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GSE58827: Dynamics of the Mouse Liver

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Results for Nfatc4

Z-value: 0.42

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Transcription factors associated with Nfatc4

Gene Symbol Gene ID Gene Info
Nfatc4
ENSMUSG00000023411.5 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.153.8e-01Click!

Activity profile of Nfatc4 motif

Sorted Z-values of Nfatc4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_20275659 3.26 ENSMUST00000011607.5
Cpb1
carboxypeptidase B1 (tissue)
chr6_-_41314700 2.53 ENSMUST00000064324.5
Try5
trypsin 5
chr11_-_53618659 0.90 ENSMUST00000000889.6
Il4
interleukin 4
chr1_-_150466165 0.75 ENSMUST00000162367.1
ENSMUST00000161611.1
ENSMUST00000161320.1
ENSMUST00000159035.1
Prg4
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr19_-_4943049 0.58 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
Peli3
pellino 3
chr8_-_84197667 0.47 ENSMUST00000181282.1
Gm26887
predicted gene, 26887
chr17_+_47726834 0.45 ENSMUST00000024782.5
ENSMUST00000144955.1
Pgc
progastricsin (pepsinogen C)
chr19_+_26623419 0.44 ENSMUST00000176584.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chrX_+_7638674 0.43 ENSMUST00000128890.1
Syp
synaptophysin
chr8_-_38661508 0.38 ENSMUST00000118896.1
Sgcz
sarcoglycan zeta
chr11_+_75468040 0.38 ENSMUST00000043598.7
ENSMUST00000108435.1
Tlcd2
TLC domain containing 2
chr13_+_24943144 0.36 ENSMUST00000021773.5
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr12_-_84450944 0.36 ENSMUST00000085192.5
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr13_-_52981027 0.35 ENSMUST00000071065.7
Nfil3
nuclear factor, interleukin 3, regulated
chr16_+_43364145 0.35 ENSMUST00000148775.1
Zbtb20
zinc finger and BTB domain containing 20
chr14_-_25927250 0.35 ENSMUST00000100811.5
Tmem254a
transmembrane protein 254a
chr14_-_25927672 0.35 ENSMUST00000185006.1
Tmem254a
transmembrane protein 254a
chr12_+_76533540 0.34 ENSMUST00000075249.4
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr19_+_8839298 0.31 ENSMUST00000160556.1
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr14_-_26067355 0.31 ENSMUST00000100819.5
Tmem254c
transmembrane protein 254c
chr10_+_23851454 0.29 ENSMUST00000020190.7
Vnn3
vanin 3
chr14_+_70555900 0.28 ENSMUST00000163060.1
Hr
hairless
chr11_-_99521258 0.27 ENSMUST00000076948.1
Krt39
keratin 39
chr11_-_99521336 0.26 ENSMUST00000107445.1
Krt39
keratin 39
chr6_-_59024470 0.25 ENSMUST00000089860.5
Fam13a
family with sequence similarity 13, member A
chr3_-_17230976 0.22 ENSMUST00000177874.1
Gm5283
predicted gene 5283
chr15_-_79932516 0.21 ENSMUST00000177044.1
ENSMUST00000109615.1
ENSMUST00000089293.4
ENSMUST00000109616.2
Cbx7
chromobox 7
chr10_+_4611971 0.20 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1
estrogen receptor 1 (alpha)
chr4_+_130107556 0.19 ENSMUST00000030563.5
Pef1
penta-EF hand domain containing 1
chr6_-_59024340 0.19 ENSMUST00000173193.1
Fam13a
family with sequence similarity 13, member A
chr9_-_13446753 0.19 ENSMUST00000167906.2
Gm17571
predicted gene, 17571
chr12_-_75416781 0.18 ENSMUST00000051079.2
Gphb5
glycoprotein hormone beta 5
chr12_+_91400990 0.18 ENSMUST00000021346.7
ENSMUST00000021343.6
Tshr
thyroid stimulating hormone receptor
chr11_-_47379405 0.18 ENSMUST00000077221.5
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr2_+_116067213 0.16 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr19_+_29101375 0.15 ENSMUST00000064393.5
Rcl1
RNA terminal phosphate cyclase-like 1
chr2_-_73660351 0.14 ENSMUST00000154258.1
Chn1
chimerin (chimaerin) 1
chr13_+_41655697 0.14 ENSMUST00000067176.8
Gm5082
predicted gene 5082
chr8_-_64205970 0.12 ENSMUST00000066166.4
Tll1
tolloid-like
chr17_-_70849644 0.12 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
Tgif1
TGFB-induced factor homeobox 1
chrX_+_48623737 0.12 ENSMUST00000114936.1
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr7_-_79920599 0.11 ENSMUST00000075657.6
Ap3s2
adaptor-related protein complex 3, sigma 2 subunit
chr4_-_148159838 0.10 ENSMUST00000151127.1
ENSMUST00000105705.2
Fbxo44
F-box protein 44
chr1_+_34005872 0.10 ENSMUST00000182296.1
Dst
dystonin
chr1_-_64121389 0.10 ENSMUST00000055001.3
Klf7
Kruppel-like factor 7 (ubiquitous)
chr11_-_35980473 0.09 ENSMUST00000018993.6
Wwc1
WW, C2 and coiled-coil domain containing 1
chr2_-_169405435 0.09 ENSMUST00000131509.1
4930529I22Rik
RIKEN cDNA 4930529I22 gene
chr13_-_56482246 0.09 ENSMUST00000022019.3
Il9
interleukin 9
chr2_+_174330006 0.08 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr18_+_42053692 0.08 ENSMUST00000074679.3
Sh3rf2
SH3 domain containing ring finger 2
chr18_-_62741387 0.08 ENSMUST00000097557.3
Spink13
serine peptidase inhibitor, Kazal type 13
chr3_+_128038694 0.08 ENSMUST00000098625.2
Gm10650
predicted gene 10650
chr3_-_37125943 0.07 ENSMUST00000029275.5
Il2
interleukin 2
chr2_+_3114220 0.07 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr1_-_56969864 0.07 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr13_+_31806627 0.07 ENSMUST00000062292.2
Foxc1
forkhead box C1
chr1_+_174430430 0.07 ENSMUST00000053178.4
Olfr414
olfactory receptor 414
chr11_+_88718442 0.07 ENSMUST00000138007.1
C030037D09Rik
RIKEN cDNA C030037D09 gene
chr8_-_67818218 0.07 ENSMUST00000059374.4
Psd3
pleckstrin and Sec7 domain containing 3
chr7_+_81114816 0.06 ENSMUST00000119083.1
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr18_+_73863672 0.06 ENSMUST00000134847.1
Mro
maestro
chr15_+_3270767 0.06 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1
selenoprotein P, plasma, 1
chr11_-_83530505 0.06 ENSMUST00000035938.2
Ccl5
chemokine (C-C motif) ligand 5
chrX_+_57099586 0.05 ENSMUST00000141936.1
Vgll1
vestigial like 1 homolog (Drosophila)
chr2_+_125136692 0.05 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr5_+_117363513 0.05 ENSMUST00000111959.1
Wsb2
WD repeat and SOCS box-containing 2
chr3_-_96594128 0.05 ENSMUST00000145001.1
ENSMUST00000091924.3
Polr3gl
polymerase (RNA) III (DNA directed) polypeptide G like
chr15_+_92051153 0.05 ENSMUST00000169825.1
Cntn1
contactin 1
chr1_-_170110491 0.05 ENSMUST00000027985.2
Ddr2
discoidin domain receptor family, member 2
chr11_-_59571813 0.05 ENSMUST00000071943.2
Olfr222
olfactory receptor 222
chr3_+_94837533 0.05 ENSMUST00000107270.2
Pogz
pogo transposable element with ZNF domain
chr7_+_81114799 0.04 ENSMUST00000026820.4
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr3_-_106001474 0.04 ENSMUST00000066319.6
Pifo
primary cilia formation
chr8_-_67818284 0.04 ENSMUST00000120071.1
Psd3
pleckstrin and Sec7 domain containing 3
chr4_+_48049080 0.04 ENSMUST00000153369.1
Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr18_+_42053648 0.03 ENSMUST00000072008.4
Sh3rf2
SH3 domain containing ring finger 2
chr9_-_35176039 0.03 ENSMUST00000119847.1
ENSMUST00000034539.5
Dcps
decapping enzyme, scavenger
chr14_+_64950037 0.03 ENSMUST00000043914.5
Ints9
integrator complex subunit 9
chr14_-_64949838 0.02 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
Hmbox1
homeobox containing 1
chr17_-_49564262 0.02 ENSMUST00000057610.6
Daam2
dishevelled associated activator of morphogenesis 2
chr2_-_165884636 0.02 ENSMUST00000177633.1
ENSMUST00000018050.7
ENSMUST00000088113.4
Zmynd8
zinc finger, MYND-type containing 8
chr8_-_41041828 0.01 ENSMUST00000051379.7
Mtus1
mitochondrial tumor suppressor 1
chr1_-_64121456 0.01 ENSMUST00000142009.1
ENSMUST00000114086.1
Klf7
Kruppel-like factor 7 (ubiquitous)
chr1_-_126830786 0.01 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr7_-_84679346 0.00 ENSMUST00000069537.2
ENSMUST00000178385.1
Zfand6
zinc finger, AN1-type domain 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 0.4 GO:0006507 GPI anchor release(GO:0006507)
0.1 0.4 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.1 0.6 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1 0.8 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.1 0.5 GO:0002760 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 0.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.2 GO:0060011 Sertoli cell proliferation(GO:0060011) prostate epithelial cord elongation(GO:0060523)
0.0 0.2 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.2 GO:1904587 response to glycoprotein(GO:1904587)
0.0 0.1 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.0 0.1 GO:0003275 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.0 0.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.0 0.1 GO:0001777 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.2 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 2.5 GO:0007586 digestion(GO:0007586)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.2 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.0 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 2.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.2 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.1 0.2 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.0 0.4 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.0 0.8 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.1 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism