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GSE58827: Dynamics of the Mouse Liver
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Results for Nr2f2
Z-value: 1.11
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Transcription factors associated with Nr2f2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr2f2 | mm10_v2_chr7_-_70360593_70360746 | 0.23 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_105269837 Show fit | 9.00 |
ENSMUST00000172525.1
ENSMUST00000174837.1 ENSMUST00000173859.1 |
heat shock transcription factor 4 |
|
| chr8_+_105269788 Show fit | 8.70 |
ENSMUST00000036127.2
ENSMUST00000163734.2 |
heat shock transcription factor 4 |
|
| chr2_+_102658640 Show fit | 6.49 |
ENSMUST00000080210.3
|
solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
|
| chr7_-_30973464 Show fit | 5.59 |
ENSMUST00000001279.8
|
lipolysis stimulated lipoprotein receptor |
|
| chr7_-_30973399 Show fit | 4.83 |
ENSMUST00000098553.4
ENSMUST00000147431.1 |
lipolysis stimulated lipoprotein receptor |
|
| chr9_-_86695897 Show fit | 4.66 |
ENSMUST00000034989.8
|
malic enzyme 1, NADP(+)-dependent, cytosolic |
|
| chr7_-_30973367 Show fit | 4.60 |
ENSMUST00000108116.3
|
lipolysis stimulated lipoprotein receptor |
|
| chrX_-_75874536 Show fit | 4.47 |
ENSMUST00000033547.7
|
plastin 3 (T-isoform) |
|
| chr7_-_99626936 Show fit | 4.10 |
ENSMUST00000178124.1
|
predicted gene 4980 |
|
| chr12_-_113260217 Show fit | 4.01 |
ENSMUST00000178282.1
|
immunoglobulin heavy constant alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr2f2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 17.7 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 5.0 | 15.0 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.8 | 11.5 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.9 | 6.5 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 1.2 | 6.2 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
| 0.8 | 5.9 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.2 | 4.8 | GO:0006625 | protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 4.5 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.0 | 4.4 | GO:0043507 | positive regulation of JUN kinase activity(GO:0043507) |
| 0.1 | 4.0 | GO:0014002 | astrocyte development(GO:0014002) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.9 | 15.0 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.2 | 6.5 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 5.7 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 4.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 4.4 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 4.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 4.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 4.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 3.7 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.3 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.8 | 15.0 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 1.0 | 11.5 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 8.2 | GO:0002020 | protease binding(GO:0002020) |
| 1.1 | 6.5 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.3 | 6.2 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
| 0.7 | 5.4 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
| 1.6 | 4.7 | GO:0004471 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.4 | 4.3 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 4.2 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 3.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 3.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 2.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.8 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 6.4 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.3 | 4.7 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.3 | 4.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 4.1 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 3.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 3.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 3.5 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 3.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 3.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |