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GSE58827: Dynamics of the Mouse Liver

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Results for Six3_Six1_Six2

Z-value: 0.62

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Transcription factors associated with Six3_Six1_Six2

Gene Symbol Gene ID Gene Info
Six3
ENSMUSG00000038805.9 sine oculis-related homeobox 3
Six1
ENSMUSG00000051367.8 sine oculis-related homeobox 1
Six2
ENSMUSG00000024134.10 sine oculis-related homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six3mm10_v2_chr17_+_85621017_85621031-0.372.5e-02Click!
Six1mm10_v2_chr12_-_73047179_73047179-0.134.7e-01Click!
Six2mm10_v2_chr17_-_85688252_85688275-0.067.1e-01Click!

Activity profile of Six3_Six1_Six2 motif

Sorted Z-values of Six3_Six1_Six2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_117797660 4.63 ENSMUST00000106331.1
6030468B19Rik
RIKEN cDNA 6030468B19 gene
chr3_+_108364882 2.39 ENSMUST00000090563.5
Mybphl
myosin binding protein H-like
chr6_+_122391379 2.20 ENSMUST00000043553.3
1700063H04Rik
RIKEN cDNA 1700063H04 gene
chrX_-_142966709 1.94 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr4_+_129906205 1.77 ENSMUST00000145196.1
ENSMUST00000141731.1
ENSMUST00000129149.1
E330017L17Rik
RIKEN cDNA E330017L17 gene
chr3_+_130068390 1.40 ENSMUST00000076703.6
Gm9396
predicted gene 9396
chr1_-_65123108 1.35 ENSMUST00000050047.3
ENSMUST00000148020.1
D630023F18Rik
RIKEN cDNA D630023F18 gene
chr17_-_53539411 1.23 ENSMUST00000056198.3
Pp2d1
protein phosphatase 2C-like domain containing 1
chr3_-_37724321 1.12 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148
predicted gene 5148
chr2_+_31245801 1.08 ENSMUST00000000199.7
Ncs1
neuronal calcium sensor 1
chr10_-_128180265 0.97 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr17_+_40811089 0.92 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr4_+_134864536 0.85 ENSMUST00000030627.7
Rhd
Rh blood group, D antigen
chr6_+_123123423 0.79 ENSMUST00000032248.7
Clec4a2
C-type lectin domain family 4, member a2
chr6_+_123123313 0.78 ENSMUST00000041779.6
Clec4a2
C-type lectin domain family 4, member a2
chr7_+_43690418 0.77 ENSMUST00000056329.6
Klk14
kallikrein related-peptidase 14
chr2_+_131491764 0.71 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox
spermine oxidase
chrX_-_74373218 0.68 ENSMUST00000178691.1
ENSMUST00000114146.1
Ubl4
Slc10a3
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr2_+_106693185 0.63 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr14_+_55765956 0.62 ENSMUST00000057569.3
Ltb4r1
leukotriene B4 receptor 1
chr7_-_100855403 0.61 ENSMUST00000156855.1
Relt
RELT tumor necrosis factor receptor
chr8_+_69832633 0.61 ENSMUST00000131637.2
ENSMUST00000081503.6
Pbx4
pre B cell leukemia homeobox 4
chr9_+_32393963 0.59 ENSMUST00000172015.1
Kcnj1
potassium inwardly-rectifying channel, subfamily J, member 1
chr1_+_139454747 0.59 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm
asp (abnormal spindle)-like, microcephaly associated (Drosophila)
chr19_-_23075853 0.58 ENSMUST00000181623.1
C330002G04Rik
RIKEN cDNA C330002G04 gene
chr8_-_106573461 0.56 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr9_+_98422961 0.48 ENSMUST00000052068.9
Rbp1
retinol binding protein 1, cellular
chr2_+_127336152 0.48 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr3_-_40509737 0.48 ENSMUST00000179966.1
1700017G19Rik
RIKEN cDNA 1700017G19 gene
chrX_+_38772671 0.48 ENSMUST00000050744.5
6030498E09Rik
RIKEN cDNA 6030498E09 gene
chr14_+_58893465 0.46 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr10_-_81627797 0.46 ENSMUST00000042923.8
Sirt6
sirtuin 6
chr15_-_82244716 0.46 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm
centromere protein M
chr7_-_30232186 0.45 ENSMUST00000006254.5
Tbcb
tubulin folding cofactor B
chr4_-_60582152 0.45 ENSMUST00000098047.2
Mup10
major urinary protein 10
chrX_-_74373260 0.44 ENSMUST00000073067.4
ENSMUST00000037967.5
Slc10a3
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr8_+_57455898 0.44 ENSMUST00000034023.3
Scrg1
scrapie responsive gene 1
chr1_+_136467958 0.41 ENSMUST00000047817.6
Kif14
kinesin family member 14
chr4_-_61303802 0.40 ENSMUST00000125461.1
Mup14
major urinary protein 14
chr17_+_35241838 0.39 ENSMUST00000173731.1
Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chrX_-_167102059 0.38 ENSMUST00000146929.1
Gm15232
predicted gene 15232
chr17_+_35241746 0.36 ENSMUST00000068056.5
ENSMUST00000174757.1
Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr19_+_46341118 0.36 ENSMUST00000128041.1
Tmem180
transmembrane protein 180
chr7_-_101903783 0.34 ENSMUST00000106969.1
Tomt
transmembrane O-methyltransferase
chr5_+_140607334 0.29 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr13_+_104229366 0.29 ENSMUST00000022227.6
Cenpk
centromere protein K
chr7_+_30231884 0.28 ENSMUST00000019882.9
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr17_-_40914350 0.28 ENSMUST00000166343.1
Glyatl3
glycine-N-acyltransferase-like 3
chr8_+_84831522 0.27 ENSMUST00000036734.5
Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr7_+_30232310 0.27 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr9_+_65141154 0.27 ENSMUST00000034961.4
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr17_+_56717759 0.24 ENSMUST00000002452.6
Ndufa11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr8_-_4275886 0.24 ENSMUST00000003029.7
Timm44
translocase of inner mitochondrial membrane 44
chr7_-_80115294 0.23 ENSMUST00000107384.3
Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr2_-_152540094 0.22 ENSMUST00000060598.3
Defb29
defensin beta 29
chr3_-_92827239 0.22 ENSMUST00000072363.4
Kprp
keratinocyte expressed, proline-rich
chr4_-_60421933 0.21 ENSMUST00000107506.2
ENSMUST00000122381.1
ENSMUST00000118759.1
ENSMUST00000122177.1
Mup9
major urinary protein 9
chr6_-_52218686 0.20 ENSMUST00000134367.2
Hoxa7
homeobox A7
chr4_+_11758147 0.19 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17
cadherin 17
chr4_-_43030440 0.18 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr6_+_38534823 0.17 ENSMUST00000019833.4
1110001J03Rik
RIKEN cDNA 1110001J03 gene
chr2_-_119029392 0.16 ENSMUST00000036470.7
ENSMUST00000110834.1
Ccdc32
coiled-coil domain containing 32
chr12_+_84773262 0.16 ENSMUST00000021667.5
Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr8_-_22653406 0.16 ENSMUST00000033938.5
Polb
polymerase (DNA directed), beta
chr16_-_60605226 0.15 ENSMUST00000068860.6
Epha6
Eph receptor A6
chr10_+_23949516 0.15 ENSMUST00000045152.4
Taar3
trace amine-associated receptor 3
chr5_+_21543525 0.15 ENSMUST00000035651.4
Lrrc17
leucine rich repeat containing 17
chr16_+_11203375 0.14 ENSMUST00000181526.1
2610020C07Rik
RIKEN cDNA 2610020C07 gene
chr5_+_104046869 0.13 ENSMUST00000031250.7
Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr2_-_119029359 0.13 ENSMUST00000110833.1
Ccdc32
coiled-coil domain containing 32
chr19_-_44135816 0.13 ENSMUST00000026218.5
Cwf19l1
CWF19-like 1, cell cycle control (S. pombe)
chrX_+_31117674 0.13 ENSMUST00000179532.1
Gm21447
predicted gene, 21447
chr11_-_87826023 0.12 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr10_+_70868633 0.12 ENSMUST00000058942.5
4930533K18Rik
RIKEN cDNA 4930533K18 gene
chr16_-_45724600 0.12 ENSMUST00000096057.4
Tagln3
transgelin 3
chr2_+_86297817 0.11 ENSMUST00000054746.2
Olfr1052
olfactory receptor 1052
chr11_-_99230998 0.11 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr7_+_30977043 0.10 ENSMUST00000058093.4
Fam187b
family with sequence similarity 187, member B
chr16_-_18235074 0.10 ENSMUST00000076957.5
Zdhhc8
zinc finger, DHHC domain containing 8
chr7_+_15750134 0.09 ENSMUST00000173455.1
Obox5
oocyte specific homeobox 5
chr19_+_8764934 0.09 ENSMUST00000184663.1
Nxf1
nuclear RNA export factor 1
chr6_+_90269106 0.09 ENSMUST00000058039.2
Vmn1r54
vomeronasal 1 receptor 54
chr7_+_15750377 0.09 ENSMUST00000098802.3
ENSMUST00000173053.1
Obox5
oocyte specific homeobox 5
chr10_+_100488289 0.09 ENSMUST00000164751.1
Cep290
centrosomal protein 290
chr7_-_141168671 0.09 ENSMUST00000106033.3
Rnh1
ribonuclease/angiogenin inhibitor 1
chr7_+_14659733 0.08 ENSMUST00000069740.7
ENSMUST00000183424.1
Gm4745
predicted gene 4745
chr2_-_13271419 0.08 ENSMUST00000028059.2
Rsu1
Ras suppressor protein 1
chr4_-_116651644 0.08 ENSMUST00000030455.8
Akr1a1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr11_-_9039585 0.07 ENSMUST00000043377.5
Sun3
Sad1 and UNC84 domain containing 3
chr14_+_57798182 0.07 ENSMUST00000111269.1
Sap18
Sin3-associated polypeptide 18
chrX_-_33702349 0.07 ENSMUST00000105117.2
Gm2933
predicted gene 2933
chr4_-_63605126 0.07 ENSMUST00000136620.1
Gm11213
predicted gene 11213
chrX_+_31336454 0.06 ENSMUST00000180197.1
Gm2784
predicted gene 2784
chr2_-_13271268 0.06 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1
Ras suppressor protein 1
chr16_-_11203259 0.06 ENSMUST00000119953.1
Rsl1d1
ribosomal L1 domain containing 1
chr9_-_35790101 0.05 ENSMUST00000034619.1
D730048I06Rik
RIKEN cDNA D730048I06 gene
chr7_-_104893626 0.05 ENSMUST00000081116.1
Olfr666
olfactory receptor 666
chr1_+_165485168 0.05 ENSMUST00000111440.1
ENSMUST00000027852.8
ENSMUST00000111439.1
Adcy10
adenylate cyclase 10
chr11_+_101987050 0.05 ENSMUST00000010985.7
1700006E09Rik
RIKEN cDNA 1700006E09 gene
chr2_+_117249725 0.05 ENSMUST00000028825.4
Fam98b
family with sequence similarity 98, member B
chr5_-_106926245 0.05 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr17_-_36951636 0.05 ENSMUST00000040402.7
ENSMUST00000174711.1
Ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr7_-_103771594 0.04 ENSMUST00000080910.1
Olfr69
olfactory receptor 69
chrX_+_169685191 0.04 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1
midline 1
chrX_+_32047829 0.04 ENSMUST00000178747.1
Gm21645
predicted gene, 21645
chr15_-_67113909 0.04 ENSMUST00000092640.5
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr14_+_57798156 0.03 ENSMUST00000128764.1
Sap18
Sin3-associated polypeptide 18
chrX_-_33956540 0.03 ENSMUST00000179466.1
Gm2964
predicted gene 2964
chrX_+_32894625 0.03 ENSMUST00000179069.1
Gm21657
predicted gene, 21657
chr18_+_62180119 0.03 ENSMUST00000067743.1
Gm9949
predicted gene 9949
chrX_-_34161499 0.03 ENSMUST00000178219.1
Gm21681
predicted gene, 21681
chr15_+_82252397 0.03 ENSMUST00000136948.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr15_+_38661904 0.03 ENSMUST00000022904.6
Atp6v1c1
ATPase, H+ transporting, lysosomal V1 subunit C1
chr7_-_24724237 0.02 ENSMUST00000081657.4
Gm4763
predicted gene 4763
chr1_-_119504736 0.02 ENSMUST00000004565.8
Ralb
v-ral simian leukemia viral oncogene homolog B (ras related)
chrX_+_33657172 0.00 ENSMUST00000177912.1
Gm2927
predicted gene 2927
chr1_-_118982551 0.00 ENSMUST00000159678.1
Gli2
GLI-Kruppel family member GLI2
chrX_-_111536325 0.00 ENSMUST00000156639.1
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr2_-_76868375 0.00 ENSMUST00000149616.1
ENSMUST00000152185.1
ENSMUST00000130915.1
ENSMUST00000155365.1
ENSMUST00000128071.1
Ttn
titin
chr7_-_48499270 0.00 ENSMUST00000098433.3
Mrgprx2
MAS-related GPR, member X2

Network of associatons between targets according to the STRING database.

First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 0.2 GO:1904464 regulation of matrix metallopeptidase secretion(GO:1904464) matrix metallopeptidase secretion(GO:1990773)
0.2 0.6 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.2 0.5 GO:0033189 response to vitamin A(GO:0033189)
0.2 0.5 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 2.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.4 GO:0033624 negative regulation of integrin activation(GO:0033624)
0.1 0.6 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.8 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.7 GO:0046208 spermine catabolic process(GO:0046208)
0.1 0.6 GO:1901979 renal sodium ion absorption(GO:0070294) regulation of inward rectifier potassium channel activity(GO:1901979)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.2 GO:0090297 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.8 GO:0007320 insemination(GO:0007320)
0.1 0.3 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.2 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.0 0.1 GO:0046032 ADP catabolic process(GO:0046032)
0.0 0.3 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.3 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
0.0 0.1 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0036449 microtubule minus-end(GO:0036449)
0.1 2.4 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.8 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 1.1 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 0.4 GO:0051233 spindle midzone(GO:0051233)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.2 1.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 0.6 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 0.5 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.2 0.8 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 2.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 1.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.5 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.6 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 1.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.6 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.6 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.9 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels