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GSE58827: Dynamics of the Mouse Liver

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Results for Nr4a2

Z-value: 0.65

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Transcription factors associated with Nr4a2

Gene Symbol Gene ID Gene Info
Nr4a2
ENSMUSG00000026826.7 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57113053_57113072-0.202.5e-01Click!

Activity profile of Nr4a2 motif

Sorted Z-values of Nr4a2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_22002599 3.22 ENSMUST00000115336.2
ENSMUST00000044926.5
Ccdc151
coiled-coil domain containing 151
chr19_-_8405060 3.16 ENSMUST00000064507.5
ENSMUST00000120540.1
ENSMUST00000096269.4
Slc22a30
solute carrier family 22, member 30
chr7_-_14438538 2.51 ENSMUST00000168252.2
2810007J24Rik
RIKEN cDNA 2810007J24 gene
chr1_+_167618246 2.13 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr10_-_92375367 2.09 ENSMUST00000182870.1
Gm20757
predicted gene, 20757
chr8_+_104847061 1.94 ENSMUST00000055052.5
Ces2c
carboxylesterase 2C
chr6_-_59024340 1.59 ENSMUST00000173193.1
Fam13a
family with sequence similarity 13, member A
chr6_-_59024470 1.54 ENSMUST00000089860.5
Fam13a
family with sequence similarity 13, member A
chr8_-_64733534 1.46 ENSMUST00000141021.1
Sc4mol
sterol-C4-methyl oxidase-like
chr5_-_66151903 1.31 ENSMUST00000167950.1
Rbm47
RNA binding motif protein 47
chr13_-_92131494 1.26 ENSMUST00000099326.3
ENSMUST00000146492.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr10_-_42478280 1.26 ENSMUST00000151747.1
Lace1
lactation elevated 1
chr5_+_30232581 1.17 ENSMUST00000145167.1
Ept1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr19_+_36554661 1.15 ENSMUST00000169036.2
ENSMUST00000047247.5
Hectd2
HECT domain containing 2
chr5_-_66151323 1.14 ENSMUST00000131838.1
Rbm47
RNA binding motif protein 47
chr15_+_25940846 1.14 ENSMUST00000110438.1
Fam134b
family with sequence similarity 134, member B
chr10_-_42478488 1.10 ENSMUST00000041024.8
Lace1
lactation elevated 1
chr4_-_42581621 1.03 ENSMUST00000178742.1
Gm10592
predicted gene 10592
chr1_+_87574016 1.03 ENSMUST00000166259.1
ENSMUST00000172222.1
ENSMUST00000163606.1
Neu2
neuraminidase 2
chr18_-_56975333 0.93 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik
RIKEN cDNA C330018D20 gene
chr13_+_93303757 0.93 ENSMUST00000109494.1
Homer1
homer homolog 1 (Drosophila)
chr4_-_141623799 0.92 ENSMUST00000038661.7
Slc25a34
solute carrier family 25, member 34
chr13_+_93304066 0.90 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr5_+_102845007 0.89 ENSMUST00000070000.4
Arhgap24
Rho GTPase activating protein 24
chr15_+_25773985 0.88 ENSMUST00000125667.1
Myo10
myosin X
chr6_+_3993776 0.83 ENSMUST00000031673.5
Gngt1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr9_-_22085391 0.79 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
Ecsit
ECSIT homolog (Drosophila)
chr2_-_73892588 0.78 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
Atf2
activating transcription factor 2
chr17_+_70522083 0.76 ENSMUST00000148486.1
ENSMUST00000133717.1
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr16_-_44139196 0.75 ENSMUST00000063661.6
ENSMUST00000114666.2
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr2_-_73892619 0.73 ENSMUST00000112007.1
ENSMUST00000112016.2
Atf2
activating transcription factor 2
chr16_-_44139630 0.73 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr10_+_67185730 0.71 ENSMUST00000173689.1
Jmjd1c
jumonji domain containing 1C
chr13_+_74121435 0.70 ENSMUST00000036208.6
Slc9a3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
chr15_-_68363139 0.70 ENSMUST00000175699.1
Gm20732
predicted gene 20732
chr2_+_61593077 0.69 ENSMUST00000112495.1
ENSMUST00000112501.2
Tank
TRAF family member-associated Nf-kappa B activator
chr7_-_141429351 0.68 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
Cend1
cell cycle exit and neuronal differentiation 1
chr7_-_89338709 0.67 ENSMUST00000137723.1
ENSMUST00000117852.1
ENSMUST00000041968.3
Tmem135
transmembrane protein 135
chrX_-_142390334 0.67 ENSMUST00000112907.1
Acsl4
acyl-CoA synthetase long-chain family member 4
chr10_+_53337686 0.67 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln
phospholamban
chr5_-_121527186 0.64 ENSMUST00000152270.1
Mapkapk5
MAP kinase-activated protein kinase 5
chr19_+_3768112 0.63 ENSMUST00000005518.9
ENSMUST00000113967.1
ENSMUST00000152935.1
ENSMUST00000176262.1
ENSMUST00000176407.1
ENSMUST00000176926.1
ENSMUST00000176512.1
Suv420h1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr19_+_3767953 0.63 ENSMUST00000113970.1
Suv420h1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr1_-_124045247 0.61 ENSMUST00000112603.2
Dpp10
dipeptidylpeptidase 10
chr10_+_28074813 0.59 ENSMUST00000166468.1
Ptprk
protein tyrosine phosphatase, receptor type, K
chr2_+_30595037 0.59 ENSMUST00000102853.3
Cstad
CSA-conditional, T cell activation-dependent protein
chr12_+_31438209 0.59 ENSMUST00000001254.5
Slc26a3
solute carrier family 26, member 3
chr9_-_13446753 0.57 ENSMUST00000167906.2
Gm17571
predicted gene, 17571
chr7_-_141429433 0.56 ENSMUST00000124444.1
Cend1
cell cycle exit and neuronal differentiation 1
chr3_+_122895072 0.56 ENSMUST00000023820.5
Fabp2
fatty acid binding protein 2, intestinal
chr1_-_24100306 0.55 ENSMUST00000027337.8
Fam135a
family with sequence similarity 135, member A
chr2_+_61593125 0.55 ENSMUST00000112494.1
Tank
TRAF family member-associated Nf-kappa B activator
chr4_-_150914401 0.54 ENSMUST00000105675.1
Park7
Parkinson disease (autosomal recessive, early onset) 7
chr10_+_110920170 0.53 ENSMUST00000020403.5
Csrp2
cysteine and glycine-rich protein 2
chr3_-_144932523 0.51 ENSMUST00000098549.3
AI747448
expressed sequence AI747448
chr16_+_44139821 0.50 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr7_+_105554360 0.50 ENSMUST00000046983.8
Smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr2_+_105668935 0.48 ENSMUST00000142772.1
Pax6
paired box gene 6
chr17_-_35909626 0.46 ENSMUST00000141132.1
Atat1
alpha tubulin acetyltransferase 1
chr15_-_76229492 0.45 ENSMUST00000074834.5
Plec
plectin
chr17_-_43667015 0.45 ENSMUST00000024705.4
Slc25a27
solute carrier family 25, member 27
chr4_+_102760294 0.45 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr8_-_13494479 0.44 ENSMUST00000033828.5
Gas6
growth arrest specific 6
chr13_+_41655697 0.43 ENSMUST00000067176.8
Gm5082
predicted gene 5082
chr2_-_120563795 0.43 ENSMUST00000055241.6
ENSMUST00000135625.1
Zfp106
zinc finger protein 106
chr1_-_63176653 0.42 ENSMUST00000027111.8
ENSMUST00000168099.2
Ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr9_+_108392820 0.40 ENSMUST00000035234.4
1700102P08Rik
RIKEN cDNA 1700102P08 gene
chr11_-_100822525 0.40 ENSMUST00000107358.2
Stat5b
signal transducer and activator of transcription 5B
chr3_-_92500493 0.39 ENSMUST00000062129.1
Sprr4
small proline-rich protein 4
chr2_+_4976113 0.39 ENSMUST00000167607.1
ENSMUST00000115010.2
Ucma
upper zone of growth plate and cartilage matrix associated
chr2_+_4976176 0.38 ENSMUST00000027978.1
Ucma
upper zone of growth plate and cartilage matrix associated
chr3_+_84925476 0.38 ENSMUST00000107675.1
Fbxw7
F-box and WD-40 domain protein 7
chr12_-_76795489 0.37 ENSMUST00000082431.3
Gpx2
glutathione peroxidase 2
chr19_+_43782181 0.36 ENSMUST00000026208.4
Abcc2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_+_182409162 0.36 ENSMUST00000117245.1
Trp53bp2
transformation related protein 53 binding protein 2
chr2_+_59160838 0.36 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
Pkp4
plakophilin 4
chr19_-_6921753 0.36 ENSMUST00000173635.1
Esrra
estrogen related receptor, alpha
chr10_+_94147982 0.34 ENSMUST00000105290.2
Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr10_-_20725023 0.33 ENSMUST00000020165.7
Pde7b
phosphodiesterase 7B
chr10_-_41303171 0.33 ENSMUST00000043814.3
Fig4
FIG4 homolog (S. cerevisiae)
chr9_-_42461414 0.32 ENSMUST00000066179.7
Tbcel
tubulin folding cofactor E-like
chr6_+_113697050 0.31 ENSMUST00000089018.4
Tatdn2
TatD DNase domain containing 2
chr3_+_14578609 0.31 ENSMUST00000029069.6
ENSMUST00000165922.2
E2f5
E2F transcription factor 5
chrX_+_160768013 0.30 ENSMUST00000033650.7
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chr5_+_63649335 0.30 ENSMUST00000159584.1
3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr4_+_102760135 0.29 ENSMUST00000066824.7
Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr15_+_102966794 0.29 ENSMUST00000001699.7
Hoxc10
homeobox C10
chr3_+_4211716 0.28 ENSMUST00000170943.1
Gm8775
predicted gene 8775
chr6_-_124814288 0.28 ENSMUST00000172132.2
Tpi1
triosephosphate isomerase 1
chr19_+_46152505 0.28 ENSMUST00000026254.7
Gbf1
golgi-specific brefeldin A-resistance factor 1
chr7_+_4119556 0.28 ENSMUST00000079415.5
Ttyh1
tweety homolog 1 (Drosophila)
chr2_-_101621033 0.28 ENSMUST00000090513.4
B230118H07Rik
RIKEN cDNA B230118H07 gene
chr11_+_96282529 0.28 ENSMUST00000125410.1
Hoxb8
homeobox B8
chr4_+_99955715 0.27 ENSMUST00000102783.4
Pgm2
phosphoglucomutase 2
chr2_+_129065934 0.26 ENSMUST00000035812.7
Ttl
tubulin tyrosine ligase
chr10_+_127078886 0.26 ENSMUST00000039259.6
Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr4_+_136357423 0.26 ENSMUST00000182167.1
Gm17388
predicted gene, 17388
chr10_-_20724696 0.26 ENSMUST00000170265.1
Pde7b
phosphodiesterase 7B
chr7_+_120635176 0.26 ENSMUST00000033176.5
Uqcrc2
ubiquinol cytochrome c reductase core protein 2
chr6_+_34920941 0.25 ENSMUST00000114999.1
Stra8
stimulated by retinoic acid gene 8
chr1_-_191907527 0.24 ENSMUST00000069573.5
1700034H15Rik
RIKEN cDNA 1700034H15 gene
chr19_-_32061438 0.24 ENSMUST00000096119.4
Asah2
N-acylsphingosine amidohydrolase 2
chr2_+_144033059 0.24 ENSMUST00000037722.2
ENSMUST00000110032.1
Banf2
barrier to autointegration factor 2
chr7_+_4119525 0.24 ENSMUST00000119661.1
ENSMUST00000129423.1
Ttyh1
tweety homolog 1 (Drosophila)
chr16_+_8830093 0.23 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr2_-_73892530 0.23 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
Atf2
activating transcription factor 2
chrX_-_48513518 0.22 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
chr8_+_70863127 0.21 ENSMUST00000050921.2
A230052G05Rik
RIKEN cDNA A230052G05 gene
chr3_-_88027465 0.21 ENSMUST00000005014.2
Hapln2
hyaluronan and proteoglycan link protein 2
chr1_+_131910458 0.21 ENSMUST00000062264.6
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chrX_+_160768179 0.20 ENSMUST00000112368.2
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chr17_-_35910032 0.19 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
Atat1
alpha tubulin acetyltransferase 1
chr4_+_33081505 0.19 ENSMUST00000147889.1
Gabrr2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr2_-_129699833 0.19 ENSMUST00000028883.5
Pdyn
prodynorphin
chr2_+_79707780 0.19 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chrX_+_7579666 0.18 ENSMUST00000115740.1
ENSMUST00000115739.1
Foxp3
forkhead box P3
chr2_+_105668888 0.17 ENSMUST00000111086.4
ENSMUST00000111087.3
Pax6
paired box gene 6
chr17_+_69439326 0.17 ENSMUST00000169935.1
A330050F15Rik
RIKEN cDNA A330050F15 gene
chr6_+_34920971 0.16 ENSMUST00000185102.1
ENSMUST00000114997.2
Stra8
stimulated by retinoic acid gene 8
chr7_+_140920940 0.16 ENSMUST00000184560.1
Nlrp6
NLR family, pyrin domain containing 6
chrX_-_73921917 0.15 ENSMUST00000114389.3
Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr9_+_118506226 0.15 ENSMUST00000084820.4
Golga4
golgi autoantigen, golgin subfamily a, 4
chr6_-_99096196 0.15 ENSMUST00000175886.1
Foxp1
forkhead box P1
chr15_+_54952939 0.14 ENSMUST00000181704.1
Gm26684
predicted gene, 26684
chr2_-_59160644 0.14 ENSMUST00000077687.5
Ccdc148
coiled-coil domain containing 148
chr17_-_17624458 0.13 ENSMUST00000041047.2
Lnpep
leucyl/cystinyl aminopeptidase
chr12_-_93929102 0.13 ENSMUST00000180321.1
Gm9726
predicted gene 9726
chr3_+_89436736 0.12 ENSMUST00000146630.1
ENSMUST00000145753.1
Pbxip1
pre B cell leukemia transcription factor interacting protein 1
chr17_-_25785533 0.11 ENSMUST00000140738.1
ENSMUST00000145053.1
ENSMUST00000138759.1
ENSMUST00000133071.1
ENSMUST00000077938.3
Haghl
hydroxyacylglutathione hydrolase-like
chrX_-_73921930 0.10 ENSMUST00000033763.8
Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr9_-_70934808 0.10 ENSMUST00000034731.8
Lipc
lipase, hepatic
chr17_-_25785324 0.10 ENSMUST00000150324.1
Haghl
hydroxyacylglutathione hydrolase-like
chrX_-_73921828 0.09 ENSMUST00000096316.3
ENSMUST00000114390.1
ENSMUST00000114391.3
ENSMUST00000114387.1
Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr13_+_94875600 0.09 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr11_-_24075054 0.09 ENSMUST00000068360.1
A830031A19Rik
RIKEN cDNA A830031A19 gene
chr2_-_26237368 0.09 ENSMUST00000036187.8
Qsox2
quiescin Q6 sulfhydryl oxidase 2
chr2_-_155945282 0.08 ENSMUST00000040162.2
Gdf5
growth differentiation factor 5
chr1_-_87573825 0.08 ENSMUST00000068681.5
Ngef
neuronal guanine nucleotide exchange factor
chr11_-_79504078 0.08 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chrX_-_167855061 0.08 ENSMUST00000112146.1
Frmpd4
FERM and PDZ domain containing 4
chr10_+_90829835 0.08 ENSMUST00000179964.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr7_+_140920896 0.07 ENSMUST00000183845.1
ENSMUST00000106045.1
Nlrp6
NLR family, pyrin domain containing 6
chr3_+_89436699 0.06 ENSMUST00000038942.3
ENSMUST00000130858.1
Pbxip1
pre B cell leukemia transcription factor interacting protein 1
chr3_-_144975011 0.05 ENSMUST00000075496.4
ENSMUST00000029923.6
Clca6
chloride channel calcium activated 6
chr7_-_133602110 0.05 ENSMUST00000033275.2
Tex36
testis expressed 36
chr10_+_90829780 0.05 ENSMUST00000179337.2
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr18_+_57142782 0.04 ENSMUST00000139892.1
Megf10
multiple EGF-like-domains 10
chr13_-_17805093 0.04 ENSMUST00000042365.7
Cdk13
cyclin-dependent kinase 13
chr9_-_106656081 0.04 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chrX_+_152233228 0.03 ENSMUST00000112588.2
ENSMUST00000082177.6
Kdm5c
lysine (K)-specific demethylase 5C
chr10_+_93589413 0.03 ENSMUST00000181835.1
4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr14_-_78088994 0.03 ENSMUST00000118785.2
ENSMUST00000066437.4
Fam216b
family with sequence similarity 216, member B
chr14_-_18893376 0.02 ENSMUST00000151926.1
Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr12_+_87973528 0.01 ENSMUST00000110148.2
Gm2046
predicted gene 2046

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr4a2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.3 1.7 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.3 1.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 2.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 3.2 GO:0015747 urate transport(GO:0015747)
0.2 0.9 GO:0050787 detoxification of mercury ion(GO:0050787)
0.2 0.7 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 3.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.7 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.1 0.7 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.1 1.0 GO:0009313 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.1 0.5 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.5 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.1 1.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.4 GO:0003104 positive regulation of glomerular filtration(GO:0003104)
0.1 0.9 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.3 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.7 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.7 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 1.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 0.2 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.7 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.1 0.4 GO:0070672 response to interleukin-15(GO:0070672)
0.1 0.6 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 0.8 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.4 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 0.2 GO:0002465 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment(GO:0002362) peripheral T cell tolerance induction(GO:0002458) peripheral tolerance induction(GO:0002465) negative regulation of histone deacetylation(GO:0031064) negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.1 0.3 GO:0030920 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.1 0.5 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 2.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.7 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.4 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.6 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.3 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.3 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.2 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.0 0.2 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.7 GO:0010918 positive regulation of mitochondrial membrane potential(GO:0010918)
0.0 0.8 GO:0007602 phototransduction(GO:0007602)
0.0 0.7 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.2 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.3 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 1.4 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.1 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.3 GO:0007625 grooming behavior(GO:0007625)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:0034382 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0 0.6 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.8 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.4 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0006308 DNA catabolic process(GO:0006308)
0.0 0.1 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.8 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.0 0.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.5 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 0.9 GO:0031415 NatA complex(GO:0031415)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.7 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.7 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0045179 apical cortex(GO:0045179)
0.0 1.8 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 3.2 GO:0005814 centriole(GO:0005814)
0.0 0.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.8 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0061702 inflammasome complex(GO:0061702)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 2.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 3.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 1.0 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.2 0.5 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.2 1.8 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 1.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.7 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 0.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.6 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.3 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.7 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.3 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.1 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.2 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.7 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.3 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.5 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.8 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.5 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 2.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 2.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1