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GSE58827: Dynamics of the Mouse Liver

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Results for Pax1_Pax9

Z-value: 0.38

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Transcription factors associated with Pax1_Pax9

Gene Symbol Gene ID Gene Info
Pax1
ENSMUSG00000037034.9 paired box 1
Pax9
ENSMUSG00000001497.12 paired box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax9mm10_v2_chr12_+_56695628_566957000.447.4e-03Click!
Pax1mm10_v2_chr2_+_147364989_1473650110.153.8e-01Click!

Activity profile of Pax1_Pax9 motif

Sorted Z-values of Pax1_Pax9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_84734050 2.60 ENSMUST00000090729.2
Ypel4
yippee-like 4 (Drosophila)
chr10_+_75573448 2.52 ENSMUST00000006508.3
Ggt1
gamma-glutamyltransferase 1
chr9_-_22389113 1.57 ENSMUST00000040912.7
Anln
anillin, actin binding protein
chr5_+_112255813 1.54 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
Crybb1
crystallin, beta B1
chr9_+_96196246 1.15 ENSMUST00000165120.2
ENSMUST00000034982.9
Tfdp2
transcription factor Dp 2
chr6_-_145048809 1.14 ENSMUST00000032402.5
Bcat1
branched chain aminotransferase 1, cytosolic
chr13_-_62607499 0.95 ENSMUST00000091563.4
6720489N17Rik
RIKEN cDNA 6720489N17 gene
chr4_+_115000174 0.95 ENSMUST00000129957.1
Stil
Scl/Tal1 interrupting locus
chr4_+_115000156 0.90 ENSMUST00000030490.6
Stil
Scl/Tal1 interrupting locus
chr5_-_129787175 0.83 ENSMUST00000031399.6
Psph
phosphoserine phosphatase
chr1_-_37719782 0.81 ENSMUST00000160589.1
2010300C02Rik
RIKEN cDNA 2010300C02 gene
chr5_+_93206518 0.72 ENSMUST00000031330.4
2010109A12Rik
RIKEN cDNA 2010109A12 gene
chr9_-_97111117 0.65 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr16_+_87553313 0.64 ENSMUST00000026700.7
Map3k7cl
Map3k7 C-terminal like
chr7_-_24299310 0.51 ENSMUST00000145131.1
Zfp61
zinc finger protein 61
chr13_-_62520451 0.41 ENSMUST00000082203.6
ENSMUST00000101547.4
Zfp934
zinc finger protein 934
chr9_+_21337828 0.41 ENSMUST00000034697.7
Slc44a2
solute carrier family 44, member 2
chr17_-_24205514 0.29 ENSMUST00000097376.3
ENSMUST00000168410.2
ENSMUST00000167791.2
ENSMUST00000040474.7
Tbc1d24
TBC1 domain family, member 24
chr7_+_118633729 0.28 ENSMUST00000057320.7
Tmc5
transmembrane channel-like gene family 5
chr4_+_11558914 0.28 ENSMUST00000178703.1
ENSMUST00000095145.5
ENSMUST00000108306.2
ENSMUST00000070755.6
Rad54b
RAD54 homolog B (S. cerevisiae)
chr13_-_62777089 0.26 ENSMUST00000167516.2
Gm5141
predicted gene 5141
chr4_-_117375453 0.19 ENSMUST00000094853.2
Rnf220
ring finger protein 220
chrX_+_74313014 0.15 ENSMUST00000114160.1
Fam50a
family with sequence similarity 50, member A
chr12_+_33957645 0.09 ENSMUST00000049089.5
Twist1
twist basic helix-loop-helix transcription factor 1
chr8_+_31150307 0.09 ENSMUST00000098842.2
Tti2
TELO2 interacting protein 2
chr4_-_143299463 0.04 ENSMUST00000119654.1
Pdpn
podoplanin
chr17_-_27909206 0.03 ENSMUST00000114848.1
Taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr5_+_129787390 0.01 ENSMUST00000031402.8
Cct6a
chaperonin containing Tcp1, subunit 6a (zeta)
chrX_+_86191764 0.01 ENSMUST00000026036.4
Nr0b1
nuclear receptor subfamily 0, group B, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax1_Pax9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:1904170 regulation of bleb assembly(GO:1904170)
0.3 2.5 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2 1.1 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 0.8 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 1.9 GO:0033504 floor plate development(GO:0033504)
0.1 0.6 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0 0.1 GO:2000793 cell proliferation involved in heart valve development(GO:2000793)
0.0 0.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.6 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.0 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 1.9 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 2.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.2 1.1 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 1.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.6 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 PID E2F PATHWAY E2F transcription factor network
0.0 1.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC