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GSE58827: Dynamics of the Mouse Liver

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Results for Smad4

Z-value: 0.80

Motif logo

Transcription factors associated with Smad4

Gene Symbol Gene ID Gene Info
ENSMUSG00000024515.7 SMAD family member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.038.8e-01Click!

Activity profile of Smad4 motif

Sorted Z-values of Smad4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_137288273 4.17 ENSMUST00000024099.4
ENSMUST00000085934.3
acetylcholinesterase
chrX_+_136270253 3.85 ENSMUST00000178632.1
ENSMUST00000053540.4
nerve growth factor receptor (TNFRSF16) associated protein 1
chr4_-_119189949 3.58 ENSMUST00000124626.1
erythroblast membrane-associated protein
chrX_+_136270302 3.12 ENSMUST00000113112.1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr4_-_134254076 2.65 ENSMUST00000060050.5
glycine/arginine rich protein 1
chr11_-_33147400 2.46 ENSMUST00000020507.7
fibroblast growth factor 18
chr4_-_119190005 2.36 ENSMUST00000138395.1
ENSMUST00000156746.1
erythroblast membrane-associated protein
chr7_+_45216671 2.33 ENSMUST00000134420.1
TEA domain family member 2
chr4_-_117178726 2.29 ENSMUST00000153953.1
ENSMUST00000106436.1
kinesin family member 2C
chr17_-_32403551 2.20 ENSMUST00000135618.1
ENSMUST00000063824.7
RAS protein activator like 3
chr7_+_45215753 1.95 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
TEA domain family member 2
chr7_+_24862193 1.89 ENSMUST00000052897.4
ENSMUST00000170837.2
predicted pseudogene 9844
predicted pseudogene 9844
chr7_-_100855403 1.85 ENSMUST00000156855.1
RELT tumor necrosis factor receptor
chr14_-_57826128 1.84 ENSMUST00000022536.2
spindle and kinetochore associated complex subunit 3
chr17_+_32403006 1.83 ENSMUST00000065921.5
RIKEN cDNA A530088E08 gene
chr17_-_32403526 1.77 ENSMUST00000137458.1
RAS protein activator like 3
chr7_+_117380937 1.74 ENSMUST00000032892.5
xylosyltransferase 1
chr15_-_103252810 1.72 ENSMUST00000154510.1
nuclear factor, erythroid derived 2
chr11_-_3504766 1.70 ENSMUST00000044507.5
inositol polyphosphate 5-phosphatase J
chr15_+_39076885 1.68 ENSMUST00000067072.3
collagen triple helix repeat containing 1
chr12_-_109600328 1.54 ENSMUST00000149046.2
retrotransposon-like 1
chr1_-_45503282 1.50 ENSMUST00000086430.4
collagen, type V, alpha 2
chr13_-_23551648 1.46 ENSMUST00000102971.1
histone cluster 1, H4f
chr17_+_34597852 1.42 ENSMUST00000174496.2
ENSMUST00000015596.3
ENSMUST00000173992.1
advanced glycosylation end product-specific receptor
chr2_+_120476911 1.39 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
calpain 3
chr2_+_29869484 1.35 ENSMUST00000047521.6
ENSMUST00000134152.1
cerebral endothelial cell adhesion molecule
chr1_+_87470258 1.33 ENSMUST00000027476.4
RIKEN cDNA 3110079O15 gene
chr13_-_22042949 1.25 ENSMUST00000091741.4
histone cluster 1, H2ag
chr17_-_29888570 1.24 ENSMUST00000171691.1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr13_+_22043189 1.22 ENSMUST00000110452.1
histone cluster 1, H2bj
chr6_+_147032528 1.21 ENSMUST00000036194.4
RAB15 effector protein
chr11_-_106160101 1.21 ENSMUST00000045923.3
LIM domain containing 2
chr14_+_54640952 1.20 ENSMUST00000169818.2
predicted gene, 17606
chr15_-_27681498 1.17 ENSMUST00000100739.3
family with sequence similarity 105, member A
chr9_-_45936049 1.15 ENSMUST00000034590.2
transgelin
chr5_-_137741102 1.12 ENSMUST00000149512.1
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
chr4_+_130055010 1.12 ENSMUST00000123617.1
collagen, type XVI, alpha 1
chr17_-_28486082 1.10 ENSMUST00000079413.3
FK506 binding protein 5
chr9_-_49798905 1.09 ENSMUST00000114476.2
neural cell adhesion molecule 1
chr18_-_52529847 1.08 ENSMUST00000171470.1
lysyl oxidase
chr9_-_14381242 1.07 ENSMUST00000167549.1
endonuclease domain containing 1
chr15_+_81936753 1.04 ENSMUST00000038757.7
cold shock domain containing C2, RNA binding
chr6_-_72958097 1.03 ENSMUST00000114049.1
thymosin, beta 10
chr8_-_92356103 1.01 ENSMUST00000034183.3
RIKEN cDNA 4933436C20 gene
chr6_+_120093348 1.00 ENSMUST00000112711.2
ninjurin 2
chr18_-_52529692 1.00 ENSMUST00000025409.7
lysyl oxidase
chr7_-_27181149 0.99 ENSMUST00000071986.6
ENSMUST00000121848.1
melanoma inhibitory activity
chr2_-_29869785 0.99 ENSMUST00000047607.1
RIKEN cDNA 2600006K01 gene
chr11_-_26591729 0.99 ENSMUST00000109504.1
vaccinia related kinase 2
chrX_-_150812932 0.96 ENSMUST00000131241.1
ENSMUST00000147152.1
ENSMUST00000143843.1
melanoma antigen, family D, 2
chr6_-_72958465 0.96 ENSMUST00000114050.1
thymosin, beta 10
chr7_-_45052865 0.91 ENSMUST00000057293.6
proline rich 12
chr11_-_106159902 0.89 ENSMUST00000064545.4
LIM domain containing 2
chr7_-_45870928 0.89 ENSMUST00000146672.1
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr7_-_45239041 0.88 ENSMUST00000131290.1
CD37 antigen
chr15_+_81936911 0.88 ENSMUST00000135663.1
cold shock domain containing C2, RNA binding
chr3_+_88607742 0.87 ENSMUST00000175903.1
rho/rac guanine nucleotide exchange factor (GEF) 2
chr17_+_75178911 0.86 ENSMUST00000112514.1
latent transforming growth factor beta binding protein 1
chr17_+_75178797 0.86 ENSMUST00000112516.1
ENSMUST00000135447.1
latent transforming growth factor beta binding protein 1
chrX_+_10485121 0.86 ENSMUST00000076354.6
ENSMUST00000115526.1
tetraspanin 7
chr1_-_133801031 0.85 ENSMUST00000143567.1
ATPase, Ca++ transporting, plasma membrane 4
chr11_-_106160708 0.85 ENSMUST00000106875.1
LIM domain containing 2
chr9_-_49798729 0.84 ENSMUST00000166811.2
neural cell adhesion molecule 1
chr11_+_69846610 0.83 ENSMUST00000152566.1
ENSMUST00000108633.2
phospholipid scramblase 3
chr6_-_129275360 0.83 ENSMUST00000032259.3
CD69 antigen
chr7_-_45238794 0.82 ENSMUST00000098461.1
ENSMUST00000107797.1
CD37 antigen
chr13_-_21832194 0.80 ENSMUST00000102979.1
histone cluster 1, H4n
chrX_+_159708593 0.79 ENSMUST00000080394.6
SH3-domain kinase binding protein 1
chr11_+_69846665 0.78 ENSMUST00000019605.2
phospholipid scramblase 3
chr3_-_102964124 0.77 ENSMUST00000058899.8
nuclear receptor subfamily 1, group H, member 5
chr11_+_59542748 0.76 ENSMUST00000149126.1
NLR family, pyrin domain containing 3
chrX_+_56779437 0.76 ENSMUST00000114773.3
four and a half LIM domains 1
chr10_-_91082704 0.74 ENSMUST00000162618.1
ENSMUST00000020157.6
ENSMUST00000160788.1
apoptotic peptidase activating factor 1
chr11_-_95514570 0.73 ENSMUST00000058866.7
neurexophilin 3
chr10_-_91082653 0.73 ENSMUST00000159110.1
apoptotic peptidase activating factor 1
chr15_-_98728120 0.72 ENSMUST00000003445.6
FK506 binding protein 11
chr11_+_35121126 0.72 ENSMUST00000069837.3
slit homolog 3 (Drosophila)
chr19_-_31664356 0.72 ENSMUST00000073581.5
protein kinase, cGMP-dependent, type I
chr4_-_148130678 0.71 ENSMUST00000030862.4
dorsal inhibitory axon guidance protein
chr5_+_19907502 0.71 ENSMUST00000101558.3
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr3_+_68572245 0.69 ENSMUST00000170788.2
schwannomin interacting protein 1
chr4_-_115781012 0.69 ENSMUST00000106521.1
testis expressed 38
chr12_-_100899436 0.68 ENSMUST00000053668.3
G protein-coupled receptor 68
chr16_-_36642742 0.67 ENSMUST00000135280.1
CD86 antigen
chr15_-_98778150 0.67 ENSMUST00000023732.5
wingless related MMTV integration site 10b
chr14_+_53683593 0.66 ENSMUST00000103663.4
T cell receptor alpha variable 4-4-DV10
chr8_+_57332111 0.65 ENSMUST00000181638.1
RIKEN cDNA 5033428I22 gene
chr11_+_60699718 0.64 ENSMUST00000052346.3
lethal giant larvae homolog 1 (Drosophila)
chr9_+_53771499 0.61 ENSMUST00000048670.8
solute carrier family 35, member F2
chr4_+_127172866 0.58 ENSMUST00000106094.2
discs, large (Drosophila) homolog-associated protein 3
chr11_+_60699758 0.58 ENSMUST00000108719.3
lethal giant larvae homolog 1 (Drosophila)
chr5_-_92278155 0.54 ENSMUST00000159345.1
ENSMUST00000113102.3
N-acylethanolamine acid amidase
chr4_-_148500449 0.54 ENSMUST00000030840.3
angiopoietin-like 7
chr19_+_5740885 0.53 ENSMUST00000081496.5
latent transforming growth factor beta binding protein 3
chr15_-_98607611 0.51 ENSMUST00000096224.4
adenylate cyclase 6
chr16_+_17898617 0.51 ENSMUST00000055374.6
testis-specific serine kinase 2
chr15_-_103366763 0.49 ENSMUST00000023128.6
integrin alpha 5 (fibronectin receptor alpha)
chr6_-_52240841 0.49 ENSMUST00000121043.1
homeobox A10
chr2_-_93046053 0.49 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
PR domain containing 11
chr1_-_153186447 0.47 ENSMUST00000027753.6
laminin, gamma 2
chr12_-_103338314 0.47 ENSMUST00000149431.1
ankyrin repeat and SOCS box-containing 2
chr17_+_72918298 0.46 ENSMUST00000024857.6
limb-bud and heart
chr9_+_57940104 0.46 ENSMUST00000043059.7
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr11_-_116110211 0.43 ENSMUST00000106441.1
ENSMUST00000021120.5
tripartite motif-containing 47
chr9_+_44072196 0.42 ENSMUST00000176671.1
ubiquitin specific peptidase 2
chr9_+_106429537 0.42 ENSMUST00000059802.6
ribosomal protein L29
chr6_-_112388013 0.41 ENSMUST00000060847.5
ssu-2 homolog (C. elegans)
chr1_+_153652943 0.41 ENSMUST00000041776.5
regulator of G-protein signaling 8
chr1_+_171682004 0.41 ENSMUST00000015499.7
ENSMUST00000068584.5
CD48 antigen
chr11_-_69413675 0.39 ENSMUST00000094077.4
KDM1 lysine (K)-specific demethylase 6B
chrX_-_104201126 0.39 ENSMUST00000056502.6
ENSMUST00000118314.1
expressed sequence C77370
chrX_+_41401476 0.39 ENSMUST00000165288.1
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr11_+_115440540 0.38 ENSMUST00000093914.4
RIKEN cDNA 4933422H20 gene
chr11_+_4160348 0.38 ENSMUST00000002198.3
splicing factor 3a, subunit 1
chr17_-_70851710 0.38 ENSMUST00000166395.2
TGFB-induced factor homeobox 1
chr8_-_47352348 0.36 ENSMUST00000110367.2
storkhead box 2
chr2_+_152736244 0.36 ENSMUST00000038368.8
ENSMUST00000109824.1
inhibitor of DNA binding 1
chr10_+_33905015 0.36 ENSMUST00000169670.1
radial spoke head 4 homolog A (Chlamydomonas)
chr3_-_146839365 0.35 ENSMUST00000084614.3
predicted gene 10288
chr7_+_45413657 0.35 ENSMUST00000058879.6
neurotrophin 5
chr17_-_35162969 0.35 ENSMUST00000174805.1
proline-rich coiled-coil 2A
chr4_-_129742275 0.35 ENSMUST00000066257.5
KH domain containing, RNA binding, signal transduction associated 1
chr7_+_82867327 0.35 ENSMUST00000082237.5
mex3 homolog B (C. elegans)
chr9_+_13621646 0.35 ENSMUST00000034401.8
mastermind like 2 (Drosophila)
chr5_+_30913398 0.35 ENSMUST00000031055.5
elastin microfibril interfacer 1
chr12_-_36156781 0.34 ENSMUST00000020856.4
basic leucine zipper and W2 domains 2
chr18_+_60526194 0.34 ENSMUST00000025505.5
dynactin 4
chr3_+_102734496 0.33 ENSMUST00000029451.5
tetraspanin 2
chr13_-_98637354 0.32 ENSMUST00000050389.4
transmembrane protein 174
chr14_-_25903100 0.31 ENSMUST00000052286.8
placenta specific 9a
chr3_+_116968267 0.30 ENSMUST00000117592.1
RIKEN cDNA 4930455H04 gene
chr7_+_4690760 0.30 ENSMUST00000048248.7
BR serine/threonine kinase 1
chr2_+_3114220 0.29 ENSMUST00000072955.5
family with sequence similarity 171, member A1
chr14_-_54554359 0.29 ENSMUST00000022784.8
HAUS augmin-like complex, subunit 4
chr7_+_101421691 0.27 ENSMUST00000163751.2
ENSMUST00000084894.7
ENSMUST00000166652.1
phosphodiesterase 2A, cGMP-stimulated
chr8_+_54954728 0.27 ENSMUST00000033915.7
glycoprotein m6a
chr14_-_55713088 0.26 ENSMUST00000002389.7
transglutaminase 1, K polypeptide
chr11_-_102319093 0.26 ENSMUST00000174302.1
ENSMUST00000178839.1
ENSMUST00000006754.7
upstream binding transcription factor, RNA polymerase I
chr6_-_138422898 0.24 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
LIM domain only 3
chr2_+_128967383 0.24 ENSMUST00000110320.2
ENSMUST00000110319.2
zinc finger CCCH type containing 6
chr7_+_101361250 0.23 ENSMUST00000137384.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr15_-_38300693 0.22 ENSMUST00000074043.5
Kruppel-like factor 10
chr15_+_58510037 0.20 ENSMUST00000161028.1
fer-1-like 6 (C. elegans)
chr5_+_75574916 0.20 ENSMUST00000144270.1
ENSMUST00000005815.6
kit oncogene
chr11_-_103208542 0.19 ENSMUST00000021323.4
ENSMUST00000107026.2
RIKEN cDNA 1700023F06 gene
chr5_+_64803513 0.19 ENSMUST00000165536.1
Kruppel-like factor 3 (basic)
chr13_-_102958084 0.19 ENSMUST00000099202.3
ENSMUST00000172264.1
microtubule associated serine/threonine kinase family member 4
chr19_-_5295397 0.19 ENSMUST00000025774.9
splicing factor 3b, subunit 2
chr14_+_64950037 0.18 ENSMUST00000043914.5
integrator complex subunit 9
chr19_-_10738971 0.18 ENSMUST00000025571.7
CD5 antigen
chr7_+_127485221 0.18 ENSMUST00000048896.6
fibrosin
chr5_+_7179299 0.17 ENSMUST00000179460.1
tubulin, beta 4B class IVB, pseudogene 1
chr3_+_96221111 0.16 ENSMUST00000090781.6
histone cluster 2, H2be
chr11_-_69122589 0.15 ENSMUST00000180487.1
RIKEN cDNA 9130213A22 gene
chr4_+_128688726 0.15 ENSMUST00000106080.1
polyhomeotic-like 2 (Drosophila)
chr6_+_38433913 0.15 ENSMUST00000160583.1
ubinuclein 2
chr5_+_19907774 0.15 ENSMUST00000115267.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr1_-_87101590 0.14 ENSMUST00000113270.2
alkaline phosphatase, intestinal
chr14_+_52835840 0.14 ENSMUST00000103586.2
T cell receptor alpha variable 7D-5
chr1_-_143702832 0.13 ENSMUST00000018337.7
cell division cycle 73, Paf1/RNA polymerase II complex component
chrX_-_150588071 0.13 ENSMUST00000140207.1
ENSMUST00000112719.1
ENSMUST00000112727.3
ENSMUST00000112721.3
ENSMUST00000026303.9
apurinic/apyrimidinic endonuclease 2
chr11_-_95699143 0.13 ENSMUST00000062249.2
predicted gene 9796
chr4_-_134245579 0.12 ENSMUST00000030644.7
zinc finger protein 593
chr9_-_36767595 0.12 ENSMUST00000120381.2
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
chr7_-_30362772 0.11 ENSMUST00000046351.5
leucine rich repeat and fibronectin type III domain containing 3
chr6_-_72520538 0.11 ENSMUST00000089687.4
ENSMUST00000163451.1
ENSMUST00000162561.1
ENSMUST00000159877.1
SH2 domain containing 6
chr8_+_95825353 0.10 ENSMUST00000074053.4
predicted gene 10094
chr3_+_36552600 0.10 ENSMUST00000029269.5
ENSMUST00000136890.1
exosome component 9
chr14_-_20496780 0.10 ENSMUST00000022353.3
MSS51 mitochondrial translational activator
chr14_+_57826210 0.10 ENSMUST00000022538.3
mitochondrial ribosomal protein 63
chr14_-_54577578 0.10 ENSMUST00000054487.8
ajuba LIM protein
chr13_+_111255010 0.09 ENSMUST00000054716.3
actin, beta-like 2
chr1_+_153891646 0.09 ENSMUST00000050660.4
transmembrane epididymal protein 1
chr1_-_180697034 0.08 ENSMUST00000027778.7
Mix1 homeobox-like 1 (Xenopus laevis)
chr1_-_64121456 0.08 ENSMUST00000142009.1
ENSMUST00000114086.1
Kruppel-like factor 7 (ubiquitous)
chr1_+_72583245 0.08 ENSMUST00000145868.1
ENSMUST00000133123.1
ENSMUST00000047615.8
SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
chr1_-_54194048 0.08 ENSMUST00000120904.1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr15_+_89532816 0.08 ENSMUST00000167173.1
SH3/ankyrin domain gene 3
chr9_+_96895617 0.07 ENSMUST00000071781.6
predicted pseudogene 10123
chrX_-_72274747 0.07 ENSMUST00000064780.3
gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
chr5_-_24445254 0.07 ENSMUST00000030800.6
Fas-activated serine/threonine kinase
chr19_+_46328179 0.06 ENSMUST00000026256.2
ENSMUST00000177667.1
F-box and leucine-rich repeat protein 15
chr7_+_110221697 0.06 ENSMUST00000033325.7
SWA-70 protein
chr10_-_127534540 0.06 ENSMUST00000095266.2
neurexophilin 4
chr7_-_4778141 0.05 ENSMUST00000094892.5
interleukin 11
chr10_+_63457505 0.05 ENSMUST00000105440.1
catenin (cadherin associated protein), alpha 3
chr5_-_24445166 0.05 ENSMUST00000115043.1
ENSMUST00000115041.1
Fas-activated serine/threonine kinase
chr7_+_45785331 0.05 ENSMUST00000120005.1
ENSMUST00000123585.1
lemur tyrosine kinase 3
chr14_+_50944499 0.04 ENSMUST00000178092.1
purine-nucleoside phosphorylase
chr19_+_4231899 0.04 ENSMUST00000025773.3
polymerase (DNA-directed), delta 4
chrX_+_99136119 0.03 ENSMUST00000052839.6
ephrin B1
chr6_+_108660772 0.03 ENSMUST00000163617.1
basic helix-loop-helix family, member e40
chr1_-_75232093 0.03 ENSMUST00000180101.1
RIKEN cDNA A630095N17 gene
chr14_+_55510445 0.02 ENSMUST00000165262.1
ENSMUST00000074225.4
copine VI
chr2_-_128967725 0.02 ENSMUST00000099385.2
predicted gene 10762
chr11_+_53433299 0.02 ENSMUST00000018382.6
growth differentiation factor 9
chr7_+_128203598 0.02 ENSMUST00000177383.1
integrin, alpha D
chr10_-_92164666 0.02 ENSMUST00000183123.1
ENSMUST00000182033.1
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr4_+_99272671 0.01 ENSMUST00000094956.1
predicted gene 10305

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:1900619 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.8 4.0 GO:0051140 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.6 1.9 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.5 1.4 GO:1905204 negative regulation of connective tissue replacement(GO:1905204) positive regulation of dendritic cell differentiation(GO:2001200)
0.5 1.4 GO:0070315 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) G1 to G0 transition involved in cell differentiation(GO:0070315)
0.5 2.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 2.5 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.4 1.5 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 0.7 GO:0051885 positive regulation of anagen(GO:0051885)
0.3 0.9 GO:0045763 regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763)
0.3 0.8 GO:2000321 positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.2 0.7 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.2 2.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 4.3 GO:0048368 lateral mesoderm development(GO:0048368)
0.2 1.5 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.2 0.5 GO:0036363 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.2 1.2 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.2 0.7 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.2 1.7 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.1 1.7 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.7 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920) regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
0.1 0.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 1.0 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.7 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.1 0.4 GO:0061193 taste bud development(GO:0061193)
0.1 0.4 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.1 1.0 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.1 0.9 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 1.7 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 1.7 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 1.2 GO:0033572 transferrin transport(GO:0033572)
0.1 1.7 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.9 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 1.2 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.1 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.5 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.3 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 0.3 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.1 0.5 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 0.4 GO:0035811 negative regulation of urine volume(GO:0035811)
0.1 1.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 1.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.2 GO:0036215 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.0 0.3 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.6 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 1.1 GO:0033622 integrin activation(GO:0033622)
0.0 1.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.9 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.5 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) regulation of somatic stem cell population maintenance(GO:1904672)
0.0 0.1 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.7 GO:0001553 luteinization(GO:0001553)
0.0 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.4 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.5 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.6 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 1.0 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.4 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 0.0 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.0 0.1 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.0 0.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 1.6 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.3 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.0 0.5 GO:0060065 uterus development(GO:0060065)
0.0 0.2 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.0 1.1 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.3 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.6 1.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.5 1.5 GO:0005588 collagen type V trimer(GO:0005588)
0.4 1.5 GO:0043293 apoptosome(GO:0043293)
0.3 4.6 GO:0043083 synaptic cleft(GO:0043083)
0.2 4.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 0.5 GO:0005610 laminin-2 complex(GO:0005607) laminin-5 complex(GO:0005610)
0.1 1.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.8 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 0.3 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 3.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.6 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.6 GO:0005686 U2 snRNP(GO:0005686)
0.0 1.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.9 GO:0097228 sperm principal piece(GO:0097228)
0.0 1.7 GO:0001772 immunological synapse(GO:0001772)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 2.6 GO:0043198 dendritic shaft(GO:0043198)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:0008305 integrin complex(GO:0008305)
0.0 0.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 1.4 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.2 GO:0004104 cholinesterase activity(GO:0004104)
0.6 1.7 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.6 1.7 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.5 2.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.4 2.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 4.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 0.7 GO:0050436 microfibril binding(GO:0050436)
0.1 0.7 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.9 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.5 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 1.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.3 GO:0036004 GAF domain binding(GO:0036004)
0.1 1.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.7 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.9 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 1.4 GO:0031432 titin binding(GO:0031432)
0.1 0.3 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 0.5 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 1.7 GO:0030275 LRR domain binding(GO:0030275)
0.1 0.9 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 1.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.4 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 1.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.3 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1 1.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 2.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 1.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0070628 proteasome binding(GO:0070628)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 1.1 GO:0019955 cytokine binding(GO:0019955)
0.0 0.6 GO:0001540 beta-amyloid binding(GO:0001540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.4 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 3.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.9 PID AURORA B PATHWAY Aurora B signaling
0.0 3.0 PID FGF PATHWAY FGF signaling pathway
0.0 0.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.4 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.5 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.9 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.4 PID IL3 PATHWAY IL3-mediated signaling events
0.0 3.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.0 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 2.3 REACTOME KINESINS Genes involved in Kinesins
0.1 7.8 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.1 0.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 3.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.7 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.5 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.8 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease