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GSE58827: Dynamics of the Mouse Liver

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Results for Trp63

Z-value: 0.52

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Transcription factors associated with Trp63

Gene Symbol Gene ID Gene Info
Trp63
ENSMUSG00000022510.8 transformation related protein 63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp63mm10_v2_chr16_+_25801907_258019280.447.3e-03Click!

Activity profile of Trp63 motif

Sorted Z-values of Trp63 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_13491900 3.46 ENSMUST00000091436.5
Cubn
cubilin (intrinsic factor-cobalamin receptor)
chr2_-_170427828 3.24 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
Bcas1
breast carcinoma amplified sequence 1
chr11_-_69948145 2.39 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
Slc2a4
solute carrier family 2 (facilitated glucose transporter), member 4
chr7_-_141443314 2.35 ENSMUST00000106005.2
Lrdd
leucine-rich and death domain containing
chr4_-_134018829 2.03 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr7_-_116038734 1.99 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chrX_-_150812932 1.69 ENSMUST00000131241.1
ENSMUST00000147152.1
ENSMUST00000143843.1
Maged2
melanoma antigen, family D, 2
chr14_-_31577318 1.60 ENSMUST00000112027.2
Colq
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr19_+_11404735 1.58 ENSMUST00000153546.1
Ms4a4c
membrane-spanning 4-domains, subfamily A, member 4C
chrX_-_150812715 1.58 ENSMUST00000112697.3
Maged2
melanoma antigen, family D, 2
chr4_-_140810646 1.27 ENSMUST00000026377.2
Padi3
peptidyl arginine deiminase, type III
chr8_-_31918203 1.26 ENSMUST00000073884.4
Nrg1
neuregulin 1
chr8_+_27085520 1.24 ENSMUST00000178514.1
ENSMUST00000033876.7
Gpr124
G protein-coupled receptor 124
chr13_-_55021287 1.10 ENSMUST00000148221.1
ENSMUST00000052949.6
Hk3
hexokinase 3
chr1_+_180935022 1.02 ENSMUST00000037361.8
Lefty1
left right determination factor 1
chr5_-_5266038 1.00 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
Cdk14
cyclin-dependent kinase 14
chr13_-_55021196 0.97 ENSMUST00000153665.1
Hk3
hexokinase 3
chrX_+_159255919 0.92 ENSMUST00000112492.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr19_+_53140430 0.84 ENSMUST00000111741.2
Add3
adducin 3 (gamma)
chr8_+_27085835 0.76 ENSMUST00000165366.2
Gpr124
G protein-coupled receptor 124
chr10_-_80671976 0.58 ENSMUST00000003433.6
Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr7_-_126160992 0.57 ENSMUST00000164741.1
Xpo6
exportin 6
chr5_-_5265224 0.56 ENSMUST00000115450.1
Cdk14
cyclin-dependent kinase 14
chr5_+_136057267 0.55 ENSMUST00000006303.4
ENSMUST00000156530.1
Upk3bl
uroplakin 3B-like
chr1_+_180893107 0.53 ENSMUST00000085797.5
Lefty2
left-right determination factor 2
chr15_-_8710409 0.51 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chrX_+_159255782 0.51 ENSMUST00000126686.1
ENSMUST00000033671.6
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr3_+_145292472 0.50 ENSMUST00000029848.4
ENSMUST00000139001.1
Col24a1
collagen, type XXIV, alpha 1
chr13_+_12702362 0.50 ENSMUST00000104944.2
Gm2399
predicted gene 2399
chr13_-_103334429 0.47 ENSMUST00000167058.1
ENSMUST00000164111.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr17_-_6449571 0.47 ENSMUST00000180035.1
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr17_+_29090969 0.45 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr8_-_87959560 0.44 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr8_+_84686300 0.28 ENSMUST00000177531.1
Trmt1
tRNA methyltransferase 1
chr2_-_87635745 0.21 ENSMUST00000090711.2
Olfr1132
olfactory receptor 1132
chr8_-_47352348 0.20 ENSMUST00000110367.2
Stox2
storkhead box 2
chr16_+_4886100 0.14 ENSMUST00000070658.8
ENSMUST00000023159.8
Mgrn1
mahogunin, ring finger 1
chr11_-_95699143 0.12 ENSMUST00000062249.2
Gm9796
predicted gene 9796
chr19_-_5875210 0.10 ENSMUST00000155227.1
Frmd8
FERM domain containing 8
chr7_-_65370908 0.08 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr11_+_98863610 0.07 ENSMUST00000142414.1
ENSMUST00000037480.8
Wipf2
WAS/WASL interacting protein family, member 2
chr2_+_119972699 0.06 ENSMUST00000066058.7
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr1_-_9700209 0.04 ENSMUST00000088658.4
Mybl1
myeloblastosis oncogene-like 1
chr7_-_114254659 0.04 ENSMUST00000033012.7
Copb1
coatomer protein complex, subunit beta 1
chr5_+_142401484 0.04 ENSMUST00000072837.5
Foxk1
forkhead box K1
chr18_-_15718046 0.03 ENSMUST00000053017.6
Chst9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr12_-_108003594 0.03 ENSMUST00000066060.4
Bcl11b
B cell leukemia/lymphoma 11B
chr4_-_96077509 0.02 ENSMUST00000097973.2
ENSMUST00000030305.6
ENSMUST00000107078.2
Cyp2j13
cytochrome P450, family 2, subfamily j, polypeptide 13
chr2_+_119237531 0.01 ENSMUST00000110817.2
Spint1
serine protease inhibitor, Kunitz type 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp63

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.5 GO:0015889 cobalamin transport(GO:0015889)
0.4 3.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.3 1.6 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.3 1.0 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.3 1.3 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.2 2.0 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 1.3 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.2 2.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 2.1 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.1 0.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.3 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 2.4 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.0 0.4 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 0.6 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 1.4 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.1 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.0 1.6 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.5 GO:0043202 lysosomal lumen(GO:0043202)
0.3 1.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 2.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.3 GO:0030673 axolemma(GO:0030673)
0.0 2.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.1 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.5 GO:0030492 hemoglobin binding(GO:0030492)
0.5 2.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.3 1.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.3 1.0 GO:0038100 nodal binding(GO:0038100)
0.3 1.3 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.2 2.1 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 2.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 0.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.6 GO:0030332 cyclin binding(GO:0030332)
0.0 1.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0004601 peroxidase activity(GO:0004601)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 2.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.5 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 2.0 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 2.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.3 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 2.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol