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GSE58827: Dynamics of the Mouse Liver

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Results for Nkx3-1

Z-value: 1.88

Motif logo

Transcription factors associated with Nkx3-1

Gene Symbol Gene ID Gene Info
ENSMUSG00000022061.8 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx3-1mm10_v2_chr14_+_69190638_691906910.241.6e-01Click!

Activity profile of Nkx3-1 motif

Sorted Z-values of Nkx3-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_58759700 36.56 ENSMUST00000026081.3
pancreatic lipase-related protein 2
chr4_-_137430517 34.02 ENSMUST00000102522.4
chymotrypsin-like elastase family, member 3B
chr6_+_78425973 28.66 ENSMUST00000079926.5
regenerating islet-derived 1
chr4_-_137409777 27.21 ENSMUST00000024200.6
predicted gene 13011
chr6_-_41035501 23.53 ENSMUST00000031931.5
RIKEN cDNA 2210010C04 gene
chr3_-_113324052 21.76 ENSMUST00000179314.1
amylase 2a3
chr3_-_113258837 19.26 ENSMUST00000098673.3
amylase 2a5
chr3_-_113291449 18.13 ENSMUST00000179568.1
amylase 2a4
chr3_-_113532288 16.52 ENSMUST00000132353.1
amylase 2a1
chr3_-_113356658 15.91 ENSMUST00000098667.3
amylase 2a2
chr5_-_145805862 8.33 ENSMUST00000067479.5
cytochrome P450, family 3, subfamily a, polypeptide 44
chr4_-_115496129 7.96 ENSMUST00000030487.2
cytochrome P450, family 4, subfamily a, polypeptide 14
chr5_-_145720124 7.51 ENSMUST00000094111.4
cytochrome P450, family 3, subfamily a, polypeptide 41A
chr5_-_145584723 7.15 ENSMUST00000075837.6
cytochrome P450, family 3, subfamily a, polypeptide 41B
chr6_-_69284319 5.88 ENSMUST00000103349.1
immunoglobulin kappa variable 4-69
chrX_+_7919816 5.01 ENSMUST00000041096.3
proprotein convertase subtilisin/kexin type 1 inhibitor
chr6_-_129913166 4.31 ENSMUST00000169901.2
ENSMUST00000167079.2
ENSMUST00000014683.6
killer cell lectin-like receptor, subfamily A, member 5
chr6_-_83527773 4.20 ENSMUST00000152029.1
actin, gamma 2, smooth muscle, enteric
chr6_-_83527986 4.19 ENSMUST00000121731.1
actin, gamma 2, smooth muscle, enteric
chr6_-_83527452 4.12 ENSMUST00000141904.1
actin, gamma 2, smooth muscle, enteric
chr4_-_140774196 3.58 ENSMUST00000026381.6
peptidyl arginine deiminase, type IV
chr11_+_69098937 3.03 ENSMUST00000021271.7
period circadian clock 1
chr14_+_53709902 2.60 ENSMUST00000103638.4
T cell receptor alpha variable 6-7-DV9
chr16_+_87553313 2.51 ENSMUST00000026700.7
Map3k7 C-terminal like
chr15_-_74983430 2.38 ENSMUST00000023250.4
ENSMUST00000166694.1
lymphocyte antigen 6 complex, locus I
chr18_+_60963517 2.32 ENSMUST00000115295.2
ENSMUST00000039904.6
calcium/calmodulin-dependent protein kinase II alpha
chrX_+_164438039 2.30 ENSMUST00000033755.5
ankyrin repeat and SOCS box-containing 11
chr6_+_86078070 2.27 ENSMUST00000032069.5
adducin 2 (beta)
chr15_-_75238768 2.21 ENSMUST00000089689.3
predicted pseudogene 10238
chr11_-_58613481 2.17 ENSMUST00000048801.7
RIKEN cDNA 2210407C18 gene
chr1_+_139501692 2.16 ENSMUST00000027615.5
coagulation factor XIII, beta subunit
chr16_+_32756336 2.14 ENSMUST00000135753.1
mucin 4
chr12_-_100899436 1.97 ENSMUST00000053668.3
G protein-coupled receptor 68
chr15_-_75111684 1.82 ENSMUST00000100542.3
lymphocyte antigen 6 complex, locus C2
chr1_+_171155512 1.72 ENSMUST00000111334.1
myelin protein zero
chr13_-_41828418 1.61 ENSMUST00000137905.1
androgen dependent TFPI regulating protein
chr3_+_62419668 1.59 ENSMUST00000161057.1
Rho guanine nucleotide exchange factor (GEF) 26
chr9_+_72438519 1.49 ENSMUST00000184604.1
meiosis-specific nuclear structural protein 1
chr1_-_175688353 1.44 ENSMUST00000104984.1
choroideremia-like
chr13_+_4436094 1.44 ENSMUST00000156277.1
aldo-keto reductase family 1, member C6
chr13_-_41847599 1.43 ENSMUST00000179758.1
androgen dependent TFPI regulating protein
chr1_-_163289214 1.40 ENSMUST00000183691.1
paired related homeobox 1
chr3_-_20242173 1.39 ENSMUST00000001921.1
carboxypeptidase A3, mast cell
chr1_-_52953179 1.36 ENSMUST00000114492.1
RIKEN cDNA 1700019D03 gene
chrX_+_56454871 1.35 ENSMUST00000039374.2
ENSMUST00000101553.2
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr6_-_130231638 1.26 ENSMUST00000088011.4
ENSMUST00000112013.1
ENSMUST00000049304.7
killer cell lectin-like receptor, subfamily A, member 7
chr11_-_99155067 1.23 ENSMUST00000103134.3
chemokine (C-C motif) receptor 7
chr15_-_75048837 1.22 ENSMUST00000179762.1
ENSMUST00000065408.9
lymphocyte antigen 6 complex, locus C1
chr13_-_41847482 1.19 ENSMUST00000072012.3
androgen dependent TFPI regulating protein
chr2_+_84734050 1.14 ENSMUST00000090729.2
yippee-like 4 (Drosophila)
chr8_+_47824459 1.12 ENSMUST00000038693.6
claudin 22
chr3_-_64287417 1.12 ENSMUST00000170244.1
ENSMUST00000176328.1
vomeronasal 2, receptor 3
chr1_+_171503410 1.11 ENSMUST00000081527.1
Aly/REF export factor 2
chr14_+_41131777 1.10 ENSMUST00000022314.3
ENSMUST00000170719.1
surfactant associated protein A1
chr2_-_93849679 1.09 ENSMUST00000068513.4
ENSMUST00000041593.8
ENSMUST00000130077.1
1-aminocyclopropane-1-carboxylate synthase (non-functional)
chr13_+_51408618 1.06 ENSMUST00000087978.3
sphingosine-1-phosphate receptor 3
chr17_+_35135196 1.03 ENSMUST00000172571.1
ENSMUST00000173491.1
BCL2-associated athanogene 6
chr11_+_46055973 1.02 ENSMUST00000011400.7
a disintegrin and metallopeptidase domain 19 (meltrin beta)
chrX_+_100625737 1.01 ENSMUST00000048962.3
kinesin family member 4
chr5_-_110046486 1.00 ENSMUST00000167969.1
predicted gene, 17655
chr1_-_174921813 0.99 ENSMUST00000055294.3
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr10_-_13324160 0.99 ENSMUST00000105545.4
phosphatase and actin regulator 2
chr17_-_25727364 0.96 ENSMUST00000170070.1
ENSMUST00000048054.7
CTF18, chromosome transmission fidelity factor 18
chr17_+_56304313 0.95 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
ubiquitin-like, containing PHD and RING finger domains, 1
chr10_-_59441748 0.94 ENSMUST00000009798.4
oncoprotein induced transcript 3
chr12_-_78983476 0.93 ENSMUST00000070174.7
transmembrane protein 229B
chrX_+_157699113 0.92 ENSMUST00000112521.1
small muscle protein, X-linked
chr18_-_6241470 0.89 ENSMUST00000163210.1
kinesin family member 5B
chr1_+_66364623 0.89 ENSMUST00000077355.5
ENSMUST00000114012.1
microtubule-associated protein 2
chr2_+_25403044 0.88 ENSMUST00000071442.5
neural proliferation, differentiation and control 1
chr12_+_52516077 0.88 ENSMUST00000110725.1
Rho GTPase activating protein 5
chr18_-_6241486 0.87 ENSMUST00000025083.7
kinesin family member 5B
chr6_-_124857707 0.87 ENSMUST00000023958.3
leprecan-like 2
chr10_-_128211788 0.86 ENSMUST00000061995.8
SPRY domain containing 4
chr5_-_86676346 0.82 ENSMUST00000038448.6
transmembrane protease, serine 11b N terminal like
chr9_+_89199209 0.82 ENSMUST00000068569.4
B cell leukemia/lymphoma 2 related protein A1b
chr10_-_13324250 0.81 ENSMUST00000105543.1
phosphatase and actin regulator 2
chr6_-_145434925 0.81 ENSMUST00000111708.2
intermediate filament tail domain containing 1
chr1_+_135799833 0.78 ENSMUST00000148201.1
troponin I, skeletal, slow 1
chr7_-_63938862 0.78 ENSMUST00000063694.8
Kruppel-like factor 13
chr3_-_127408937 0.78 ENSMUST00000183095.1
ENSMUST00000182610.1
ankyrin 2, brain
chr11_-_121519326 0.77 ENSMUST00000092298.5
zinc finger protein 750
chr16_-_48771956 0.77 ENSMUST00000170861.1
T cell receptor associated transmembrane adaptor 1
chr14_-_43923368 0.77 ENSMUST00000163652.1
eosinophil-associated, ribonuclease A family, member 10
chr14_-_73049107 0.75 ENSMUST00000044664.4
ENSMUST00000169168.1
cysteinyl leukotriene receptor 2
chr9_-_103222063 0.70 ENSMUST00000170904.1
transferrin
chr19_+_4711153 0.70 ENSMUST00000008991.6
spectrin beta, non-erythrocytic 2
chr8_-_106011422 0.68 ENSMUST00000058579.5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr3_-_127409014 0.68 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
ankyrin 2, brain
chr17_+_35135174 0.68 ENSMUST00000166426.2
ENSMUST00000025250.7
BCL2-associated athanogene 6
chr9_+_77921908 0.64 ENSMUST00000133757.1
ELOVL family member 5, elongation of long chain fatty acids (yeast)
chr5_+_32247351 0.64 ENSMUST00000101376.2
phospholipase B1
chr3_-_127408986 0.64 ENSMUST00000182588.1
ENSMUST00000182959.1
ENSMUST00000182452.1
ankyrin 2, brain
chr2_+_25403128 0.63 ENSMUST00000154809.1
ENSMUST00000055921.7
ENSMUST00000141567.1
neural proliferation, differentiation and control 1
chr9_-_43116514 0.63 ENSMUST00000061833.4
transmembrane protein 136
chr9_-_62537036 0.63 ENSMUST00000048043.5
coronin, actin binding protein, 2B
chr1_-_173766876 0.62 ENSMUST00000111214.2
interferon activated gene 204
chr3_-_104818539 0.61 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
Moloney leukemia virus 10
chr9_-_18512885 0.61 ENSMUST00000034653.6
mucin 16
chr1_-_133907053 0.58 ENSMUST00000149380.1
ENSMUST00000124051.2
opticin
chr6_+_128362919 0.58 ENSMUST00000073316.6
forkhead box M1
chr17_-_65772686 0.57 ENSMUST00000070673.7
RAB31, member RAS oncogene family
chr8_-_69791170 0.56 ENSMUST00000131784.1
zinc finger protein 866
chr3_+_57425314 0.53 ENSMUST00000029377.7
transmembrane 4 superfamily member 4
chr1_-_173741717 0.53 ENSMUST00000127730.1
expressed sequence AI607873
chr11_+_118443471 0.52 ENSMUST00000133558.1
C1q and tumor necrosis factor related protein 1
chr1_+_152954966 0.50 ENSMUST00000043313.8
nicotinamide nucleotide adenylyltransferase 2
chr2_+_23069210 0.49 ENSMUST00000155602.1
acyl-Coenzyme A binding domain containing 5
chr4_-_108217897 0.49 ENSMUST00000106690.1
ENSMUST00000043793.6
zyg-11 family member A, cell cycle regulator
chr10_-_60752773 0.48 ENSMUST00000117513.1
ENSMUST00000119595.1
solute carrier family 29 (nucleoside transporters), member 3
chrX_-_101222426 0.47 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
sorting nexin 12
chr19_-_17356631 0.46 ENSMUST00000174236.1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_-_193035651 0.46 ENSMUST00000016344.7
synaptotagmin XIV
chr4_+_116708571 0.45 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
coiled-coil domain containing 163
chr3_-_101029543 0.45 ENSMUST00000147399.2
CD101 antigen
chr18_+_82910863 0.44 ENSMUST00000171238.1
zinc finger protein 516
chrX_+_8843994 0.43 ENSMUST00000115563.1
predicted gene 6592
chr19_-_59943000 0.43 ENSMUST00000170819.1
RAB11 family interacting protein 2 (class I)
chr2_-_27142429 0.41 ENSMUST00000151224.2
family with sequence similarity 163, member B
chr5_-_38491948 0.39 ENSMUST00000129099.1
solute carrier family 2 (facilitated glucose transporter), member 9
chr1_-_133906973 0.39 ENSMUST00000126123.1
opticin
chr3_-_127409044 0.38 ENSMUST00000182704.1
ankyrin 2, brain
chr8_+_69791163 0.37 ENSMUST00000034326.6
ATPase type 13A1
chr13_+_80886095 0.37 ENSMUST00000161441.1
arrestin domain containing 3
chr14_-_55788810 0.36 ENSMUST00000022830.6
ENSMUST00000168716.1
ENSMUST00000178399.1
receptor-interacting serine-threonine kinase 3
chr14_+_61309753 0.33 ENSMUST00000055159.7
ADP-ribosylation factor-like 11
chr15_+_75268379 0.32 ENSMUST00000023247.6
lymphocyte antigen 6 complex, locus F
chr9_+_72438534 0.32 ENSMUST00000034746.8
meiosis-specific nuclear structural protein 1
chr17_+_38145393 0.32 ENSMUST00000173610.1
olfactory receptor 133
chr6_-_108185552 0.32 ENSMUST00000167338.1
ENSMUST00000172188.1
ENSMUST00000032191.9
sulfatase modifying factor 1
chr11_-_61378306 0.31 ENSMUST00000148671.1
solute carrier family 47, member 1
chr5_+_66968416 0.31 ENSMUST00000038188.7
LIM and calponin homology domains 1
chr2_+_174076296 0.30 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
syntaxin 16
chr4_-_129378116 0.30 ENSMUST00000030610.2
zinc finger and BTB domain containing 8a
chr2_+_3114220 0.30 ENSMUST00000072955.5
family with sequence similarity 171, member A1
chr10_+_5639210 0.29 ENSMUST00000019906.4
vasoactive intestinal polypeptide
chr6_+_145953429 0.29 ENSMUST00000111701.1
sarcospan
chr14_-_52213379 0.28 ENSMUST00000140603.1
chromodomain helicase DNA binding protein 8
chr1_+_106980979 0.24 ENSMUST00000027564.1
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
chr4_-_99654983 0.24 ENSMUST00000136525.1
predicted gene 12688
chr12_-_52028063 0.24 ENSMUST00000040161.4
G protein-coupled receptor 33
chr11_-_106193511 0.24 ENSMUST00000007444.7
ENSMUST00000152008.1
ENSMUST00000103072.3
ENSMUST00000106867.1
STE20-related kinase adaptor alpha
chr7_+_75455534 0.24 ENSMUST00000147005.1
ENSMUST00000166315.1
A kinase (PRKA) anchor protein 13
chr2_-_149017237 0.22 ENSMUST00000099266.2
predicted gene 10750
chr19_-_61297069 0.21 ENSMUST00000179346.1
predicted gene, 21060
chr11_-_17008647 0.19 ENSMUST00000102881.3
pleckstrin
chr1_+_157506728 0.19 ENSMUST00000086130.2
SEC16 homolog B (S. cerevisiae)
chrY_-_38800793 0.18 ENSMUST00000180177.1
predicted gene, 20901
chr1_+_157506777 0.18 ENSMUST00000027881.8
SEC16 homolog B (S. cerevisiae)
chr1_-_86111970 0.17 ENSMUST00000027431.6
5-hydroxytryptamine (serotonin) receptor 2B
chr7_+_58658181 0.17 ENSMUST00000168747.1
ATPase, class V, type 10A
chr11_-_21370452 0.15 ENSMUST00000102875.4
UDP-glucose pyrophosphorylase 2
chr12_+_59095653 0.14 ENSMUST00000021384.4
melanoma inhibitory activity 2
chr10_+_69219357 0.14 ENSMUST00000172261.1
Rho-related BTB domain containing 1
chrX_+_134187492 0.12 ENSMUST00000064476.4
ADP-ribosylation factor-like 13A
chr8_-_123318553 0.12 ENSMUST00000118395.1
ENSMUST00000035495.8
Fanconi anemia, complementation group A
chrX_+_56317608 0.11 ENSMUST00000151426.1
ENSMUST00000138262.1
RIKEN cDNA 1600025M17 gene
chr15_+_78597047 0.10 ENSMUST00000043069.5
cytohesin 4
chr5_+_10236829 0.10 ENSMUST00000101606.3
predicted gene 10482
chr17_-_15564322 0.10 ENSMUST00000147532.1
PR domain containing 9
chr5_+_138161071 0.09 ENSMUST00000019638.8
ENSMUST00000110951.1
COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)
chr6_+_24748325 0.08 ENSMUST00000031691.2
hyaluronoglucosaminidase 4
chr17_+_37270214 0.08 ENSMUST00000038580.6
histocompatibility 2, M region locus 3
chr1_+_174041933 0.07 ENSMUST00000052975.4
olfactory receptor 433
chr14_+_47663756 0.05 ENSMUST00000022391.7
kinectin 1
chr9_+_74976096 0.04 ENSMUST00000081746.5
family with sequence similarity 214, member A
chr17_+_22689771 0.04 ENSMUST00000055305.8
predicted gene 9805
chr4_-_149737957 0.04 ENSMUST00000105687.2
ENSMUST00000054459.4
ENSMUST00000103208.1
transmembrane protein 201
chr12_+_101404673 0.04 ENSMUST00000055156.4
catsper channel auxiliary subunit beta
chr11_-_103697661 0.03 ENSMUST00000107013.2
golgi SNAP receptor complex member 2
chr5_-_122697603 0.02 ENSMUST00000071235.4
predicted gene 10064
chr10_-_4432285 0.01 ENSMUST00000155172.1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr5_-_72559599 0.01 ENSMUST00000074948.4
ENSMUST00000087216.5
nuclear transcription factor, X-box binding-like 1
chr7_+_110627650 0.00 ENSMUST00000033054.8
adrenomedullin

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 36.6 GO:0019377 galactolipid metabolic process(GO:0019374) glycolipid catabolic process(GO:0019377)
1.9 28.7 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.7 3.6 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.6 3.0 GO:0097167 circadian regulation of translation(GO:0097167)
0.5 2.0 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.5 1.4 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.4 1.2 GO:2000412 lymphocyte migration into lymphoid organs(GO:0097021) positive regulation of thymocyte migration(GO:2000412) regulation of dendritic cell dendrite assembly(GO:2000547)
0.4 2.1 GO:0002838 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
0.4 1.8 GO:0072386 stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 1.0 GO:0060300 regulation of cytokine activity(GO:0060300)
0.3 2.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 1.7 GO:1904378 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.2 2.3 GO:0098953 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.2 0.8 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 29.9 GO:0008203 cholesterol metabolic process(GO:0008203)
0.2 0.4 GO:2000449 regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449)
0.2 1.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.2 0.5 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.2 0.6 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 5.0 GO:0002021 response to dietary excess(GO:0002021)
0.1 0.7 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 1.7 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.1 1.1 GO:0008228 opsonization(GO:0008228)
0.1 0.4 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 1.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 1.4 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 1.0 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 2.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.5 GO:0034627 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.7 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.1 0.3 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 1.8 GO:0070986 left/right axis specification(GO:0070986)
0.1 1.4 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.6 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.1 1.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.1 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 0.6 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.1 1.0 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.1 0.5 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.2 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208) positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.6 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.2 GO:0019255 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.2 GO:0097283 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.0 0.6 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.0 1.9 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 6.6 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.8 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.0 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.2 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920) protein secretion by platelet(GO:0070560)
0.0 0.8 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.4 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.1 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.7 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.2 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 0.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.3 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.3 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945) negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.5 GO:0015858 nucleoside transport(GO:0015858)
0.0 1.0 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.6 GO:0090382 phagosome maturation(GO:0090382)
0.0 0.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.9 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 19.7 GO:0055114 oxidation-reduction process(GO:0055114)
0.0 0.3 GO:0015695 drug transmembrane transport(GO:0006855) organic cation transport(GO:0015695)
0.0 0.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.4 GO:0009409 response to cold(GO:0009409)
0.0 0.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 36.6 GO:0042589 zymogen granule membrane(GO:0042589)
1.9 28.7 GO:0042588 zymogen granule(GO:0042588)
0.6 2.3 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.3 1.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 1.7 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2 2.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 0.6 GO:0097447 dendritic tree(GO:0097447)
0.1 0.9 GO:0005927 muscle tendon junction(GO:0005927)
0.1 1.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.7 GO:0008091 spectrin(GO:0008091)
0.1 0.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.8 GO:0035253 ciliary rootlet(GO:0035253)
0.1 2.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 12.2 GO:0072562 blood microparticle(GO:0072562)
0.1 2.5 GO:0031430 M band(GO:0031430)
0.0 78.2 GO:0005615 extracellular space(GO:0005615)
0.0 0.4 GO:0097342 ripoptosome(GO:0097342)
0.0 0.8 GO:0005861 troponin complex(GO:0005861)
0.0 1.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 17.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 3.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.8 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0000791 euchromatin(GO:0000791)
0.0 2.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 44.0 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.3 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.6 GO:0031526 brush border membrane(GO:0031526)
0.0 0.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 75.1 GO:0004556 alpha-amylase activity(GO:0004556)
2.9 22.9 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
2.4 36.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.3 8.0 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.7 3.6 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.5 2.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.5 1.4 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.3 55.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 1.8 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 0.6 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.2 2.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 0.8 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 28.7 GO:0008083 growth factor activity(GO:0008083)
0.2 1.0 GO:0031493 nucleosomal histone binding(GO:0031493)
0.2 0.5 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1 1.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.5 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 0.7 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 1.7 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.0 GO:0036122 BMP binding(GO:0036122)
0.1 0.4 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.1 0.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 2.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.0 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 4.8 GO:0030507 spectrin binding(GO:0030507)
0.1 1.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.6 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 3.0 GO:0070888 E-box binding(GO:0070888)
0.0 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.8 GO:0051400 BH domain binding(GO:0051400)
0.0 0.2 GO:0004875 complement receptor activity(GO:0004875)
0.0 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.3 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.9 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.2 GO:0051378 serotonin binding(GO:0051378)
0.0 0.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557) uridylyltransferase activity(GO:0070569)
0.0 0.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 3.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 34.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 4.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.2 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.9 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.8 PID ENDOTHELIN PATHWAY Endothelins
0.0 2.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 35.2 REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.3 12.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 0.8 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.6 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.4 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules