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GSE58827: Dynamics of the Mouse Liver
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Results for Zfp524
Z-value: 0.86
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Transcription factors associated with Zfp524
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfp524 | mm10_v2_chr7_+_5015466_5015509 | -0.54 | 7.2e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_54045182 Show fit | 6.00 |
ENSMUST00000036700.5
|
adrenergic receptor, alpha 2a |
|
| chr7_-_120982260 Show fit | 5.70 |
ENSMUST00000033169.8
|
cerebellar degeneration-related 2 |
|
| chr3_-_98339921 Show fit | 4.93 |
ENSMUST00000065793.5
|
3-phosphoglycerate dehydrogenase |
|
| chr10_+_75573448 Show fit | 4.58 |
ENSMUST00000006508.3
|
gamma-glutamyltransferase 1 |
|
| chr5_+_76657673 Show fit | 3.85 |
ENSMUST00000128112.1
|
RIKEN cDNA C530008M17 gene |
|
| chr15_+_82341179 Show fit | 3.64 |
ENSMUST00000050349.2
|
family with sequence similarity 109, member B |
|
| chr7_-_142578093 Show fit | 3.62 |
ENSMUST00000149974.1
ENSMUST00000152754.1 |
H19 fetal liver mRNA |
|
| chr9_-_44288535 Show fit | 3.52 |
ENSMUST00000161354.1
|
ATP-binding cassette, sub-family G (WHITE), member 4 |
|
| chr4_-_4138432 Show fit | 3.07 |
ENSMUST00000070375.7
|
preproenkephalin |
|
| chr16_+_32608973 Show fit | 3.01 |
ENSMUST00000120680.1
|
transferrin receptor |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zfp524
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.5 | 7.0 | GO:0060087 | relaxation of vascular smooth muscle(GO:0060087) |
| 1.0 | 6.0 | GO:0035624 | receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) |
| 0.0 | 5.4 | GO:0007411 | axon guidance(GO:0007411) |
| 1.2 | 4.9 | GO:0006566 | threonine metabolic process(GO:0006566) |
| 0.3 | 4.8 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.2 | 4.7 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.6 | 4.6 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.1 | 4.6 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 1.3 | 4.0 | GO:1904959 | regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 6.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.4 | 4.8 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.3 | 4.6 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 3.6 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 3.5 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.3 | 3.4 | GO:0000796 | condensin complex(GO:0000796) |
| 0.4 | 3.2 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.8 | 3.1 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.5 | 2.9 | GO:0031262 | Ndc80 complex(GO:0031262) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 8.0 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.1 | 6.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.5 | 6.0 | GO:0004938 | alpha2-adrenergic receptor activity(GO:0004938) |
| 0.1 | 5.1 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 1.6 | 4.8 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 0.1 | 4.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.4 | 4.6 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 4.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 4.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 3.7 | GO:0019894 | kinesin binding(GO:0019894) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.1 | 4.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 4.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 4.2 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 3.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 3.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 3.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 3.1 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 2.7 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.0 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.2 | 6.9 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.2 | 6.0 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 5.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 4.4 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 4.4 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.2 | 4.2 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 3.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 3.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 3.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |