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GSE58827: Dynamics of the Mouse Liver
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Results for Tfcp2l1
Z-value: 0.58
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Transcription factors associated with Tfcp2l1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfcp2l1 | mm10_v2_chr1_+_118627943_118627951 | 0.01 | 9.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_98004634 Show fit | 2.19 |
ENSMUST00000131560.1
ENSMUST00000088355.5 |
collagen, type II, alpha 1 |
|
| chr17_-_26199008 Show fit | 2.06 |
ENSMUST00000142410.1
ENSMUST00000120333.1 ENSMUST00000039113.7 |
protein disulfide isomerase associated 2 |
|
| chr15_-_98004695 Show fit | 2.04 |
ENSMUST00000023123.8
|
collagen, type II, alpha 1 |
|
| chr10_+_43579161 Show fit | 1.98 |
ENSMUST00000058714.8
|
CD24a antigen |
|
| chr16_-_18622403 Show fit | 1.48 |
ENSMUST00000167388.1
|
glycoprotein Ib, beta polypeptide |
|
| chr16_-_22161450 Show fit | 1.40 |
ENSMUST00000115379.1
|
insulin-like growth factor 2 mRNA binding protein 2 |
|
| chr14_+_55765956 Show fit | 1.40 |
ENSMUST00000057569.3
|
leukotriene B4 receptor 1 |
|
| chr8_-_72009619 Show fit | 1.35 |
ENSMUST00000003574.4
|
cytochrome P450, family 4, subfamily f, polypeptide 18 |
|
| chr7_-_99238564 Show fit | 1.22 |
ENSMUST00000064231.7
|
monoacylglycerol O-acyltransferase 2 |
|
| chr12_-_114406773 Show fit | 1.20 |
ENSMUST00000177949.1
|
immunoglobulin heavy variable V6-4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfcp2l1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.2 | GO:0060174 | limb bud formation(GO:0060174) |
| 0.1 | 2.1 | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) |
| 0.7 | 2.0 | GO:0002842 | positive regulation of T cell mediated immune response to tumor cell(GO:0002842) |
| 0.6 | 1.9 | GO:0061360 | optic nerve formation(GO:0021634) optic chiasma development(GO:0061360) regulation of optic nerve formation(GO:2000595) positive regulation of optic nerve formation(GO:2000597) |
| 0.2 | 1.5 | GO:0030421 | defecation(GO:0030421) |
| 0.0 | 1.4 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 1.4 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.4 | 1.3 | GO:0042374 | menaquinone metabolic process(GO:0009233) phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662) |
| 0.4 | 1.2 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) |
| 0.4 | 1.2 | GO:2001226 | negative regulation of chloride transport(GO:2001226) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.2 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 2.3 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 2.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 1.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 0.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.2 | 0.6 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.0 | 0.6 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 0.5 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.4 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.2 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.2 | 2.1 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.2 | 1.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 1.5 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.3 | 1.4 | GO:0004974 | leukotriene receptor activity(GO:0004974) |
| 0.1 | 1.4 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.4 | 1.3 | GO:0052871 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) |
| 0.0 | 1.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.2 | 1.2 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 0.1 | 1.2 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 1.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.4 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 2.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 2.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 1.1 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 0.7 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.6 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.6 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.4 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |