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GSE58827: Dynamics of the Mouse Liver

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Results for Pax3

Z-value: 0.66

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Transcription factors associated with Pax3

Gene Symbol Gene ID Gene Info
Pax3
ENSMUSG00000004872.9 paired box 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax3mm10_v2_chr1_-_78196832_781968450.289.4e-02Click!

Activity profile of Pax3 motif

Sorted Z-values of Pax3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_84167466 6.38 ENSMUST00000050771.7
Gm11437
predicted gene 11437
chr19_-_46148369 4.67 ENSMUST00000026259.9
Pitx3
paired-like homeodomain transcription factor 3
chr2_+_102659213 4.62 ENSMUST00000111213.1
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr5_-_87092546 4.46 ENSMUST00000132667.1
ENSMUST00000145617.1
ENSMUST00000094649.4
Ugt2b36
UDP glucuronosyltransferase 2 family, polypeptide B36
chr13_+_4434306 3.81 ENSMUST00000021630.8
Akr1c6
aldo-keto reductase family 1, member C6
chr7_-_133782721 1.61 ENSMUST00000063669.1
Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr4_-_25281801 1.44 ENSMUST00000102994.3
Ufl1
UFM1 specific ligase 1
chr14_+_51893610 1.43 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2
solute carrier family 39 (zinc transporter), member 2
chr11_-_88851462 1.42 ENSMUST00000107903.1
Akap1
A kinase (PRKA) anchor protein 1
chr7_-_31111148 1.38 ENSMUST00000164929.1
Hpn
hepsin
chr19_-_36736653 1.32 ENSMUST00000087321.2
Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr4_-_25281752 1.03 ENSMUST00000038705.7
Ufl1
UFM1 specific ligase 1
chr4_+_127077374 0.94 ENSMUST00000046751.6
ENSMUST00000094713.3
Zmym6
zinc finger, MYM-type 6
chr8_-_71043040 0.87 ENSMUST00000170101.1
Gm17576
predicted gene, 17576
chr17_+_21691860 0.78 ENSMUST00000072133.4
Gm10226
predicted gene 10226
chr1_-_130887408 0.75 ENSMUST00000121040.1
Il24
interleukin 24
chr10_+_82138253 0.73 ENSMUST00000105314.2
AU041133
expressed sequence AU041133
chr10_-_128923948 0.73 ENSMUST00000131271.1
Bloc1s1
biogenesis of lysosome-related organelles complex-1, subunit 1
chr8_+_33428709 0.72 ENSMUST00000059351.7
5930422O12Rik
RIKEN cDNA 5930422O12 gene
chr2_+_133552159 0.66 ENSMUST00000028836.6
Bmp2
bone morphogenetic protein 2
chr6_-_48766519 0.66 ENSMUST00000038811.8
Gimap3
GTPase, IMAP family member 3
chr13_-_21716143 0.65 ENSMUST00000091756.1
Hist1h2bl
histone cluster 1, H2bl
chr3_+_36159522 0.63 ENSMUST00000165956.2
D3Ertd254e
DNA segment, Chr 3, ERATO Doi 254, expressed
chr12_-_72184990 0.58 ENSMUST00000021494.4
Ccdc175
coiled-coil domain containing 175
chr8_+_110618577 0.57 ENSMUST00000034190.9
Vac14
Vac14 homolog (S. cerevisiae)
chr16_+_20548577 0.55 ENSMUST00000003319.5
Abcf3
ATP-binding cassette, sub-family F (GCN20), member 3
chr16_-_32877723 0.54 ENSMUST00000119810.1
1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr13_+_14630237 0.52 ENSMUST00000178289.1
ENSMUST00000038690.4
AW209491
expressed sequence AW209491
chr10_-_128923439 0.52 ENSMUST00000153731.1
ENSMUST00000026405.3
Bloc1s1
biogenesis of lysosome-related organelles complex-1, subunit 1
chr16_+_32877775 0.49 ENSMUST00000023489.4
ENSMUST00000171325.1
Fyttd1
forty-two-three domain containing 1
chr1_+_176814660 0.49 ENSMUST00000056773.8
ENSMUST00000027785.8
Sdccag8
serologically defined colon cancer antigen 8
chr4_-_63745055 0.47 ENSMUST00000062246.6
Tnfsf15
tumor necrosis factor (ligand) superfamily, member 15
chr11_-_59571813 0.46 ENSMUST00000071943.2
Olfr222
olfactory receptor 222
chr11_+_70970467 0.45 ENSMUST00000178822.1
ENSMUST00000108529.3
ENSMUST00000169965.1
ENSMUST00000167509.1
Rpain
RPA interacting protein
chr13_+_24327415 0.42 ENSMUST00000167746.1
Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr9_+_64235201 0.39 ENSMUST00000039011.3
Uchl4
ubiquitin carboxyl-terminal esterase L4
chr6_+_34920971 0.37 ENSMUST00000185102.1
ENSMUST00000114997.2
Stra8
stimulated by retinoic acid gene 8
chr3_+_108186332 0.34 ENSMUST00000050909.6
ENSMUST00000106659.2
ENSMUST00000106656.1
ENSMUST00000106661.2
Amigo1
adhesion molecule with Ig like domain 1
chr18_+_35562158 0.34 ENSMUST00000166793.1
Matr3
matrin 3
chr3_-_75451818 0.31 ENSMUST00000178270.1
Wdr49
WD repeat domain 49
chr16_-_88056176 0.27 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
Grik1
glutamate receptor, ionotropic, kainate 1
chr8_+_71887264 0.23 ENSMUST00000034259.7
Zfp709
zinc finger protein 709
chr10_+_104194042 0.18 ENSMUST00000181615.1
Gm4340
predicted gene 4340
chr10_+_104142987 0.18 ENSMUST00000181634.1
Gm6763
predicted gene 6763
chr10_+_104151497 0.18 ENSMUST00000181287.1
Gm6763
predicted gene 6763
chr10_+_104160006 0.18 ENSMUST00000181179.1
Gm8764
predicted gene 8764
chr10_+_104168515 0.18 ENSMUST00000181059.1
Gm21304
predicted gene, 21304
chr10_+_104177024 0.18 ENSMUST00000180889.1
Gm21312
predicted gene, 21312
chr10_+_104185533 0.18 ENSMUST00000181703.1
Gm20765
predicted gene, 20765
chr18_+_34759551 0.16 ENSMUST00000097622.3
Fam53c
family with sequence similarity 53, member C
chr10_+_104194457 0.16 ENSMUST00000181036.1
Gm4340
predicted gene 4340
chr10_+_104143402 0.16 ENSMUST00000180664.1
Gm6763
predicted gene 6763
chr10_+_104151912 0.16 ENSMUST00000180692.1
Gm6763
predicted gene 6763
chr10_+_104160421 0.16 ENSMUST00000181166.1
Gm8764
predicted gene 8764
chr10_+_104168930 0.16 ENSMUST00000180568.1
Gm21304
predicted gene, 21304
chr10_+_104177439 0.16 ENSMUST00000181239.1
Gm21312
predicted gene, 21312
chr10_+_104185948 0.16 ENSMUST00000181707.1
Gm20765
predicted gene, 20765
chr3_-_59262825 0.15 ENSMUST00000050360.7
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr18_+_34758890 0.14 ENSMUST00000049281.5
Fam53c
family with sequence similarity 53, member C
chr17_+_37529957 0.14 ENSMUST00000097325.3
Olfr111
olfactory receptor 111
chr19_+_34008247 0.13 ENSMUST00000054260.6
Lipk
lipase, family member K
chr17_+_87107621 0.09 ENSMUST00000041369.6
Socs5
suppressor of cytokine signaling 5
chrX_+_114474312 0.09 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4
kelch-like 4
chrX_-_103623704 0.05 ENSMUST00000130063.1
ENSMUST00000125419.1
Ftx
Ftx transcript, Xist regulator (non-protein coding)
chr10_-_107912134 0.05 ENSMUST00000165341.3
Otogl
otogelin-like
chr2_-_136387929 0.03 ENSMUST00000035264.2
ENSMUST00000077200.3
Pak7
p21 protein (Cdc42/Rac)-activated kinase 7

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
1.3 3.8 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.7 4.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.4 2.5 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.3 1.4 GO:0034769 basement membrane disassembly(GO:0034769)
0.2 1.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.2 0.7 GO:0035054 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) embryonic heart tube anterior/posterior pattern specification(GO:0035054) corticotropin hormone secreting cell differentiation(GO:0060128)
0.1 0.4 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.1 0.3 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.1 1.2 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 1.4 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.5 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.7 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 1.3 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.7 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.1 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.3 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.6 GO:0043550 regulation of lipid kinase activity(GO:0043550)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0042587 glycogen granule(GO:0042587)
0.1 4.6 GO:0030673 axolemma(GO:0030673)
0.1 0.6 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 1.4 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.8 2.5 GO:0071568 UFM1 transferase activity(GO:0071568)
0.8 4.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.4 GO:0030338 CMP-N-acetylneuraminate monooxygenase activity(GO:0030338)
0.1 4.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.7 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 1.4 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 1.4 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 1.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.6 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 1.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.7 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors