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GSE58827: Dynamics of the Mouse Liver

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Results for Smad2

Z-value: 0.34

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Transcription factors associated with Smad2

Gene Symbol Gene ID Gene Info
Smad2
ENSMUSG00000024563.9 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76241892_76242046-0.144.1e-01Click!

Activity profile of Smad2 motif

Sorted Z-values of Smad2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_126463100 2.08 ENSMUST00000032974.6
Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr7_+_19411086 1.78 ENSMUST00000003643.1
Ckm
creatine kinase, muscle
chr15_-_101924725 1.11 ENSMUST00000023797.6
Krt4
keratin 4
chr6_+_30639218 0.79 ENSMUST00000031806.9
Cpa1
carboxypeptidase A1, pancreatic
chr6_-_55175019 0.51 ENSMUST00000003569.5
Inmt
indolethylamine N-methyltransferase
chr2_-_84822546 0.42 ENSMUST00000028471.5
Smtnl1
smoothelin-like 1
chr15_-_84123174 0.39 ENSMUST00000019012.3
Pnpla5
patatin-like phospholipase domain containing 5
chr7_+_26307190 0.38 ENSMUST00000098657.3
Cyp2a4
cytochrome P450, family 2, subfamily a, polypeptide 4
chr1_-_172297989 0.30 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr10_-_118868903 0.26 ENSMUST00000004281.8
Dyrk2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr14_-_20496780 0.23 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr7_-_34654342 0.22 ENSMUST00000108069.1
Kctd15
potassium channel tetramerisation domain containing 15
chr10_-_49788743 0.20 ENSMUST00000105483.1
ENSMUST00000105487.1
Grik2
glutamate receptor, ionotropic, kainate 2 (beta 2)
chr8_-_105637403 0.20 ENSMUST00000182046.1
Gm5914
predicted gene 5914
chr3_+_89136133 0.17 ENSMUST00000047111.6
Pklr
pyruvate kinase liver and red blood cell
chr11_-_116654245 0.17 ENSMUST00000021166.5
Cygb
cytoglobin
chr14_-_12345847 0.16 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr10_+_80150448 0.16 ENSMUST00000153477.1
Midn
midnolin
chr3_+_89136572 0.16 ENSMUST00000107482.3
ENSMUST00000127058.1
Pklr
pyruvate kinase liver and red blood cell
chr11_+_4135233 0.13 ENSMUST00000124670.1
Rnf215
ring finger protein 215
chr2_+_177768044 0.13 ENSMUST00000108942.3
Gm14322
predicted gene 14322
chr15_+_57694651 0.12 ENSMUST00000096430.4
Zhx2
zinc fingers and homeoboxes 2
chr17_-_46032366 0.12 ENSMUST00000071648.5
ENSMUST00000142351.2
ENSMUST00000167860.1
Vegfa
vascular endothelial growth factor A
chr11_-_69122589 0.11 ENSMUST00000180487.1
9130213A22Rik
RIKEN cDNA 9130213A22 gene
chr15_-_101562889 0.11 ENSMUST00000023714.4
4732456N10Rik
RIKEN cDNA 4732456N10 gene
chr11_-_33147400 0.11 ENSMUST00000020507.7
Fgf18
fibroblast growth factor 18
chr8_-_87959560 0.11 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr15_+_102102926 0.11 ENSMUST00000169627.1
ENSMUST00000046144.9
Tenc1
tensin like C1 domain-containing phosphatase
chr10_+_80300997 0.10 ENSMUST00000140828.1
ENSMUST00000138909.1
Apc2
adenomatosis polyposis coli 2
chr17_+_69439326 0.10 ENSMUST00000169935.1
A330050F15Rik
RIKEN cDNA A330050F15 gene
chr17_+_3397189 0.09 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr4_+_148591482 0.09 ENSMUST00000006611.8
Srm
spermidine synthase
chr3_+_116968267 0.09 ENSMUST00000117592.1
4930455H04Rik
RIKEN cDNA 4930455H04 gene
chr3_+_135438280 0.08 ENSMUST00000106291.3
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr15_+_82252397 0.08 ENSMUST00000136948.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr13_-_100104064 0.08 ENSMUST00000038104.5
Bdp1
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr9_+_44107286 0.08 ENSMUST00000152956.1
ENSMUST00000114815.1
C1qtnf5
C1q and tumor necrosis factor related protein 5
chrX_-_94123087 0.08 ENSMUST00000113925.1
Zfx
zinc finger protein X-linked
chr17_-_35980197 0.08 ENSMUST00000055454.7
Prr3
proline-rich polypeptide 3
chrX_-_92599572 0.08 ENSMUST00000113955.1
Mageb18
melanoma antigen family B, 18
chr8_+_47822143 0.08 ENSMUST00000079639.2
Cldn24
claudin 24
chr11_-_75190458 0.07 ENSMUST00000044949.4
Dph1
DPH1 homolog (S. cerevisiae)
chr13_+_96542727 0.07 ENSMUST00000077672.4
ENSMUST00000109444.2
Col4a3bp
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr3_+_135438722 0.07 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr11_-_100762928 0.07 ENSMUST00000107360.2
ENSMUST00000055083.3
Hcrt
hypocretin
chr10_+_5069192 0.07 ENSMUST00000180100.1
Gm10097
predicted gene 10097
chr14_-_18331855 0.06 ENSMUST00000022296.6
Ube2e1
ubiquitin-conjugating enzyme E2E 1
chr17_-_34615776 0.06 ENSMUST00000168353.2
Egfl8
EGF-like domain 8
chr13_-_104816908 0.06 ENSMUST00000022228.6
Cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr14_+_21500879 0.05 ENSMUST00000182964.1
Kat6b
K(lysine) acetyltransferase 6B
chr16_+_64851991 0.05 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr7_+_101321703 0.05 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
Stard10
START domain containing 10
chr2_-_128967725 0.04 ENSMUST00000099385.2
Gm10762
predicted gene 10762
chr10_-_42583628 0.04 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr4_+_42950369 0.04 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr18_-_42579652 0.04 ENSMUST00000054738.3
Gpr151
G protein-coupled receptor 151
chr12_+_33147754 0.04 ENSMUST00000146040.1
ENSMUST00000125192.1
Atxn7l1
ataxin 7-like 1
chr3_+_58576636 0.04 ENSMUST00000107924.1
Selt
selenoprotein T
chr7_-_29180699 0.04 ENSMUST00000059642.10
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr6_+_125009261 0.04 ENSMUST00000112427.1
Zfp384
zinc finger protein 384
chr7_-_29180454 0.03 ENSMUST00000182328.1
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr3_-_83129246 0.03 ENSMUST00000047876.6
Gm10710
predicted gene 10710
chr6_+_125009232 0.03 ENSMUST00000112428.1
Zfp384
zinc finger protein 384
chr15_+_62178175 0.03 ENSMUST00000182476.1
Pvt1
plasmacytoma variant translocation 1
chrX_-_94123359 0.03 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
Zfx
zinc finger protein X-linked
chr3_+_127633134 0.03 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr2_+_156863110 0.03 ENSMUST00000029165.3
1110008F13Rik
RIKEN cDNA 1110008F13 gene
chr10_+_80151154 0.02 ENSMUST00000146516.1
ENSMUST00000144526.1
Midn
midnolin
chr6_+_125009665 0.02 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
Zfp384
zinc finger protein 384
chr11_-_101119814 0.02 ENSMUST00000107295.3
Fam134c
family with sequence similarity 134, member C
chrX_-_136741155 0.02 ENSMUST00000166930.1
ENSMUST00000113095.1
ENSMUST00000155207.1
ENSMUST00000080411.6
ENSMUST00000169418.1
Morf4l2
mortality factor 4 like 2
chr19_+_5878622 0.02 ENSMUST00000136833.1
ENSMUST00000141362.1
Slc25a45
solute carrier family 25, member 45
chr8_-_70439557 0.02 ENSMUST00000076615.5
Crtc1
CREB regulated transcription coactivator 1
chrX_+_99821021 0.02 ENSMUST00000096363.2
Tmem28
transmembrane protein 28
chr11_+_101119938 0.02 ENSMUST00000043680.8
Tubg1
tubulin, gamma 1
chr18_+_37307445 0.01 ENSMUST00000056712.2
Pcdhb4
protocadherin beta 4
chr18_+_40258361 0.01 ENSMUST00000091927.4
Kctd16
potassium channel tetramerisation domain containing 16
chr18_-_31609893 0.01 ENSMUST00000060396.6
Slc25a46
solute carrier family 25, member 46
chr11_-_101119889 0.01 ENSMUST00000017946.5
Fam134c
family with sequence similarity 134, member C
chr14_-_31168587 0.01 ENSMUST00000036618.7
Stab1
stabilin 1
chr17_-_34615965 0.01 ENSMUST00000097345.3
ENSMUST00000015611.7
Egfl8
EGF-like domain 8
chr18_+_77375065 0.01 ENSMUST00000123410.1
Loxhd1
lipoxygenase homology domains 1
chr13_+_23752267 0.01 ENSMUST00000091703.2
Hist1h3b
histone cluster 1, H3b
chr12_+_33147693 0.01 ENSMUST00000077456.6
ENSMUST00000110824.2
Atxn7l1
ataxin 7-like 1
chr8_-_69184177 0.01 ENSMUST00000185176.1
Lzts1
leucine zipper, putative tumor suppressor 1
chr6_-_6882068 0.01 ENSMUST00000142635.1
ENSMUST00000052609.8
Dlx5
distal-less homeobox 5
chr10_-_5069044 0.00 ENSMUST00000095899.3
Syne1
spectrin repeat containing, nuclear envelope 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) maintenance of mitochondrion location(GO:0051659) relaxation of skeletal muscle(GO:0090076)
0.1 0.3 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.0 0.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.1 GO:0038189 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190)
0.0 0.3 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.2 GO:0021853 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 1.8 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.0 0.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.4 GO:0014823 response to activity(GO:0014823)
0.0 0.4 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.4 GO:0019433 triglyceride catabolic process(GO:0019433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0004111 creatine kinase activity(GO:0004111)
0.2 2.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.5 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.2 GO:0004096 catalase activity(GO:0004096)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.3 GO:1990239 sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239)
0.0 0.1 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0097001 ceramide binding(GO:0097001)
0.0 0.4 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors