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GSE58827: Dynamics of the Mouse Liver

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Results for Pou3f3

Z-value: 0.80

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Transcription factors associated with Pou3f3

Gene Symbol Gene ID Gene Info
Pou3f3
ENSMUSG00000045515.2 POU domain, class 3, transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pou3f3mm10_v2_chr1_+_42697146_426971460.271.1e-01Click!

Activity profile of Pou3f3 motif

Sorted Z-values of Pou3f3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_76656512 9.48 ENSMUST00000086909.4
Gm10430
predicted gene 10430
chr14_+_27000362 6.60 ENSMUST00000035433.8
Hesx1
homeobox gene expressed in ES cells
chr5_+_66676098 6.28 ENSMUST00000031131.9
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr4_+_134510999 5.98 ENSMUST00000105866.2
Aunip
aurora kinase A and ninein interacting protein
chr12_-_114416895 5.04 ENSMUST00000179796.1
Ighv6-5
immunoglobulin heavy variable V6-5
chr4_-_149137536 4.27 ENSMUST00000176124.1
ENSMUST00000177408.1
ENSMUST00000105695.1
ENSMUST00000030813.3
Apitd1
apoptosis-inducing, TAF9-like domain 1
chr3_+_83766300 4.11 ENSMUST00000029625.7
Sfrp2
secreted frizzled-related protein 2
chr11_+_9191934 3.73 ENSMUST00000042740.6
Abca13
ATP-binding cassette, sub-family A (ABC1), member 13
chr3_-_123034943 2.79 ENSMUST00000029761.7
Myoz2
myozenin 2
chr6_+_129350237 2.49 ENSMUST00000065289.4
Clec12a
C-type lectin domain family 12, member a
chr17_-_50094277 1.99 ENSMUST00000113195.1
Rftn1
raftlin lipid raft linker 1
chr15_-_42676967 1.90 ENSMUST00000022921.5
Angpt1
angiopoietin 1
chr2_+_25180737 1.83 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr11_-_99244058 1.39 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr5_-_74065736 1.14 ENSMUST00000145016.1
Usp46
ubiquitin specific peptidase 46
chr7_-_126792469 0.73 ENSMUST00000032936.6
Ppp4c
protein phosphatase 4, catalytic subunit
chr3_-_144849301 0.51 ENSMUST00000159989.1
Clca4
chloride channel calcium activated 4
chr2_+_110721587 0.47 ENSMUST00000111017.2
Muc15
mucin 15
chr3_-_146108047 0.47 ENSMUST00000160285.1
Wdr63
WD repeat domain 63
chrX_+_112011007 0.44 ENSMUST00000131304.1
Tex16
testis expressed gene 16
chr10_+_26229707 0.36 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3
sterile alpha motif domain containing 3
chr8_-_105295934 0.35 ENSMUST00000057855.3
Exoc3l
exocyst complex component 3-like
chr5_-_66514815 0.06 ENSMUST00000161879.1
ENSMUST00000159357.1
Apbb2
amyloid beta (A4) precursor protein-binding, family B, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou3f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:2000041 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
1.0 6.3 GO:0007412 axon target recognition(GO:0007412)
0.7 6.6 GO:0030916 otic vesicle formation(GO:0030916)
0.6 1.9 GO:0030210 heparin biosynthetic process(GO:0030210)
0.3 2.0 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 1.8 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 5.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 1.1 GO:0008343 adult feeding behavior(GO:0008343)
0.0 6.0 GO:0007051 spindle organization(GO:0007051)
0.0 2.8 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.4 GO:0051601 exocyst localization(GO:0051601)
0.0 0.7 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 0.7 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.1 0.4 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.0 6.0 GO:0000922 spindle pole(GO:0000922)
0.0 6.3 GO:0044306 neuron projection terminus(GO:0044306)
0.0 1.9 GO:0005902 microvillus(GO:0005902)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 2.2 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.6 2.8 GO:0051373 FATZ binding(GO:0051373)
0.5 4.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 5.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.7 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 1.9 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 6.6 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 3.7 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 2.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 4.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.9 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 3.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 4.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis