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GSE58827: Dynamics of the Mouse Liver

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Results for Phox2a

Z-value: 0.63

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Transcription factors associated with Phox2a

Gene Symbol Gene ID Gene Info
Phox2a
ENSMUSG00000007946.9 paired-like homeobox 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Phox2amm10_v2_chr7_+_101818306_1018183210.652.0e-05Click!

Activity profile of Phox2a motif

Sorted Z-values of Phox2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_168767136 6.66 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4
sal-like 4 (Drosophila)
chr2_-_168767029 6.12 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr16_-_42340595 5.53 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr14_+_27000362 4.00 ENSMUST00000035433.8
Hesx1
homeobox gene expressed in ES cells
chrX_-_139871637 3.99 ENSMUST00000033811.7
ENSMUST00000087401.5
Morc4
microrchidia 4
chr6_-_30958990 3.91 ENSMUST00000101589.3
Klf14
Kruppel-like factor 14
chr1_-_89933290 3.40 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr9_+_119063429 3.00 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill
villin-like
chrX_+_9885622 2.19 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5
synaptotagmin-like 5
chr15_-_34356421 1.59 ENSMUST00000179647.1
9430069I07Rik
RIKEN cDNA 9430069I07 gene
chr19_-_55241236 1.49 ENSMUST00000069183.6
Gucy2g
guanylate cyclase 2g
chr19_-_47692042 1.46 ENSMUST00000026045.7
ENSMUST00000086923.5
Col17a1
collagen, type XVII, alpha 1
chr1_+_172555932 1.35 ENSMUST00000061835.3
Vsig8
V-set and immunoglobulin domain containing 8
chr1_-_172027269 1.33 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr11_-_99244058 1.09 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr5_+_13398688 1.01 ENSMUST00000125629.1
Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr2_+_36230426 0.91 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr6_+_92816460 0.80 ENSMUST00000057977.3
A730049H05Rik
RIKEN cDNA A730049H05 gene
chr5_-_118244861 0.75 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2
ring finger protein, transmembrane 2
chr2_-_164585447 0.56 ENSMUST00000109342.1
Wfdc6a
WAP four-disulfide core domain 6A
chr13_-_102906046 0.54 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr3_-_72967854 0.41 ENSMUST00000167334.1
Sis
sucrase isomaltase (alpha-glucosidase)
chr16_-_29544852 0.36 ENSMUST00000039090.8
Atp13a4
ATPase type 13A4
chr8_+_107031218 0.30 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chr18_+_55057557 0.27 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chr3_+_66219909 0.23 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr4_-_14621805 0.21 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr4_+_134930898 0.09 ENSMUST00000030622.2
Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of Phox2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 12.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.6 5.5 GO:0016198 axon choice point recognition(GO:0016198)
0.5 3.9 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.4 1.3 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.4 3.4 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.4 4.0 GO:0030916 otic vesicle formation(GO:0030916)
0.2 1.0 GO:1903375 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.2 0.9 GO:0035633 cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633)
0.1 0.3 GO:1903774 mitotic cytokinesis checkpoint(GO:0044878) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.6 GO:1901317 regulation of sperm motility(GO:1901317)
0.1 0.2 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.1 2.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 3.0 GO:0051693 actin filament capping(GO:0051693)
0.0 1.5 GO:0006182 cGMP biosynthetic process(GO:0006182)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0060187 cell pole(GO:0060187)
0.2 5.5 GO:0031527 filopodium membrane(GO:0031527)
0.1 12.8 GO:0000792 heterochromatin(GO:0000792)
0.1 1.5 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.5 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 0.4 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 7.3 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191) chemorepellent activity(GO:0045499)
0.1 1.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 2.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 4.0 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 12.4 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.9 GO:0004601 peroxidase activity(GO:0004601)
0.0 3.0 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 12.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation