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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Creb3l2

Z-value: 1.47

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Transcription factors associated with Creb3l2

Gene Symbol Gene ID Gene Info
Creb3l2
ENSMUSG00000038648.5 cAMP responsive element binding protein 3-like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Creb3l2mm10_v2_chr6_-_37442095_374421540.573.0e-04Click!

Activity profile of Creb3l2 motif

Sorted Z-values of Creb3l2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_26199008 10.76 ENSMUST00000142410.1
ENSMUST00000120333.1
ENSMUST00000039113.7
Pdia2
protein disulfide isomerase associated 2
chr5_-_30945393 8.61 ENSMUST00000031051.6
Cgref1
cell growth regulator with EF hand domain 1
chrX_+_8271133 7.28 ENSMUST00000127103.1
ENSMUST00000115591.1
Slc38a5
solute carrier family 38, member 5
chrX_+_8271381 7.23 ENSMUST00000033512.4
Slc38a5
solute carrier family 38, member 5
chr9_-_67832325 6.19 ENSMUST00000054500.5
C2cd4a
C2 calcium-dependent domain containing 4A
chr10_+_13090788 5.98 ENSMUST00000121646.1
ENSMUST00000121325.1
ENSMUST00000121766.1
Plagl1
pleiomorphic adenoma gene-like 1
chr7_+_78914216 4.49 ENSMUST00000120331.2
Isg20
interferon-stimulated protein
chr7_+_78913765 4.09 ENSMUST00000038142.8
Isg20
interferon-stimulated protein
chrX_+_8271642 3.98 ENSMUST00000115590.1
Slc38a5
solute carrier family 38, member 5
chrX_+_50841434 3.97 ENSMUST00000114887.2
2610018G03Rik
RIKEN cDNA 2610018G03 gene
chr6_-_38299236 3.95 ENSMUST00000058524.2
Zc3hav1l
zinc finger CCCH-type, antiviral 1-like
chr10_+_128909866 3.67 ENSMUST00000026407.7
Cd63
CD63 antigen
chr2_-_35979624 3.18 ENSMUST00000028248.4
ENSMUST00000112976.2
Ttll11
tubulin tyrosine ligase-like family, member 11
chr4_-_45084538 3.06 ENSMUST00000052236.6
Fbxo10
F-box protein 10
chr19_+_34922351 2.94 ENSMUST00000087341.5
Kif20b
kinesin family member 20B
chr14_-_56262233 2.89 ENSMUST00000015581.4
Gzmb
granzyme B
chr11_-_94653964 2.84 ENSMUST00000039949.4
Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr2_+_129198757 2.75 ENSMUST00000028880.3
Slc20a1
solute carrier family 20, member 1
chr6_-_83317589 2.60 ENSMUST00000005810.6
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr2_+_150786735 2.50 ENSMUST00000045441.7
Pygb
brain glycogen phosphorylase
chr2_+_84840612 2.49 ENSMUST00000111625.1
Slc43a1
solute carrier family 43, member 1
chr3_+_153973436 2.43 ENSMUST00000089948.5
Slc44a5
solute carrier family 44, member 5
chr2_-_92370999 2.37 ENSMUST00000176810.1
ENSMUST00000090582.4
Gyltl1b
glycosyltransferase-like 1B
chr2_-_92371039 2.20 ENSMUST00000068586.6
Gyltl1b
glycosyltransferase-like 1B
chr11_+_100415722 2.16 ENSMUST00000107400.2
Fkbp10
FK506 binding protein 10
chr6_-_145076106 2.15 ENSMUST00000111742.1
ENSMUST00000048252.4
Bcat1
branched chain aminotransferase 1, cytosolic
chrX_-_8145679 2.14 ENSMUST00000115619.1
ENSMUST00000115617.3
ENSMUST00000040010.3
Rbm3
RNA binding motif protein 3
chr11_+_100415697 2.09 ENSMUST00000001595.3
Fkbp10
FK506 binding protein 10
chr5_+_118560719 2.07 ENSMUST00000100816.4
Med13l
mediator complex subunit 13-like
chr7_+_30421724 2.04 ENSMUST00000108176.1
Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr19_-_40588453 2.03 ENSMUST00000025979.6
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr19_-_40588374 2.01 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chrX_+_153139941 1.94 ENSMUST00000039720.4
ENSMUST00000144175.2
Rragb
Ras-related GTP binding B
chr19_+_46056539 1.86 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1
peroxisome proliferative activated receptor, gamma, coactivator-related 1
chr4_-_132075250 1.85 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1
erythrocyte protein band 4.1
chr19_-_40588338 1.81 ENSMUST00000176939.1
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chrX_+_74329058 1.77 ENSMUST00000004326.3
Plxna3
plexin A3
chr2_-_105399286 1.73 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr12_+_17544873 1.71 ENSMUST00000171737.1
Odc1
ornithine decarboxylase, structural 1
chr2_-_92370968 1.71 ENSMUST00000176774.1
Gyltl1b
glycosyltransferase-like 1B
chr1_+_63176818 1.63 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr11_+_44518959 1.63 ENSMUST00000019333.3
Rnf145
ring finger protein 145
chr7_+_79392305 1.50 ENSMUST00000117227.1
ENSMUST00000118959.1
ENSMUST00000036865.6
Fanci
Fanconi anemia, complementation group I
chr6_+_87887814 1.47 ENSMUST00000113607.3
ENSMUST00000049966.5
Copg1
coatomer protein complex, subunit gamma 1
chr2_+_130274437 1.46 ENSMUST00000141872.1
Nop56
NOP56 ribonucleoprotein
chr11_-_120643643 1.46 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
Pycr1
pyrroline-5-carboxylate reductase 1
chr4_+_130047914 1.34 ENSMUST00000142293.1
Col16a1
collagen, type XVI, alpha 1
chrX_+_7822289 1.32 ENSMUST00000009875.4
Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr5_+_137641334 1.28 ENSMUST00000177466.1
ENSMUST00000166099.2
Sap25
sin3 associated polypeptide
chr15_+_79516396 1.28 ENSMUST00000010974.7
Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr4_+_119422806 1.27 ENSMUST00000094819.4
Zmynd12
zinc finger, MYND domain containing 12
chr5_-_135251209 1.27 ENSMUST00000062572.2
Fzd9
frizzled homolog 9 (Drosophila)
chr14_-_70443219 1.27 ENSMUST00000180358.1
Polr3d
polymerase (RNA) III (DNA directed) polypeptide D
chr2_+_164074122 1.26 ENSMUST00000018353.7
Stk4
serine/threonine kinase 4
chr4_+_148039035 1.25 ENSMUST00000097788.4
Mthfr
5,10-methylenetetrahydrofolate reductase
chr10_+_4266323 1.23 ENSMUST00000045730.5
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr16_-_78376758 1.22 ENSMUST00000023570.7
Btg3
B cell translocation gene 3
chr15_+_79690869 1.18 ENSMUST00000046463.8
Gtpbp1
GTP binding protein 1
chr2_+_69861638 1.18 ENSMUST00000112260.1
Ssb
Sjogren syndrome antigen B
chr2_+_130274424 1.15 ENSMUST00000103198.4
Nop56
NOP56 ribonucleoprotein
chr10_-_19014549 1.13 ENSMUST00000146388.1
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr6_-_8778439 1.12 ENSMUST00000115520.1
ENSMUST00000038403.5
ENSMUST00000115518.1
Ica1
islet cell autoantigen 1
chr4_-_108406676 1.10 ENSMUST00000184609.1
Gpx7
glutathione peroxidase 7
chr5_-_35679416 1.10 ENSMUST00000114233.2
Htra3
HtrA serine peptidase 3
chr4_-_155653184 1.06 ENSMUST00000030937.1
Mmp23
matrix metallopeptidase 23
chr6_-_8778106 1.01 ENSMUST00000151758.1
ENSMUST00000115519.1
ENSMUST00000153390.1
Ica1
islet cell autoantigen 1
chr11_+_70000578 0.99 ENSMUST00000019362.8
Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr4_+_148039097 0.99 ENSMUST00000141283.1
Mthfr
5,10-methylenetetrahydrofolate reductase
chr1_-_36683115 0.93 ENSMUST00000170295.1
ENSMUST00000114981.1
Fam178b
family with sequence similarity 178, member B
chr18_-_60848911 0.92 ENSMUST00000177172.1
ENSMUST00000175934.1
ENSMUST00000176630.1
Tcof1
Treacher Collins Franceschetti syndrome 1, homolog
chr16_+_5050012 0.84 ENSMUST00000052449.5
Ubn1
ubinuclein 1
chr3_-_20155069 0.82 ENSMUST00000184552.1
ENSMUST00000178328.1
Gyg
glycogenin
chr18_+_53176345 0.81 ENSMUST00000037850.5
Snx2
sorting nexin 2
chr12_-_102878406 0.81 ENSMUST00000045652.6
Btbd7
BTB (POZ) domain containing 7
chr2_-_180334665 0.81 ENSMUST00000015771.2
Gata5
GATA binding protein 5
chr5_+_31054766 0.79 ENSMUST00000013773.5
ENSMUST00000114646.1
Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr10_-_119240006 0.72 ENSMUST00000020315.6
Cand1
cullin associated and neddylation disassociated 1
chr5_+_31054821 0.71 ENSMUST00000174367.1
ENSMUST00000170329.1
ENSMUST00000031049.6
Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr11_+_69935796 0.70 ENSMUST00000018698.5
Ybx2
Y box protein 2
chr15_+_34495302 0.70 ENSMUST00000052290.7
ENSMUST00000079028.5
Pop1
processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
chr3_-_37724321 0.70 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148
predicted gene 5148
chr8_-_124663368 0.69 ENSMUST00000034464.6
2310022B05Rik
RIKEN cDNA 2310022B05 gene
chr17_+_29032664 0.67 ENSMUST00000130216.1
Srsf3
serine/arginine-rich splicing factor 3
chr14_-_70443442 0.64 ENSMUST00000000793.5
Polr3d
polymerase (RNA) III (DNA directed) polypeptide D
chr11_-_97500340 0.61 ENSMUST00000056955.1
4933428G20Rik
RIKEN cDNA 4933428G20 gene
chr4_-_132303331 0.58 ENSMUST00000040411.6
Rab42
RAB42, member RAS oncogene family
chr10_-_19015347 0.57 ENSMUST00000019997.4
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr3_+_96697076 0.56 ENSMUST00000162778.2
ENSMUST00000064900.9
Pias3
protein inhibitor of activated STAT 3
chr2_+_180725263 0.56 ENSMUST00000094218.3
Slc17a9
solute carrier family 17, member 9
chr3_-_27710413 0.51 ENSMUST00000046157.4
Fndc3b
fibronectin type III domain containing 3B
chr6_+_127453667 0.50 ENSMUST00000112193.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr19_-_4201591 0.49 ENSMUST00000025740.6
Rad9a
RAD9 homolog A
chr3_+_104638658 0.49 ENSMUST00000046212.1
Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr3_-_108226598 0.48 ENSMUST00000029486.7
ENSMUST00000156371.1
ENSMUST00000141387.1
Sypl2
synaptophysin-like 2
chr11_-_5099036 0.47 ENSMUST00000102930.3
Ewsr1
Ewing sarcoma breakpoint region 1
chr5_-_137610626 0.46 ENSMUST00000142675.1
Pcolce
procollagen C-endopeptidase enhancer protein
chr5_+_108268897 0.46 ENSMUST00000031190.4
Dr1
down-regulator of transcription 1
chr18_+_67464849 0.42 ENSMUST00000025411.7
Slmo1
slowmo homolog 1 (Drosophila)
chr2_+_144368961 0.42 ENSMUST00000028911.8
ENSMUST00000147747.1
ENSMUST00000183618.1
Csrp2bp
Pet117
cysteine and glycine-rich protein 2 binding protein
PET117 homolog (S. cerevisiae)
chr11_-_5099053 0.42 ENSMUST00000093365.5
ENSMUST00000073308.4
Ewsr1
Ewing sarcoma breakpoint region 1
chr15_-_83350151 0.41 ENSMUST00000067215.7
Arfgap3
ADP-ribosylation factor GTPase activating protein 3
chr2_+_69861562 0.40 ENSMUST00000090852.4
ENSMUST00000166411.1
Ssb
Sjogren syndrome antigen B
chr4_-_129742275 0.40 ENSMUST00000066257.5
Khdrbs1
KH domain containing, RNA binding, signal transduction associated 1
chr3_+_96697100 0.40 ENSMUST00000107077.3
Pias3
protein inhibitor of activated STAT 3
chr11_-_103954015 0.40 ENSMUST00000103075.4
Nsf
N-ethylmaleimide sensitive fusion protein
chr9_+_89909775 0.39 ENSMUST00000034912.4
ENSMUST00000034909.4
Rasgrf1
RAS protein-specific guanine nucleotide-releasing factor 1
chr11_-_97782377 0.38 ENSMUST00000128801.1
Rpl23
ribosomal protein L23
chr11_-_97782409 0.38 ENSMUST00000103146.4
Rpl23
ribosomal protein L23
chr7_+_16875302 0.35 ENSMUST00000108493.1
Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr17_-_12769605 0.34 ENSMUST00000024599.7
Igf2r
insulin-like growth factor 2 receptor
chr7_+_19094594 0.32 ENSMUST00000049454.5
Six5
sine oculis-related homeobox 5
chr15_-_102510681 0.28 ENSMUST00000171565.1
Map3k12
mitogen-activated protein kinase kinase kinase 12
chr4_+_128654686 0.28 ENSMUST00000030588.6
ENSMUST00000136377.1
Phc2
polyhomeotic-like 2 (Drosophila)
chr5_+_137518880 0.25 ENSMUST00000031727.7
Gigyf1
GRB10 interacting GYF protein 1
chr9_-_106887000 0.25 ENSMUST00000055843.7
Rbm15b
RNA binding motif protein 15B
chr8_+_14911663 0.23 ENSMUST00000084207.5
ENSMUST00000161162.1
ENSMUST00000110800.2
Arhgef10
Rho guanine nucleotide exchange factor (GEF) 10
chr5_-_100416115 0.21 ENSMUST00000182886.1
ENSMUST00000094578.4
Sec31a
Sec31 homolog A (S. cerevisiae)
chr1_+_119526125 0.20 ENSMUST00000183952.1
TMEM185B
Transmembrane protein 185B
chr11_-_100759942 0.20 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr10_+_111164794 0.17 ENSMUST00000105275.1
ENSMUST00000095310.1
Osbpl8
oxysterol binding protein-like 8
chr19_+_6975048 0.17 ENSMUST00000070850.6
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_+_44756609 0.16 ENSMUST00000143385.1
Zcchc7
zinc finger, CCHC domain containing 7
chr11_-_5099223 0.15 ENSMUST00000079949.6
Ewsr1
Ewing sarcoma breakpoint region 1
chr2_-_155473788 0.15 ENSMUST00000109670.1
ENSMUST00000123293.1
Ncoa6
nuclear receptor coactivator 6
chr3_-_108086590 0.15 ENSMUST00000102638.1
ENSMUST00000102637.1
Ampd2
adenosine monophosphate deaminase 2
chr2_+_68861433 0.14 ENSMUST00000028426.2
Cers6
ceramide synthase 6
chr16_-_4880284 0.14 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr6_+_129512538 0.13 ENSMUST00000032263.5
Tmem52b
transmembrane protein 52B
chr6_+_87042838 0.12 ENSMUST00000113658.1
ENSMUST00000113657.1
ENSMUST00000113655.1
ENSMUST00000032057.7
Gfpt1
glutamine fructose-6-phosphate transaminase 1
chr7_-_105640308 0.12 ENSMUST00000133519.1
ENSMUST00000084782.2
ENSMUST00000131446.1
Arfip2
ADP-ribosylation factor interacting protein 2
chr19_-_6840590 0.12 ENSMUST00000170516.2
ENSMUST00000025903.5
Rps6ka4
ribosomal protein S6 kinase, polypeptide 4
chr14_-_26638183 0.10 ENSMUST00000166902.1
4930570N19Rik
RIKEN cDNA 4930570N19 gene
chr14_-_70351354 0.09 ENSMUST00000143153.1
ENSMUST00000127000.1
ENSMUST00000068044.7
ENSMUST00000022688.3
Slc39a14
solute carrier family 39 (zinc transporter), member 14
chr17_+_87107621 0.08 ENSMUST00000041369.6
Socs5
suppressor of cytokine signaling 5
chr12_+_69241832 0.08 ENSMUST00000063445.6
Klhdc1
kelch domain containing 1
chrX_+_163908982 0.08 ENSMUST00000069041.8
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chrX_-_73786888 0.07 ENSMUST00000052761.8
Idh3g
isocitrate dehydrogenase 3 (NAD+), gamma
chr10_+_78574492 0.07 ENSMUST00000105384.3
Ilvbl
ilvB (bacterial acetolactate synthase)-like
chr11_+_3649494 0.04 ENSMUST00000093389.2
Morc2a
microrchidia 2A
chr1_+_87326997 0.03 ENSMUST00000027475.8
Gigyf2
GRB10 interacting GYF protein 2
chr14_+_26638074 0.02 ENSMUST00000022429.2
Arf4
ADP-ribosylation factor 4
chr5_+_30105161 0.02 ENSMUST00000058045.4
Gareml
GRB2 associated, regulator of MAPK1-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3l2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0006592 ornithine biosynthetic process(GO:0006592)
1.7 8.6 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.0 18.5 GO:0015816 glycine transport(GO:0015816)
1.0 2.9 GO:1903436 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.7 3.7 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.6 2.9 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.6 1.7 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.6 2.8 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.6 1.7 GO:0072573 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.6 2.2 GO:0070829 heterochromatin maintenance(GO:0070829)
0.4 1.3 GO:1990523 bone regeneration(GO:1990523)
0.4 3.2 GO:0051013 microtubule severing(GO:0051013)
0.4 1.6 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.4 1.5 GO:0006561 proline biosynthetic process(GO:0006561)
0.4 2.2 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.3 1.3 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3 1.8 GO:1902287 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.3 0.8 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.3 9.8 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.2 1.9 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.2 1.5 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.2 1.0 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.2 2.0 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.1 4.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.4 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.1 1.5 GO:0051683 establishment of Golgi localization(GO:0051683)
0.1 2.6 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.1 0.9 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.7 GO:0016078 tRNA catabolic process(GO:0016078)
0.1 1.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 2.7 GO:0006817 phosphate ion transport(GO:0006817)
0.1 2.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 2.5 GO:0009251 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 0.5 GO:0035879 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 0.9 GO:0014029 neural crest formation(GO:0014029)
0.1 0.8 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 2.6 GO:0000154 rRNA modification(GO:0000154)
0.1 1.0 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 1.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.8 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.1 6.0 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 0.2 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.1 0.8 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.1 0.8 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 1.9 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 0.7 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 8.5 GO:0007050 cell cycle arrest(GO:0007050)
0.0 2.1 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.0 0.5 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 1.3 GO:0033622 integrin activation(GO:0033622) positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 1.2 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.5 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.0 0.3 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 1.6 GO:0006414 translational elongation(GO:0006414)
0.0 0.3 GO:0014842 skeletal muscle satellite cell proliferation(GO:0014841) regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.0 0.4 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.8 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.1 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 4.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.7 GO:0048255 mRNA stabilization(GO:0048255)
0.0 0.1 GO:0072015 IMP salvage(GO:0032264) glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.4 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.6 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.1 GO:0071638 negative regulation of T-helper 2 cell differentiation(GO:0045629) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.4 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.8 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.7 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.9 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.2 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.6 2.9 GO:0044194 cytolytic granule(GO:0044194)
0.6 2.8 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.4 1.9 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.4 2.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 1.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3 0.8 GO:0030905 retromer, tubulation complex(GO:0030905)
0.2 2.9 GO:1990023 mitotic spindle midzone(GO:1990023)
0.2 8.6 GO:0015030 Cajal body(GO:0015030)
0.1 1.5 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 1.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 1.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.5 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 1.3 GO:0031527 filopodium membrane(GO:0031527)
0.0 2.1 GO:0016592 mediator complex(GO:0016592)
0.0 2.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)
0.0 1.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.6 GO:0008859 exoribonuclease II activity(GO:0008859)
2.0 5.9 GO:0004349 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
1.3 18.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.9 2.7 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.9 2.6 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.8 9.0 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.7 2.2 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.6 2.5 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.5 1.5 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.4 1.5 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.4 2.2 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.4 2.8 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.3 0.9 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.3 1.1 GO:0004096 catalase activity(GO:0004096)
0.3 1.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 2.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 0.7 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.2 0.9 GO:0046923 ER retention sequence binding(GO:0046923)
0.2 1.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 4.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 0.8 GO:1990460 leptin receptor binding(GO:1990460)
0.2 2.6 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 2.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 1.8 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.5 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.8 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 1.9 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 2.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.8 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 5.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 2.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 1.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 2.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 1.0 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 3.9 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.4 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.7 GO:0045182 translation regulator activity(GO:0045182)
0.0 9.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.5 GO:0016504 peptidase activator activity(GO:0016504)
0.0 1.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 6.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.0 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 7.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.0 PID BARD1 PATHWAY BARD1 signaling events
0.1 1.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 2.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.8 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 21.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 7.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 8.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.5 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 2.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.4 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.9 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 2.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.7 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 3.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 2.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.4 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.5 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 2.0 REACTOME TRANSLATION Genes involved in Translation