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GSE58827: Dynamics of the Mouse Liver

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Results for Rfx5

Z-value: 0.55

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Transcription factors associated with Rfx5

Gene Symbol Gene ID Gene Info
Rfx5
ENSMUSG00000005774.6 regulatory factor X, 5 (influences HLA class II expression)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_949542260.019.3e-01Click!

Activity profile of Rfx5 motif

Sorted Z-values of Rfx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_19692596 3.68 ENSMUST00000108451.2
ENSMUST00000045035.4
Apoc1
apolipoprotein C-I
chr5_-_145879857 2.83 ENSMUST00000035918.7
Cyp3a11
cytochrome P450, family 3, subfamily a, polypeptide 11
chr17_+_34305883 2.42 ENSMUST00000074557.8
H2-Eb1
histocompatibility 2, class II antigen E beta
chr17_+_34263209 2.26 ENSMUST00000040828.5
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr18_+_60803838 1.92 ENSMUST00000050487.8
ENSMUST00000097563.2
ENSMUST00000167610.1
Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
chr1_+_88211956 1.90 ENSMUST00000073049.6
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr17_+_34153072 1.69 ENSMUST00000114232.2
H2-DMb1
histocompatibility 2, class II, locus Mb1
chr2_-_28563362 1.62 ENSMUST00000028161.5
Cel
carboxyl ester lipase
chr17_+_34187545 1.52 ENSMUST00000170086.1
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_-_34187219 1.49 ENSMUST00000173831.1
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr7_+_101378183 1.44 ENSMUST00000084895.5
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr17_+_34197715 1.44 ENSMUST00000173441.1
ENSMUST00000025196.8
Psmb8
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
chr17_+_34187789 1.44 ENSMUST00000041633.8
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_+_122147680 1.38 ENSMUST00000102476.4
B2m
beta-2 microglobulin
chr17_+_35439155 1.36 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
H2-Q7
histocompatibility 2, Q region locus 7
chr12_+_108334341 1.31 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr17_+_35379608 1.29 ENSMUST00000081435.4
H2-Q4
histocompatibility 2, Q region locus 4
chr7_+_45277502 1.26 ENSMUST00000176276.1
1700039E15Rik
RIKEN cDNA 1700039E15 gene
chr14_+_53649387 1.06 ENSMUST00000103660.2
Trav15-2-dv6-2
T cell receptor alpha variable 15-2-DV6-2
chr17_+_36121666 1.01 ENSMUST00000173128.1
Gm19684
predicted gene, 19684
chr7_+_28180226 1.00 ENSMUST00000172467.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr9_+_44772909 1.00 ENSMUST00000002099.3
Ift46
intraflagellar transport 46
chr7_+_28180272 0.98 ENSMUST00000173223.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr9_+_44772951 0.97 ENSMUST00000128150.1
Ift46
intraflagellar transport 46
chr6_+_94500313 0.97 ENSMUST00000061118.8
Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr8_+_27042555 0.96 ENSMUST00000033875.8
ENSMUST00000098851.4
Prosc
proline synthetase co-transcribed
chr17_+_34238914 0.90 ENSMUST00000167280.1
H2-Ob
histocompatibility 2, O region beta locus
chr1_-_155146755 0.89 ENSMUST00000027744.8
Mr1
major histocompatibility complex, class I-related
chr5_-_125294107 0.83 ENSMUST00000127148.1
Scarb1
scavenger receptor class B, member 1
chr17_+_34238896 0.75 ENSMUST00000095342.3
H2-Ob
histocompatibility 2, O region beta locus
chr9_+_44773191 0.75 ENSMUST00000147559.1
Ift46
intraflagellar transport 46
chr5_+_104170676 0.70 ENSMUST00000112771.1
Dspp
dentin sialophosphoprotein
chr9_+_44773027 0.69 ENSMUST00000125877.1
Ift46
intraflagellar transport 46
chr17_+_34135182 0.68 ENSMUST00000042121.9
H2-DMa
histocompatibility 2, class II, locus DMa
chr7_+_28179469 0.67 ENSMUST00000085901.6
ENSMUST00000172761.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr12_-_87102350 0.65 ENSMUST00000110176.1
Ngb
neuroglobin
chr5_-_36830647 0.61 ENSMUST00000031002.3
Man2b2
mannosidase 2, alpha B2
chr19_+_32757497 0.60 ENSMUST00000013807.7
Pten
phosphatase and tensin homolog
chr17_+_37270214 0.59 ENSMUST00000038580.6
H2-M3
histocompatibility 2, M region locus 3
chr10_-_78307550 0.59 ENSMUST00000150828.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr7_-_101921186 0.54 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
Lrrc51
leucine rich repeat containing 51
chr3_-_57692537 0.50 ENSMUST00000099091.3
Gm410
predicted gene 410
chr17_-_24886304 0.46 ENSMUST00000044252.5
Nubp2
nucleotide binding protein 2
chr17_+_34145231 0.44 ENSMUST00000171231.1
H2-DMb2
histocompatibility 2, class II, locus Mb2
chr7_-_101921175 0.42 ENSMUST00000098236.2
Lrrc51
leucine rich repeat containing 51
chr17_+_34325658 0.39 ENSMUST00000050325.8
H2-Eb2
histocompatibility 2, class II antigen E beta2
chr17_+_34145311 0.39 ENSMUST00000041982.7
H2-DMb2
histocompatibility 2, class II, locus Mb2
chr5_+_11257157 0.34 ENSMUST00000177727.1
Gm8890
predicted gene 8890
chr13_-_23488840 0.33 ENSMUST00000041541.4
ENSMUST00000110432.1
ENSMUST00000110433.3
Btn2a2
butyrophilin, subfamily 2, member A2
chr1_+_194619815 0.33 ENSMUST00000027952.5
Plxna2
plexin A2
chr4_+_107968332 0.32 ENSMUST00000106713.3
Slc1a7
solute carrier family 1 (glutamate transporter), member 7
chr5_+_11128868 0.29 ENSMUST00000178863.1
Gm8879
predicted gene 8879
chr5_+_11683236 0.29 ENSMUST00000178989.1
Gm8922
predicted gene 8922
chr5_+_11184207 0.29 ENSMUST00000168407.2
Gm5861
predicted gene 5861
chr3_-_95882031 0.28 ENSMUST00000161994.1
Gm129
predicted gene 129
chr5_+_11342679 0.28 ENSMUST00000179482.1
Speer1-ps1
spermatogenesis associated glutamate (E)-rich protein 1, pseudogene 1
chr5_+_11771686 0.28 ENSMUST00000178158.1
Gm8926
predicted gene 8926
chr17_-_34305715 0.27 ENSMUST00000174074.1
Gm20513
predicted gene 20513
chr11_+_117523526 0.26 ENSMUST00000132261.1
Gm11734
predicted gene 11734
chr9_-_51102062 0.25 ENSMUST00000170947.1
4833427G06Rik
RIKEN cDNA 4833427G06 gene
chr5_+_10867186 0.25 ENSMUST00000168057.2
Gm6455
predicted gene 6455
chr2_-_92434027 0.24 ENSMUST00000111278.1
ENSMUST00000090559.5
Cry2
cryptochrome 2 (photolyase-like)
chr7_-_45694369 0.24 ENSMUST00000040636.6
Sec1
secretory blood group 1
chr17_+_24886643 0.23 ENSMUST00000117890.1
ENSMUST00000168265.1
ENSMUST00000120943.1
ENSMUST00000068508.6
ENSMUST00000119829.1
Spsb3
splA/ryanodine receptor domain and SOCS box containing 3
chr7_-_105752193 0.23 ENSMUST00000033184.4
Tpp1
tripeptidyl peptidase I
chr18_-_51865881 0.20 ENSMUST00000091905.2
Gm4950
predicted pseudogene 4950
chr6_-_83831736 0.19 ENSMUST00000058383.8
Paip2b
poly(A) binding protein interacting protein 2B
chr14_+_41072936 0.16 ENSMUST00000161837.1
Dydc1
DPY30 domain containing 1
chr3_-_95882193 0.15 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
Gm129
predicted gene 129
chr4_-_115781012 0.15 ENSMUST00000106521.1
Tex38
testis expressed 38
chr14_+_111675113 0.14 ENSMUST00000042767.7
Slitrk5
SLIT and NTRK-like family, member 5
chr11_+_98682554 0.13 ENSMUST00000017365.8
Psmd3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr5_+_139150211 0.12 ENSMUST00000026975.6
Heatr2
HEAT repeat containing 2
chr2_+_69380431 0.08 ENSMUST00000063690.3
Dhrs9
dehydrogenase/reductase (SDR family) member 9
chrX_+_42526585 0.08 ENSMUST00000101619.3
Gm10483
predicted gene 10483
chr3_+_16183177 0.08 ENSMUST00000108345.2
ENSMUST00000108346.2
Ythdf3
YTH domain family 3
chr10_-_127263346 0.08 ENSMUST00000099172.3
Kif5a
kinesin family member 5A
chrX_+_45090882 0.07 ENSMUST00000040002.3
1110059M19Rik
RIKEN cDNA 1110059M19 gene
chr13_+_24831661 0.07 ENSMUST00000038039.2
Tdp2
tyrosyl-DNA phosphodiesterase 2
chr3_-_95882232 0.04 ENSMUST00000161866.1
Gm129
predicted gene 129
chr10_-_7663569 0.01 ENSMUST00000162606.1
Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.0 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.8 2.3 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.6 1.9 GO:0018879 biphenyl metabolic process(GO:0018879)
0.6 0.6 GO:1901630 negative regulation of presynaptic membrane organization(GO:1901630)
0.6 3.0 GO:0046967 cytosol to ER transport(GO:0046967)
0.6 1.7 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.5 7.5 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.3 0.8 GO:0010899 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.2 2.9 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 0.7 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.2 1.0 GO:0051182 coenzyme transport(GO:0051182)
0.1 2.8 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.1 0.3 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.1 3.5 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 0.2 GO:2000847 negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.1 0.6 GO:0015671 oxygen transport(GO:0015671)
0.1 0.6 GO:0006013 mannose metabolic process(GO:0006013)
0.1 2.9 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 2.7 GO:0007520 myoblast fusion(GO:0007520) adipose tissue development(GO:0060612)
0.0 1.4 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.3 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 3.7 GO:0006641 triglyceride metabolic process(GO:0006641)
0.0 0.1 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.1 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 11.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.6 2.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 5.5 GO:0042611 MHC protein complex(GO:0042611)
0.4 3.0 GO:0042825 TAP complex(GO:0042825)
0.1 3.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 1.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 3.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.6 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 1.6 GO:0042588 zymogen granule(GO:0042588)
0.0 0.8 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.5 1.6 GO:0050253 sterol esterase activity(GO:0004771) retinyl-palmitate esterase activity(GO:0050253)
0.4 2.8 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.3 6.8 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 2.7 GO:0046977 TAP binding(GO:0046977)
0.2 0.8 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.2 0.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.2 2.3 GO:1990405 protein antigen binding(GO:1990405)
0.2 1.0 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 2.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.9 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 0.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.2 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.1 0.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 2.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.6 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 1.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 3.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 3.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.6 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA