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GSE58827: Dynamics of the Mouse Liver

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Results for Msx3

Z-value: 0.56

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Transcription factors associated with Msx3

Gene Symbol Gene ID Gene Info
Msx3
ENSMUSG00000025469.9 msh homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Msx3mm10_v2_chr7_-_140049083_1400490890.325.6e-02Click!

Activity profile of Msx3 motif

Sorted Z-values of Msx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_168767029 6.60 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr2_-_168767136 5.70 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4
sal-like 4 (Drosophila)
chr14_+_27000362 4.15 ENSMUST00000035433.8
Hesx1
homeobox gene expressed in ES cells
chr1_-_52190901 2.90 ENSMUST00000156887.1
ENSMUST00000129107.1
Gls
glutaminase
chr9_+_96258697 2.87 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr10_-_76110956 2.65 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr3_-_116253467 2.47 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr8_+_57511833 2.45 ENSMUST00000067925.6
Hmgb2
high mobility group box 2
chr12_+_102128718 2.00 ENSMUST00000159329.1
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr15_-_34356421 1.89 ENSMUST00000179647.1
9430069I07Rik
RIKEN cDNA 9430069I07 gene
chr8_-_24725762 1.81 ENSMUST00000171438.1
ENSMUST00000171611.1
ENSMUST00000033958.7
Adam3
a disintegrin and metallopeptidase domain 3 (cyritestin)
chrX_+_9885622 1.77 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5
synaptotagmin-like 5
chr2_-_160619971 1.40 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chrX_+_101449078 1.38 ENSMUST00000033674.5
Itgb1bp2
integrin beta 1 binding protein 2
chr17_-_24527925 1.37 ENSMUST00000176652.1
Traf7
TNF receptor-associated factor 7
chr9_-_53975246 1.34 ENSMUST00000048409.7
Elmod1
ELMO/CED-12 domain containing 1
chr17_-_24527830 1.31 ENSMUST00000176353.1
ENSMUST00000176237.1
Traf7
TNF receptor-associated factor 7
chr16_+_49699198 1.26 ENSMUST00000046777.4
ENSMUST00000142682.1
Ift57
intraflagellar transport 57
chr10_+_81257277 1.11 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
Matk
megakaryocyte-associated tyrosine kinase
chr2_-_33087169 1.08 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr1_-_172027269 1.07 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr10_-_88379051 1.06 ENSMUST00000138159.1
Dram1
DNA-damage regulated autophagy modulator 1
chr2_-_45117349 1.03 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr9_+_72806874 0.99 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr7_+_101896817 0.89 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr7_+_45621805 0.87 ENSMUST00000033100.4
Izumo1
izumo sperm-egg fusion 1
chr7_+_101896340 0.84 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15
anaphase prompoting complex C subunit 15
chr13_-_58354862 0.77 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr17_+_56613392 0.76 ENSMUST00000080492.5
Rpl36
ribosomal protein L36
chr17_+_21383725 0.73 ENSMUST00000056107.4
ENSMUST00000162659.1
Zfp677
zinc finger protein 677
chr5_-_105051047 0.72 ENSMUST00000112718.4
Gbp8
guanylate-binding protein 8
chr12_+_71136848 0.69 ENSMUST00000149564.1
ENSMUST00000045907.8
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr2_-_20943413 0.67 ENSMUST00000140230.1
Arhgap21
Rho GTPase activating protein 21
chr11_+_70018421 0.66 ENSMUST00000108588.1
Dlg4
discs, large homolog 4 (Drosophila)
chr9_+_35423582 0.64 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr19_+_5474681 0.62 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2
epidermal growth factor-containing fibulin-like extracellular matrix protein 2
chr2_+_163658370 0.60 ENSMUST00000164399.1
ENSMUST00000064703.6
ENSMUST00000099105.2
ENSMUST00000152418.1
ENSMUST00000126182.1
ENSMUST00000131228.1
Pkig
protein kinase inhibitor, gamma
chr9_+_43310763 0.58 ENSMUST00000034511.5
Trim29
tripartite motif-containing 29
chr2_-_33086366 0.57 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr15_+_82252397 0.56 ENSMUST00000136948.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr6_-_135254326 0.50 ENSMUST00000111911.2
ENSMUST00000111910.2
Gsg1
germ cell-specific gene 1
chr3_-_41742471 0.47 ENSMUST00000026866.8
Sclt1
sodium channel and clathrin linker 1
chr11_-_99244058 0.44 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr17_+_49615104 0.42 ENSMUST00000162854.1
Kif6
kinesin family member 6
chr7_+_27486910 0.42 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr9_-_40984460 0.42 ENSMUST00000180872.1
Crtam
cytotoxic and regulatory T cell molecule
chr12_+_72441852 0.41 ENSMUST00000162159.1
Lrrc9
leucine rich repeat containing 9
chr1_-_34439672 0.40 ENSMUST00000042493.8
Ccdc115
coiled-coil domain containing 115
chr13_-_102958084 0.32 ENSMUST00000099202.3
ENSMUST00000172264.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr4_+_94739276 0.32 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek
endothelial-specific receptor tyrosine kinase
chrX_+_133850980 0.32 ENSMUST00000033602.8
Tnmd
tenomodulin
chr4_-_129378116 0.31 ENSMUST00000030610.2
Zbtb8a
zinc finger and BTB domain containing 8a
chr3_+_106034661 0.29 ENSMUST00000170669.2
Gm4540
predicted gene 4540
chr11_+_53433299 0.29 ENSMUST00000018382.6
Gdf9
growth differentiation factor 9
chr4_-_14621805 0.28 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr19_-_11283813 0.25 ENSMUST00000067673.6
Ms4a5
membrane-spanning 4-domains, subfamily A, member 5
chr19_+_29951808 0.24 ENSMUST00000136850.1
Il33
interleukin 33
chr9_+_100597686 0.22 ENSMUST00000124487.1
Stag1
stromal antigen 1
chr13_+_67863324 0.22 ENSMUST00000078471.5
BC048507
cDNA sequence BC048507
chr16_-_29544852 0.22 ENSMUST00000039090.8
Atp13a4
ATPase type 13A4
chr12_+_72441933 0.21 ENSMUST00000161284.1
Lrrc9
leucine rich repeat containing 9
chr8_+_107031218 0.20 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chr3_+_83055516 0.20 ENSMUST00000150268.1
ENSMUST00000122128.1
Plrg1
pleiotropic regulator 1, PRL1 homolog (Arabidopsis)
chr2_-_174346712 0.18 ENSMUST00000168292.1
Gm20721
predicted gene, 20721
chr3_+_32515295 0.13 ENSMUST00000029203.7
Zfp639
zinc finger protein 639
chr4_+_134930898 0.12 ENSMUST00000030622.2
Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr12_-_11208948 0.12 ENSMUST00000049877.1
Msgn1
mesogenin 1
chr2_-_150255591 0.11 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr1_-_4360256 0.09 ENSMUST00000027032.4
Rp1
retinitis pigmentosa 1 (human)
chr6_-_135254170 0.09 ENSMUST00000111909.1
Gsg1
germ cell-specific gene 1
chr1_+_34439851 0.06 ENSMUST00000027303.7
Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr8_+_66511732 0.06 ENSMUST00000002025.3
Tktl2
transketolase-like 2
chr14_+_122034660 0.05 ENSMUST00000045976.6
Timm8a2
translocase of inner mitochondrial membrane 8A2
chr1_-_127840290 0.05 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr3_+_66985680 0.04 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr10_-_116896879 0.04 ENSMUST00000048229.7
Myrfl
myelin regulatory factor-like
chr3_+_41742615 0.01 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
D3Ertd751e
DNA segment, Chr 3, ERATO Doi 751, expressed
chr14_-_118735143 0.01 ENSMUST00000184172.1
RP24-241I19.1
RP24-241I19.1

Network of associatons between targets according to the STRING database.

First level regulatory network of Msx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.6 2.5 GO:0061743 motor learning(GO:0061743)
0.5 2.9 GO:0006543 glutamine catabolic process(GO:0006543)
0.4 4.2 GO:0030916 otic vesicle formation(GO:0030916)
0.4 1.1 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 2.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.2 2.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 2.6 GO:1904659 glucose transmembrane transport(GO:1904659)
0.2 1.0 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.4 GO:0002355 detection of tumor cell(GO:0002355)
0.1 1.7 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.6 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.9 GO:0097186 amelogenesis(GO:0097186)
0.1 0.9 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.1 0.3 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.1 0.2 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.7 GO:0051683 establishment of Golgi localization(GO:0051683)
0.1 0.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.7 GO:0098970 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 1.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.2 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.4 GO:1905146 lysosomal protein catabolic process(GO:1905146)
0.0 1.8 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 1.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.8 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.3 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 1.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.1 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.8 GO:0002181 cytoplasmic translation(GO:0002181)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0060187 cell pole(GO:0060187)
0.1 12.3 GO:0000792 heterochromatin(GO:0000792)
0.1 0.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.3 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.5 GO:0071439 clathrin complex(GO:0071439)
0.0 0.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.9 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.3 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 2.4 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.0 2.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.9 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 GO:0004359 glutaminase activity(GO:0004359)
0.3 2.0 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.3 2.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.2 2.6 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 0.9 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.7 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 2.2 GO:0030276 clathrin binding(GO:0030276)
0.0 1.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 4.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.1 GO:0030519 snoRNP binding(GO:0030519)
0.0 2.9 GO:0003774 motor activity(GO:0003774)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 14.1 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 1.4 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 12.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.1 PID E2F PATHWAY E2F transcription factor network
0.0 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.1 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides