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GSE58827: Dynamics of the Mouse Liver

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Results for Nkx1-1_Nkx1-2

Z-value: 0.51

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Transcription factors associated with Nkx1-1_Nkx1-2

Gene Symbol Gene ID Gene Info
Nkx1-1
ENSMUSG00000029112.5 NK1 homeobox 1
Nkx1-2
ENSMUSG00000048528.7 NK1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx1-1mm10_v2_chr5_-_33433976_334339760.231.8e-01Click!
Nkx1-2mm10_v2_chr7_-_132599637_1325996370.019.8e-01Click!

Activity profile of Nkx1-1_Nkx1-2 motif

Sorted Z-values of Nkx1-1_Nkx1-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_7966000 5.13 ENSMUST00000182102.1
ENSMUST00000075619.4
Slc22a27
solute carrier family 22, member 27
chr1_-_150466165 2.17 ENSMUST00000162367.1
ENSMUST00000161611.1
ENSMUST00000161320.1
ENSMUST00000159035.1
Prg4
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr10_+_127898515 0.93 ENSMUST00000047134.7
Sdr9c7
4short chain dehydrogenase/reductase family 9C, member 7
chr14_-_70429072 0.90 ENSMUST00000048129.4
Piwil2
piwi-like RNA-mediated gene silencing 2
chr5_+_90561102 0.85 ENSMUST00000094615.4
5830473C10Rik
RIKEN cDNA 5830473C10 gene
chr5_+_9100681 0.73 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chr11_+_43682038 0.62 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr7_-_73537621 0.55 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr11_-_99244058 0.53 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr13_+_94083490 0.52 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr6_+_37870786 0.52 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24
tripartite motif-containing 24
chr4_+_102570065 0.52 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr6_-_57535422 0.49 ENSMUST00000042766.3
Ppm1k
protein phosphatase 1K (PP2C domain containing)
chr10_-_41587753 0.48 ENSMUST00000160751.1
Ccdc162
coiled-coil domain containing 162
chr13_-_102905740 0.48 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_94372794 0.47 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr18_+_4993795 0.47 ENSMUST00000153016.1
Svil
supervillin
chr11_+_43681998 0.46 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr8_-_86580664 0.45 ENSMUST00000131423.1
ENSMUST00000152438.1
Abcc12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
chr15_+_9436028 0.44 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr1_-_91459254 0.43 ENSMUST00000069620.8
Per2
period circadian clock 2
chrX_-_60893430 0.40 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr12_-_112802646 0.37 ENSMUST00000124526.1
Ahnak2
AHNAK nucleoprotein 2
chr19_+_11965817 0.37 ENSMUST00000025590.9
Osbp
oxysterol binding protein
chr2_-_102400257 0.36 ENSMUST00000152929.1
Trim44
tripartite motif-containing 44
chr10_+_116301374 0.35 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B
chr16_+_23146536 0.34 ENSMUST00000023593.5
ENSMUST00000171309.1
Adipoq
adiponectin, C1Q and collagen domain containing
chr8_+_113635787 0.33 ENSMUST00000035777.8
Mon1b
MON1 homolog b (yeast)
chr11_-_20332654 0.33 ENSMUST00000004634.6
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_-_21371143 0.32 ENSMUST00000060895.5
Ugp2
UDP-glucose pyrophosphorylase 2
chr11_-_20332689 0.32 ENSMUST00000109594.1
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr2_-_165388245 0.32 ENSMUST00000103084.3
Zfp334
zinc finger protein 334
chr8_+_113635550 0.32 ENSMUST00000179926.1
Mon1b
MON1 homolog b (yeast)
chr14_-_59365410 0.32 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d
PHD finger protein 11D
chr2_-_69712461 0.30 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1
FAST kinase domains 1
chr14_-_59365465 0.28 ENSMUST00000095157.4
Phf11d
PHD finger protein 11D
chr17_-_34000257 0.27 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
H2-K1
histocompatibility 2, K1, K region
chr4_-_141599835 0.27 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
Fblim1
filamin binding LIM protein 1
chr11_-_99851608 0.25 ENSMUST00000107437.1
Krtap4-16
keratin associated protein 4-16
chr6_+_68161415 0.25 ENSMUST00000168090.1
Igkv1-115
immunoglobulin kappa variable 1-115
chr7_+_51880312 0.24 ENSMUST00000145049.1
Gas2
growth arrest specific 2
chr13_-_102906046 0.24 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr7_+_27195781 0.23 ENSMUST00000108379.1
ENSMUST00000179391.1
BC024978
cDNA sequence BC024978
chr2_-_37703845 0.22 ENSMUST00000155237.1
Strbp
spermatid perinuclear RNA binding protein
chrX_+_20364481 0.22 ENSMUST00000033372.6
ENSMUST00000115391.1
ENSMUST00000115387.1
Rp2h
retinitis pigmentosa 2 homolog (human)
chr8_-_3694167 0.22 ENSMUST00000005678.4
Fcer2a
Fc receptor, IgE, low affinity II, alpha polypeptide
chr11_-_100762928 0.20 ENSMUST00000107360.2
ENSMUST00000055083.3
Hcrt
hypocretin
chr3_+_121953213 0.20 ENSMUST00000037958.7
ENSMUST00000128366.1
Arhgap29
Rho GTPase activating protein 29
chr8_-_34965631 0.19 ENSMUST00000033929.4
Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr6_-_129775849 0.18 ENSMUST00000095409.2
Gm156
predicted gene 156
chr4_+_99030946 0.18 ENSMUST00000030280.6
Angptl3
angiopoietin-like 3
chrX_+_57212110 0.18 ENSMUST00000033466.1
Cd40lg
CD40 ligand
chr13_-_105054895 0.18 ENSMUST00000063551.5
Rgs7bp
regulator of G-protein signalling 7 binding protein
chr2_-_45112890 0.18 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr14_-_8666236 0.17 ENSMUST00000102996.3
4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr6_-_3399545 0.16 ENSMUST00000120087.3
Samd9l
sterile alpha motif domain containing 9-like
chrX_+_160768013 0.15 ENSMUST00000033650.7
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chr3_+_55782500 0.15 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr9_-_54661870 0.14 ENSMUST00000034822.5
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr18_+_12741324 0.14 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
Cabyr
calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
chr16_+_52031549 0.14 ENSMUST00000114471.1
Cblb
Casitas B-lineage lymphoma b
chr4_+_43493345 0.13 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107
coiled-coil domain containing 107
chr7_+_29983948 0.13 ENSMUST00000148442.1
Zfp568
zinc finger protein 568
chr5_+_103425181 0.13 ENSMUST00000048957.9
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr7_-_143460989 0.12 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c
cyclin-dependent kinase inhibitor 1C (P57)
chrX_-_74085656 0.12 ENSMUST00000033770.6
Mecp2
methyl CpG binding protein 2
chr17_+_34931253 0.11 ENSMUST00000007253.5
Neu1
neuraminidase 1
chr16_+_44765732 0.11 ENSMUST00000057488.8
Cd200r1
CD200 receptor 1
chr6_+_78380700 0.11 ENSMUST00000101272.1
Reg3a
regenerating islet-derived 3 alpha
chr17_-_57031468 0.11 ENSMUST00000007814.8
Khsrp
KH-type splicing regulatory protein
chr6_+_145615757 0.10 ENSMUST00000087445.6
Tuba3b
tubulin, alpha 3B
chrX_+_160768179 0.10 ENSMUST00000112368.2
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chrX_+_107255878 0.10 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174
G protein-coupled receptor 174
chr10_+_94575257 0.10 ENSMUST00000121471.1
Tmcc3
transmembrane and coiled coil domains 3
chr14_-_50681645 0.09 ENSMUST00000078075.4
Olfr747
olfactory receptor 747
chr7_-_19629355 0.09 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr16_-_16359016 0.09 ENSMUST00000023477.7
ENSMUST00000096229.3
ENSMUST00000115749.1
Dnm1l
dynamin 1-like
chr10_+_81137953 0.09 ENSMUST00000117956.1
Zbtb7a
zinc finger and BTB domain containing 7a
chr9_-_107872403 0.08 ENSMUST00000183035.1
Rbm6
RNA binding motif protein 6
chr15_+_41830921 0.08 ENSMUST00000166917.1
Oxr1
oxidation resistance 1
chr5_-_34660068 0.08 ENSMUST00000041364.9
Nop14
NOP14 nucleolar protein
chr9_-_97369958 0.08 ENSMUST00000035026.4
Trim42
tripartite motif-containing 42
chr11_+_99873389 0.08 ENSMUST00000093936.3
Krtap9-1
keratin associated protein 9-1
chr8_+_40354303 0.08 ENSMUST00000136835.1
Micu3
mitochondrial calcium uptake family, member 3
chr15_+_22549022 0.07 ENSMUST00000163361.1
Cdh18
cadherin 18
chr7_-_30552255 0.07 ENSMUST00000108165.1
ENSMUST00000153594.1
BC053749
cDNA sequence BC053749
chr9_-_54661666 0.07 ENSMUST00000128624.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chrX_-_74085586 0.07 ENSMUST00000123362.1
ENSMUST00000140399.1
ENSMUST00000100750.3
Mecp2
methyl CpG binding protein 2
chr6_+_145934113 0.06 ENSMUST00000032383.7
Sspn
sarcospan
chr8_+_83972951 0.06 ENSMUST00000005606.6
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
chr11_+_21572221 0.05 ENSMUST00000020568.3
ENSMUST00000131135.1
Wdpcp
WD repeat containing planar cell polarity effector
chr14_+_8666369 0.04 ENSMUST00000181914.1
ENSMUST00000180444.1
4930455B14Rik
RIKEN cDNA 4930455B14 gene
chr2_+_91265252 0.04 ENSMUST00000028691.6
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr7_+_24271568 0.04 ENSMUST00000032696.6
Zfp93
zinc finger protein 93
chr10_+_116966274 0.03 ENSMUST00000033651.3
D630029K05Rik
RIKEN cDNA D630029K05 gene
chr1_+_174501796 0.03 ENSMUST00000030039.7
Fmn2
formin 2
chr4_-_132463873 0.03 ENSMUST00000102567.3
Med18
mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
chr3_-_116423930 0.03 ENSMUST00000106491.2
Cdc14a
CDC14 cell division cycle 14A
chr6_-_52260780 0.03 ENSMUST00000114416.1
ENSMUST00000147595.3
Hoxa13
homeobox A13
chr8_-_104534630 0.03 ENSMUST00000162466.1
ENSMUST00000034349.9
Nae1
NEDD8 activating enzyme E1 subunit 1
chr17_-_63863791 0.03 ENSMUST00000050753.3
A930002H24Rik
RIKEN cDNA A930002H24 gene
chr10_+_88147061 0.03 ENSMUST00000169309.1
Nup37
nucleoporin 37
chr7_-_24724237 0.03 ENSMUST00000081657.4
Gm4763
predicted gene 4763
chr19_+_29367447 0.02 ENSMUST00000016640.7
Cd274
CD274 antigen
chr3_-_116424007 0.02 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr7_+_3645267 0.02 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr7_+_128744870 0.02 ENSMUST00000042942.8
Sec23ip
Sec23 interacting protein
chr7_-_100964371 0.02 ENSMUST00000060174.4
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr5_+_104202609 0.02 ENSMUST00000066708.5
Dmp1
dentin matrix protein 1
chr9_-_55919605 0.01 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr17_+_7170101 0.01 ENSMUST00000024575.6
Rps6ka2
ribosomal protein S6 kinase, polypeptide 2
chr5_+_138187485 0.01 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr2_-_132247747 0.01 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
Tmem230
transmembrane protein 230
chr7_+_104003259 0.00 ENSMUST00000098184.1
Olfr638
olfactory receptor 638
chr10_+_88146992 0.00 ENSMUST00000052355.7
Nup37
nucleoporin 37
chr5_-_74531619 0.00 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2
Sec1 family domain containing 2
chr12_-_4769217 0.00 ENSMUST00000053458.5
Fam228b
family with sequence similarity 228, member B

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.1 GO:0015747 urate transport(GO:0015747)
0.3 0.9 GO:0000239 pachytene(GO:0000239)
0.3 2.2 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.2 0.7 GO:0019085 early viral transcription(GO:0019085)
0.2 0.7 GO:0015825 L-serine transport(GO:0015825)
0.1 0.4 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.1 0.3 GO:2000583 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.3 GO:0019255 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.2 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 0.3 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.2 GO:1901608 dense core granule localization(GO:0032253) positive regulation of histone H3-K9 trimethylation(GO:1900114) regulation of vesicle transport along microtubule(GO:1901608) dense core granule transport(GO:1901950) regulation of dense core granule transport(GO:1904809) positive regulation of dense core granule transport(GO:1904811)
0.1 0.2 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.1 0.3 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.0 0.5 GO:0072615 interleukin-17 secretion(GO:0072615)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.2 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.0 0.1 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.2 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0 0.6 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.4 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.0 0.1 GO:0009313 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.0 0.4 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.0 GO:0070649 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:1990923 PET complex(GO:1990923)
0.1 0.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.2 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.1 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 0.9 GO:0034584 piRNA binding(GO:0034584)
0.1 0.5 GO:0008142 oxysterol binding(GO:0008142)
0.1 2.2 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.5 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.7 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.9 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0019863 IgE binding(GO:0019863)
0.0 0.4 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.3 GO:0070569 pyrimidine ribonucleotide binding(GO:0032557) uridylyltransferase activity(GO:0070569)
0.0 0.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.3 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0016997 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions