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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Barhl1

Z-value: 0.59

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Transcription factors associated with Barhl1

Gene Symbol Gene ID Gene Info
Barhl1
ENSMUSG00000026805.8 BarH like homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Barhl1mm10_v2_chr2_-_28916412_28916440-0.202.5e-01Click!

Activity profile of Barhl1 motif

Sorted Z-values of Barhl1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_90490714 3.99 ENSMUST00000042755.3
Afp
alpha fetoprotein
chr17_+_7025837 2.58 ENSMUST00000089120.5
Gm1604b
predicted gene 1604b
chr17_-_8101228 2.25 ENSMUST00000097422.4
Gm1604A
predicted gene 1604A
chr3_-_75270073 1.70 ENSMUST00000039047.4
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr19_-_34166037 1.63 ENSMUST00000025686.7
Ankrd22
ankyrin repeat domain 22
chr8_+_31089471 1.27 ENSMUST00000036631.7
ENSMUST00000170204.1
Dusp26
dual specificity phosphatase 26 (putative)
chr1_-_75278345 1.25 ENSMUST00000039534.4
Resp18
regulated endocrine-specific protein 18
chr6_-_129876659 1.23 ENSMUST00000014687.4
ENSMUST00000122219.1
Klra17
killer cell lectin-like receptor, subfamily A, member 17
chr18_-_32559914 0.87 ENSMUST00000174000.1
ENSMUST00000174459.1
Gypc
glycophorin C
chr6_+_123123423 0.86 ENSMUST00000032248.7
Clec4a2
C-type lectin domain family 4, member a2
chr7_+_30763750 0.80 ENSMUST00000165887.1
ENSMUST00000085691.4
ENSMUST00000085688.4
ENSMUST00000054427.6
Dmkn
dermokine
chr18_+_53551594 0.76 ENSMUST00000115398.1
Prdm6
PR domain containing 6
chrX_-_164250368 0.71 ENSMUST00000112263.1
Bmx
BMX non-receptor tyrosine kinase
chr6_-_41636389 0.71 ENSMUST00000031902.5
Trpv6
transient receptor potential cation channel, subfamily V, member 6
chr11_+_116198853 0.62 ENSMUST00000021130.6
Ten1
TEN1 telomerase capping complex subunit
chr2_-_45110336 0.52 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2
zinc finger E-box binding homeobox 2
chrX_+_112604274 0.51 ENSMUST00000071814.6
Zfp711
zinc finger protein 711
chr6_+_72097561 0.51 ENSMUST00000069994.4
ENSMUST00000114112.1
St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr9_+_36832684 0.50 ENSMUST00000034630.8
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr7_-_45896656 0.48 ENSMUST00000120299.1
Syngr4
synaptogyrin 4
chrX_+_109196750 0.47 ENSMUST00000139259.1
ENSMUST00000060013.3
Gm6377
predicted gene 6377
chr8_-_84840627 0.46 ENSMUST00000003911.6
ENSMUST00000109761.2
ENSMUST00000128035.1
Rad23a
RAD23a homolog (S. cerevisiae)
chr11_+_89073841 0.43 ENSMUST00000100619.4
Gm525
predicted gene 525
chr5_+_149678224 0.43 ENSMUST00000100404.3
B3galtl
beta 1,3-galactosyltransferase-like
chr4_-_117156144 0.42 ENSMUST00000102696.4
Rps8
ribosomal protein S8
chr1_-_63214543 0.41 ENSMUST00000050536.7
Gpr1
G protein-coupled receptor 1
chr7_+_97842917 0.40 ENSMUST00000033040.5
Pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr15_+_101473472 0.40 ENSMUST00000088049.3
Krt86
keratin 86
chr2_-_104849876 0.38 ENSMUST00000028593.4
Prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr6_+_129591782 0.35 ENSMUST00000112063.2
ENSMUST00000032268.7
ENSMUST00000119520.1
Klrd1
killer cell lectin-like receptor, subfamily D, member 1
chr2_-_73453918 0.33 ENSMUST00000102679.1
Wipf1
WAS/WASL interacting protein family, member 1
chr2_+_122426432 0.32 ENSMUST00000110525.1
Slc28a2
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
chr4_+_112232245 0.30 ENSMUST00000038455.5
ENSMUST00000170945.1
Skint3
selection and upkeep of intraepithelial T cells 3
chr14_+_25980039 0.29 ENSMUST00000173155.1
Duxbl1
double homeobox B-like 1
chr5_-_104077608 0.23 ENSMUST00000164471.1
ENSMUST00000178967.1
Gm17660
predicted gene, 17660
chr7_-_45896677 0.23 ENSMUST00000039049.7
Syngr4
synaptogyrin 4
chrX_-_75578188 0.22 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr3_-_19265007 0.19 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chr3_-_130709419 0.19 ENSMUST00000043937.7
Ostc
oligosaccharyltransferase complex subunit
chr10_+_128747850 0.18 ENSMUST00000163377.2
Wibg
within bgcn homolog (Drosophila)
chr3_-_19264959 0.16 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr5_+_138187485 0.16 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr14_+_63860290 0.15 ENSMUST00000022528.4
Pinx1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr13_+_19342154 0.13 ENSMUST00000103566.3
Tcrg-C4
T cell receptor gamma, constant 4
chr16_+_92292380 0.12 ENSMUST00000047383.3
Kcne2
potassium voltage-gated channel, Isk-related subfamily, gene 2
chr18_+_12972225 0.11 ENSMUST00000025290.5
Impact
imprinted and ancient
chr5_+_34915915 0.10 ENSMUST00000050535.1
Msantd1
Myb/SANT-like DNA-binding domain containing 1
chr3_-_88410295 0.09 ENSMUST00000056370.7
Pmf1
polyamine-modulated factor 1
chr11_+_78826575 0.09 ENSMUST00000147875.2
ENSMUST00000141321.1
Lyrm9
LYR motif containing 9
chr10_+_102159000 0.08 ENSMUST00000020039.6
Mgat4c
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr15_+_81744848 0.08 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr2_-_177921815 0.08 ENSMUST00000108986.2
C330013J21Rik
RIKEN cDNA C330013J21 gene
chr12_-_54795698 0.08 ENSMUST00000005798.8
Snx6
sorting nexin 6
chr16_-_29544852 0.07 ENSMUST00000039090.8
Atp13a4
ATPase type 13A4
chr18_-_42262053 0.07 ENSMUST00000097590.3
Lars
leucyl-tRNA synthetase
chr17_+_55892184 0.07 ENSMUST00000054780.8
Zfp959
zinc finger protein 959
chr2_+_27165233 0.06 ENSMUST00000000910.6
Dbh
dopamine beta hydroxylase
chr10_-_127030813 0.05 ENSMUST00000040560.4
Tsfm
Ts translation elongation factor, mitochondrial
chr10_-_127030789 0.04 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm
Ts translation elongation factor, mitochondrial
chr10_+_102158858 0.03 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_+_115684727 0.02 ENSMUST00000043725.7
Cntnap5a
contactin associated protein-like 5A
chr2_-_80128834 0.02 ENSMUST00000102654.4
ENSMUST00000102655.3
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr17_-_25115905 0.02 ENSMUST00000024987.5
ENSMUST00000115181.2
Telo2
TEL2, telomere maintenance 2, homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of Barhl1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.2 4.0 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.2 0.8 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.4 GO:0021764 amygdala development(GO:0021764) negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 0.3 GO:1901642 purine nucleoside transmembrane transport(GO:0015860) nucleoside transmembrane transport(GO:1901642)
0.1 0.7 GO:1990035 parathyroid hormone secretion(GO:0035898) calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 0.8 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.2 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 0.7 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.1 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.0 0.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 0.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.5 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.0 0.1 GO:0046333 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.0 0.1 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 0.1 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.5 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.0 0.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.6 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.4 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0097422 tubular endosome(GO:0097422)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.4 1.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.3 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1 0.3 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.1 1.2 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.5 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.1 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.4 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.5 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.6 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.7 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions