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GSE58827: Dynamics of the Mouse Liver

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Results for Nfkb2

Z-value: 0.55

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Transcription factors associated with Nfkb2

Gene Symbol Gene ID Gene Info
Nfkb2
ENSMUSG00000025225.8 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46304709_463048110.483.1e-03Click!

Activity profile of Nfkb2 motif

Sorted Z-values of Nfkb2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_80000292 5.32 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr8_+_79028587 2.50 ENSMUST00000119254.1
Zfp827
zinc finger protein 827
chr19_+_7268296 2.44 ENSMUST00000066646.4
Rcor2
REST corepressor 2
chr7_-_44532064 2.12 ENSMUST00000098483.2
ENSMUST00000035323.4
Spib
Spi-B transcription factor (Spi-1/PU.1 related)
chr8_+_79028317 2.03 ENSMUST00000087927.4
ENSMUST00000098614.2
Zfp827
zinc finger protein 827
chr1_+_74791516 1.86 ENSMUST00000006718.8
Wnt10a
wingless related MMTV integration site 10a
chr1_+_135133272 1.74 ENSMUST00000167080.1
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr2_-_102451792 1.73 ENSMUST00000099678.3
Fjx1
four jointed box 1 (Drosophila)
chr7_+_30422389 1.61 ENSMUST00000108175.1
Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr11_+_101176041 1.58 ENSMUST00000103109.3
Cntnap1
contactin associated protein-like 1
chr1_+_135132693 1.51 ENSMUST00000049449.4
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr7_+_30421724 1.42 ENSMUST00000108176.1
Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr8_+_120002720 1.33 ENSMUST00000108972.3
Crispld2
cysteine-rich secretory protein LCCL domain containing 2
chr1_+_153740344 1.24 ENSMUST00000027748.7
Rgs16
regulator of G-protein signaling 16
chr3_+_97658212 1.15 ENSMUST00000045743.6
Prkab2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chrX_-_7671341 1.13 ENSMUST00000033486.5
Plp2
proteolipid protein 2
chr1_+_167001457 1.08 ENSMUST00000126198.1
Fam78b
family with sequence similarity 78, member B
chr4_+_129985098 1.02 ENSMUST00000106017.1
ENSMUST00000121049.1
Bai2
brain-specific angiogenesis inhibitor 2
chr5_+_37245792 0.98 ENSMUST00000031004.7
Crmp1
collapsin response mediator protein 1
chr1_+_34801704 0.80 ENSMUST00000047664.9
Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr4_+_100776664 0.80 ENSMUST00000030257.8
ENSMUST00000097955.2
Cachd1
cache domain containing 1
chr11_-_72037474 0.71 ENSMUST00000048207.3
Aipl1
aryl hydrocarbon receptor-interacting protein-like 1
chr11_-_33147400 0.68 ENSMUST00000020507.7
Fgf18
fibroblast growth factor 18
chr4_+_129984833 0.68 ENSMUST00000120204.1
Bai2
brain-specific angiogenesis inhibitor 2
chr11_+_70657196 0.63 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
Eno3
enolase 3, beta muscle
chr5_-_114690906 0.60 ENSMUST00000112212.1
ENSMUST00000112214.1
Gltp
glycolipid transfer protein
chr3_-_116423930 0.59 ENSMUST00000106491.2
Cdc14a
CDC14 cell division cycle 14A
chr9_+_5308828 0.56 ENSMUST00000162846.1
ENSMUST00000027012.7
Casp4
caspase 4, apoptosis-related cysteine peptidase
chr11_+_70657687 0.54 ENSMUST00000134087.1
ENSMUST00000170716.1
Eno3
enolase 3, beta muscle
chr5_+_110544326 0.54 ENSMUST00000040001.7
Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr3_-_116424007 0.54 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr4_+_150927918 0.52 ENSMUST00000139826.1
ENSMUST00000116257.1
Tnfrsf9
tumor necrosis factor receptor superfamily, member 9
chr14_-_30607808 0.51 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
Prkcd
protein kinase C, delta
chr17_-_35205305 0.50 ENSMUST00000025266.5
Lta
lymphotoxin A
chr11_+_70029742 0.47 ENSMUST00000132597.2
Dlg4
discs, large homolog 4 (Drosophila)
chr17_+_35866606 0.44 ENSMUST00000113814.4
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr1_-_63114255 0.43 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
Ino80d
INO80 complex subunit D
chr2_-_37422869 0.43 ENSMUST00000112936.1
ENSMUST00000112934.1
Rc3h2
ring finger and CCCH-type zinc finger domains 2
chrX_+_163909132 0.41 ENSMUST00000033734.7
ENSMUST00000112294.2
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr14_-_30626196 0.39 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
Prkcd
protein kinase C, delta
chr5_+_90759299 0.38 ENSMUST00000031318.4
Cxcl5
chemokine (C-X-C motif) ligand 5
chr11_+_77686155 0.37 ENSMUST00000100802.4
ENSMUST00000181023.1
Nufip2
nuclear fragile X mental retardation protein interacting protein 2
chr15_-_76918010 0.34 ENSMUST00000048854.7
Zfp647
zinc finger protein 647
chr1_-_63114516 0.33 ENSMUST00000097718.2
Ino80d
INO80 complex subunit D
chr19_-_46338632 0.33 ENSMUST00000051234.8
ENSMUST00000167861.1
Cuedc2
CUE domain containing 2
chr4_+_141088333 0.32 ENSMUST00000051907.2
Spata21
spermatogenesis associated 21
chr11_-_70656467 0.26 ENSMUST00000131642.1
Gm12319
predicted gene 12319
chr4_-_125127817 0.23 ENSMUST00000036188.7
Zc3h12a
zinc finger CCCH type containing 12A
chr16_+_32914094 0.23 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
Lrch3
leucine-rich repeats and calponin homology (CH) domain containing 3
chr2_+_102550012 0.22 ENSMUST00000028612.7
Pamr1
peptidase domain containing associated with muscle regeneration 1
chr11_-_84870812 0.21 ENSMUST00000168434.1
Ggnbp2
gametogenetin binding protein 2
chr17_+_35866056 0.19 ENSMUST00000122899.1
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr2_-_32312162 0.19 ENSMUST00000155269.1
Dnm1
dynamin 1
chr1_+_167001417 0.19 ENSMUST00000165874.1
Fam78b
family with sequence similarity 78, member B
chr7_-_126200474 0.19 ENSMUST00000168189.1
Xpo6
exportin 6
chrX_+_163908982 0.18 ENSMUST00000069041.8
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr19_+_45015198 0.13 ENSMUST00000179108.1
Lzts2
leucine zipper, putative tumor suppressor 2
chr7_-_19629355 0.12 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr11_+_102885160 0.11 ENSMUST00000100369.3
Fam187a
family with sequence similarity 187, member A
chr11_-_84870712 0.11 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
Ggnbp2
gametogenetin binding protein 2
chr7_+_3290553 0.10 ENSMUST00000096744.5
Myadm
myeloid-associated differentiation marker
chr7_-_126200413 0.09 ENSMUST00000163959.1
Xpo6
exportin 6
chr8_-_104631312 0.08 ENSMUST00000034351.6
Rrad
Ras-related associated with diabetes
chr17_-_35980197 0.08 ENSMUST00000055454.7
Prr3
proline-rich polypeptide 3
chr7_-_126200397 0.06 ENSMUST00000009344.9
Xpo6
exportin 6
chr7_+_19176416 0.06 ENSMUST00000117338.1
Eml2
echinoderm microtubule associated protein like 2
chr11_-_54962903 0.06 ENSMUST00000108885.1
ENSMUST00000102730.2
ENSMUST00000018482.6
ENSMUST00000108886.1
ENSMUST00000102731.1
Tnip1
TNFAIP3 interacting protein 1
chr9_-_107609182 0.03 ENSMUST00000102531.1
Sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr17_+_34898931 0.02 ENSMUST00000097342.3
ENSMUST00000013931.5
Ehmt2
euchromatic histone lysine N-methyltransferase 2
chr17_+_35979851 0.01 ENSMUST00000087200.3
Gnl1
guanine nucleotide binding protein-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfkb2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.3 3.0 GO:0033085 negative regulation of T cell differentiation in thymus(GO:0033085)
0.2 1.0 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.2 0.9 GO:0060697 glucosylceramide catabolic process(GO:0006680) positive regulation of phospholipid catabolic process(GO:0060697)
0.2 0.5 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.1 0.7 GO:0018343 protein farnesylation(GO:0018343)
0.1 0.5 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.1 0.7 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 1.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 1.8 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 5.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.6 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.2 GO:1990868 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.1 0.3 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 0.4 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.0 1.7 GO:0010842 retina layer formation(GO:0010842)
0.0 2.1 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.5 GO:0098953 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.4 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 1.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.6 GO:0060612 adipose tissue development(GO:0060612)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 GO:0042581 specific granule(GO:0042581)
0.1 0.6 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 1.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.6 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.9 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.0 GO:0031941 filamentous actin(GO:0031941)
0.0 1.2 GO:0072686 mitotic spindle(GO:0072686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0070976 TIR domain binding(GO:0070976)
0.1 0.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 1.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 3.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.5 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 1.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 1.1 GO:0019956 chemokine binding(GO:0019956)
0.0 0.6 GO:0050700 CARD domain binding(GO:0050700)
0.0 1.0 GO:0031005 filamin binding(GO:0031005)
0.0 1.9 GO:0005109 frizzled binding(GO:0005109)
0.0 4.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.6 GO:0051861 glycolipid binding(GO:0051861)
0.0 1.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 5.3 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.9 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.5 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.1 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 1.8 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 1.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)