5 | 6.5 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |