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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Arnt2

Z-value: 0.34

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Transcription factors associated with Arnt2

Gene Symbol Gene ID Gene Info
Arnt2
ENSMUSG00000015709.8 aryl hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Arnt2mm10_v2_chr7_-_84409959_844100020.742.8e-07Click!

Activity profile of Arnt2 motif

Sorted Z-values of Arnt2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_54085542 0.75 ENSMUST00000100089.2
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr2_+_79255500 0.59 ENSMUST00000099972.4
Itga4
integrin alpha 4
chr1_-_58973421 0.57 ENSMUST00000173590.1
ENSMUST00000027186.5
Trak2
trafficking protein, kinesin binding 2
chr7_+_130865835 0.45 ENSMUST00000075181.4
ENSMUST00000048180.5
Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_-_91649785 0.44 ENSMUST00000111333.1
Zfp408
zinc finger protein 408
chr2_+_27886416 0.43 ENSMUST00000028280.7
Col5a1
collagen, type V, alpha 1
chr11_+_43528759 0.42 ENSMUST00000050574.6
Ccnjl
cyclin J-like
chr7_+_130865756 0.39 ENSMUST00000120441.1
Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr5_-_115300957 0.38 ENSMUST00000009157.3
Dynll1
dynein light chain LC8-type 1
chr5_-_115300912 0.37 ENSMUST00000112090.1
Dynll1
dynein light chain LC8-type 1
chr2_-_91649751 0.37 ENSMUST00000099714.3
Zfp408
zinc finger protein 408
chr4_-_123116686 0.34 ENSMUST00000166337.1
Gm17244
predicted gene, 17244
chr7_-_118491912 0.33 ENSMUST00000178344.1
Itpripl2
inositol 1,4,5-triphosphate receptor interacting protein-like 2
chr2_+_14604252 0.32 ENSMUST00000114723.2
Cacnb2
calcium channel, voltage-dependent, beta 2 subunit
chr5_-_135251209 0.32 ENSMUST00000062572.2
Fzd9
frizzled homolog 9 (Drosophila)
chr7_-_45091713 0.31 ENSMUST00000141576.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr4_-_41275091 0.30 ENSMUST00000030143.6
ENSMUST00000108068.1
Ubap2
ubiquitin-associated protein 2
chr4_+_123116246 0.29 ENSMUST00000102648.4
Oxct2b
3-oxoacid CoA transferase 2B
chr4_-_123323603 0.25 ENSMUST00000102640.1
Oxct2a
3-oxoacid CoA transferase 2A
chr19_+_43612299 0.24 ENSMUST00000057178.9
Nkx2-3
NK2 homeobox 3
chr19_-_5098418 0.22 ENSMUST00000025805.6
Cnih2
cornichon homolog 2 (Drosophila)
chr7_-_45092130 0.19 ENSMUST00000148175.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr18_+_31634368 0.19 ENSMUST00000178164.1
Sap130
Sin3A associated protein
chr13_+_13590402 0.19 ENSMUST00000110559.1
Lyst
lysosomal trafficking regulator
chr4_+_101496648 0.19 ENSMUST00000106930.1
ENSMUST00000154120.1
Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr18_+_31634374 0.17 ENSMUST00000025109.7
Sap130
Sin3A associated protein
chr3_+_96697076 0.17 ENSMUST00000162778.2
ENSMUST00000064900.9
Pias3
protein inhibitor of activated STAT 3
chrX_-_53269786 0.14 ENSMUST00000114841.1
ENSMUST00000071023.5
Fam122b
family with sequence similarity 122, member B
chr2_+_5951440 0.13 ENSMUST00000060092.6
Upf2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr7_-_45370559 0.11 ENSMUST00000003971.7
Lin7b
lin-7 homolog B (C. elegans)
chr8_+_83900706 0.11 ENSMUST00000045393.8
ENSMUST00000132500.1
ENSMUST00000152978.1
Lphn1
latrophilin 1
chr3_+_96697100 0.10 ENSMUST00000107077.3
Pias3
protein inhibitor of activated STAT 3
chr13_+_118714678 0.10 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr1_+_87327008 0.09 ENSMUST00000172794.1
ENSMUST00000164992.2
Gigyf2
GRB10 interacting GYF protein 2
chr11_+_107547925 0.09 ENSMUST00000100305.1
ENSMUST00000075012.1
ENSMUST00000106746.1
Helz
helicase with zinc finger domain
chr1_+_87327044 0.09 ENSMUST00000173173.1
Gigyf2
GRB10 interacting GYF protein 2
chr5_+_64803513 0.08 ENSMUST00000165536.1
Klf3
Kruppel-like factor 3 (basic)
chr1_+_59912972 0.04 ENSMUST00000036540.5
Fam117b
family with sequence similarity 117, member B
chr6_+_4601124 0.03 ENSMUST00000181734.1
ENSMUST00000141359.1
Casd1
CAS1 domain containing 1
chr5_-_44226601 0.03 ENSMUST00000055128.7
Tapt1
transmembrane anterior posterior transformation 1
chr1_+_87326997 0.03 ENSMUST00000027475.8
Gigyf2
GRB10 interacting GYF protein 2
chr7_-_44869788 0.02 ENSMUST00000046575.9
Ptov1
prostate tumor over expressed gene 1
chr1_-_52817503 0.02 ENSMUST00000162576.1
Inpp1
inositol polyphosphate-1-phosphatase

Network of associatons between targets according to the STRING database.

First level regulatory network of Arnt2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0050904 diapedesis(GO:0050904)
0.1 0.5 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.3 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 0.3 GO:1990523 bone regeneration(GO:1990523)
0.1 0.2 GO:1901608 regulation of vesicle transport along microtubule(GO:1901608)
0.1 0.8 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.6 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.0 0.8 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.1 GO:0061033 bronchiole development(GO:0060435) secretion by lung epithelial cell involved in lung growth(GO:0061033) positive regulation of hair follicle cell proliferation(GO:0071338)
0.0 0.2 GO:0072318 clathrin coat disassembly(GO:0072318)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.8 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.6 GO:0008305 integrin complex(GO:0008305)
0.0 0.4 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 0.6 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.1 0.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.8 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions