ISMARA results: Tcf7l1

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GSE58827: Dynamics of the Mouse Liver

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Results for Tcf7l1

Z-value: 0.86

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Transcription factors associated with Tcf7l1

Gene Symbol	Gene ID	Gene Info
Tcf7l1 Ensembl NCBI MGI UniProt	ENSMUSG00000055799.7	transcription factor 7 like 1 (T cell specific, HMG box)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tcf7l1	mm10_v2_chr6_-_72789240_72789262	0.63	4.4e-05	Click!

Activity profile of Tcf7l1 motif

Sorted Z-values of Tcf7l1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_173021902 Show fit	4.03	ENSMUST00000029014.9	Rbm38 Ensembl NCBI MGI UniProt Show fit	RNA binding motif protein 38
chr12_+_24831583 Show fit	3.74	ENSMUST00000110942.3 ENSMUST00000078902.6	Mboat2 Ensembl NCBI MGI UniProt Show fit	membrane bound O-acyltransferase domain containing 2
chr9_+_98490522 Show fit	3.71	ENSMUST00000035029.2	Rbp2 Ensembl NCBI MGI UniProt Show fit	retinol binding protein 2, cellular
chr4_+_115057683 Show fit	3.64	ENSMUST00000161601.1	Tal1 Ensembl NCBI MGI UniProt Show fit	T cell acute lymphocytic leukemia 1
chr18_+_21072329 Show fit	3.64	ENSMUST00000082235.4	Mep1b Ensembl NCBI MGI UniProt Show fit	meprin 1 beta
chr5_-_148392810 Show fit	3.63	ENSMUST00000138257.1	Slc7a1 Ensembl NCBI MGI UniProt Show fit	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr10_+_43579161 Show fit	3.52	ENSMUST00000058714.8	Cd24a Ensembl NCBI MGI UniProt Show fit	CD24a antigen
chr2_+_173022360 Show fit	3.41	ENSMUST00000173997.1	Rbm38 Ensembl NCBI MGI UniProt Show fit	RNA binding motif protein 38
chr5_-_122050102 Show fit	3.16	ENSMUST00000154139.1	Cux2 Ensembl NCBI MGI UniProt Show fit	cut-like homeobox 2
chr7_+_45216671 Show fit	2.99	ENSMUST00000134420.1	Tead2 Ensembl NCBI MGI UniProt Show fit	TEA domain family member 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tcf7l1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	7.4	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0	4.7	GO:0008654	phospholipid biosynthetic process(GO:0008654)
0.5	4.2	GO:0070294	renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.5	3.7	GO:0006776	vitamin A metabolic process(GO:0006776)
0.1	3.7	GO:1901998	toxin transport(GO:1901998)
0.0	3.7	GO:0016485	protein processing(GO:0016485)
1.2	3.6	GO:0060217	hemangioblast cell differentiation(GO:0060217)
0.2	3.6	GO:0015809	arginine transport(GO:0015809)
1.2	3.5	GO:0002842	positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.1	3.2	GO:0007614	short-term memory(GO:0007614)

Showing 1 to 10 of 113 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.7	GO:0016323	basolateral plasma membrane(GO:0016323)
1.2	3.6	GO:0033193	Lsd1/2 complex(GO:0033193)
0.1	3.2	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
1.0	3.0	GO:0071149	TEAD-2-YAP complex(GO:0071149)
0.1	2.5	GO:0051233	spindle midzone(GO:0051233)
0.0	2.1	GO:0016460	myosin II complex(GO:0016460)
0.0	1.9	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	1.8	GO:0030175	filopodium(GO:0030175)
0.0	1.7	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2	1.6	GO:0001739	sex chromatin(GO:0001739)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.4	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.1	3.8	GO:0004190	aspartic-type endopeptidase activity(GO:0004190)
0.6	3.7	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.3	3.7	GO:0016918	retinal binding(GO:0016918) retinol binding(GO:0019841)
0.1	3.7	GO:0031005	filamin binding(GO:0031005)
0.5	3.6	GO:0015181	arginine transmembrane transporter activity(GO:0015181)
0.2	3.5	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	3.4	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	3.0	GO:0070888	E-box binding(GO:0070888)
0.0	2.8	GO:0004222	metalloendopeptidase activity(GO:0004222)

Showing 1 to 10 of 86 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.5	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	2.4	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	2.2	PID ENDOTHELIN PATHWAY	Endothelins
0.0	2.0	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.9	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	1.7	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	1.6	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	1.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.4	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.9	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	4.0	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1	3.7	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.2	2.7	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.1	2.7	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	2.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	1.9	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	1.7	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0	1.6	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.0	1.5	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions

Showing 1 to 10 of 27 entries

Results for Tcf7l1

Z-value: 0.86

Motif logo

Transcription factors associated with Tcf7l1

Activity-expression correlation:

Activity profile of Tcf7l1 motif

Sorted Z-values of Tcf7l1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tcf7l1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: