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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for En1
Z-value: 1.52
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Transcription factors associated with En1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| En1 | mm10_v2_chr1_+_120602405_120602418 | 0.11 | 5.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_81975742 Show fit | 9.21 |
ENSMUST00000029645.8
|
tryptophan 2,3-dioxygenase |
|
| chr8_+_105048592 Show fit | 7.49 |
ENSMUST00000093222.5
ENSMUST00000093223.3 |
carboxylesterase 3A |
|
| chr10_-_128960965 Show fit | 7.09 |
ENSMUST00000026398.3
|
methyltransferase like 7B |
|
| chr1_+_72824482 Show fit | 5.59 |
ENSMUST00000047328.4
|
insulin-like growth factor binding protein 2 |
|
| chr17_-_84682932 Show fit | 5.00 |
ENSMUST00000066175.3
|
ATP-binding cassette, sub-family G (WHITE), member 5 |
|
| chr4_-_49383576 Show fit | 4.94 |
ENSMUST00000107698.1
|
acyl-coenzyme A amino acid N-acyltransferase 2 |
|
| chr6_-_141856171 Show fit | 4.90 |
ENSMUST00000165990.1
ENSMUST00000163678.1 |
solute carrier organic anion transporter family, member 1a4 |
|
| chr3_+_130617645 Show fit | 4.24 |
ENSMUST00000163620.1
|
ethanolamine phosphate phospholyase |
|
| chr8_+_67490758 Show fit | 4.06 |
ENSMUST00000026677.3
|
N-acetyl transferase 1 |
|
| chr14_-_51146757 Show fit | 4.02 |
ENSMUST00000080126.2
|
ribonuclease, RNase A family, 1 (pancreatic) |
Network of associatons between targets according to the STRING database.
First level regulatory network of En1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.2 | GO:0019442 | tryptophan catabolic process to acetyl-CoA(GO:0019442) |
| 3.0 | 9.0 | GO:0045796 | negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730) |
| 1.8 | 9.0 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 1.6 | 6.2 | GO:0009698 | phenylpropanoid metabolic process(GO:0009698) |
| 0.2 | 6.0 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 5.8 | GO:0090501 | RNA phosphodiester bond hydrolysis(GO:0090501) |
| 0.2 | 5.6 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.5 | 4.9 | GO:1900194 | receptor guanylyl cyclase signaling pathway(GO:0007168) negative regulation of oocyte maturation(GO:1900194) |
| 0.1 | 4.4 | GO:0006637 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
| 0.4 | 4.1 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 3.0 | 9.0 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.8 | 9.0 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.2 | 5.4 | GO:0042627 | chylomicron(GO:0042627) |
| 0.2 | 4.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.1 | 4.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 4.4 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.3 | 3.9 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.2 | 3.7 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 3.7 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.4 | 11.4 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 2.3 | 9.2 | GO:0004833 | tryptophan 2,3-dioxygenase activity(GO:0004833) |
| 0.1 | 7.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.1 | 6.9 | GO:0047023 | androsterone dehydrogenase activity(GO:0047023) |
| 0.3 | 6.0 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.6 | 5.6 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 5.5 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.0 | 5.4 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.0 | 5.3 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.3 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 4.2 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 3.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 2.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 1.7 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 1.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.5 | PID ALK1 PATHWAY | ALK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.4 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.5 | 11.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.6 | 10.3 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.4 | 7.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 4.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 3.9 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 3.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 3.2 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 2.9 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 2.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |