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GSE58827: Dynamics of the Mouse Liver

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Results for Nkx2-5

Z-value: 1.21

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Transcription factors associated with Nkx2-5

Gene Symbol Gene ID Gene Info
Nkx2-5
ENSMUSG00000015579.4 NK2 homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-5mm10_v2_chr17_-_26841565_268415910.363.3e-02Click!

Activity profile of Nkx2-5 motif

Sorted Z-values of Nkx2-5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_30639218 19.30 ENSMUST00000031806.9
Cpa1
carboxypeptidase A1, pancreatic
chr6_+_41521782 18.69 ENSMUST00000070380.4
Prss2
protease, serine, 2
chr6_+_41302265 16.90 ENSMUST00000031913.4
Try4
trypsin 4
chr6_+_30541582 11.26 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr4_-_137409777 9.93 ENSMUST00000024200.6
Gm13011
predicted gene 13011
chr4_-_141846277 8.43 ENSMUST00000105781.1
Ctrc
chymotrypsin C (caldecrin)
chr6_-_136922169 5.89 ENSMUST00000032343.6
Erp27
endoplasmic reticulum protein 27
chr4_-_4138432 4.05 ENSMUST00000070375.7
Penk
preproenkephalin
chr14_+_80000292 3.06 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr17_+_47726834 2.92 ENSMUST00000024782.5
ENSMUST00000144955.1
Pgc
progastricsin (pepsinogen C)
chr6_+_72304592 2.35 ENSMUST00000183018.1
Sftpb
surfactant associated protein B
chr1_-_170927540 1.65 ENSMUST00000162136.1
ENSMUST00000162887.1
Fcrla
Fc receptor-like A
chr1_-_170927567 1.59 ENSMUST00000046322.7
ENSMUST00000159171.1
Fcrla
Fc receptor-like A
chr11_+_115974709 1.26 ENSMUST00000021107.7
ENSMUST00000106461.1
ENSMUST00000169928.1
Itgb4
integrin beta 4
chr3_-_106024911 1.15 ENSMUST00000066537.3
ENSMUST00000054973.3
Chi3l7
chitinase 3-like 7
chr1_+_74278550 1.14 ENSMUST00000077985.3
Gpbar1
G protein-coupled bile acid receptor 1
chr14_+_41131777 1.10 ENSMUST00000022314.3
ENSMUST00000170719.1
Sftpa1
surfactant associated protein A1
chr1_-_75133866 0.91 ENSMUST00000027405.4
Slc23a3
solute carrier family 23 (nucleobase transporters), member 3
chr9_+_57940104 0.83 ENSMUST00000043059.7
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr8_+_72761868 0.83 ENSMUST00000058099.8
F2rl3
coagulation factor II (thrombin) receptor-like 3
chr15_-_82224330 0.75 ENSMUST00000089161.2
ENSMUST00000109535.2
Tnfrsf13c
tumor necrosis factor receptor superfamily, member 13c
chr15_-_98778150 0.73 ENSMUST00000023732.5
Wnt10b
wingless related MMTV integration site 10b
chr6_-_5193817 0.70 ENSMUST00000002663.5
Pon1
paraoxonase 1
chr15_-_99457712 0.64 ENSMUST00000161948.1
Nckap5l
NCK-associated protein 5-like
chr15_+_99591028 0.59 ENSMUST00000169082.1
Aqp5
aquaporin 5
chr9_+_54917252 0.57 ENSMUST00000039742.7
Hykk
hydroxylysine kinase 1
chr11_-_98018308 0.56 ENSMUST00000107561.2
Cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr4_+_103619580 0.54 ENSMUST00000106827.1
Dab1
disabled 1
chr4_+_119637704 0.54 ENSMUST00000024015.2
Guca2a
guanylate cyclase activator 2a (guanylin)
chr8_+_113643206 0.53 ENSMUST00000034219.4
ENSMUST00000095173.1
Syce1l
synaptonemal complex central element protein 1 like
chr3_+_52268337 0.52 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr18_-_68429235 0.52 ENSMUST00000052347.6
Mc2r
melanocortin 2 receptor
chr6_+_72304625 0.51 ENSMUST00000070437.8
Sftpb
surfactant associated protein B
chr11_+_67171095 0.51 ENSMUST00000018641.7
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr14_+_51893610 0.50 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2
solute carrier family 39 (zinc transporter), member 2
chr16_+_44943678 0.48 ENSMUST00000114613.2
ENSMUST00000114612.1
ENSMUST00000077178.6
ENSMUST00000048479.7
ENSMUST00000114611.3
ENSMUST00000164007.1
ENSMUST00000171779.1
Cd200r3
CD200 receptor 3
chr5_+_128601106 0.47 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chr14_+_20674311 0.47 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr2_-_127270032 0.47 ENSMUST00000099407.1
Gm10766
predicted gene 10766
chr11_+_67171027 0.46 ENSMUST00000170159.1
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr2_+_148395369 0.44 ENSMUST00000109962.2
ENSMUST00000047292.2
Sstr4
somatostatin receptor 4
chr14_+_21500879 0.43 ENSMUST00000182964.1
Kat6b
K(lysine) acetyltransferase 6B
chr6_+_115853470 0.42 ENSMUST00000112925.1
ENSMUST00000112923.1
ENSMUST00000038234.6
Ift122
intraflagellar transport 122
chr5_-_8997324 0.42 ENSMUST00000003720.4
Crot
carnitine O-octanoyltransferase
chr12_+_4082596 0.41 ENSMUST00000049584.5
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr11_+_101987050 0.41 ENSMUST00000010985.7
1700006E09Rik
RIKEN cDNA 1700006E09 gene
chr18_-_31949571 0.37 ENSMUST00000064016.5
Gpr17
G protein-coupled receptor 17
chr7_+_29170204 0.36 ENSMUST00000098609.2
Ggn
gametogenetin
chr8_+_124793061 0.35 ENSMUST00000041106.7
Trim67
tripartite motif-containing 67
chr2_+_174076296 0.35 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16
syntaxin 16
chr2_+_32288317 0.35 ENSMUST00000131712.1
ENSMUST00000133113.1
ENSMUST00000081670.6
ENSMUST00000147707.1
ENSMUST00000129193.1
Golga2
golgi autoantigen, golgin subfamily a, 2
chr15_-_79328154 0.35 ENSMUST00000166977.2
Pla2g6
phospholipase A2, group VI
chr9_-_44526397 0.34 ENSMUST00000062215.7
Cxcr5
chemokine (C-X-C motif) receptor 5
chrX_+_114474312 0.34 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4
kelch-like 4
chrX_-_75416533 0.32 ENSMUST00000033542.4
Mtcp1
mature T cell proliferation 1
chr16_-_44139630 0.32 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr7_-_4844665 0.32 ENSMUST00000066041.5
ENSMUST00000172377.1
Shisa7
shisa homolog 7 (Xenopus laevis)
chr18_+_49832622 0.32 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr12_+_91400990 0.32 ENSMUST00000021346.7
ENSMUST00000021343.6
Tshr
thyroid stimulating hormone receptor
chr15_-_54919961 0.31 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr5_-_124327812 0.30 ENSMUST00000184951.1
Mphosph9
M-phase phosphoprotein 9
chr18_-_79109391 0.30 ENSMUST00000025430.8
ENSMUST00000161465.2
Setbp1
SET binding protein 1
chr15_-_99457742 0.30 ENSMUST00000023747.7
Nckap5l
NCK-associated protein 5-like
chr19_-_57360668 0.29 ENSMUST00000181921.1
B230217O12Rik
RIKEN cDNA B230217O12 gene
chr4_-_41275091 0.28 ENSMUST00000030143.6
ENSMUST00000108068.1
Ubap2
ubiquitin-associated protein 2
chrX_+_114474509 0.26 ENSMUST00000113370.2
Klhl4
kelch-like 4
chr14_+_51129055 0.25 ENSMUST00000095923.3
Rnase6
ribonuclease, RNase A family, 6
chr2_-_173276144 0.25 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr2_+_32608704 0.25 ENSMUST00000129165.1
St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr4_+_137594140 0.24 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
Usp48
ubiquitin specific peptidase 48
chr13_+_30136529 0.23 ENSMUST00000152798.1
Mboat1
membrane bound O-acyltransferase domain containing 1
chr6_-_101377342 0.22 ENSMUST00000151175.1
Pdzrn3
PDZ domain containing RING finger 3
chr11_+_69655314 0.21 ENSMUST00000047373.5
Sox15
SRY-box containing gene 15
chr2_-_5942740 0.21 ENSMUST00000026924.5
ENSMUST00000095147.2
ENSMUST00000169865.1
Dhtkd1
dehydrogenase E1 and transketolase domain containing 1
chr4_-_87806276 0.20 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_-_86359455 0.20 ENSMUST00000027438.6
Ncl
nucleolin
chr2_+_23069210 0.20 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr15_-_79328201 0.19 ENSMUST00000173163.1
ENSMUST00000047816.8
ENSMUST00000172403.2
ENSMUST00000173632.1
Pla2g6
phospholipase A2, group VI
chr1_-_66817536 0.19 ENSMUST00000068168.3
ENSMUST00000113987.1
Kansl1l
KAT8 regulatory NSL complex subunit 1-like
chr15_-_54920115 0.19 ENSMUST00000171545.1
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr5_-_124327883 0.18 ENSMUST00000031344.6
Mphosph9
M-phase phosphoprotein 9
chr4_-_126968124 0.16 ENSMUST00000106108.2
Zmym4
zinc finger, MYM-type 4
chr11_+_64435315 0.16 ENSMUST00000058652.5
Hs3st3a1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chrX_-_111463149 0.16 ENSMUST00000096348.3
ENSMUST00000113428.2
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr14_-_7994563 0.16 ENSMUST00000026315.7
Dnase1l3
deoxyribonuclease 1-like 3
chr7_+_128246953 0.15 ENSMUST00000167965.1
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr6_-_115853346 0.14 ENSMUST00000032469.6
Mbd4
methyl-CpG binding domain protein 4
chr12_+_4082574 0.14 ENSMUST00000020986.7
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr19_-_47171134 0.13 ENSMUST00000169692.1
Gm6970
predicted gene 6970
chr6_+_127577963 0.12 ENSMUST00000071563.4
Efcab4b
EF-hand calcium binding domain 4B
chr11_+_87566653 0.10 ENSMUST00000060360.5
Gm11492
predicted gene 11492
chr5_+_90561102 0.10 ENSMUST00000094615.4
5830473C10Rik
RIKEN cDNA 5830473C10 gene
chr18_-_15063560 0.10 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr7_+_29170345 0.06 ENSMUST00000033886.7
Ggn
gametogenetin
chr14_-_63271682 0.06 ENSMUST00000132122.1
Gata4
GATA binding protein 4
chr4_+_85205120 0.06 ENSMUST00000107188.3
Sh3gl2
SH3-domain GRB2-like 2
chr9_+_106170918 0.06 ENSMUST00000020490.5
Wdr82
WD repeat domain containing 82
chr13_+_30136498 0.04 ENSMUST00000047311.8
Mboat1
membrane bound O-acyltransferase domain containing 1
chr3_-_153725062 0.04 ENSMUST00000064460.5
St6galnac3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr15_+_76351303 0.03 ENSMUST00000023212.8
ENSMUST00000160172.1
Maf1
MAF1 homolog (S. cerevisiae)
chr7_+_128246812 0.02 ENSMUST00000164710.1
ENSMUST00000070656.5
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr4_-_87806296 0.01 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr11_-_101987004 0.01 ENSMUST00000107173.2
ENSMUST00000107172.1
Dusp3
dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
chrX_-_75416562 0.01 ENSMUST00000033543.7
ENSMUST00000149863.2
ENSMUST00000114081.1
Mtcp1
Mtcp1
mature T cell proliferation 1
mature T cell proliferation 1
chr9_-_120023558 0.00 ENSMUST00000111635.2
Xirp1
xin actin-binding repeat containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 18.7 GO:0031000 response to caffeine(GO:0031000)
0.7 4.0 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.6 2.9 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2 0.7 GO:1902617 response to fluoride(GO:1902617)
0.2 0.8 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.2 0.8 GO:0031296 B cell costimulation(GO:0031296)
0.2 0.5 GO:0045204 MAPK export from nucleus(GO:0045204)
0.2 0.7 GO:0071374 positive regulation of anagen(GO:0051885) cellular response to parathyroid hormone stimulus(GO:0071374)
0.2 0.5 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 1.1 GO:0008228 opsonization(GO:0008228)
0.1 17.1 GO:0007586 digestion(GO:0007586)
0.1 1.3 GO:0035878 nail development(GO:0035878)
0.1 0.4 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 0.5 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1 0.2 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) myoblast development(GO:0048627)
0.1 0.5 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 1.0 GO:0001778 plasma membrane repair(GO:0001778)
0.1 1.1 GO:2000810 regulation of bicellular tight junction assembly(GO:2000810)
0.1 3.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.3 GO:1904587 response to glycoprotein(GO:1904587)
0.1 0.5 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.1 0.8 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.3 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
0.0 0.5 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324)
0.0 2.9 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.4 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.4 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.3 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.4 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:2000232 regulation of rRNA processing(GO:2000232)
0.0 0.1 GO:0061026 septum secundum development(GO:0003285) cardiac muscle tissue regeneration(GO:0061026) negative regulation of connective tissue replacement(GO:1905204)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 36.0 GO:0006508 proteolysis(GO:0006508)
0.0 0.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.2 GO:0010623 apoptotic DNA fragmentation(GO:0006309) programmed cell death involved in cell development(GO:0010623)
0.0 0.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.3 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.4 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.5 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0032280 symmetric synapse(GO:0032280)
0.2 2.9 GO:0097208 alveolar lamellar body(GO:0097208)
0.2 2.9 GO:0042581 specific granule(GO:0042581)
0.1 1.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 1.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 69.2 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:0001651 dense fibrillar component(GO:0001651)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.9 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 30.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.6 4.0 GO:0001515 opioid peptide activity(GO:0001515)
0.2 0.7 GO:0004063 aryldialkylphosphatase activity(GO:0004063)
0.2 1.1 GO:0038181 bile acid receptor activity(GO:0038181)
0.2 43.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 0.8 GO:0015057 thrombin receptor activity(GO:0015057)
0.2 1.3 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.5 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.1 2.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 0.4 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 0.5 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 0.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.4 GO:0016406 carnitine O-acyltransferase activity(GO:0016406)
0.0 0.6 GO:0015250 water channel activity(GO:0015250)
0.0 0.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 0.3 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.1 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 18.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 3.5 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 18.7 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 5.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.8 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.1 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.1 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)