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GSE58827: Dynamics of the Mouse Liver

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Results for Rest

Z-value: 0.96

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Transcription factors associated with Rest

Gene Symbol Gene ID Gene Info
Rest
ENSMUSG00000029249.9 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77265454_77265549-0.212.1e-01Click!

Activity profile of Rest motif

Sorted Z-values of Rest motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_23890805 13.61 ENSMUST00000004480.3
Sst
somatostatin
chr12_+_102554966 4.54 ENSMUST00000021610.5
Chga
chromogranin A
chr13_-_23991158 3.36 ENSMUST00000021770.7
Scgn
secretagogin, EF-hand calcium binding protein
chr2_+_132781278 2.46 ENSMUST00000028826.3
Chgb
chromogranin B
chr2_-_181314500 1.78 ENSMUST00000103045.3
Stmn3
stathmin-like 3
chr7_+_27653906 1.76 ENSMUST00000008088.7
Ttc9b
tetratricopeptide repeat domain 9B
chr11_+_74619594 1.64 ENSMUST00000100866.2
E130309D14Rik
RIKEN cDNA E130309D14 gene
chrX_-_73869804 1.62 ENSMUST00000066576.5
ENSMUST00000114430.1
L1cam
L1 cell adhesion molecule
chr13_-_99900645 1.59 ENSMUST00000022150.6
Cartpt
CART prepropeptide
chr2_+_153031852 1.48 ENSMUST00000037235.6
Xkr7
X Kell blood group precursor related family member 7 homolog
chr10_+_5639210 1.40 ENSMUST00000019906.4
Vip
vasoactive intestinal polypeptide
chr15_-_76722161 1.20 ENSMUST00000049956.4
Lrrc24
leucine rich repeat containing 24
chr5_+_137030275 1.15 ENSMUST00000041543.8
Vgf
VGF nerve growth factor inducible
chr7_-_81493883 1.13 ENSMUST00000082090.7
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr1_-_193035651 1.08 ENSMUST00000016344.7
Syt14
synaptotagmin XIV
chr19_+_42255704 1.05 ENSMUST00000087123.5
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr12_-_84698769 0.91 ENSMUST00000095550.2
Syndig1l
synapse differentiation inducing 1 like
chr11_+_77930800 0.84 ENSMUST00000093995.3
ENSMUST00000000646.7
Sez6
seizure related gene 6
chr13_-_54749849 0.82 ENSMUST00000135343.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr1_-_84696182 0.75 ENSMUST00000049126.6
Dner
delta/notch-like EGF-related receptor
chr13_-_54749627 0.73 ENSMUST00000099506.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr15_-_75747922 0.70 ENSMUST00000062002.4
Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
chrX_+_7638674 0.66 ENSMUST00000128890.1
Syp
synaptophysin
chr2_-_27142429 0.53 ENSMUST00000151224.2
Fam163b
family with sequence similarity 163, member B
chr15_-_76521902 0.53 ENSMUST00000164703.1
ENSMUST00000096365.3
Scrt1
scratch homolog 1, zinc finger protein (Drosophila)
chr8_+_84946987 0.50 ENSMUST00000067472.7
ENSMUST00000109740.2
Rtbdn
retbindin
chr9_+_108826320 0.49 ENSMUST00000024238.5
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr7_+_63444741 0.45 ENSMUST00000058476.7
Otud7a
OTU domain containing 7A
chr17_+_69439326 0.43 ENSMUST00000169935.1
A330050F15Rik
RIKEN cDNA A330050F15 gene
chr5_-_31138829 0.43 ENSMUST00000043475.2
Ucn
urocortin
chr7_-_79594924 0.43 ENSMUST00000172788.1
Rhcg
Rhesus blood group-associated C glycoprotein
chr11_+_69914179 0.41 ENSMUST00000057884.5
Gps2
G protein pathway suppressor 2
chr15_+_101473472 0.41 ENSMUST00000088049.3
Krt86
keratin 86
chr12_-_112511136 0.40 ENSMUST00000066791.5
Tmem179
transmembrane protein 179
chr6_-_121473630 0.37 ENSMUST00000046373.5
Iqsec3
IQ motif and Sec7 domain 3
chr2_-_122313644 0.37 ENSMUST00000147788.1
ENSMUST00000154412.1
ENSMUST00000110537.1
ENSMUST00000148417.1
Duoxa1
dual oxidase maturation factor 1
chr2_+_155775333 0.37 ENSMUST00000029141.5
Mmp24
matrix metallopeptidase 24
chr7_+_19345135 0.33 ENSMUST00000160369.1
Ercc1
excision repair cross-complementing rodent repair deficiency, complementation group 1
chr18_-_31447383 0.33 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr10_+_6788809 0.33 ENSMUST00000105611.1
ENSMUST00000052751.7
ENSMUST00000135502.1
ENSMUST00000105605.1
ENSMUST00000154906.1
ENSMUST00000092731.4
ENSMUST00000000783.6
ENSMUST00000078634.5
ENSMUST00000105602.1
ENSMUST00000105604.1
ENSMUST00000105603.1
Oprm1
opioid receptor, mu 1
chr4_+_130055010 0.32 ENSMUST00000123617.1
Col16a1
collagen, type XVI, alpha 1
chr2_-_25319095 0.32 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr2_-_180104463 0.30 ENSMUST00000056480.3
Hrh3
histamine receptor H3
chr1_+_70725902 0.29 ENSMUST00000161937.1
ENSMUST00000162182.1
Vwc2l
von Willebrand factor C domain-containing protein 2-like
chr17_-_83631892 0.27 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr19_+_22139028 0.26 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
Trpm3
transient receptor potential cation channel, subfamily M, member 3
chr9_-_63146980 0.26 ENSMUST00000055281.7
ENSMUST00000119146.1
Skor1
SKI family transcriptional corepressor 1
chr1_+_70725715 0.26 ENSMUST00000053922.5
Vwc2l
von Willebrand factor C domain-containing protein 2-like
chr1_+_81077204 0.25 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr2_+_152143552 0.23 ENSMUST00000089112.5
Tcf15
transcription factor 15
chr11_-_35798884 0.22 ENSMUST00000160726.2
Fbll1
fibrillarin-like 1
chr9_+_59578192 0.22 ENSMUST00000118549.1
ENSMUST00000034840.3
Celf6
CUGBP, Elav-like family member 6
chr8_+_18846251 0.21 ENSMUST00000149565.1
ENSMUST00000033847.4
Agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr14_+_32321987 0.21 ENSMUST00000022480.7
Ogdhl
oxoglutarate dehydrogenase-like
chr13_-_56895737 0.20 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7
transient receptor potential cation channel, subfamily C, member 7
chr12_+_119945957 0.20 ENSMUST00000058644.8
Tmem196
transmembrane protein 196
chr8_+_69088646 0.17 ENSMUST00000006435.7
Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
chr8_-_104310032 0.17 ENSMUST00000160596.1
ENSMUST00000164175.1
Cmtm1
CKLF-like MARVEL transmembrane domain containing 1
chr2_-_25319187 0.16 ENSMUST00000114312.1
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr9_+_40873981 0.15 ENSMUST00000067375.3
Bsx
brain specific homeobox
chr7_-_27396542 0.15 ENSMUST00000108363.1
Sptbn4
spectrin beta, non-erythrocytic 4
chr10_+_90829409 0.15 ENSMUST00000182202.1
ENSMUST00000182966.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr19_-_45046614 0.14 ENSMUST00000145391.1
Pdzd7
PDZ domain containing 7
chr4_-_129121234 0.13 ENSMUST00000030572.3
Hpca
hippocalcin
chr2_-_28916668 0.13 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr11_+_76202007 0.13 ENSMUST00000094014.3
Fam57a
family with sequence similarity 57, member A
chr8_-_104310109 0.13 ENSMUST00000159039.1
Cmtm1
CKLF-like MARVEL transmembrane domain containing 1
chr15_-_11037968 0.13 ENSMUST00000058007.5
Rxfp3
relaxin family peptide receptor 3
chr10_-_41072279 0.13 ENSMUST00000061796.6
Gpr6
G protein-coupled receptor 6
chr11_-_55607733 0.13 ENSMUST00000108853.1
ENSMUST00000075603.4
Glra1
glycine receptor, alpha 1 subunit
chr2_+_157456917 0.12 ENSMUST00000109529.1
Src
Rous sarcoma oncogene
chr9_+_40269430 0.11 ENSMUST00000171835.2
Scn3b
sodium channel, voltage-gated, type III, beta
chr1_-_162548484 0.11 ENSMUST00000028017.9
Mettl13
methyltransferase like 13
chr2_+_22622183 0.11 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2
chr13_+_54371340 0.10 ENSMUST00000026985.8
Cplx2
complexin 2
chr11_-_3774706 0.10 ENSMUST00000155197.1
Osbp2
oxysterol binding protein 2
chr10_+_90829538 0.08 ENSMUST00000179694.2
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_26208281 0.07 ENSMUST00000054099.9
Lhx3
LIM homeobox protein 3
chr19_-_8929323 0.07 ENSMUST00000096242.3
Rom1
rod outer segment membrane protein 1
chr4_+_15881255 0.07 ENSMUST00000029876.1
Calb1
calbindin 1
chr17_+_28575718 0.07 ENSMUST00000080780.6
Lhfpl5
lipoma HMGIC fusion partner-like 5
chr2_-_92401237 0.07 ENSMUST00000050312.2
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr1_+_34579693 0.06 ENSMUST00000052670.8
Amer3
APC membrane recruitment 3
chr9_+_40269273 0.04 ENSMUST00000176185.1
Scn3b
sodium channel, voltage-gated, type III, beta
chr8_+_55940453 0.04 ENSMUST00000000275.7
Glra3
glycine receptor, alpha 3 subunit
chr11_+_76202084 0.03 ENSMUST00000169560.1
Fam57a
family with sequence similarity 57, member A
chr12_+_102949450 0.03 ENSMUST00000179002.1
Unc79
unc-79 homolog (C. elegans)
chr17_+_25240166 0.03 ENSMUST00000063574.6
Tsr3
TSR3 20S rRNA accumulation
chr11_-_55608189 0.02 ENSMUST00000102716.3
Glra1
glycine receptor, alpha 1 subunit
chr5_+_38260372 0.01 ENSMUST00000119047.1
Tmem128
transmembrane protein 128

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.5 1.4 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.4 1.6 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.2 0.7 GO:2000474 regulation of opioid receptor signaling pathway(GO:2000474)
0.2 1.8 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 0.5 GO:1900673 olefin metabolic process(GO:1900673)
0.1 1.6 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 0.3 GO:0006296 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296) positive regulation of t-circle formation(GO:1904431)
0.1 0.3 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635) cellular response to isoquinoline alkaloid(GO:0071317)
0.1 0.4 GO:0035483 gastric emptying(GO:0035483)
0.1 0.4 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.1 1.0 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.2 GO:0043084 penile erection(GO:0043084)
0.1 0.5 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.1 0.4 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 0.8 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.3 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.0 0.1 GO:0030824 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.0 0.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.0 0.3 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.4 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.0 0.8 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.8 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.4 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.7 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.3 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.0 0.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0 0.1 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.1 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 0.1 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 13.2 GO:0030334 regulation of cell migration(GO:0030334)
0.0 0.4 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.8 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 3.7 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.5 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.5 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.1 0.5 GO:0044307 dendritic branch(GO:0044307)
0.1 1.7 GO:0044294 dendritic growth cone(GO:0044294)
0.1 0.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 1.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.8 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.1 GO:1990696 USH2 complex(GO:1990696)
0.0 0.1 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.3 GO:0097449 astrocyte projection(GO:0097449)
0.0 0.9 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 17.2 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 3.9 GO:0030141 secretory granule(GO:0030141)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0033691 sialic acid binding(GO:0033691)
0.2 18.1 GO:0005179 hormone activity(GO:0005179)
0.1 0.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.5 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.3 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 0.3 GO:0004985 melanocortin receptor activity(GO:0004977) opioid receptor activity(GO:0004985)
0.0 0.1 GO:0030977 taurine binding(GO:0030977)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 13.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.4 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.8 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix