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GSE58827: Dynamics of the Mouse Liver

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Results for Thrb

Z-value: 1.26

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Transcription factors associated with Thrb

Gene Symbol Gene ID Gene Info
Thrb
ENSMUSG00000021779.10 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Thrbmm10_v2_chr14_+_17981633_179816440.539.7e-04Click!

Activity profile of Thrb motif

Sorted Z-values of Thrb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_14863495 17.54 ENSMUST00000029076.4
Car3
carbonic anhydrase 3
chr7_+_25897620 14.88 ENSMUST00000072438.6
ENSMUST00000005477.5
Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
chr8_+_105048592 14.84 ENSMUST00000093222.5
ENSMUST00000093223.3
Ces3a
carboxylesterase 3A
chr17_+_36942910 13.67 ENSMUST00000040498.5
Rnf39
ring finger protein 39
chr14_-_34355383 12.38 ENSMUST00000052126.5
Fam25c
family with sequence similarity 25, member C
chr17_+_36943025 12.12 ENSMUST00000173072.1
Rnf39
ring finger protein 39
chr2_-_24049389 7.49 ENSMUST00000051416.5
Hnmt
histamine N-methyltransferase
chr9_+_44673227 7.24 ENSMUST00000034609.4
ENSMUST00000071219.5
Treh
trehalase (brush-border membrane glycoprotein)
chr11_-_113709520 6.94 ENSMUST00000173655.1
ENSMUST00000100248.4
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr10_+_87521920 6.88 ENSMUST00000142088.1
Pah
phenylalanine hydroxylase
chr11_-_113710017 6.52 ENSMUST00000018871.1
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr7_-_105600103 6.45 ENSMUST00000033185.8
Hpx
hemopexin
chr12_+_108334341 6.28 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr2_-_25470031 6.24 ENSMUST00000114251.1
Ptgds
prostaglandin D2 synthase (brain)
chr2_-_25500613 5.59 ENSMUST00000040042.4
C8g
complement component 8, gamma polypeptide
chr14_-_61360395 5.11 ENSMUST00000022494.8
Ebpl
emopamil binding protein-like
chr2_+_119167758 4.94 ENSMUST00000057454.3
Gchfr
GTP cyclohydrolase I feedback regulator
chr10_+_87521795 4.88 ENSMUST00000020241.8
Pah
phenylalanine hydroxylase
chr2_-_25469742 4.71 ENSMUST00000114259.2
ENSMUST00000015234.6
Ptgds
prostaglandin D2 synthase (brain)
chr17_+_56162477 4.46 ENSMUST00000077788.6
Tnfaip8l1
tumor necrosis factor, alpha-induced protein 8-like 1
chr14_-_7994563 4.07 ENSMUST00000026315.7
Dnase1l3
deoxyribonuclease 1-like 3
chr9_-_107668967 3.22 ENSMUST00000177567.1
Slc38a3
solute carrier family 38, member 3
chr4_+_152178126 2.91 ENSMUST00000075363.3
Acot7
acyl-CoA thioesterase 7
chr3_-_79842662 2.62 ENSMUST00000029568.1
Tmem144
transmembrane protein 144
chr11_+_70459611 2.40 ENSMUST00000039093.3
Zmynd15
zinc finger, MYND-type containing 15
chr11_-_115612491 2.13 ENSMUST00000106507.2
Mif4gd
MIF4G domain containing
chr3_-_116712198 1.95 ENSMUST00000120120.1
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr11_-_49114874 1.89 ENSMUST00000109201.1
Olfr1396
olfactory receptor 1396
chr4_+_20042046 1.87 ENSMUST00000098242.3
Ggh
gamma-glutamyl hydrolase
chr12_+_112620030 1.75 ENSMUST00000180015.1
ENSMUST00000021726.6
Adssl1
adenylosuccinate synthetase like 1
chrX_-_71492799 1.75 ENSMUST00000037391.5
ENSMUST00000114586.2
ENSMUST00000114587.2
Cd99l2
CD99 antigen-like 2
chr5_+_35814356 1.46 ENSMUST00000130233.1
Ablim2
actin-binding LIM protein 2
chr5_+_94218025 1.38 ENSMUST00000179743.1
Gm3106
predicted gene 3106
chr11_+_109485606 1.16 ENSMUST00000106697.1
Arsg
arylsulfatase G
chr8_-_121544315 1.13 ENSMUST00000182460.1
1700018B08Rik
RIKEN cDNA 1700018B08 gene
chr5_+_94873797 1.12 ENSMUST00000180076.1
Gm3183
predicted gene 3183
chr9_+_102626278 1.05 ENSMUST00000038673.7
Anapc13
anaphase promoting complex subunit 13
chr3_-_36475688 0.96 ENSMUST00000029266.8
Anxa5
annexin A5
chr11_-_58938851 0.67 ENSMUST00000094151.5
Rnf187
ring finger protein 187
chr2_+_171193222 0.61 ENSMUST00000125631.1
Gm14266
predicted gene 14266
chr11_+_100859351 0.54 ENSMUST00000004145.7
ENSMUST00000133036.1
Stat5a
signal transducer and activator of transcription 5A
chr5_+_130219706 0.53 ENSMUST00000065329.6
Tmem248
transmembrane protein 248
chr10_+_31248140 0.33 ENSMUST00000050717.8
Gm5422
predicted pseudogene 5422
chr11_+_100859492 0.21 ENSMUST00000107356.1
Stat5a
signal transducer and activator of transcription 5A
chr11_-_83522126 0.07 ENSMUST00000019069.3
Gm11435
predicted gene 11435
chrX_+_112311334 0.03 ENSMUST00000026599.3
ENSMUST00000113415.1
Apool
apolipoprotein O-like
chr13_+_37857934 0.01 ENSMUST00000138110.1
Rreb1
ras responsive element binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Thrb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:0006571 tyrosine biosynthetic process(GO:0006571) aromatic amino acid family biosynthetic process(GO:0009073) aromatic amino acid family biosynthetic process, prephenate pathway(GO:0009095)
2.2 10.9 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
2.1 14.9 GO:0042738 exogenous drug catabolic process(GO:0042738)
1.5 7.5 GO:0001692 histamine metabolic process(GO:0001692)
1.4 7.2 GO:0005984 disaccharide metabolic process(GO:0005984)
1.3 6.5 GO:0015886 heme transport(GO:0015886)
1.1 13.5 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
1.1 3.2 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) regulation of glutamine transport(GO:2000485)
0.7 2.9 GO:1900535 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.6 1.9 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.6 1.7 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.4 6.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.4 17.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.4 2.0 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.3 5.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 4.1 GO:0006309 apoptotic DNA fragmentation(GO:0006309) programmed cell death involved in cell development(GO:0010623)
0.2 0.8 GO:0060376 positive regulation of mast cell differentiation(GO:0060376)
0.2 1.0 GO:0070459 prolactin secretion(GO:0070459)
0.1 2.6 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 4.5 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 5.1 GO:0016125 sterol metabolic process(GO:0016125)
0.0 1.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 4.9 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 2.4 GO:0007286 spermatid development(GO:0007286)
0.0 0.7 GO:0070936 protein K48-linked ubiquitination(GO:0070936)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.5 5.6 GO:0005579 membrane attack complex(GO:0005579)
0.1 4.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 10.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 7.4 GO:0072562 blood microparticle(GO:0072562)
0.0 7.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 33.4 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 3.2 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.9 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
2.4 11.8 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
1.6 6.5 GO:0015232 heme transporter activity(GO:0015232)
1.5 17.5 GO:0016151 nickel cation binding(GO:0016151)
1.1 3.2 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.5 14.9 GO:0070330 aromatase activity(GO:0070330)
0.4 5.6 GO:0019841 retinol binding(GO:0019841)
0.3 5.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 13.5 GO:0004521 endoribonuclease activity(GO:0004521)
0.2 2.9 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 6.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 4.9 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 1.9 GO:0008242 omega peptidase activity(GO:0008242)
0.1 14.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 2.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 1.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 2.6 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.1 4.1 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 7.2 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 1.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.7 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 1.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 2.4 GO:0042826 histone deacetylase binding(GO:0042826)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 7.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.5 6.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 4.9 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 5.6 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 1.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 11.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 2.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules