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GSE58827: Dynamics of the Mouse Liver

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Results for Pou4f3

Z-value: 0.50

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Transcription factors associated with Pou4f3

Gene Symbol Gene ID Gene Info
Pou4f3
ENSMUSG00000024497.3 POU domain, class 4, transcription factor 3

Activity profile of Pou4f3 motif

Sorted Z-values of Pou4f3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_80000292 4.87 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr4_-_119189949 4.64 ENSMUST00000124626.1
Ermap
erythroblast membrane-associated protein
chr14_+_27000362 3.26 ENSMUST00000035433.8
Hesx1
homeobox gene expressed in ES cells
chr4_-_119190005 3.09 ENSMUST00000138395.1
ENSMUST00000156746.1
Ermap
erythroblast membrane-associated protein
chr10_+_37139558 2.09 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr18_-_68429235 1.98 ENSMUST00000052347.6
Mc2r
melanocortin 2 receptor
chrX_+_9885622 1.94 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5
synaptotagmin-like 5
chr5_-_43981757 1.83 ENSMUST00000061299.7
Fgfbp1
fibroblast growth factor binding protein 1
chr6_+_41521782 1.81 ENSMUST00000070380.4
Prss2
protease, serine, 2
chr1_-_89933290 1.74 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr1_-_126830632 1.68 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5
NCK-associated protein 5
chr7_+_43427622 1.38 ENSMUST00000177164.2
Lim2
lens intrinsic membrane protein 2
chr17_-_48432723 1.36 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr2_-_160619971 1.22 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr18_+_11633276 1.13 ENSMUST00000115861.2
Rbbp8
retinoblastoma binding protein 8
chr15_+_66670749 1.06 ENSMUST00000065916.7
Tg
thyroglobulin
chr17_-_50094277 1.01 ENSMUST00000113195.1
Rftn1
raftlin lipid raft linker 1
chr12_-_8539545 0.96 ENSMUST00000095863.3
ENSMUST00000165657.1
Slc7a15
solute carrier family 7 (cationic amino acid transporter, y+ system), member 15
chr2_+_4300462 0.89 ENSMUST00000175669.1
Frmd4a
FERM domain containing 4A
chr16_-_69863718 0.88 ENSMUST00000076500.7
Speer2
spermatogenesis associated glutamate (E)-rich protein 2
chr2_-_140671400 0.74 ENSMUST00000056760.3
Flrt3
fibronectin leucine rich transmembrane protein 3
chr13_-_58354862 0.73 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr3_-_17230976 0.71 ENSMUST00000177874.1
Gm5283
predicted gene 5283
chr10_-_76110956 0.70 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr1_+_45795485 0.68 ENSMUST00000147308.1
Wdr75
WD repeat domain 75
chr4_+_63558748 0.65 ENSMUST00000077709.4
6330416G13Rik
RIKEN cDNA 6330416G13 gene
chr8_+_83666827 0.64 ENSMUST00000019608.5
Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr1_-_126830786 0.63 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr5_+_13398688 0.63 ENSMUST00000125629.1
Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr8_+_15057646 0.62 ENSMUST00000033842.3
Myom2
myomesin 2
chr15_+_79690869 0.61 ENSMUST00000046463.8
Gtpbp1
GTP binding protein 1
chr4_-_58499398 0.57 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr14_-_75754475 0.56 ENSMUST00000049168.7
Cog3
component of oligomeric golgi complex 3
chr7_+_103928825 0.55 ENSMUST00000106863.1
Olfr631
olfactory receptor 631
chr14_+_58893465 0.53 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr4_+_148901128 0.48 ENSMUST00000147270.1
Casz1
castor zinc finger 1
chr2_+_36230426 0.47 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr5_-_69590783 0.42 ENSMUST00000173927.1
Gnpda2
glucosamine-6-phosphate deaminase 2
chr7_+_35802593 0.42 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr8_-_83458386 0.42 ENSMUST00000081506.3
Scoc
short coiled-coil protein
chr10_-_37138863 0.37 ENSMUST00000092584.5
Marcks
myristoylated alanine rich protein kinase C substrate
chr5_-_118244861 0.31 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2
ring finger protein, transmembrane 2
chr17_+_21691860 0.21 ENSMUST00000072133.4
Gm10226
predicted gene 10226
chr12_-_103694657 0.20 ENSMUST00000117053.1
Serpina1f
serine (or cysteine) peptidase inhibitor, clade A, member 1F
chr9_-_118014160 0.18 ENSMUST00000111769.3
Zcwpw2
zinc finger, CW type with PWWP domain 2
chr9_+_110132015 0.16 ENSMUST00000088716.5
ENSMUST00000111969.1
ENSMUST00000035057.7
ENSMUST00000111966.1
ENSMUST00000111968.1
Smarcc1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr10_-_87008015 0.14 ENSMUST00000035288.8
Stab2
stabilin 2
chr3_-_72967854 0.11 ENSMUST00000167334.1
Sis
sucrase isomaltase (alpha-glucosidase)
chr12_-_103694713 0.10 ENSMUST00000118101.1
Serpina1f
serine (or cysteine) peptidase inhibitor, clade A, member 1F
chr17_-_33033367 0.10 ENSMUST00000087654.4
Zfp763
zinc finger protein 763
chr18_+_55057557 0.08 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chr7_+_106814135 0.06 ENSMUST00000075414.1
ENSMUST00000166880.1
Olfr701
olfactory receptor 701
chr12_-_82496537 0.02 ENSMUST00000179295.1
Gm5435
predicted gene 5435
chr2_+_3424123 0.01 ENSMUST00000061852.5
ENSMUST00000100463.3
ENSMUST00000102988.3
ENSMUST00000115066.1
Dclre1c
DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou4f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.3 GO:0030916 otic vesicle formation(GO:0030916)
0.2 0.7 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.2 1.8 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.2 1.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.2 1.7 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.2 1.0 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.2 0.5 GO:0060220 camera-type eye photoreceptor cell fate commitment(GO:0060220) negative regulation of neural retina development(GO:0061076) negative regulation of retina development in camera-type eye(GO:1902867) negative regulation of amacrine cell differentiation(GO:1902870)
0.1 0.6 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 1.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.6 GO:0021824 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 1.8 GO:0031000 response to caffeine(GO:0031000)
0.1 0.7 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1 1.1 GO:0015705 iodide transport(GO:0015705)
0.1 4.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633)
0.0 0.7 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 1.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.4 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.7 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 2.0 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 0.4 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.6 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 1.4 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.2 GO:0006337 nucleosome disassembly(GO:0006337)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.9 GO:0042581 specific granule(GO:0042581)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.6 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.6 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.6 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.7 GO:0044295 axonal growth cone(GO:0044295)
0.0 2.3 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.7 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0004977 melanocortin receptor activity(GO:0004977)
0.2 1.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.6 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 0.4 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 1.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.4 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.7 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 1.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 1.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.7 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 3.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.0 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 1.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 4.9 GO:0045296 cadherin binding(GO:0045296)
0.0 1.1 GO:0051087 chaperone binding(GO:0051087)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME DEFENSINS Genes involved in Defensins
0.1 0.6 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation