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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Atf4

Z-value: 1.96

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Transcription factors associated with Atf4

Gene Symbol Gene ID Gene Info
Atf4
ENSMUSG00000042406.7 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.473.7e-03Click!

Activity profile of Atf4 motif

Sorted Z-values of Atf4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_148399901 10.72 ENSMUST00000048116.8
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr16_-_36367623 10.37 ENSMUST00000096089.2
BC100530
cDNA sequence BC100530
chr2_+_148798785 9.39 ENSMUST00000028931.3
ENSMUST00000109947.1
Cst8
cystatin 8 (cystatin-related epididymal spermatogenic)
chr14_-_56102458 9.36 ENSMUST00000015583.1
Ctsg
cathepsin G
chr7_-_3502465 8.07 ENSMUST00000065703.7
Tarm1
T cell-interacting, activating receptor on myeloid cells 1
chr16_-_36334330 7.43 ENSMUST00000114850.2
BC117090
cDNA sequence BC1179090
chr7_+_78913436 7.33 ENSMUST00000121645.1
Isg20
interferon-stimulated protein
chr7_+_78914216 7.31 ENSMUST00000120331.2
Isg20
interferon-stimulated protein
chr7_+_78913401 6.91 ENSMUST00000118867.1
Isg20
interferon-stimulated protein
chr7_+_78913765 6.82 ENSMUST00000038142.8
Isg20
interferon-stimulated protein
chr15_+_89322969 6.34 ENSMUST00000066991.5
Adm2
adrenomedullin 2
chr19_-_15924928 6.26 ENSMUST00000025542.3
Psat1
phosphoserine aminotransferase 1
chr14_-_69284982 5.69 ENSMUST00000183882.1
ENSMUST00000037064.4
Slc25a37
solute carrier family 25, member 37
chr4_+_43957678 5.38 ENSMUST00000107855.1
Glipr2
GLI pathogenesis-related 2
chr11_-_120643643 4.57 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
Pycr1
pyrroline-5-carboxylate reductase 1
chr11_+_9191934 4.52 ENSMUST00000042740.6
Abca13
ATP-binding cassette, sub-family A (ABC1), member 13
chr9_-_44344159 4.40 ENSMUST00000077353.7
Hmbs
hydroxymethylbilane synthase
chr14_+_55540266 4.15 ENSMUST00000048781.3
Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr6_-_129507107 4.04 ENSMUST00000183258.1
ENSMUST00000182784.1
ENSMUST00000032265.6
ENSMUST00000162815.1
Olr1
oxidized low density lipoprotein (lectin-like) receptor 1
chr4_+_46450892 4.00 ENSMUST00000102926.4
Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr19_-_40588453 3.99 ENSMUST00000025979.6
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr19_-_40588374 3.96 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr2_+_172393900 3.93 ENSMUST00000109136.2
Cass4
Cas scaffolding protein family member 4
chr2_+_119047116 3.84 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5
cancer susceptibility candidate 5
chr19_-_40588338 3.77 ENSMUST00000176939.1
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr3_-_96263311 3.63 ENSMUST00000171473.1
Hist2h4
histone cluster 2, H4
chr6_-_83317589 3.42 ENSMUST00000005810.6
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr11_-_87826023 3.33 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr3_-_105932664 3.19 ENSMUST00000098758.2
I830077J02Rik
RIKEN cDNA I830077J02 gene
chr17_+_48462355 3.16 ENSMUST00000162132.1
Unc5cl
unc-5 homolog C (C. elegans)-like
chr2_+_119047129 3.14 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5
cancer susceptibility candidate 5
chr7_+_44468020 3.08 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
Josd2
Josephin domain containing 2
chr7_+_44468051 2.85 ENSMUST00000118493.1
Josd2
Josephin domain containing 2
chr7_+_44467980 2.84 ENSMUST00000035844.4
Josd2
Josephin domain containing 2
chr12_+_85599047 2.73 ENSMUST00000177587.1
Jdp2
Jun dimerization protein 2
chr3_+_88616133 2.60 ENSMUST00000176500.1
ENSMUST00000177498.1
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr4_+_117835387 2.57 ENSMUST00000169885.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr8_-_92356103 2.51 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr12_+_85599388 2.43 ENSMUST00000050687.6
Jdp2
Jun dimerization protein 2
chrX_+_164438039 2.22 ENSMUST00000033755.5
Asb11
ankyrin repeat and SOCS box-containing 11
chr1_+_134455524 2.09 ENSMUST00000112232.1
ENSMUST00000027725.4
ENSMUST00000116528.1
Klhl12
kelch-like 12
chr3_-_127409014 1.99 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
Ank2
ankyrin 2, brain
chr8_+_75093591 1.94 ENSMUST00000005548.6
Hmox1
heme oxygenase (decycling) 1
chr3_-_127409044 1.93 ENSMUST00000182704.1
Ank2
ankyrin 2, brain
chr6_-_16898441 1.92 ENSMUST00000031533.7
Tfec
transcription factor EC
chr7_+_125603420 1.91 ENSMUST00000033000.6
Il21r
interleukin 21 receptor
chr6_-_129533267 1.91 ENSMUST00000181594.1
1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr3_-_127408986 1.89 ENSMUST00000182588.1
ENSMUST00000182959.1
ENSMUST00000182452.1
Ank2
ankyrin 2, brain
chr15_-_98953541 1.70 ENSMUST00000097014.5
Tuba1a
tubulin, alpha 1A
chr11_-_20332689 1.66 ENSMUST00000109594.1
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr15_-_50889691 1.64 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1
trichorhinophalangeal syndrome I (human)
chr19_+_53140430 1.63 ENSMUST00000111741.2
Add3
adducin 3 (gamma)
chr19_-_50678642 1.62 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1
VPS10 domain receptor protein SORCS 1
chr14_-_32685246 1.60 ENSMUST00000096038.3
3425401B19Rik
RIKEN cDNA 3425401B19 gene
chr11_-_20332654 1.58 ENSMUST00000004634.6
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr3_+_89715016 1.52 ENSMUST00000098924.2
Adar
adenosine deaminase, RNA-specific
chr11_+_67171027 1.43 ENSMUST00000170159.1
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr6_+_55037988 1.42 ENSMUST00000003572.8
Gars
glycyl-tRNA synthetase
chr11_+_67171095 1.39 ENSMUST00000018641.7
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr4_+_127021311 1.37 ENSMUST00000030623.7
Sfpq
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr10_+_127290774 1.33 ENSMUST00000026475.8
ENSMUST00000139091.1
Ddit3
DNA-damage inducible transcript 3
chr4_+_129189760 1.22 ENSMUST00000106054.2
ENSMUST00000001365.2
Yars
tyrosyl-tRNA synthetase
chr13_+_49682191 1.19 ENSMUST00000172254.1
Iars
isoleucine-tRNA synthetase
chr5_-_36695969 1.17 ENSMUST00000031091.9
ENSMUST00000140063.1
D5Ertd579e
DNA segment, Chr 5, ERATO Doi 579, expressed
chr10_-_83533383 1.12 ENSMUST00000146640.1
Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr2_+_172393794 1.06 ENSMUST00000099061.2
ENSMUST00000103073.2
Cass4
Cas scaffolding protein family member 4
chr11_+_100320596 0.89 ENSMUST00000152521.1
Eif1
eukaryotic translation initiation factor 1
chr11_-_118290188 0.86 ENSMUST00000106296.2
ENSMUST00000092382.3
Usp36
ubiquitin specific peptidase 36
chr7_-_126502094 0.86 ENSMUST00000179818.1
Atxn2l
ataxin 2-like
chr3_-_127408937 0.84 ENSMUST00000183095.1
ENSMUST00000182610.1
Ank2
ankyrin 2, brain
chr5_-_31179901 0.84 ENSMUST00000101411.2
ENSMUST00000140793.1
Gtf3c2
general transcription factor IIIC, polypeptide 2, beta
chr11_-_118290167 0.80 ENSMUST00000144153.1
Usp36
ubiquitin specific peptidase 36
chr18_-_42262053 0.79 ENSMUST00000097590.3
Lars
leucyl-tRNA synthetase
chr8_-_122476036 0.79 ENSMUST00000014614.3
Rnf166
ring finger protein 166
chr7_+_144896523 0.76 ENSMUST00000033389.5
Fgf15
fibroblast growth factor 15
chr11_-_98400453 0.76 ENSMUST00000090827.5
Pgap3
post-GPI attachment to proteins 3
chr7_-_126502312 0.75 ENSMUST00000166682.2
Atxn2l
ataxin 2-like
chr17_+_35108279 0.75 ENSMUST00000037849.2
Ly6g5c
lymphocyte antigen 6 complex, locus G5C
chr11_-_98400393 0.72 ENSMUST00000128897.1
Pgap3
post-GPI attachment to proteins 3
chr4_+_124741844 0.68 ENSMUST00000094782.3
ENSMUST00000153837.1
ENSMUST00000154229.1
Inpp5b
inositol polyphosphate-5-phosphatase B
chr7_-_126502380 0.64 ENSMUST00000167759.1
Atxn2l
ataxin 2-like
chr3_-_59130610 0.64 ENSMUST00000065220.6
ENSMUST00000091112.4
P2ry14
purinergic receptor P2Y, G-protein coupled, 14
chr1_-_191183244 0.63 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chr1_+_71653339 0.58 ENSMUST00000125934.1
Apol7d
apolipoprotein L 7d
chr13_+_49682100 0.57 ENSMUST00000165316.1
ENSMUST00000047363.7
Iars
isoleucine-tRNA synthetase
chr10_-_127311740 0.56 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars
methionine-tRNA synthetase
chrX_+_103422010 0.54 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr1_-_78488846 0.52 ENSMUST00000068333.7
ENSMUST00000170217.1
Farsb
phenylalanyl-tRNA synthetase, beta subunit
chr7_-_126625676 0.48 ENSMUST00000032961.3
Nupr1
nuclear protein transcription regulator 1
chr3_+_138143799 0.47 ENSMUST00000159622.1
Trmt10a
tRNA methyltransferase 10A
chr5_-_31180110 0.45 ENSMUST00000043161.6
ENSMUST00000088010.5
Gtf3c2
general transcription factor IIIC, polypeptide 2, beta
chr14_-_54870913 0.45 ENSMUST00000146642.1
Homez
homeodomain leucine zipper-encoding gene
chr2_-_3512746 0.41 ENSMUST00000056700.7
ENSMUST00000027961.5
Hspa14
Hspa14
heat shock protein 14
heat shock protein 14
chr1_-_53187596 0.39 ENSMUST00000072235.3
1700019A02Rik
RIKEN cDNA 1700019A02 gene
chr8_-_105701077 0.38 ENSMUST00000042608.6
Acd
adrenocortical dysplasia
chr9_-_15112100 0.37 ENSMUST00000159985.1
Hephl1
hephaestin-like 1
chr18_-_64516547 0.32 ENSMUST00000025483.9
Nars
asparaginyl-tRNA synthetase
chr16_-_29544852 0.30 ENSMUST00000039090.8
Atp13a4
ATPase type 13A4
chr15_-_83510861 0.26 ENSMUST00000109479.1
ENSMUST00000109480.1
ENSMUST00000016897.4
Ttll1
tubulin tyrosine ligase-like 1
chr15_+_82147238 0.25 ENSMUST00000023100.6
Srebf2
sterol regulatory element binding factor 2
chr17_-_29078953 0.22 ENSMUST00000133221.1
Trp53cor1
tumor protein p53 pathway corepressor 1
chr7_-_61311679 0.21 ENSMUST00000107533.3
ENSMUST00000154958.1
A230006K03Rik
RIKEN cDNA A230006K03 gene
chr11_+_96271453 0.18 ENSMUST00000000010.8
ENSMUST00000174042.1
Hoxb9
homeobox B9
chr7_+_126565919 0.17 ENSMUST00000180459.1
G730046D07Rik
RIKEN cDNA G730046D07 gene
chr4_-_118179628 0.13 ENSMUST00000097911.2
Kdm4a
lysine (K)-specific demethylase 4A
chr1_+_156838915 0.12 ENSMUST00000111720.1
Angptl1
angiopoietin-like 1
chr10_+_102158858 0.12 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_+_163995503 0.12 ENSMUST00000131288.1
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr15_-_83510793 0.11 ENSMUST00000154401.1
Ttll1
tubulin tyrosine ligase-like 1
chr8_+_117157972 0.10 ENSMUST00000064488.4
ENSMUST00000162997.1
Gan
giant axonal neuropathy
chrX_+_106187100 0.09 ENSMUST00000081593.6
Pgk1
phosphoglycerate kinase 1
chr5_+_145140362 0.07 ENSMUST00000162594.1
ENSMUST00000162308.1
ENSMUST00000159018.1
ENSMUST00000160075.1
Bud31
BUD31 homolog (yeast)
chrX_-_75578188 0.07 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr14_+_63436394 0.04 ENSMUST00000121288.1
Fam167a
family with sequence similarity 167, member A
chr13_-_118387224 0.03 ENSMUST00000022245.8
Mrps30
mitochondrial ribosomal protein S30
chr12_-_108893197 0.03 ENSMUST00000161154.1
ENSMUST00000161410.1
Wars
tryptophanyl-tRNA synthetase
chr3_+_93319740 0.02 ENSMUST00000090856.3
ENSMUST00000093774.3
Hrnr
hornerin

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 28.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
3.9 11.7 GO:0006592 ornithine biosynthetic process(GO:0006592)
1.2 6.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.1 4.6 GO:0006561 proline biosynthetic process(GO:0006561)
1.0 9.4 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.9 2.6 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.8 3.2 GO:0015825 L-serine transport(GO:0015825)
0.7 6.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.7 4.2 GO:0006116 NADH oxidation(GO:0006116)
0.7 10.7 GO:0015809 arginine transport(GO:0015809)
0.6 1.9 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.6 1.8 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.5 1.5 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.4 1.3 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.4 1.1 GO:0009258 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.4 4.4 GO:0018065 protein-cofactor linkage(GO:0018065)
0.3 2.6 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.3 1.4 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.2 0.2 GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368)
0.2 2.1 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 0.8 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.2 1.4 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.2 2.8 GO:0001778 plasma membrane repair(GO:0001778)
0.2 3.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 5.2 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.2 3.4 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.2 4.0 GO:0043486 histone exchange(GO:0043486)
0.2 0.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 3.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 0.6 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.8 GO:1904252 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1 0.4 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 2.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 5.7 GO:0006826 iron ion transport(GO:0006826)
0.1 6.3 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.1 5.4 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 0.3 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 10.4 GO:0016579 protein deubiquitination(GO:0016579)
0.1 1.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.6 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.1 0.9 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 5.7 GO:2000117 negative regulation of cysteine-type endopeptidase activity(GO:2000117)
0.0 0.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.3 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 1.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.5 GO:2000194 regulation of female gonad development(GO:2000194)
0.0 1.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.4 GO:0006825 copper ion transport(GO:0006825)
0.0 3.2 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 0.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 28.3 GO:0015030 Cajal body(GO:0015030)
0.4 1.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.4 2.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.3 1.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 3.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 0.5 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.2 1.4 GO:0042382 paraspeckles(GO:0042382)
0.2 1.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 10.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 6.6 GO:0031430 M band(GO:0031430)
0.1 3.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 2.6 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:0070187 telosome(GO:0070187)
0.0 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 6.0 GO:0000793 condensed chromosome(GO:0000793)
0.0 3.2 GO:0005882 intermediate filament(GO:0005882)
0.0 1.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 9.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.0 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 1.9 GO:0005901 caveola(GO:0005901)
0.0 5.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 10.1 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 28.4 GO:0008859 exoribonuclease II activity(GO:0008859)
3.9 11.7 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
1.3 10.7 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
1.1 4.6 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
1.1 3.4 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.7 4.4 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.6 1.8 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.5 1.5 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.5 1.9 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.5 5.7 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.4 1.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.3 3.2 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.3 4.0 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.3 2.6 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.2 0.7 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.2 0.8 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.1 1.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.3 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.1 10.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 0.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 6.6 GO:0030507 spectrin binding(GO:0030507)
0.1 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.4 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 1.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 3.3 GO:0004601 peroxidase activity(GO:0004601)
0.0 4.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 9.0 GO:0008201 heparin binding(GO:0008201)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 4.9 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 6.8 GO:0042393 histone binding(GO:0042393)
0.0 6.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 1.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.4 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 7.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 2.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.0 PID REELIN PATHWAY Reelin signaling pathway
0.0 4.2 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 29.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.5 13.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 9.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 14.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 6.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 2.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 7.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 4.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 6.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 3.0 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 1.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK