Project

GSE58827: Dynamics of the Mouse Liver

Navigation
Downloads

Results for Nkx2-6

Z-value: 0.58

Motif logo

logo of

Transcription factors associated with Nkx2-6

Gene Symbol Gene ID Gene Info
Nkx2-6
ENSMUSG00000044186.9 NK2 homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-6mm10_v2_chr14_+_69171576_69171576-0.889.3e-13Click!

Activity profile of Nkx2-6 motif

Sorted Z-values of Nkx2-6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_41704339 13.72 ENSMUST00000031899.8
Kel
Kell blood group
chr14_-_20269162 12.08 ENSMUST00000024155.7
Kcnk16
potassium channel, subfamily K, member 16
chr15_+_73723131 3.95 ENSMUST00000165541.1
ENSMUST00000167582.1
Ptp4a3
protein tyrosine phosphatase 4a3
chr7_-_116031047 2.38 ENSMUST00000106612.1
Sox6
SRY-box containing gene 6
chr2_-_119229885 1.69 ENSMUST00000076084.5
Ppp1r14d
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr19_+_8802486 1.60 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr5_+_110330697 1.31 ENSMUST00000112481.1
Pole
polymerase (DNA directed), epsilon
chr2_-_119229849 1.13 ENSMUST00000110820.2
Ppp1r14d
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr10_+_100488289 1.00 ENSMUST00000164751.1
Cep290
centrosomal protein 290
chr12_-_108702265 0.83 ENSMUST00000167978.1
ENSMUST00000021691.4
Degs2
degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase
chr15_-_78773452 0.74 ENSMUST00000018313.5
Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr13_+_22087878 0.71 ENSMUST00000091739.1
Vmn1r188
vomeronasal 1 receptor 188
chr2_+_3114220 0.46 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr4_-_109665249 0.41 ENSMUST00000063531.4
Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chrX_+_107149580 0.32 ENSMUST00000137107.1
ENSMUST00000067249.2
A630033H20Rik
RIKEN cDNA A630033H20 gene
chr1_+_179961110 0.29 ENSMUST00000076687.5
ENSMUST00000097450.3
Cdc42bpa
CDC42 binding protein kinase alpha
chr7_-_116237767 0.25 ENSMUST00000182834.1
Plekha7
pleckstrin homology domain containing, family A member 7
chrX_+_107149454 0.23 ENSMUST00000125676.1
ENSMUST00000180182.1
A630033H20Rik
RIKEN cDNA A630033H20 gene
chr14_-_73049107 0.14 ENSMUST00000044664.4
ENSMUST00000169168.1
Cysltr2
cysteinyl leukotriene receptor 2
chr19_+_8819401 0.10 ENSMUST00000096753.3
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr1_+_179960472 0.07 ENSMUST00000097453.2
ENSMUST00000111117.1
Cdc42bpa
CDC42 binding protein kinase alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 13.7 GO:0031133 regulation of axon diameter(GO:0031133)
0.8 12.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.4 1.3 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 0.8 GO:0006667 sphinganine metabolic process(GO:0006667)
0.3 3.9 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.2 2.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.7 GO:0019236 response to pheromone(GO:0019236)
0.0 1.0 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 2.8 GO:0035304 regulation of protein dephosphorylation(GO:0035304)
0.0 0.4 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.4 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.0 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 12.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 0.7 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 0.8 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.2 1.3 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 13.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.7 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 3.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 12.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.3 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes