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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Etv6
Z-value: 1.60
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Transcription factors associated with Etv6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Etv6 | mm10_v2_chr6_+_134035691_134035717 | -0.81 | 2.3e-09 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_155517948 Show fit | 3.36 |
ENSMUST00000029135.8
ENSMUST00000065973.2 ENSMUST00000103142.5 |
acyl-CoA synthetase short-chain family member 2 |
|
| chr3_-_89764581 Show fit | 3.06 |
ENSMUST00000029562.3
|
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) |
|
| chr2_-_130424242 Show fit | 2.92 |
ENSMUST00000089581.4
|
PC-esterase domain containing 1A |
|
| chr1_+_58586381 Show fit | 2.61 |
ENSMUST00000027193.8
|
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 |
|
| chr5_+_147860615 Show fit | 2.37 |
ENSMUST00000031654.6
|
proteasome maturation protein |
|
| chr11_-_20112876 Show fit | 2.20 |
ENSMUST00000000137.7
|
ARP2 actin-related protein 2 |
|
| chr15_+_58933774 Show fit | 2.20 |
ENSMUST00000022980.3
|
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 |
|
| chr16_+_13903152 Show fit | 2.16 |
ENSMUST00000128757.1
|
Mpv17 transgene, kidney disease mutant-like |
|
| chr11_+_120098910 Show fit | 2.09 |
ENSMUST00000106223.2
|
RIKEN cDNA 1810043H04 gene |
|
| chr3_-_94886945 Show fit | 1.99 |
ENSMUST00000005923.6
|
proteasome (prosome, macropain) subunit, beta type 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Etv6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.4 | GO:0071569 | protein ufmylation(GO:0071569) |
| 0.1 | 4.2 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 3.9 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity(GO:0032088) |
| 0.6 | 3.6 | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) |
| 0.6 | 3.4 | GO:0051790 | acetate metabolic process(GO:0006083) short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.2 | 3.4 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.1 | 3.4 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 0.2 | 3.2 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 1.0 | 3.1 | GO:0060084 | synaptic transmission involved in micturition(GO:0060084) |
| 0.8 | 3.1 | GO:1903751 | regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 5.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 4.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 4.6 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 4.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.6 | 3.9 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.4 | 3.4 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.8 | 3.1 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.2 | 3.1 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 2.8 | GO:0005839 | proteasome core complex(GO:0005839) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 6.1 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
| 0.2 | 5.4 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.4 | 4.0 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 1.1 | 3.4 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.1 | 3.4 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.1 | 3.2 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.8 | 3.1 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.8 | 3.1 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 0.2 | 3.1 | GO:0042166 | acetylcholine binding(GO:0042166) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 4.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 3.9 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 3.3 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 3.0 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.2 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.1 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 6.4 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 4.7 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.6 | 3.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 3.4 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.2 | 3.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.2 | 3.1 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 3.1 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 2.9 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.1 | 2.7 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |