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GSE58827: Dynamics of the Mouse Liver

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Results for Sox1

Z-value: 0.73

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Transcription factors associated with Sox1

Gene Symbol Gene ID Gene Info
Sox1
ENSMUSG00000096014.1 SRY (sex determining region Y)-box 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox1mm10_v2_chr8_+_12395287_12395295-0.173.1e-01Click!

Activity profile of Sox1 motif

Sorted Z-values of Sox1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_8218832 8.33 ENSMUST00000113298.2
Slc22a29
solute carrier family 22. member 29
chr7_+_13623967 8.10 ENSMUST00000108525.2
Sult2a5
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5
chr7_-_14123042 4.15 ENSMUST00000098809.2
Sult2a3
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
chr10_+_84756055 3.27 ENSMUST00000060397.6
Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr17_+_34263209 2.44 ENSMUST00000040828.5
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr6_+_37530173 2.31 ENSMUST00000040987.7
Akr1d1
aldo-keto reductase family 1, member D1
chr5_+_21186267 2.28 ENSMUST00000036031.8
Gsap
gamma-secretase activating protein
chr6_+_37530204 2.04 ENSMUST00000151256.1
Akr1d1
aldo-keto reductase family 1, member D1
chr17_-_34287770 2.03 ENSMUST00000174751.1
ENSMUST00000040655.6
H2-Aa
histocompatibility 2, class II antigen A, alpha
chr7_+_67655414 1.63 ENSMUST00000107470.1
Ttc23
tetratricopeptide repeat domain 23
chr5_+_21737141 1.34 ENSMUST00000030882.5
Pmpcb
peptidase (mitochondrial processing) beta
chr9_+_124121534 1.32 ENSMUST00000111442.1
ENSMUST00000171499.2
Ccr5
chemokine (C-C motif) receptor 5
chr16_-_37654408 1.14 ENSMUST00000023514.3
Ndufb4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
chr4_-_120747248 1.14 ENSMUST00000030376.7
Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr11_+_104282371 1.13 ENSMUST00000106988.1
ENSMUST00000106989.1
Mapt
microtubule-associated protein tau
chr13_+_42301270 1.08 ENSMUST00000021796.7
Edn1
endothelin 1
chr14_-_30923754 1.06 ENSMUST00000006697.8
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr15_-_74997634 1.06 ENSMUST00000023248.6
Ly6a
lymphocyte antigen 6 complex, locus A
chr6_+_114648811 1.05 ENSMUST00000182510.1
Atg7
autophagy related 7
chr7_-_127890918 0.98 ENSMUST00000121394.1
Prss53
protease, serine, 53
chr8_+_13159135 0.91 ENSMUST00000033824.6
Lamp1
lysosomal-associated membrane protein 1
chr9_-_108305941 0.87 ENSMUST00000044725.7
Tcta
T cell leukemia translocation altered gene
chr17_-_47692466 0.77 ENSMUST00000113300.1
Prickle4
prickle homolog 4 (Drosophila)
chr14_-_30923547 0.76 ENSMUST00000170415.1
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr2_-_84650760 0.76 ENSMUST00000111691.1
Ctnnd1
catenin (cadherin associated protein), delta 1
chr1_-_195131536 0.75 ENSMUST00000075451.6
Cr1l
complement component (3b/4b) receptor 1-like
chr2_+_34406845 0.74 ENSMUST00000124443.1
ENSMUST00000113124.1
Mapkap1
mitogen-activated protein kinase associated protein 1
chr12_+_52097737 0.65 ENSMUST00000040090.9
Nubpl
nucleotide binding protein-like
chr7_+_80343091 0.65 ENSMUST00000032747.5
Hddc3
HD domain containing 3
chr6_+_121183667 0.63 ENSMUST00000118234.1
ENSMUST00000088561.3
ENSMUST00000137432.1
ENSMUST00000120066.1
Pex26
peroxisomal biogenesis factor 26
chr10_+_77011984 0.61 ENSMUST00000099552.2
Gm10787
predicted gene 10787
chr6_+_117841174 0.61 ENSMUST00000112859.1
ENSMUST00000137224.1
ENSMUST00000164472.1
ENSMUST00000112861.1
ENSMUST00000035638.8
Zfp637
zinc finger protein 637
chr2_-_84650714 0.50 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
Ctnnd1
catenin (cadherin associated protein), delta 1
chr7_+_119690026 0.49 ENSMUST00000047045.8
Acsm4
acyl-CoA synthetase medium-chain family member 4
chr17_+_34969912 0.44 ENSMUST00000173680.1
Gm20481
predicted gene 20481
chr5_-_13121766 0.42 ENSMUST00000078246.4
Gm10108
predicted pseudogene 10108
chr7_-_46919915 0.40 ENSMUST00000143413.1
ENSMUST00000014546.8
Tsg101
tumor susceptibility gene 101
chr11_+_96134219 0.40 ENSMUST00000107680.1
Ttll6
tubulin tyrosine ligase-like family, member 6
chr11_+_96133786 0.37 ENSMUST00000167258.1
Ttll6
tubulin tyrosine ligase-like family, member 6
chr3_-_34005490 0.37 ENSMUST00000060997.2
Gm9791
predicted pseudogene 9791
chr9_+_44326804 0.29 ENSMUST00000054708.3
Dpagt1
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr11_-_68853119 0.17 ENSMUST00000018880.7
Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr5_-_129670074 0.13 ENSMUST00000049778.6
Zfp11
zinc finger protein 11
chr2_-_110761564 0.11 ENSMUST00000140777.1
Ano3
anoctamin 3
chr7_-_57509995 0.11 ENSMUST00000068456.6
Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr3_+_90590247 0.06 ENSMUST00000179550.1
S100a2
S100 calcium binding protein A2
chr7_-_120145286 0.05 ENSMUST00000033207.4
Zp2
zona pellucida glycoprotein 2
chr17_-_66594592 0.04 ENSMUST00000024914.2
Themis3
thymocyte selection associated family member 3
chrX_+_164162167 0.04 ENSMUST00000131543.1
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chrX_+_74297097 0.03 ENSMUST00000019231.5
ENSMUST00000147900.1
ENSMUST00000147275.1
ENSMUST00000114171.3
Atp6ap1
ATPase, H+ transporting, lysosomal accessory protein 1
chr1_+_109983737 0.02 ENSMUST00000172005.1
Cdh7
cadherin 7, type 2
chr18_+_37496997 0.01 ENSMUST00000059571.5
Pcdhb19
protocadherin beta 19

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0030573 bile acid catabolic process(GO:0030573)
0.8 2.4 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.7 3.3 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.6 8.3 GO:0015747 urate transport(GO:0015747)
0.3 1.0 GO:0034727 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157)
0.3 0.9 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.3 1.1 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.3 1.3 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) negative regulation of macrophage apoptotic process(GO:2000110)
0.3 1.3 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.2 1.1 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.2 2.3 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.9 GO:0072675 osteoclast fusion(GO:0072675)
0.1 2.0 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 0.4 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 1.1 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 0.7 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 1.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.8 GO:0051013 microtubule severing(GO:0051013)
0.1 0.8 GO:0045916 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.1 0.6 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 1.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 1.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.3 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.1 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 0.9 GO:0032010 phagolysosome(GO:0032010)
0.2 1.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 1.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 1.3 GO:0005915 zonula adherens(GO:0005915)
0.1 1.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.7 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.1 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 12.3 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
1.5 4.4 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.6 8.3 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3 1.0 GO:0019778 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.3 1.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 2.4 GO:1990405 protein antigen binding(GO:1990405)
0.2 1.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 1.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.8 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.1 0.3 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 0.5 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 2.0 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.4 GO:0046790 virion binding(GO:0046790)
0.0 0.7 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 2.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)
0.0 0.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.7 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.1 PID ENDOTHELIN PATHWAY Endothelins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.3 1.3 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 1.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 1.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein