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GSE58827: Dynamics of the Mouse Liver

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Results for Onecut1_Cux2

Z-value: 0.86

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Transcription factors associated with Onecut1_Cux2

Gene Symbol Gene ID Gene Info
Onecut1
ENSMUSG00000043013.9 one cut domain, family member 1
Cux2
ENSMUSG00000042589.12 cut-like homeobox 2
Cux2
ENSMUSG00000072641.1 cut-like homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.456.4e-03Click!
Cux2mm10_v2_chr5_-_122049822_122049882-0.298.2e-02Click!

Activity profile of Onecut1_Cux2 motif

Sorted Z-values of Onecut1_Cux2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_60921270 10.50 ENSMUST00000096418.3
A1bg
alpha-1-B glycoprotein
chr16_+_22951072 7.89 ENSMUST00000023590.8
Hrg
histidine-rich glycoprotein
chr7_+_44207307 5.93 ENSMUST00000077354.4
Klk1b4
kallikrein 1-related pepidase b4
chr4_-_104876383 5.77 ENSMUST00000064873.8
ENSMUST00000106808.3
ENSMUST00000048947.8
C8a
complement component 8, alpha polypeptide
chr6_+_121346618 5.67 ENSMUST00000032200.9
Slc6a12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr6_-_23132981 4.34 ENSMUST00000031707.7
Aass
aminoadipate-semialdehyde synthase
chr4_-_46991842 4.20 ENSMUST00000107749.2
Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr2_-_148040196 3.75 ENSMUST00000136555.1
9030622O22Rik
RIKEN cDNA 9030622O22 gene
chr2_-_84775420 3.38 ENSMUST00000111641.1
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84775388 3.34 ENSMUST00000023994.3
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr11_+_101367542 3.25 ENSMUST00000019469.2
G6pc
glucose-6-phosphatase, catalytic
chr4_-_63154130 3.22 ENSMUST00000030041.4
Ambp
alpha 1 microglobulin/bikunin
chr3_+_28697901 3.02 ENSMUST00000029240.7
Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2
chr3_+_146597077 2.90 ENSMUST00000029837.7
ENSMUST00000121133.1
Uox
urate oxidase
chr2_-_148046896 2.84 ENSMUST00000172928.1
ENSMUST00000047315.3
Foxa2
forkhead box A2
chr1_+_172698046 2.66 ENSMUST00000038495.3
Crp
C-reactive protein, pentraxin-related
chr3_+_94372794 2.61 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr11_+_78499087 2.55 ENSMUST00000017488.4
Vtn
vitronectin
chr7_+_51880312 2.35 ENSMUST00000145049.1
Gas2
growth arrest specific 2
chr2_-_32451396 2.30 ENSMUST00000028160.8
ENSMUST00000113310.2
Slc25a25
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr14_-_30943275 2.26 ENSMUST00000006704.8
ENSMUST00000163118.1
Itih1
inter-alpha trypsin inhibitor, heavy chain 1
chr14_+_17981633 2.12 ENSMUST00000022304.8
Thrb
thyroid hormone receptor beta
chr15_-_78468620 1.83 ENSMUST00000017086.3
Tmprss6
transmembrane serine protease 6
chr15_+_55112420 1.77 ENSMUST00000100660.4
Deptor
DEP domain containing MTOR-interacting protein
chr3_-_146596588 1.69 ENSMUST00000029836.4
Dnase2b
deoxyribonuclease II beta
chr11_-_60036917 1.66 ENSMUST00000102692.3
Pemt
phosphatidylethanolamine N-methyltransferase
chrX_+_101377267 1.54 ENSMUST00000052130.7
Gjb1
gap junction protein, beta 1
chr15_+_55112317 1.42 ENSMUST00000096433.3
Deptor
DEP domain containing MTOR-interacting protein
chr19_+_26750939 1.42 ENSMUST00000175953.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_+_56294552 1.42 ENSMUST00000034026.8
Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
chr7_+_67647405 1.37 ENSMUST00000032774.8
ENSMUST00000107471.1
Ttc23
tetratricopeptide repeat domain 23
chr7_+_67655414 1.33 ENSMUST00000107470.1
Ttc23
tetratricopeptide repeat domain 23
chr6_-_136922169 1.32 ENSMUST00000032343.6
Erp27
endoplasmic reticulum protein 27
chr12_+_55598917 1.32 ENSMUST00000051857.3
Insm2
insulinoma-associated 2
chr19_-_57197377 1.28 ENSMUST00000111546.1
Ablim1
actin-binding LIM protein 1
chr9_-_50739365 1.22 ENSMUST00000117093.1
ENSMUST00000121634.1
Dixdc1
DIX domain containing 1
chr2_-_69342600 1.19 ENSMUST00000102709.1
ENSMUST00000102710.3
ENSMUST00000180142.1
Abcb11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr3_+_5218516 1.15 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr1_+_191717834 1.15 ENSMUST00000110855.1
ENSMUST00000133076.1
Lpgat1
lysophosphatidylglycerol acyltransferase 1
chr9_-_114844090 1.14 ENSMUST00000047013.3
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chrM_+_14138 1.13 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr19_-_32061438 1.11 ENSMUST00000096119.4
Asah2
N-acylsphingosine amidohydrolase 2
chr8_+_127064107 1.08 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr15_-_76209056 1.07 ENSMUST00000071869.5
ENSMUST00000170915.1
Plec
plectin
chr14_-_55092277 1.07 ENSMUST00000036328.8
Zfhx2
zinc finger homeobox 2
chr8_-_13200576 1.03 ENSMUST00000165605.2
Grtp1
GH regulated TBC protein 1
chr19_-_57197435 1.03 ENSMUST00000111550.1
Ablim1
actin-binding LIM protein 1
chr3_+_5218546 1.03 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr9_-_29963112 1.00 ENSMUST00000075069.4
Ntm
neurotrimin
chr3_+_5218589 1.00 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr15_+_22549022 0.99 ENSMUST00000163361.1
Cdh18
cadherin 18
chr3_+_102010138 0.97 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr8_+_127064022 0.96 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr8_-_91801547 0.95 ENSMUST00000093312.4
Irx3
Iroquois related homeobox 3 (Drosophila)
chrM_-_14060 0.94 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr5_+_3596066 0.91 ENSMUST00000006061.6
ENSMUST00000121291.1
ENSMUST00000142516.1
Pex1
peroxisomal biogenesis factor 1
chr9_+_59589288 0.88 ENSMUST00000121266.1
ENSMUST00000118164.1
Celf6
CUGBP, Elav-like family member 6
chr2_+_147364989 0.87 ENSMUST00000109968.2
Pax1
paired box gene 1
chr16_-_37384915 0.84 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l
syntaxin binding protein 5-like
chr3_-_79842662 0.83 ENSMUST00000029568.1
Tmem144
transmembrane protein 144
chr19_+_56287911 0.81 ENSMUST00000095948.4
Habp2
hyaluronic acid binding protein 2
chr5_+_92683625 0.80 ENSMUST00000168878.1
Shroom3
shroom family member 3
chrX_-_142196917 0.76 ENSMUST00000042530.3
Gucy2f
guanylate cyclase 2f
chrX_+_41401128 0.75 ENSMUST00000115103.2
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr19_+_31082841 0.69 ENSMUST00000066039.6
Cstf2t
cleavage stimulation factor, 3' pre-RNA subunit 2, tau
chr10_-_112928974 0.69 ENSMUST00000099276.2
Atxn7l3b
ataxin 7-like 3B
chrX_+_82948861 0.64 ENSMUST00000114000.1
Dmd
dystrophin, muscular dystrophy
chr10_-_64090265 0.61 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr7_-_127449109 0.59 ENSMUST00000053392.4
Zfp689
zinc finger protein 689
chr19_-_57197496 0.59 ENSMUST00000111544.1
Ablim1
actin-binding LIM protein 1
chr7_-_127448993 0.57 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr16_-_37384940 0.56 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l
syntaxin binding protein 5-like
chr6_-_34726905 0.56 ENSMUST00000075773.2
Npn2
neoplastic progression 2
chr6_+_139843648 0.55 ENSMUST00000087657.6
Pik3c2g
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
chr17_+_56990264 0.52 ENSMUST00000002735.7
Clpp
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit
chr16_-_95459245 0.45 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
Erg
avian erythroblastosis virus E-26 (v-ets) oncogene related
chr1_-_173131236 0.44 ENSMUST00000073663.2
Olfr1408
olfactory receptor 1408
chr2_-_72986716 0.44 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr10_-_64090241 0.44 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr8_+_58911755 0.37 ENSMUST00000062978.6
BC030500
cDNA sequence BC030500
chrX_-_50942710 0.36 ENSMUST00000060650.5
Frmd7
FERM domain containing 7
chrX_+_56609751 0.34 ENSMUST00000144068.1
Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr11_+_117484368 0.33 ENSMUST00000092394.3
Gm11733
predicted gene 11733
chr18_-_72351029 0.32 ENSMUST00000114943.3
Dcc
deleted in colorectal carcinoma
chr19_-_57197556 0.32 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chr18_-_72351009 0.31 ENSMUST00000073379.5
Dcc
deleted in colorectal carcinoma
chr8_-_79399513 0.30 ENSMUST00000066091.7
ENSMUST00000109885.1
ENSMUST00000066081.3
Smad1
SMAD family member 1
chr18_+_35965088 0.30 ENSMUST00000175734.1
Psd2
pleckstrin and Sec7 domain containing 2
chr3_+_125404292 0.28 ENSMUST00000144344.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr18_+_57468478 0.28 ENSMUST00000091892.2
Ctxn3
cortexin 3
chr4_-_97584605 0.28 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr5_+_63649335 0.27 ENSMUST00000159584.1
3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr3_-_33082004 0.25 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr4_-_97584612 0.23 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr11_+_97315716 0.23 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45
mitochondrial ribosomal protein L45
chr1_-_158958367 0.23 ENSMUST00000159861.2
Pappa2
pappalysin 2
chr1_+_88406956 0.21 ENSMUST00000027518.5
Spp2
secreted phosphoprotein 2
chr17_-_54299034 0.19 ENSMUST00000095712.3
Slc5a7
solute carrier family 5 (choline transporter), member 7
chr8_+_22624019 0.18 ENSMUST00000033936.6
Dkk4
dickkopf homolog 4 (Xenopus laevis)
chr9_+_54980880 0.18 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr8_+_113643206 0.16 ENSMUST00000034219.4
ENSMUST00000095173.1
Syce1l
synaptonemal complex central element protein 1 like
chr11_-_120624973 0.16 ENSMUST00000106183.2
ENSMUST00000080202.5
Sirt7
sirtuin 7
chr1_-_54194048 0.16 ENSMUST00000120904.1
Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr3_+_70007613 0.16 ENSMUST00000053013.5
Otol1
otolin 1 homolog (zebrafish)
chr19_-_45235811 0.16 ENSMUST00000099401.4
Lbx1
ladybird homeobox homolog 1 (Drosophila)
chr10_-_117238665 0.16 ENSMUST00000020392.4
9530003J23Rik
RIKEN cDNA 9530003J23 gene
chr5_-_138272786 0.14 ENSMUST00000161279.1
ENSMUST00000161647.1
Gal3st4
galactose-3-O-sulfotransferase 4
chr11_+_4902212 0.14 ENSMUST00000142543.1
Thoc5
THO complex 5
chr5_-_138272733 0.13 ENSMUST00000161665.1
ENSMUST00000100530.1
Gal3st4
galactose-3-O-sulfotransferase 4
chr13_-_54688246 0.13 ENSMUST00000122935.1
ENSMUST00000128257.1
Rnf44
ring finger protein 44
chr4_-_110292719 0.13 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr19_+_59219648 0.12 ENSMUST00000065204.6
Kcnk18
potassium channel, subfamily K, member 18
chrX_-_43274786 0.11 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr10_-_117238647 0.10 ENSMUST00000159193.1
9530003J23Rik
RIKEN cDNA 9530003J23 gene
chr5_-_3596071 0.09 ENSMUST00000121877.1
Rbm48
RNA binding motif protein 48
chr5_-_3596540 0.08 ENSMUST00000042753.7
Rbm48
RNA binding motif protein 48
chr7_-_105810947 0.06 ENSMUST00000176887.1
ENSMUST00000124482.1
Mrpl17
mitochondrial ribosomal protein L17
chr16_+_32430895 0.03 ENSMUST00000115137.1
ENSMUST00000079791.4
Pcyt1a
phosphate cytidylyltransferase 1, choline, alpha isoform
chr15_+_92161343 0.01 ENSMUST00000068378.5
Cntn1
contactin 1
chr16_+_32431225 0.01 ENSMUST00000115140.1
Pcyt1a
phosphate cytidylyltransferase 1, choline, alpha isoform
chr19_+_55894508 0.01 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chrX_-_102505359 0.00 ENSMUST00000087916.4
Hdac8
histone deacetylase 8
chr8_-_58911627 0.00 ENSMUST00000077447.4
Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut1_Cux2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
2.2 6.7 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
1.4 4.3 GO:0006553 lysine metabolic process(GO:0006553)
1.4 5.7 GO:0009992 cellular water homeostasis(GO:0009992)
0.9 2.8 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.6 3.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.5 3.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.5 2.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.4 2.7 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.4 5.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 2.0 GO:0003383 apical constriction(GO:0003383)
0.3 3.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.3 1.7 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.3 2.6 GO:0097421 liver regeneration(GO:0097421)
0.2 2.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.2 1.1 GO:0033762 response to glucagon(GO:0033762)
0.2 0.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 2.9 GO:0046415 urate metabolic process(GO:0046415)
0.2 1.2 GO:0046618 drug export(GO:0046618)
0.2 5.9 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.2 1.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 3.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 0.9 GO:0061056 sclerotome development(GO:0061056)
0.1 1.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 1.8 GO:0097264 self proteolysis(GO:0097264)
0.1 1.5 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.1 0.9 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.1 4.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.6 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 1.4 GO:0007567 parturition(GO:0007567)
0.1 1.2 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 1.7 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 2.3 GO:0014823 response to activity(GO:0014823)
0.1 1.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.5 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 1.0 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.2 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.1 1.2 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 0.7 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 1.9 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.2 GO:0045896 regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0 0.8 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.3 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0 2.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.8 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 1.0 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.9 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 0.9 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.2 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.6 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 1.4 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.1 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 3.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.5 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.2 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324)
0.0 0.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.0 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0032010 phagolysosome(GO:0032010)
0.8 4.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.5 5.8 GO:0005579 membrane attack complex(GO:0005579)
0.4 2.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 2.0 GO:0033269 internode region of axon(GO:0033269)
0.1 21.7 GO:0072562 blood microparticle(GO:0072562)
0.1 1.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 1.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.1 1.5 GO:0005922 connexon complex(GO:0005922)
0.1 0.6 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.3 GO:0044308 axonal spine(GO:0044308)
0.1 1.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 4.7 GO:0031526 brush border membrane(GO:0031526)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.6 GO:0031527 filopodium membrane(GO:0031527)
0.0 3.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.7 GO:0030175 filopodium(GO:0030175)
0.0 3.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 3.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.9 GO:0070469 respiratory chain(GO:0070469)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.9 5.7 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.7 4.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.6 3.0 GO:0055056 dehydroascorbic acid transporter activity(GO:0033300) D-glucose transmembrane transporter activity(GO:0055056)
0.6 15.1 GO:0001848 complement binding(GO:0001848)
0.5 2.6 GO:0008142 oxysterol binding(GO:0008142)
0.4 1.7 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.4 2.9 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 2.1 GO:0004887 thyroid hormone receptor activity(GO:0004887) thyroid hormone binding(GO:0070324)
0.2 1.4 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.2 3.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 4.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.2 2.3 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.2 1.1 GO:0017040 ceramidase activity(GO:0017040)
0.2 1.7 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 1.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.6 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.5 GO:0005243 gap junction channel activity(GO:0005243)
0.1 7.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 2.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 6.1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 2.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.3 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 1.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220) choline binding(GO:0033265)
0.0 1.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.3 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 1.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 2.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.8 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 2.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0042166 acetylcholine binding(GO:0042166)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.5 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 9.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 21.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 2.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.3 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.4 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.5 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 6.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 5.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 5.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 3.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 4.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 3.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 7.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 1.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 4.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 4.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)