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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Cdc5l

Z-value: 0.61

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Transcription factors associated with Cdc5l

Gene Symbol Gene ID Gene Info
Cdc5l
ENSMUSG00000023932.8 cell division cycle 5-like (S. pombe)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cdc5lmm10_v2_chr17_-_45433682_45433709-0.316.2e-02Click!

Activity profile of Cdc5l motif

Sorted Z-values of Cdc5l motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_109990430 2.06 ENSMUST00000001720.7
ENSMUST00000143741.1
Tat
tyrosine aminotransferase
chr2_+_58755177 1.99 ENSMUST00000102755.3
Upp2
uridine phosphorylase 2
chr5_-_87591582 1.64 ENSMUST00000031201.7
Sult1e1
sulfotransferase family 1E, member 1
chr14_+_66635251 1.52 ENSMUST00000159365.1
ENSMUST00000054661.1
ENSMUST00000159068.1
Adra1a
adrenergic receptor, alpha 1a
chr3_+_138217814 1.21 ENSMUST00000090171.5
Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr4_-_119383732 0.78 ENSMUST00000044781.2
ENSMUST00000084307.3
Ccdc30
coiled-coil domain containing 30
chr5_-_86518578 0.77 ENSMUST00000134179.1
Tmprss11g
transmembrane protease, serine 11g
chr7_-_103741322 0.74 ENSMUST00000051346.2
Olfr629
olfactory receptor 629
chr2_+_126034967 0.72 ENSMUST00000110442.1
Fgf7
fibroblast growth factor 7
chr5_+_92387846 0.67 ENSMUST00000138687.1
ENSMUST00000124509.1
Art3
ADP-ribosyltransferase 3
chr6_+_88724828 0.65 ENSMUST00000089449.2
Mgll
monoglyceride lipase
chr4_+_95967205 0.61 ENSMUST00000030306.7
Hook1
hook homolog 1 (Drosophila)
chr6_+_142298419 0.59 ENSMUST00000041993.2
Iapp
islet amyloid polypeptide
chr12_+_59129757 0.57 ENSMUST00000069430.8
ENSMUST00000177370.1
Ctage5
CTAGE family, member 5
chr9_-_96752822 0.56 ENSMUST00000152594.1
Zbtb38
zinc finger and BTB domain containing 38
chr2_-_64975762 0.53 ENSMUST00000156765.1
Grb14
growth factor receptor bound protein 14
chr6_+_86526271 0.53 ENSMUST00000180896.1
1600020E01Rik
RIKEN cDNA 1600020E01 gene
chr12_+_59129720 0.51 ENSMUST00000175912.1
ENSMUST00000176892.1
Ctage5
CTAGE family, member 5
chr15_-_13173607 0.49 ENSMUST00000036439.4
Cdh6
cadherin 6
chr7_-_101868667 0.43 ENSMUST00000150184.1
Folr1
folate receptor 1 (adult)
chr19_+_26749726 0.43 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr14_-_54966925 0.37 ENSMUST00000111456.1
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr10_+_52391606 0.36 ENSMUST00000067085.4
Nepn
nephrocan
chr14_+_73237891 0.36 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr2_-_72986716 0.35 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr14_-_54966570 0.35 ENSMUST00000124930.1
ENSMUST00000134256.1
ENSMUST00000081857.6
ENSMUST00000145322.1
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr3_-_83049797 0.33 ENSMUST00000048246.3
Fgb
fibrinogen beta chain
chr7_-_101869012 0.31 ENSMUST00000123321.1
Folr1
folate receptor 1 (adult)
chr11_+_59306920 0.31 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a
wingless-type MMTV integration site 9A
chr19_-_35924488 0.30 ENSMUST00000178904.1
A830019P07Rik
RIKEN cDNA A830019P07 gene
chr10_+_23938572 0.29 ENSMUST00000079134.4
Taar2
trace amine-associated receptor 2
chr11_-_50953745 0.28 ENSMUST00000162420.1
ENSMUST00000051159.2
Prop1
paired like homeodomain factor 1
chr6_-_86526164 0.26 ENSMUST00000053015.5
Pcbp1
poly(rC) binding protein 1
chr18_-_22850738 0.24 ENSMUST00000092015.4
ENSMUST00000069215.6
Nol4
nucleolar protein 4
chr1_+_17601893 0.23 ENSMUST00000088476.2
Pi15
peptidase inhibitor 15
chr5_-_87490869 0.23 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr13_-_18382041 0.19 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2
POU domain, class 6, transcription factor 2
chr1_+_143640664 0.16 ENSMUST00000038252.2
B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chrX_+_136822671 0.16 ENSMUST00000033800.6
Plp1
proteolipid protein (myelin) 1
chr5_-_136883115 0.15 ENSMUST00000057497.6
ENSMUST00000111103.1
Col26a1
collagen, type XXVI, alpha 1
chr1_+_86526688 0.15 ENSMUST00000045897.8
Ptma
prothymosin alpha
chr9_-_55919605 0.15 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr7_-_11166148 0.15 ENSMUST00000067210.4
ENSMUST00000094850.4
ENSMUST00000165848.2
Zscan4d
zinc finger and SCAN domain containing 4D
chr1_-_30863256 0.15 ENSMUST00000088310.3
Phf3
PHD finger protein 3
chr19_-_5797410 0.14 ENSMUST00000173314.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr3_+_93468751 0.14 ENSMUST00000029516.2
Tchhl1
trichohyalin-like 1
chr2_+_90148460 0.13 ENSMUST00000165784.1
Gm4222
predicted gene 4222
chr5_-_31220491 0.12 ENSMUST00000031032.7
Ppm1g
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
chr5_+_87925624 0.12 ENSMUST00000113271.2
Csn3
casein kappa
chr10_+_17723220 0.10 ENSMUST00000038107.7
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chrX_+_136822781 0.08 ENSMUST00000113085.1
Plp1
proteolipid protein (myelin) 1
chr5_+_20702129 0.08 ENSMUST00000101556.4
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr12_+_74297474 0.07 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chr10_-_107912134 0.07 ENSMUST00000165341.3
Otogl
otogelin-like
chr5_+_66968416 0.07 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr18_-_31447383 0.07 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr1_+_180111339 0.07 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chrX_-_94366777 0.06 ENSMUST00000044989.5
4932442L08Rik
RIKEN cDNA 4932442L08 gene
chr1_-_180330550 0.06 ENSMUST00000050581.3
Gm5069
predicted pseudogene 5069
chr6_-_14755250 0.05 ENSMUST00000045096.4
Ppp1r3a
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr5_+_87925579 0.04 ENSMUST00000001667.6
ENSMUST00000113267.1
Csn3
casein kappa
chrX_-_37104523 0.04 ENSMUST00000130324.1
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chrX_-_50942710 0.02 ENSMUST00000060650.5
Frmd7
FERM domain containing 7
chr5_+_66968559 0.01 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Cdc5l

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0001983 baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.5 2.9 GO:0006068 ethanol catabolic process(GO:0006068)
0.4 2.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 0.7 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.2 0.5 GO:1903537 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.1 0.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.7 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.1 0.6 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.3 GO:0060126 hypophysis morphogenesis(GO:0048850) somatotropin secreting cell differentiation(GO:0060126)
0.0 0.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.7 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.1 GO:0035802 adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 2.0 GO:0009166 nucleotide catabolic process(GO:0009166)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.6 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.3 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0045098 type III intermediate filament(GO:0045098)
0.1 0.6 GO:0070695 FHF complex(GO:0070695)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.7 GO:0043196 varicosity(GO:0043196)
0.0 0.7 GO:0032982 muscle myosin complex(GO:0005859) myosin filament(GO:0032982)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 1.5 GO:0030315 T-tubule(GO:0030315)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.4 1.2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.4 2.0 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.4 1.5 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.2 1.6 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.1 0.7 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.1 0.7 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.7 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.7 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 1.7 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.7 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions