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GSE58827: Dynamics of the Mouse Liver

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Results for Pax7

Z-value: 0.71

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Transcription factors associated with Pax7

Gene Symbol Gene ID Gene Info
Pax7
ENSMUSG00000028736.7 paired box 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax7mm10_v2_chr4_-_139833524_1398335350.438.9e-03Click!

Activity profile of Pax7 motif

Sorted Z-values of Pax7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_15924928 5.43 ENSMUST00000025542.3
Psat1
phosphoserine aminotransferase 1
chr19_-_15924560 5.38 ENSMUST00000162053.1
Psat1
phosphoserine aminotransferase 1
chr5_-_138170992 5.28 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr10_-_62379852 3.94 ENSMUST00000143236.1
ENSMUST00000133429.1
ENSMUST00000132926.1
ENSMUST00000116238.2
Hk1
hexokinase 1
chr12_+_117843489 3.77 ENSMUST00000021592.9
Cdca7l
cell division cycle associated 7 like
chr9_-_20959785 3.30 ENSMUST00000177754.1
Dnmt1
DNA methyltransferase (cytosine-5) 1
chrX_+_9885622 2.98 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5
synaptotagmin-like 5
chr6_+_123262107 2.85 ENSMUST00000032240.2
Clec4d
C-type lectin domain family 4, member d
chr1_-_52952834 2.56 ENSMUST00000050567.4
1700019D03Rik
RIKEN cDNA 1700019D03 gene
chr9_+_119063429 2.36 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill
villin-like
chr11_-_87359011 2.24 ENSMUST00000055438.4
Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr15_+_9436028 2.21 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr13_+_76579670 2.18 ENSMUST00000126960.1
ENSMUST00000109583.2
Mctp1
multiple C2 domains, transmembrane 1
chr11_-_102946688 2.05 ENSMUST00000057849.5
C1ql1
complement component 1, q subcomponent-like 1
chr4_-_99654983 1.60 ENSMUST00000136525.1
Gm12688
predicted gene 12688
chr19_+_8802486 1.47 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr17_-_35516780 1.44 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19
transcription factor 19
chr3_-_75270073 1.44 ENSMUST00000039047.4
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr11_-_99244058 1.43 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr18_-_77047243 1.42 ENSMUST00000137354.1
ENSMUST00000137498.1
Katnal2
katanin p60 subunit A-like 2
chr3_-_17230976 1.38 ENSMUST00000177874.1
Gm5283
predicted gene 5283
chr18_-_77047282 1.38 ENSMUST00000154665.1
ENSMUST00000026486.6
ENSMUST00000123650.1
ENSMUST00000126153.1
Katnal2
katanin p60 subunit A-like 2
chr13_-_22042949 1.34 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr19_-_55241236 1.29 ENSMUST00000069183.6
Gucy2g
guanylate cyclase 2g
chr13_+_22043189 1.27 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr13_+_23533869 1.22 ENSMUST00000073261.2
Hist1h2af
histone cluster 1, H2af
chr2_+_78051155 1.12 ENSMUST00000145972.1
4930440I19Rik
RIKEN cDNA 4930440I19 gene
chr2_+_105126505 1.12 ENSMUST00000143043.1
Wt1
Wilms tumor 1 homolog
chr6_-_87533219 1.11 ENSMUST00000113637.2
ENSMUST00000071024.6
Arhgap25
Rho GTPase activating protein 25
chr3_-_87174657 1.05 ENSMUST00000159976.1
ENSMUST00000107618.2
Kirrel
kin of IRRE like (Drosophila)
chr2_+_125068118 1.01 ENSMUST00000070353.3
Slc24a5
solute carrier family 24, member 5
chr13_+_55445301 0.99 ENSMUST00000001115.8
ENSMUST00000099482.3
Grk6
G protein-coupled receptor kinase 6
chr2_+_86007778 0.95 ENSMUST00000062166.1
Olfr1032
olfactory receptor 1032
chr11_+_43682038 0.95 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr13_+_76579681 0.94 ENSMUST00000109589.2
Mctp1
multiple C2 domains, transmembrane 1
chr13_-_102906046 0.81 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr5_+_26817357 0.74 ENSMUST00000071500.6
Dpp6
dipeptidylpeptidase 6
chr4_+_136286061 0.69 ENSMUST00000069195.4
ENSMUST00000130658.1
Zfp46
zinc finger protein 46
chr9_+_38877126 0.68 ENSMUST00000078289.2
Olfr926
olfactory receptor 926
chr11_+_43681998 0.67 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr6_+_6248659 0.66 ENSMUST00000181633.1
ENSMUST00000176283.1
ENSMUST00000175814.1
ENSMUST00000181192.1
Gm20619
predicted gene 20619
chr14_+_53324632 0.65 ENSMUST00000178100.1
Trav7n-6
T cell receptor alpha variable 7N-6
chr7_+_45621805 0.65 ENSMUST00000033100.4
Izumo1
izumo sperm-egg fusion 1
chr8_-_34965631 0.64 ENSMUST00000033929.4
Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr2_-_85675173 0.58 ENSMUST00000099917.1
Olfr1006
olfactory receptor 1006
chr14_+_32785963 0.58 ENSMUST00000039191.6
1810011H11Rik
RIKEN cDNA 1810011H11 gene
chr16_+_58408443 0.57 ENSMUST00000046663.7
Dcbld2
discoidin, CUB and LCCL domain containing 2
chr6_+_92816460 0.57 ENSMUST00000057977.3
A730049H05Rik
RIKEN cDNA A730049H05 gene
chr19_-_11283813 0.55 ENSMUST00000067673.6
Ms4a5
membrane-spanning 4-domains, subfamily A, member 5
chr2_+_85979312 0.54 ENSMUST00000170610.1
Olfr1030
olfactory receptor 1030
chr7_-_19715395 0.51 ENSMUST00000032555.9
ENSMUST00000093552.5
Tomm40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr14_-_69707546 0.47 ENSMUST00000118374.1
R3hcc1
R3H domain and coiled-coil containing 1
chr1_-_55226768 0.47 ENSMUST00000027121.8
ENSMUST00000114428.2
Rftn2
raftlin family member 2
chr2_+_32727682 0.43 ENSMUST00000113242.2
Sh2d3c
SH2 domain containing 3C
chr1_+_72284367 0.42 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169
transmembrane protein 169
chr13_+_75707484 0.41 ENSMUST00000001583.6
Ell2
elongation factor RNA polymerase II 2
chr11_+_99857915 0.40 ENSMUST00000107434.1
Gm11568
predicted gene 11568
chr14_-_69707493 0.38 ENSMUST00000121142.1
R3hcc1
R3H domain and coiled-coil containing 1
chr9_-_96719404 0.37 ENSMUST00000140121.1
Zbtb38
zinc finger and BTB domain containing 38
chr2_+_78051220 0.37 ENSMUST00000144728.1
4930440I19Rik
RIKEN cDNA 4930440I19 gene
chr3_-_106790143 0.36 ENSMUST00000038845.8
Cd53
CD53 antigen
chr2_+_86041317 0.36 ENSMUST00000111589.1
Olfr1033
olfactory receptor 1033
chr10_+_85386813 0.35 ENSMUST00000105307.1
ENSMUST00000020231.3
Btbd11
BTB (POZ) domain containing 11
chr13_-_102905740 0.33 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_96268654 0.28 ENSMUST00000098843.2
Hist2h3b
histone cluster 2, H3b
chr8_+_107031218 0.27 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chr7_-_46667375 0.27 ENSMUST00000107669.2
Tph1
tryptophan hydroxylase 1
chr3_-_72967854 0.26 ENSMUST00000167334.1
Sis
sucrase isomaltase (alpha-glucosidase)
chr2_-_116067391 0.24 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr7_+_27486910 0.24 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr12_+_72441852 0.19 ENSMUST00000162159.1
Lrrc9
leucine rich repeat containing 9
chr13_-_113042243 0.16 ENSMUST00000099162.2
Gm10735
predicted gene 10735
chr2_-_144270852 0.15 ENSMUST00000110030.3
Snx5
sorting nexin 5
chr10_-_24092320 0.13 ENSMUST00000092654.2
Taar8b
trace amine-associated receptor 8B
chr12_+_72441933 0.13 ENSMUST00000161284.1
Lrrc9
leucine rich repeat containing 9
chr9_-_96719549 0.12 ENSMUST00000128269.1
Zbtb38
zinc finger and BTB domain containing 38
chr18_+_77332394 0.07 ENSMUST00000148341.1
Loxhd1
lipoxygenase homology domains 1
chr2_+_86046451 0.02 ENSMUST00000079298.2
Olfr1034
olfactory receptor 1034
chr4_-_14621805 0.01 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr17_+_35517100 0.00 ENSMUST00000164242.2
ENSMUST00000045956.7
Cchcr1
coiled-coil alpha-helical rod protein 1
chr2_+_27165233 0.00 ENSMUST00000000910.6
Dbh
dopamine beta hydroxylase
chr2_-_150255591 0.00 ENSMUST00000063463.5
Gm21994
predicted gene 21994

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 10.8 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.8 3.3 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.6 2.8 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.5 5.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.5 2.0 GO:0061743 motor learning(GO:0061743)
0.5 3.9 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.4 1.1 GO:2001074 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076)
0.3 1.0 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.2 1.0 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.2 0.6 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 2.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.3 GO:1903774 mitotic cytokinesis checkpoint(GO:0044878) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 3.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.4 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 0.5 GO:0032596 protein transport into membrane raft(GO:0032596)
0.1 0.6 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 1.4 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 2.4 GO:0051693 actin filament capping(GO:0051693)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 2.6 GO:0006342 chromatin silencing(GO:0006342)
0.0 2.9 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.4 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 1.0 GO:0007588 excretion(GO:0007588)
0.0 0.7 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.7 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0044301 climbing fiber(GO:0044301)
0.4 5.3 GO:0042555 MCM complex(GO:0042555)
0.1 3.9 GO:0097228 sperm principal piece(GO:0097228)
0.1 3.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.2 GO:0097422 tubular endosome(GO:0097422)
0.0 0.6 GO:0002080 acrosomal membrane(GO:0002080)
0.0 3.2 GO:0001650 fibrillar center(GO:0001650)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.9 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.4 3.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.4 10.8 GO:0008483 transaminase activity(GO:0008483)
0.4 2.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 1.0 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.2 1.0 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 1.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 5.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 2.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.5 GO:0015288 porin activity(GO:0015288)
0.1 0.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.3 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 3.1 GO:0005549 odorant binding(GO:0005549)
0.0 3.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 1.0 GO:0017022 myosin binding(GO:0017022)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.3 PID ATR PATHWAY ATR signaling pathway
0.0 3.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 4.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.8 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.3 PID CXCR4 PATHWAY CXCR4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.3 5.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 3.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport