ISMARA results: Vsx2

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GSE58827: Dynamics of the Mouse Liver

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Results for Vsx2_Dlx3

Z-value: 0.95

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Transcription factors associated with Vsx2_Dlx3

Gene Symbol	Gene ID	Gene Info
Vsx2 Ensembl NCBI MGI UniProt	ENSMUSG00000021239.6	visual system homeobox 2
Dlx3 Ensembl NCBI MGI UniProt	ENSMUSG00000001510.7	distal-less homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Dlx3	mm10_v2_chr11_+_95120089_95120125	0.55	5.1e-04	Click!
Vsx2	mm10_v2_chr12_+_84569762_84569840	0.22	1.9e-01	Click!

Activity profile of Vsx2_Dlx3 motif

Sorted Z-values of Vsx2_Dlx3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_168767136 Show fit	12.44	ENSMUST00000029061.5 ENSMUST00000103074.1	Sall4 Ensembl NCBI MGI UniProt Show fit	sal-like 4 (Drosophila)
chr2_-_168767029 Show fit	9.87	ENSMUST00000075044.3	Sall4 Ensembl NCBI MGI UniProt Show fit	sal-like 4 (Drosophila)
chr4_+_34893772 Show fit	9.18	ENSMUST00000029975.3 ENSMUST00000135871.1 ENSMUST00000108130.1	Cga Ensembl NCBI MGI UniProt Show fit	glycoprotein hormones, alpha subunit
chr12_+_109545390 Show fit	7.71	ENSMUST00000146701.1	Meg3 Ensembl NCBI MGI UniProt Show fit	maternally expressed 3
chr14_+_27000362 Show fit	7.08	ENSMUST00000035433.8	Hesx1 Ensembl NCBI MGI UniProt Show fit	homeobox gene expressed in ES cells
chr2_+_84734050 Show fit	6.39	ENSMUST00000090729.2	Ypel4 Ensembl NCBI MGI UniProt Show fit	yippee-like 4 (Drosophila)
chr16_-_42340595 Show fit	5.94	ENSMUST00000102817.4	Gap43 Ensembl NCBI MGI UniProt Show fit	growth associated protein 43
chr3_-_116253467 Show fit	5.53	ENSMUST00000090473.5	Gpr88 Ensembl NCBI MGI UniProt Show fit	G-protein coupled receptor 88
chr3_+_51661167 Show fit	5.41	ENSMUST00000099106.3	Mgst2 Ensembl NCBI MGI UniProt Show fit	microsomal glutathione S-transferase 2
chr19_+_38132767 Show fit	5.20	ENSMUST00000025956.5 ENSMUST00000112329.1	Pde6c Ensembl NCBI MGI UniProt Show fit	phosphodiesterase 6C, cGMP specific, cone, alpha prime

Showing 1 to 10 of 171 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Vsx2_Dlx3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	22.3	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.7	9.2	GO:0046884	follicle-stimulating hormone secretion(GO:0046884)
0.9	8.7	GO:0030916	otic vesicle formation(GO:0030916)
0.3	7.7	GO:0008340	determination of adult lifespan(GO:0008340)
0.7	5.9	GO:0016198	axon choice point recognition(GO:0016198)
1.4	5.5	GO:0061743	motor learning(GO:0061743)
0.1	5.5	GO:0032094	response to food(GO:0032094)
0.4	5.4	GO:0019370	leukotriene biosynthetic process(GO:0019370)
0.4	5.2	GO:0046549	retinal cone cell development(GO:0046549)
0.3	4.7	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)

Showing 1 to 10 of 68 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	22.3	GO:0000792	heterochromatin(GO:0000792)
0.3	5.9	GO:0031527	filopodium membrane(GO:0031527)
0.0	5.3	GO:0005635	nuclear envelope(GO:0005635)
0.0	3.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	2.9	GO:0005814	centriole(GO:0005814)
0.2	2.8	GO:0071439	clathrin complex(GO:0071439)
0.1	2.6	GO:0031045	dense core granule(GO:0031045)
0.0	2.4	GO:0031225	anchored component of membrane(GO:0031225)
0.6	2.2	GO:0060187	cell pole(GO:0060187)
0.2	2.1	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)

Showing 1 to 10 of 33 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	33.7	GO:0008134	transcription factor binding(GO:0008134)
0.1	8.1	GO:0005179	hormone activity(GO:0005179)
0.0	6.2	GO:0003774	motor activity(GO:0003774)
0.7	5.9	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.2	5.9	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
1.4	5.4	GO:0004464	leukotriene-C4 synthase activity(GO:0004464)
0.2	5.2	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.4	4.2	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.1	3.5	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	3.5	GO:0003735	structural constituent of ribosome(GO:0003735)

Showing 1 to 10 of 44 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	19.9	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	9.2	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.1	5.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	5.2	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	3.8	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	2.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	1.3	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	1.2	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	0.5	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway

Showing 1 to 9 of 9 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	9.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
1.1	9.2	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.1	4.5	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0	3.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	3.2	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	1.8	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	1.6	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.0	1.3	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	1.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK

Showing 1 to 10 of 18 entries

Results for Vsx2_Dlx3

Z-value: 0.95

Motif logo

Transcription factors associated with Vsx2_Dlx3

Activity-expression correlation:

Activity profile of Vsx2_Dlx3 motif

Sorted Z-values of Vsx2_Dlx3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Vsx2_Dlx3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: