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GSE58827: Dynamics of the Mouse Liver

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Results for Nr0b1

Z-value: 0.76

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Transcription factors associated with Nr0b1

Gene Symbol Gene ID Gene Info
Nr0b1
ENSMUSG00000025056.4 nuclear receptor subfamily 0, group B, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr0b1mm10_v2_chrX_+_86191764_86191782-0.581.8e-04Click!

Activity profile of Nr0b1 motif

Sorted Z-values of Nr0b1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_88087802 5.33 ENSMUST00000113139.1
Ugt1a8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr17_-_57059795 3.99 ENSMUST00000040280.7
Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr16_-_20621255 2.78 ENSMUST00000052939.2
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr4_+_148130883 2.29 ENSMUST00000084129.2
Mad2l2
MAD2 mitotic arrest deficient-like 2
chr7_+_28180226 2.23 ENSMUST00000172467.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr7_+_28180272 2.18 ENSMUST00000173223.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr16_+_44173239 2.15 ENSMUST00000119746.1
Gm608
predicted gene 608
chr13_-_29984219 1.98 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr9_+_80165013 1.63 ENSMUST00000035889.8
ENSMUST00000113268.1
Myo6
myosin VI
chr9_+_80165079 1.62 ENSMUST00000184480.1
Myo6
myosin VI
chr6_+_134830145 1.57 ENSMUST00000046303.5
Crebl2
cAMP responsive element binding protein-like 2
chr8_-_95434869 1.57 ENSMUST00000034249.6
Gtl3
gene trap locus 3
chr11_+_94328242 1.53 ENSMUST00000021227.5
Ankrd40
ankyrin repeat domain 40
chr10_-_128589650 1.52 ENSMUST00000082059.6
Erbb3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr2_+_157279065 1.49 ENSMUST00000029171.5
Rpn2
ribophorin II
chr10_+_116301374 1.47 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B
chr10_-_127666673 1.41 ENSMUST00000026469.2
Nab2
Ngfi-A binding protein 2
chr2_-_65238573 1.40 ENSMUST00000090896.3
ENSMUST00000155082.1
Cobll1
Cobl-like 1
chr1_+_140246216 1.38 ENSMUST00000119786.1
ENSMUST00000120796.1
ENSMUST00000060201.8
ENSMUST00000120709.1
Kcnt2
potassium channel, subfamily T, member 2
chr2_+_4718145 1.36 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr16_-_45844228 1.30 ENSMUST00000076333.5
Phldb2
pleckstrin homology-like domain, family B, member 2
chr16_-_45844303 1.29 ENSMUST00000036355.6
Phldb2
pleckstrin homology-like domain, family B, member 2
chr2_+_59160884 1.29 ENSMUST00000037903.8
Pkp4
plakophilin 4
chr2_+_157279026 1.28 ENSMUST00000116380.2
Rpn2
ribophorin II
chr6_+_134830216 1.27 ENSMUST00000111937.1
Crebl2
cAMP responsive element binding protein-like 2
chr17_-_26508463 1.25 ENSMUST00000025025.6
Dusp1
dual specificity phosphatase 1
chr4_-_118134869 1.17 ENSMUST00000097912.1
ENSMUST00000030263.2
ENSMUST00000106410.1
St3gal3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
chr9_+_57521232 1.14 ENSMUST00000000090.6
Cox5a
cytochrome c oxidase subunit Va
chr17_-_23745829 1.11 ENSMUST00000046525.8
Kremen2
kringle containing transmembrane protein 2
chr3_-_30509462 1.10 ENSMUST00000173899.1
Mecom
MDS1 and EVI1 complex locus
chr11_+_94327984 1.07 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40
ankyrin repeat domain 40
chr8_+_71371283 1.03 ENSMUST00000110051.1
ENSMUST00000002469.8
ENSMUST00000110052.1
Ocel1
occludin/ELL domain containing 1
chr2_-_80581234 1.02 ENSMUST00000028386.5
Nckap1
NCK-associated protein 1
chr2_-_65238625 1.01 ENSMUST00000112429.2
ENSMUST00000102726.1
ENSMUST00000112430.1
Cobll1
Cobl-like 1
chr13_-_64274879 1.00 ENSMUST00000109770.1
Cdc14b
CDC14 cell division cycle 14B
chr2_-_80581380 0.97 ENSMUST00000111760.2
Nckap1
NCK-associated protein 1
chr11_+_23306884 0.97 ENSMUST00000180046.1
Usp34
ubiquitin specific peptidase 34
chr3_-_139075178 0.97 ENSMUST00000098574.2
ENSMUST00000029796.6
Rap1gds1
RAP1, GTP-GDP dissociation stimulator 1
chr8_+_55940453 0.95 ENSMUST00000000275.7
Glra3
glycine receptor, alpha 3 subunit
chr14_+_11553523 0.94 ENSMUST00000022264.6
Ptprg
protein tyrosine phosphatase, receptor type, G
chr7_-_80371197 0.92 ENSMUST00000098346.3
Man2a2
mannosidase 2, alpha 2
chr4_+_116221633 0.86 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chrX_-_92016183 0.85 ENSMUST00000099471.2
ENSMUST00000072269.1
Mageb1
melanoma antigen, family B, 1
chr5_+_121711609 0.84 ENSMUST00000051950.7
Atxn2
ataxin 2
chr8_-_85080652 0.84 ENSMUST00000152785.1
Wdr83
WD repeat domain containing 83
chr8_-_85080679 0.78 ENSMUST00000093357.5
Wdr83
WD repeat domain containing 83
chr3_+_54156039 0.77 ENSMUST00000029311.6
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr18_+_35829798 0.77 ENSMUST00000060722.6
Cxxc5
CXXC finger 5
chr13_-_31559333 0.75 ENSMUST00000170573.1
A530084C06Rik
RIKEN cDNA A530084C06 gene
chr17_-_70851189 0.74 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr10_+_39732099 0.73 ENSMUST00000019986.6
Rev3l
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)
chr3_-_107458895 0.70 ENSMUST00000009617.8
Kcnc4
potassium voltage gated channel, Shaw-related subfamily, member 4
chr10_+_90829409 0.70 ENSMUST00000182202.1
ENSMUST00000182966.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_+_116221590 0.70 ENSMUST00000147292.1
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr10_-_81350389 0.67 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b
high mobility group 20B
chr17_-_80728026 0.66 ENSMUST00000112389.2
ENSMUST00000025089.7
Map4k3
mitogen-activated protein kinase kinase kinase kinase 3
chr3_+_86224665 0.66 ENSMUST00000107635.1
Lrba
LPS-responsive beige-like anchor
chr15_+_35371498 0.65 ENSMUST00000048646.7
Vps13b
vacuolar protein sorting 13B (yeast)
chr13_+_41249841 0.65 ENSMUST00000165561.2
Smim13
small integral membrane protein 13
chr1_+_162570687 0.64 ENSMUST00000050010.4
ENSMUST00000150040.1
Vamp4
vesicle-associated membrane protein 4
chr17_-_84790517 0.63 ENSMUST00000112308.2
Lrpprc
leucine-rich PPR-motif containing
chr5_-_99037035 0.63 ENSMUST00000031277.6
Prkg2
protein kinase, cGMP-dependent, type II
chr17_+_88530113 0.59 ENSMUST00000038551.6
Ppp1r21
protein phosphatase 1, regulatory subunit 21
chr4_-_138913915 0.57 ENSMUST00000097830.3
Otud3
OTU domain containing 3
chr10_+_90829538 0.57 ENSMUST00000179694.2
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr6_+_47454320 0.54 ENSMUST00000031697.8
Cul1
cullin 1
chr2_-_144331695 0.54 ENSMUST00000103171.3
Ovol2
ovo-like 2 (Drosophila)
chr11_-_70687917 0.54 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
Camta2
calmodulin binding transcription activator 2
chr16_+_57121705 0.53 ENSMUST00000166897.1
Tomm70a
translocase of outer mitochondrial membrane 70 homolog A (yeast)
chr5_-_99037342 0.51 ENSMUST00000161490.1
Prkg2
protein kinase, cGMP-dependent, type II
chr4_-_123750236 0.48 ENSMUST00000102636.3
Akirin1
akirin 1
chr10_+_127078886 0.48 ENSMUST00000039259.6
Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr10_+_38965515 0.48 ENSMUST00000019992.5
Lama4
laminin, alpha 4
chr4_-_135971894 0.45 ENSMUST00000105852.1
Lypla2
lysophospholipase 2
chr11_+_105181527 0.43 ENSMUST00000106941.2
Tlk2
tousled-like kinase 2 (Arabidopsis)
chr7_-_65371210 0.39 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr6_-_52191695 0.38 ENSMUST00000101395.2
Hoxa4
homeobox A4
chr5_+_110230975 0.38 ENSMUST00000031474.7
ENSMUST00000086674.5
Ankle2
ankyrin repeat and LEM domain containing 2
chr15_-_38078842 0.38 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr11_+_23306910 0.37 ENSMUST00000137823.1
Usp34
ubiquitin specific peptidase 34
chr11_+_105181793 0.37 ENSMUST00000092537.3
ENSMUST00000015107.6
ENSMUST00000145048.1
Tlk2
tousled-like kinase 2 (Arabidopsis)
chr13_+_94358943 0.35 ENSMUST00000022196.3
Ap3b1
adaptor-related protein complex 3, beta 1 subunit
chr11_-_74723829 0.35 ENSMUST00000102520.2
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr4_-_11386394 0.34 ENSMUST00000155519.1
Esrp1
epithelial splicing regulatory protein 1
chr2_+_153842981 0.32 ENSMUST00000175856.1
Efcab8
EF-hand calcium binding domain 8
chr5_-_31193105 0.30 ENSMUST00000166769.1
Eif2b4
eukaryotic translation initiation factor 2B, subunit 4 delta
chr2_+_30066419 0.30 ENSMUST00000067996.6
Set
SET nuclear oncogene
chr1_+_59764264 0.28 ENSMUST00000087435.5
Bmpr2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr5_-_31193008 0.26 ENSMUST00000114605.1
ENSMUST00000114603.1
Eif2b4
eukaryotic translation initiation factor 2B, subunit 4 delta
chr9_-_110117379 0.25 ENSMUST00000111991.2
ENSMUST00000149199.1
ENSMUST00000035056.7
ENSMUST00000148287.1
ENSMUST00000127744.1
Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr4_-_132422484 0.24 ENSMUST00000102568.3
Phactr4
phosphatase and actin regulator 4
chr4_-_129696817 0.23 ENSMUST00000102588.3
Tmem39b
transmembrane protein 39b
chr7_+_79500081 0.23 ENSMUST00000181511.2
ENSMUST00000182937.1
AI854517
expressed sequence AI854517
chr18_+_80046854 0.16 ENSMUST00000070219.7
Pard6g
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr12_+_49385174 0.16 ENSMUST00000110746.1
3110039M20Rik
RIKEN cDNA 3110039M20 gene
chr13_-_106936907 0.15 ENSMUST00000080856.7
Ipo11
importin 11
chr2_+_85037448 0.15 ENSMUST00000168266.1
ENSMUST00000130729.1
Ssrp1
structure specific recognition protein 1
chr3_-_123690806 0.15 ENSMUST00000154668.1
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr1_+_42697146 0.13 ENSMUST00000054883.2
Pou3f3
POU domain, class 3, transcription factor 3
chr9_-_109059711 0.10 ENSMUST00000061973.4
Trex1
three prime repair exonuclease 1
chr18_-_10030017 0.09 ENSMUST00000116669.1
ENSMUST00000092096.6
Usp14
ubiquitin specific peptidase 14
chr9_+_110333402 0.08 ENSMUST00000133114.1
ENSMUST00000125759.1
Scap
SREBF chaperone
chr4_+_116221689 0.07 ENSMUST00000106490.2
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr2_-_144332146 0.04 ENSMUST00000037423.3
Ovol2
ovo-like 2 (Drosophila)
chr17_+_34898463 0.03 ENSMUST00000114033.2
ENSMUST00000078061.6
Ehmt2
euchromatic histone lysine N-methyltransferase 2
chr4_+_99656299 0.03 ENSMUST00000087285.3
Foxd3
forkhead box D3
chr14_+_75845296 0.02 ENSMUST00000142061.1
Tpt1
tumor protein, translationally-controlled 1
chr2_-_157279519 0.01 ENSMUST00000143663.1
Mroh8
maestro heat-like repeat family member 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr0b1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0097274 urea homeostasis(GO:0097274)
0.6 2.3 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.4 5.3 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.4 1.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.4 2.6 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.3 2.0 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354) mesodermal cell migration(GO:0008078) establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.2 0.7 GO:1904057 negative regulation of sensory perception of pain(GO:1904057)
0.2 3.2 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.2 2.0 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 1.4 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.2 0.6 GO:1990167 protein K6-linked deubiquitination(GO:0044313) protein K27-linked deubiquitination(GO:1990167)
0.2 0.6 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.1 0.4 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.4 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 0.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.4 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 1.0 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 1.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.9 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.3 GO:2000793 negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137) cell proliferation involved in heart valve development(GO:2000793)
0.1 0.9 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 2.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 1.5 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 1.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.6 GO:0090003 regulation of Golgi to plasma membrane protein transport(GO:0042996) regulation of establishment of protein localization to plasma membrane(GO:0090003)
0.1 4.4 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.5 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.0 GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration(GO:0032471) positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.1 1.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 0.6 GO:0060214 endocardium formation(GO:0060214)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.8 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 0.6 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.2 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 2.8 GO:0046326 positive regulation of glucose import(GO:0046326)
0.0 0.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 1.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.7 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.8 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.8 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 3.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 1.6 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.1 GO:0061386 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 1.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.1 GO:0072236 metanephric loop of Henle development(GO:0072236)
0.0 0.5 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 1.2 GO:0001706 endoderm formation(GO:0001706)
0.0 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.9 GO:1901998 toxin transport(GO:1901998)
0.0 0.5 GO:0003299 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 1.1 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 0.0 GO:0071314 cellular response to cocaine(GO:0071314)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.0 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.2 2.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 0.7 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.2 2.6 GO:0045180 basal cortex(GO:0045180)
0.2 2.0 GO:0031209 SCAR complex(GO:0031209)
0.1 0.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 3.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.3 GO:0000235 astral microtubule(GO:0000235)
0.1 1.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.3 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.5 GO:0005605 basal lamina(GO:0005605)
0.0 1.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.0 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.1 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.4 1.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.3 4.0 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.3 1.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2 1.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 2.8 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 1.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.4 GO:0038132 neuregulin binding(GO:0038132)
0.1 5.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.9 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 3.0 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.5 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.1 0.9 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 4.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 2.4 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.2 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.0 0.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.8 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.5 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.7 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.3 GO:0036122 BMP binding(GO:0036122) BMP receptor activity(GO:0098821)
0.0 2.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.1 GO:0032405 MutLalpha complex binding(GO:0032405)
0.0 3.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 2.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 3.2 GO:0003774 motor activity(GO:0003774)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.6 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.7 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.4 GO:0030742 GTP-dependent protein binding(GO:0030742)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.6 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.2 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.1 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 2.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.7 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.3 PID REELIN PATHWAY Reelin signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 3.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 2.0 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 0.8 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.9 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 2.8 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 3.0 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import