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GSE58827: Dynamics of the Mouse Liver
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Results for Mef2b
Z-value: 0.79
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Transcription factors associated with Mef2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2b | mm10_v2_chr8_+_70152754_70152781 | 0.59 | 1.6e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_46039202 Show fit | 5.68 |
ENSMUST00000156200.1
|
tropomodulin 1 |
|
| chr14_-_63417125 Show fit | 3.99 |
ENSMUST00000014597.3
|
B lymphoid kinase |
|
| chr6_+_41458923 Show fit | 3.90 |
ENSMUST00000031910.7
|
protease, serine, 1 (trypsin 1) |
|
| chr1_-_66935333 Show fit | 3.73 |
ENSMUST00000120415.1
ENSMUST00000119429.1 |
myosin, light polypeptide 1 |
|
| chr3_-_123034943 Show fit | 3.39 |
ENSMUST00000029761.7
|
myozenin 2 |
|
| chr2_+_148798785 Show fit | 3.32 |
ENSMUST00000028931.3
ENSMUST00000109947.1 |
cystatin 8 (cystatin-related epididymal spermatogenic) |
|
| chr15_-_89425856 Show fit | 3.29 |
ENSMUST00000109313.2
|
carnitine palmitoyltransferase 1b, muscle |
|
| chr7_-_103843154 Show fit | 3.20 |
ENSMUST00000063957.4
|
hemoglobin Z, beta-like embryonic chain |
|
| chr6_+_87778084 Show fit | 3.13 |
ENSMUST00000032133.3
|
glycoprotein 9 (platelet) |
|
| chr7_+_142441808 Show fit | 2.94 |
ENSMUST00000105971.1
ENSMUST00000145287.1 |
troponin I, skeletal, fast 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mef2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 15.8 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 6.9 | GO:0006941 | striated muscle contraction(GO:0006941) |
| 0.1 | 5.8 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 5.3 | GO:0015909 | long-chain fatty acid transport(GO:0015909) |
| 0.0 | 4.8 | GO:2000117 | negative regulation of cysteine-type endopeptidase activity(GO:2000117) |
| 0.1 | 4.7 | GO:0030239 | myofibril assembly(GO:0030239) |
| 0.1 | 4.0 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.5 | 3.6 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.4 | 3.2 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 3.2 | GO:0007586 | digestion(GO:0007586) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.2 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 7.6 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 7.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.3 | 5.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.2 | 5.7 | GO:0036379 | myofilament(GO:0036379) |
| 1.7 | 5.2 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.2 | 4.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 4.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 3.8 | GO:0031672 | A band(GO:0031672) |
| 0.1 | 3.7 | GO:0030016 | myofibril(GO:0030016) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.2 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 6.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.2 | 5.9 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.1 | 5.9 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.6 | 5.8 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.4 | 5.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 1.0 | 5.1 | GO:0016416 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.1 | 4.0 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 4.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.7 | 3.4 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 4.6 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 3.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 3.0 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 2.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.4 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 2.1 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 2.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 1.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 21.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 5.1 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 4.0 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.2 | 3.4 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 3.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 3.1 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 2.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 2.3 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 2.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |