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GSE58827: Dynamics of the Mouse Liver

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Results for Msx2_Hoxd4

Z-value: 0.85

Motif logo

Transcription factors associated with Msx2_Hoxd4

Gene Symbol Gene ID Gene Info
ENSMUSG00000021469.8 msh homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_534730740.401.7e-02Click!

Activity profile of Msx2_Hoxd4 motif

Sorted Z-values of Msx2_Hoxd4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_79285502 10.45 ENSMUST00000165408.1
BAI1-associated protein 2-like 2
chr15_-_79285470 7.47 ENSMUST00000170955.1
BAI1-associated protein 2-like 2
chr15_-_36879816 5.60 ENSMUST00000100713.2
predicted gene 10384
chr2_+_4017727 4.90 ENSMUST00000177457.1
FERM domain containing 4A
chrX_+_21484532 4.69 ENSMUST00000089188.2
angiotensin II receptor, type 2
chr6_-_36811361 4.19 ENSMUST00000101534.1
pleiotrophin
chr1_-_132390301 4.18 ENSMUST00000132435.1
transmembrane and coiled-coil domains 2
chr11_+_95010277 3.61 ENSMUST00000124735.1
sterile alpha motif domain containing 14
chr11_+_67171095 2.83 ENSMUST00000018641.7
myosin, heavy polypeptide 2, skeletal muscle, adult
chr3_+_40800778 2.74 ENSMUST00000169566.1
polo-like kinase 4
chr3_-_150073620 2.67 ENSMUST00000057740.5
ribosomal protein SA, pseudogene 10
chrX_+_56454871 2.61 ENSMUST00000039374.2
ENSMUST00000101553.2
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr11_+_67171027 2.59 ENSMUST00000170159.1
myosin, heavy polypeptide 2, skeletal muscle, adult
chr3_-_36571952 2.27 ENSMUST00000029270.3
cyclin A2
chr18_+_34840575 2.18 ENSMUST00000043484.7
receptor accessory protein 2
chr19_-_46044914 2.15 ENSMUST00000026252.7
LIM domain binding 1
chrX_+_159303266 1.91 ENSMUST00000112491.1
ribosomal protein S6 kinase polypeptide 3
chr3_+_68869563 1.88 ENSMUST00000054551.2
RIKEN cDNA 1110032F04 gene
chr1_-_163289214 1.85 ENSMUST00000183691.1
paired related homeobox 1
chr2_+_109280738 1.81 ENSMUST00000028527.7
kinesin family member 18A
chrX_+_106583184 1.73 ENSMUST00000101296.2
ENSMUST00000101297.3
predicted gene 5127
chrX_-_162964557 1.71 ENSMUST00000038769.2
S100 calcium binding protein G
chrX_+_136245065 1.66 ENSMUST00000048687.4
WW domain binding protein 5
chrX_-_74246534 1.63 ENSMUST00000101454.2
ENSMUST00000033699.6
filamin, alpha
chr3_-_116253467 1.62 ENSMUST00000090473.5
G-protein coupled receptor 88
chr16_-_58524164 1.58 ENSMUST00000126978.1
ENSMUST00000123918.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chrX_+_159708593 1.52 ENSMUST00000080394.6
SH3-domain kinase binding protein 1
chr6_-_136941887 1.48 ENSMUST00000111891.1
Rho, GDP dissociation inhibitor (GDI) beta
chr7_-_115824699 1.42 ENSMUST00000169129.1
SRY-box containing gene 6
chr4_-_141078302 1.41 ENSMUST00000030760.8
NECAP endocytosis associated 2
chr6_-_87533219 1.36 ENSMUST00000113637.2
ENSMUST00000071024.6
Rho GTPase activating protein 25
chr18_+_44104407 1.35 ENSMUST00000081271.5
serine peptidase inhibitor, Kazal type 11
chr3_-_14778452 1.32 ENSMUST00000094365.4
carbonic anhydrase 1
chr2_-_72986716 1.31 ENSMUST00000112062.1
predicted gene 11084
chr15_-_101694299 1.29 ENSMUST00000023788.6
keratin 6A
chr7_-_121074501 1.29 ENSMUST00000047194.2
immunoglobulin superfamily, member 6
chr10_-_63203930 1.26 ENSMUST00000095580.2
myopalladin
chrX_-_150814265 1.26 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
melanoma antigen, family D, 2
chr1_+_63176818 1.17 ENSMUST00000129339.1
eukaryotic translation elongation factor 1 beta 2
chr2_-_73453918 1.13 ENSMUST00000102679.1
WAS/WASL interacting protein family, member 1
chr9_-_77544870 1.13 ENSMUST00000183873.1
leucine rich repeat containing 1
chr13_+_23544052 1.13 ENSMUST00000075558.2
histone cluster 1, H3f
chr13_+_49544443 1.13 ENSMUST00000177948.1
ENSMUST00000021820.6
asporin
chr3_-_75270073 1.12 ENSMUST00000039047.4
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr11_-_109472611 1.11 ENSMUST00000168740.1
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr7_+_144838590 1.10 ENSMUST00000105898.1
fibroblast growth factor 3
chrX_+_150547375 1.08 ENSMUST00000066337.6
ENSMUST00000112715.1
aminolevulinic acid synthase 2, erythroid
chr4_-_129121889 1.07 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
hippocalcin
chr2_-_164389095 1.05 ENSMUST00000167427.1
secretory leukocyte peptidase inhibitor
chr10_+_14523062 1.01 ENSMUST00000096020.5
predicted gene 10335
chr9_-_77544829 1.01 ENSMUST00000183734.1
leucine rich repeat containing 1
chr4_-_149126688 0.99 ENSMUST00000030815.2
cortistatin
chr8_-_8639363 0.99 ENSMUST00000152698.1
ephrin B2
chr1_-_174250976 0.97 ENSMUST00000061990.4
olfactory receptor 419
chr7_-_45921418 0.96 ENSMUST00000038876.5
epithelial membrane protein 3
chr14_+_115042752 0.95 ENSMUST00000134140.2
Mir17 host gene 1 (non-protein coding)
chr12_+_36314160 0.94 ENSMUST00000041407.5
sclerostin domain containing 1
chrX_-_164258186 0.94 ENSMUST00000112265.2
BMX non-receptor tyrosine kinase
chr4_-_3872105 0.93 ENSMUST00000105158.1
Moloney sarcoma oncogene
chr4_+_101507947 0.93 ENSMUST00000149047.1
ENSMUST00000106929.3
DnaJ (Hsp40) homolog, subfamily C, member 6
chr3_+_64081642 0.91 ENSMUST00000029406.4
vomeronasal 2, receptor 1
chr17_+_46161021 0.89 ENSMUST00000024748.7
ENSMUST00000172170.1
GTP binding protein 2
chr13_+_75967704 0.87 ENSMUST00000022081.1
spermatogenesis associated 9
chr14_+_53795455 0.85 ENSMUST00000103671.2
RIKEN cDNA B230359F08 gene
chr2_-_45110336 0.82 ENSMUST00000028229.6
ENSMUST00000152232.1
zinc finger E-box binding homeobox 2
chr3_-_102964124 0.82 ENSMUST00000058899.8
nuclear receptor subfamily 1, group H, member 5
chr12_+_38783503 0.80 ENSMUST00000159334.1
ets variant gene 1
chr11_+_103133333 0.80 ENSMUST00000124928.1
ENSMUST00000062530.4
hexamethylene bis-acetamide inducible 2
chr6_+_136518820 0.79 ENSMUST00000032335.6
activating transcription factor 7 interacting protein
chr7_+_126950518 0.77 ENSMUST00000106335.1
ENSMUST00000146017.1
seizure related 6 homolog like 2
chr19_-_53371766 0.76 ENSMUST00000086887.1
predicted gene 10197
chr7_-_45920830 0.75 ENSMUST00000164119.1
epithelial membrane protein 3
chr2_-_33428222 0.73 ENSMUST00000091037.2
zinc finger and BTB domain containing 34
chr2_-_45112890 0.73 ENSMUST00000076836.6
zinc finger E-box binding homeobox 2
chr2_+_80638798 0.72 ENSMUST00000028382.6
ENSMUST00000124377.1
nucleoporin 35
chr6_-_131316398 0.72 ENSMUST00000121078.1
serine/threonine/tyrosine kinase 1
chr1_+_136683375 0.72 ENSMUST00000181524.1
predicted gene, 19705
chr18_+_68337504 0.71 ENSMUST00000172148.1
melanocortin 5 receptor
chr1_+_186749368 0.71 ENSMUST00000180869.1
RIKEN cDNA A430105J06 gene
chr1_+_191025350 0.70 ENSMUST00000181050.1
RIKEN cDNA A230020J21 gene
chr9_-_112187766 0.70 ENSMUST00000111872.2
ENSMUST00000164754.2
cyclic AMP-regulated phosphoprotein, 21
chr1_-_149961230 0.66 ENSMUST00000070200.8
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr17_-_14694223 0.64 ENSMUST00000170872.1
thrombospondin 2
chr10_-_13324160 0.63 ENSMUST00000105545.4
phosphatase and actin regulator 2
chr19_+_46396885 0.61 ENSMUST00000039922.6
ENSMUST00000111867.2
ENSMUST00000120778.1
suppressor of fused homolog (Drosophila)
chr11_+_103133303 0.59 ENSMUST00000107037.1
hexamethylene bis-acetamide inducible 2
chr13_+_23555023 0.59 ENSMUST00000045301.6
histone cluster 1, H1d
chr17_-_24073479 0.59 ENSMUST00000017090.5
potassium channel tetramerisation domain containing 5
chr11_-_87826023 0.58 ENSMUST00000103177.3
lactoperoxidase
chr15_+_85510812 0.57 ENSMUST00000079690.2
predicted pseudogene 4825
chr1_-_183147461 0.56 ENSMUST00000171366.1
dispatched homolog 1 (Drosophila)
chr5_-_53707532 0.56 ENSMUST00000031093.3
cholecystokinin A receptor
chr18_+_37518341 0.55 ENSMUST00000097609.1
protocadherin beta 22
chr18_-_43477764 0.52 ENSMUST00000057110.9
eukaryotic translation initiation factor 3, subunit J2
chr4_-_73950834 0.51 ENSMUST00000095023.1
ENSMUST00000030101.3
RIKEN cDNA 2310002L09 gene
chr2_+_155751117 0.51 ENSMUST00000029140.5
ENSMUST00000132608.1
protein C receptor, endothelial
chr2_-_152580300 0.50 ENSMUST00000053180.3
defensin beta 19
chr1_-_152625212 0.50 ENSMUST00000027760.7
ral guanine nucleotide dissociation stimulator,-like 1
chr4_-_82850721 0.50 ENSMUST00000139401.1
zinc finger, DHHC domain containing 21
chr1_-_150164943 0.49 ENSMUST00000181308.1
predicted gene, 26687
chrX_-_94123359 0.49 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
zinc finger protein X-linked
chr9_-_114390633 0.48 ENSMUST00000084881.4
cartilage associated protein
chr2_-_60125651 0.47 ENSMUST00000112550.1
bromodomain adjacent to zinc finger domain, 2B
chr2_+_57997884 0.46 ENSMUST00000112616.1
ENSMUST00000166729.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5
chr9_-_107770945 0.46 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
RNA binding motif protein 5
chr4_+_3940747 0.46 ENSMUST00000119403.1
coiled-coil-helix-coiled-coil-helix domain containing 7
chr19_-_55241236 0.46 ENSMUST00000069183.6
guanylate cyclase 2g
chr4_-_119492563 0.44 ENSMUST00000049994.7
ribosomal modification protein rimK-like family member A
chr7_+_126950687 0.44 ENSMUST00000106333.1
seizure related 6 homolog like 2
chr3_-_49757257 0.44 ENSMUST00000035931.7
protocadherin 18
chr2_+_76650264 0.43 ENSMUST00000099986.2
deafness, autosomal recessive 59 (human)
chr2_-_169962987 0.43 ENSMUST00000087964.2
cDNA sequence AY702102
chr4_-_99829180 0.41 ENSMUST00000146258.1
integrin beta 3 binding protein (beta3-endonexin)
chr4_+_101507855 0.40 ENSMUST00000038207.5
DnaJ (Hsp40) homolog, subfamily C, member 6
chr15_+_21111452 0.40 ENSMUST00000075132.6
cadherin 12
chr5_+_48242549 0.40 ENSMUST00000172493.1
slit homolog 2 (Drosophila)
chr18_+_52767994 0.38 ENSMUST00000025413.7
ENSMUST00000163742.2
ENSMUST00000178011.1
synuclein, alpha interacting protein (synphilin)
chr9_+_30942541 0.38 ENSMUST00000068135.6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
chr1_+_159737510 0.38 ENSMUST00000111669.3
tenascin R
chr5_-_62765618 0.38 ENSMUST00000159470.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_-_66296807 0.37 ENSMUST00000029419.7
ventricular zone expressed PH domain-containing 1
chr2_-_72813665 0.37 ENSMUST00000136807.1
ENSMUST00000148327.1
RIKEN cDNA 6430710C18 gene
chrX_+_133850980 0.37 ENSMUST00000033602.8
tenomodulin
chr6_-_124779686 0.36 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
leucine rich repeat containing 23
chr5_-_31179901 0.35 ENSMUST00000101411.2
ENSMUST00000140793.1
general transcription factor IIIC, polypeptide 2, beta
chr5_-_72168142 0.34 ENSMUST00000013693.6
COMM domain containing 8
chr8_-_120228221 0.34 ENSMUST00000183235.1
RIKEN cDNA A330074K22 gene
chr13_-_102906046 0.34 ENSMUST00000171791.1
microtubule associated serine/threonine kinase family member 4
chr1_-_133661318 0.33 ENSMUST00000179598.1
ENSMUST00000027736.6
zinc finger, BED domain containing 6
zinc finger CCCH type containing 11A
chr1_+_171840557 0.32 ENSMUST00000135386.1
CD84 antigen
chr17_+_17402672 0.32 ENSMUST00000115576.2
limb expression 1 homolog (chicken)
chr1_-_78968079 0.32 ENSMUST00000049117.5
predicted pseudogene 5830
chr4_-_62519885 0.32 ENSMUST00000107444.1
ENSMUST00000030090.3
aminolevulinate, delta-, dehydratase
chr10_+_115569986 0.31 ENSMUST00000173620.1
RIKEN cDNA A930009A15 gene
chr8_+_81856324 0.31 ENSMUST00000109851.2
inositol polyphosphate-4-phosphatase, type II
chr9_-_118014160 0.31 ENSMUST00000111769.3
zinc finger, CW type with PWWP domain 2
chr7_+_126950837 0.31 ENSMUST00000106332.1
seizure related 6 homolog like 2
chr1_+_106938953 0.30 ENSMUST00000112724.2
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12
chr13_-_75943812 0.30 ENSMUST00000022078.5
ENSMUST00000109606.1
Rho-related BTB domain containing 3
chr3_+_84952146 0.29 ENSMUST00000029727.7
F-box and WD-40 domain protein 7
chr1_+_70725902 0.29 ENSMUST00000161937.1
ENSMUST00000162182.1
von Willebrand factor C domain-containing protein 2-like
chr2_-_163417092 0.29 ENSMUST00000127038.1
oxidative stress responsive serine rich 1
chr10_+_128303322 0.28 ENSMUST00000005825.6
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr13_+_93304799 0.26 ENSMUST00000080127.5
homer homolog 1 (Drosophila)
chr2_-_33086366 0.26 ENSMUST00000049618.2
GTPase activating RANGAP domain-like 3
chr14_-_88471396 0.26 ENSMUST00000061628.5
protocadherin 20
chr18_+_59062462 0.24 ENSMUST00000058633.2
ENSMUST00000175897.1
ENSMUST00000118510.1
ENSMUST00000175830.1
RIKEN cDNA A730017C20 gene
chr18_+_37320374 0.24 ENSMUST00000078271.2
protocadherin beta 5
chr6_-_67491849 0.23 ENSMUST00000118364.1
interleukin 23 receptor
chr5_-_31180110 0.22 ENSMUST00000043161.6
ENSMUST00000088010.5
general transcription factor IIIC, polypeptide 2, beta
chr5_-_151586924 0.22 ENSMUST00000165928.1
vomeronasal 2, receptor 18
chrX_+_101640056 0.22 ENSMUST00000119299.1
ENSMUST00000044475.4
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr11_+_73350839 0.22 ENSMUST00000120137.1
olfactory receptor 20
chr7_+_123123870 0.22 ENSMUST00000094053.5
trinucleotide repeat containing 6a
chr1_+_70725715 0.21 ENSMUST00000053922.5
von Willebrand factor C domain-containing protein 2-like
chr5_+_87925579 0.21 ENSMUST00000001667.6
ENSMUST00000113267.1
casein kappa
chr12_+_108179738 0.20 ENSMUST00000101055.4
cyclin K
chr6_-_119963733 0.19 ENSMUST00000161512.2
WNK lysine deficient protein kinase 1
chr8_+_31111816 0.18 ENSMUST00000046941.7
ring finger protein 122
chr2_+_36452587 0.17 ENSMUST00000072854.1
olfactory receptor 340
chr13_+_51408618 0.16 ENSMUST00000087978.3
sphingosine-1-phosphate receptor 3
chr9_+_38877126 0.16 ENSMUST00000078289.2
olfactory receptor 926
chr2_+_74691090 0.16 ENSMUST00000061745.3
homeobox D10
chr4_-_73790602 0.16 ENSMUST00000058292.6
ENSMUST00000102837.2
RAS and EF hand domain containing
chr11_-_74724670 0.16 ENSMUST00000021091.8
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr4_+_35152056 0.16 ENSMUST00000058595.6
interferon kappa
chr18_+_4920509 0.15 ENSMUST00000126977.1
supervillin
chr1_+_180109192 0.14 ENSMUST00000143176.1
ENSMUST00000135056.1
CDC42 binding protein kinase alpha
chr2_+_180710117 0.14 ENSMUST00000029090.2
GID complex subunit 8 homolog (S. cerevisiae)
chr1_+_72284367 0.14 ENSMUST00000027380.5
ENSMUST00000141783.1
transmembrane protein 169
chr12_+_52516077 0.13 ENSMUST00000110725.1
Rho GTPase activating protein 5
chr1_-_186749304 0.13 ENSMUST00000001339.5
ribosomal RNA processing 15 homolog (S. cerevisiae)
chr3_+_59952185 0.13 ENSMUST00000094227.3
predicted gene 9696
chr11_+_96292453 0.12 ENSMUST00000173432.1
homeobox B6
chr10_-_14718191 0.12 ENSMUST00000020016.4
gap junction protein, epsilon 1
chr9_+_64235201 0.12 ENSMUST00000039011.3
ubiquitin carboxyl-terminal esterase L4
chr7_-_38019505 0.11 ENSMUST00000085513.4
URI1, prefoldin-like chaperone
chr19_-_39740999 0.10 ENSMUST00000099472.3
cytochrome P450, family 2, subfamily c, polypeptide 68
chr1_+_137928100 0.10 ENSMUST00000054333.2
RIKEN cDNA A130050O07 gene
chr10_+_5593718 0.10 ENSMUST00000051809.8
myc target 1
chr10_-_129160982 0.09 ENSMUST00000078914.2
olfactory receptor 771
chr5_-_23616528 0.09 ENSMUST00000088392.4
serine/arginine-rich protein specific kinase 2
chr18_-_37969742 0.08 ENSMUST00000166148.1
ENSMUST00000163131.1
ENSMUST00000043437.7
FCH and double SH3 domains 1
chr13_+_93304066 0.08 ENSMUST00000109493.1
homer homolog 1 (Drosophila)
chr3_+_106113229 0.07 ENSMUST00000079132.5
ENSMUST00000139086.1
chitinase, acidic
chr11_-_99322943 0.06 ENSMUST00000038004.2
keratin 25
chr7_+_84853573 0.05 ENSMUST00000078172.4
olfactory receptor 291
chr12_-_27160498 0.04 ENSMUST00000182592.1
predicted gene 9866
chr6_-_23650206 0.04 ENSMUST00000115354.1
ring finger protein 133
chr14_-_52036143 0.04 ENSMUST00000052560.4
olfactory receptor 221
chr9_-_89705017 0.02 ENSMUST00000058488.6
transmembrane emp24 domain containing 3
chr15_+_92597104 0.01 ENSMUST00000035399.8
PDZ domain containing RING finger 4
chr11_+_98798653 0.01 ENSMUST00000037930.6
male-specific lethal 1 homolog (Drosophila)
chr17_-_35046539 0.01 ENSMUST00000007250.7
mutS homolog 5 (E. coli)
chr12_-_27160311 0.00 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
predicted gene 9866
chr3_+_116968267 0.00 ENSMUST00000117592.1
RIKEN cDNA 4930455H04 gene
chr13_+_76098734 0.00 ENSMUST00000091466.3
tetratricopeptide repeat domain 37

Network of associatons between targets according to the STRING database.

First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0035566 regulation of metanephros size(GO:0035566)
1.0 4.2 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.8 17.9 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.5 1.6 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.5 2.1 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.4 1.6 GO:0061743 motor learning(GO:0061743)
0.4 2.7 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.4 2.2 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.4 5.4 GO:0001778 plasma membrane repair(GO:0001778)
0.4 1.1 GO:0031283 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 0.9 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.3 0.9 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.3 1.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 1.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 0.9 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.2 1.3 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 0.6 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.2 1.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 1.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.4 GO:0090260 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 1.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.4 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 1.0 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 1.1 GO:0030916 otic vesicle formation(GO:0030916)
0.1 1.9 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.7 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 4.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.3 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
0.1 1.7 GO:0032060 bleb assembly(GO:0032060)
0.1 0.6 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 1.3 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 1.1 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.4 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 1.0 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 1.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 4.0 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.1 0.9 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.3 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.2 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.0 1.4 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.5 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 2.3 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.8 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.2 GO:0043622 cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660)
0.0 1.4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.7 GO:0006999 nuclear pore organization(GO:0006999)
0.0 1.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.2 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.6 GO:0060539 diaphragm development(GO:0060539)
0.0 1.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.0 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 1.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.6 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 1.1 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.9 GO:0019236 response to pheromone(GO:0019236)
0.0 0.4 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 1.2 GO:0006414 translational elongation(GO:0006414)
0.0 0.3 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.5 GO:0060746 parental behavior(GO:0060746)
0.0 0.7 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.3 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.0 1.9 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.2 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.6 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.3 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 0.2 GO:0002827 positive regulation of T-helper 1 type immune response(GO:0002827)
0.0 0.2 GO:1901550 regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.0 0.7 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.4 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.0 0.7 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 17.9 GO:0071439 clathrin complex(GO:0071439)
0.7 5.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.5 2.7 GO:0098536 deuterosome(GO:0098536)
0.4 1.6 GO:0031523 Myb complex(GO:0031523)
0.3 2.3 GO:0001940 male pronucleus(GO:0001940)
0.3 1.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.2 1.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.4 GO:0072534 perineuronal net(GO:0072534)
0.1 0.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.3 GO:0031251 PAN complex(GO:0031251)
0.1 1.1 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.6 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.2 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.1 1.4 GO:0030125 clathrin vesicle coat(GO:0030125)
0.1 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 4.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.6 GO:0031091 platelet alpha granule(GO:0031091)
0.0 4.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.7 GO:0042588 zymogen granule(GO:0042588)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 1.6 GO:0000786 nucleosome(GO:0000786)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.2 4.7 GO:0004945 angiotensin type II receptor activity(GO:0004945)
0.4 1.6 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.4 1.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.3 1.6 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 1.7 GO:0005499 vitamin D binding(GO:0005499)
0.2 1.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 2.1 GO:0030274 LIM domain binding(GO:0030274)
0.2 1.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 1.3 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.7 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 1.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.9 GO:0036122 BMP binding(GO:0036122) BMP receptor activity(GO:0098821)
0.1 0.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.3 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 0.4 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.0 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 2.5 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.0 1.9 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0015197 peptide transporter activity(GO:0015197)
0.0 1.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 15.2 GO:0005543 phospholipid binding(GO:0005543)
0.0 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 4.9 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.4 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.2 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 3.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 4.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.6 GO:0004601 peroxidase activity(GO:0004601)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 2.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 6.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.6 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.0 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.9 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.8 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID BMP PATHWAY BMP receptor signaling
0.0 3.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.3 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.8 REACTOME KINESINS Genes involved in Kinesins
0.1 1.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.9 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 1.1 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 2.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.7 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.5 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 6.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.5 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases