ISMARA results: Mzf1

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GSE58827: Dynamics of the Mouse Liver

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Results for Mzf1

Z-value: 0.87

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Transcription factors associated with Mzf1

Gene Symbol	Gene ID	Gene Info
Mzf1 Ensembl NCBI MGI UniProt	ENSMUSG00000030380.10	myeloid zinc finger 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mzf1	mm10_v2_chr7_-_13054665_13054764	-0.21	2.2e-01	Click!

Activity profile of Mzf1 motif

Sorted Z-values of Mzf1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_60582152 Show fit	2.40	ENSMUST00000098047.2	Mup10 Ensembl NCBI MGI UniProt Show fit	major urinary protein 10
chr17_+_29490812 Show fit	2.20	ENSMUST00000024811.6	Pim1 Ensembl NCBI MGI UniProt Show fit	proviral integration site 1
chr4_-_60222580 Show fit	2.20	ENSMUST00000095058.4 ENSMUST00000163931.1	Mup8 Ensembl NCBI MGI UniProt Show fit	major urinary protein 8
chr4_-_61303998 Show fit	2.19	ENSMUST00000071005.8 ENSMUST00000075206.5	Mup14 Ensembl NCBI MGI UniProt Show fit	major urinary protein 14
chr4_-_60421933 Show fit	2.09	ENSMUST00000107506.2 ENSMUST00000122381.1 ENSMUST00000118759.1 ENSMUST00000122177.1	Mup9 Ensembl NCBI MGI UniProt Show fit	major urinary protein 9
chr4_-_61303802 Show fit	2.05	ENSMUST00000125461.1	Mup14 Ensembl NCBI MGI UniProt Show fit	major urinary protein 14
chr4_-_60741275 Show fit	2.05	ENSMUST00000117932.1	Mup12 Ensembl NCBI MGI UniProt Show fit	major urinary protein 12
chr4_-_60501903 Show fit	2.02	ENSMUST00000084548.4 ENSMUST00000103012.3 ENSMUST00000107499.3	Mup1 Ensembl NCBI MGI UniProt Show fit	major urinary protein 1
chr14_-_54712139 Show fit	1.95	ENSMUST00000064290.6	Cebpe Ensembl NCBI MGI UniProt Show fit	CCAAT/enhancer binding protein (C/EBP), epsilon
chr9_-_114564315 Show fit	1.71	ENSMUST00000111816.2	Trim71 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 71

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Mzf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.3	GO:0015671	oxygen transport(GO:0015671)
0.2	2.2	GO:1902033	regulation of hematopoietic stem cell proliferation(GO:1902033)
0.0	2.2	GO:0000209	protein polyubiquitination(GO:0000209)
0.2	2.0	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
0.2	1.9	GO:0090343	positive regulation of cell aging(GO:0090343)
0.1	1.8	GO:0040033	miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1	1.8	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.6	1.7	GO:0061537	glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1	1.7	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	1.7	GO:0043171	peptide catabolic process(GO:0043171)

Showing 1 to 10 of 253 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.5	GO:0005833	hemoglobin complex(GO:0005833)
0.0	2.1	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.2	2.0	GO:0005642	annulate lamellae(GO:0005642)
0.1	1.5	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
0.1	1.5	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	1.4	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	1.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1	1.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.1	1.1	GO:0031143	pseudopodium(GO:0031143)
0.1	1.1	GO:0035686	sperm fibrous sheath(GO:0035686)

Showing 1 to 10 of 100 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	GO:0001786	phosphatidylserine binding(GO:0001786)
0.3	2.3	GO:0005344	oxygen transporter activity(GO:0005344)
0.2	2.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.7	2.0	GO:0005186	insulin-activated receptor activity(GO:0005009) pheromone activity(GO:0005186)
0.1	1.8	GO:0035198	miRNA binding(GO:0035198)
0.1	1.7	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.1	1.6	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	1.6	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	1.4	GO:0070412	R-SMAD binding(GO:0070412)
0.1	1.3	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)

Showing 1 to 10 of 141 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	2.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	1.8	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	1.2	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	1.1	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	1.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	1.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.8	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.7	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.6	PID RHOA PATHWAY	RhoA signaling pathway

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	2.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	1.8	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	1.7	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	1.6	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	1.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	1.3	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	1.3	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	1.2	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	1.1	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation

Showing 1 to 10 of 53 entries

Results for Mzf1

Z-value: 0.87

Motif logo

Transcription factors associated with Mzf1

Activity-expression correlation:

Activity profile of Mzf1 motif

Sorted Z-values of Mzf1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mzf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: