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GSE58827: Dynamics of the Mouse Liver
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Results for Nr2f1_Nr4a1
Z-value: 1.50
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Transcription factors associated with Nr2f1_Nr4a1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr2f1 | mm10_v2_chr13_-_78196373_78196440 | -0.42 | 1.0e-02 | Click! |
| Nr4a1 | mm10_v2_chr15_+_101266839_101266859 | -0.18 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr2f1_Nr4a1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.9 | 55.5 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 3.3 | 20.0 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.7 | 18.4 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 0.4 | 16.4 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 4.9 | 14.8 | GO:0061402 | positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) |
| 1.0 | 13.6 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 1.7 | 13.3 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.9 | 13.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.3 | 11.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.0 | 11.7 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 57.1 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 47.6 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 37.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 29.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 21.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 18.7 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 18.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 13.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 12.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.5 | 11.7 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.9 | 55.5 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 3.3 | 20.0 | GO:0004359 | glutaminase activity(GO:0004359) |
| 1.5 | 14.7 | GO:0035473 | lipase binding(GO:0035473) |
| 0.1 | 13.8 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.6 | 13.6 | GO:0005550 | pheromone binding(GO:0005550) |
| 2.4 | 12.0 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.3 | 12.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 11.9 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.2 | 11.4 | GO:0005109 | frizzled binding(GO:0005109) |
| 2.7 | 10.7 | GO:0015232 | heme transporter activity(GO:0015232) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 11.5 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.3 | 7.0 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 6.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 3.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 3.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 3.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 69.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.6 | 44.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.0 | 26.5 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 20.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 19.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 1.2 | 16.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.9 | 15.1 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.6 | 12.9 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.7 | 12.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.5 | 11.7 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |