ISMARA results: Foxa2

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Foxa2_Foxa1

Z-value: 2.63

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Transcription factors associated with Foxa2_Foxa1

Gene Symbol	Gene ID	Gene Info
Foxa2 Ensembl NCBI MGI UniProt	ENSMUSG00000037025.5	forkhead box A2
Foxa1 Ensembl NCBI MGI UniProt	ENSMUSG00000035451.6	forkhead box A1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Foxa2	mm10_v2_chr2_-_148046896_148046991	0.68	4.1e-06	Click!
Foxa1	mm10_v2_chr12_-_57546121_57546141	0.33	5.2e-02	Click!

Activity profile of Foxa2_Foxa1 motif

Sorted Z-values of Foxa2_Foxa1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_113258837 Show fit	55.12	ENSMUST00000098673.3	Amy2a5 Ensembl NCBI MGI UniProt Show fit	amylase 2a5
chr3_-_113532288 Show fit	39.00	ENSMUST00000132353.1	Amy2a1 Ensembl NCBI MGI UniProt Show fit	amylase 2a1
chr6_+_30541582 Show fit	28.17	ENSMUST00000096066.4	Cpa2 Ensembl NCBI MGI UniProt Show fit	carboxypeptidase A2, pancreatic
chr3_-_20275659 Show fit	27.11	ENSMUST00000011607.5	Cpb1 Ensembl NCBI MGI UniProt Show fit	carboxypeptidase B1 (tissue)
chr17_-_31144271 Show fit	25.50	ENSMUST00000024826.7	Tff2 Ensembl NCBI MGI UniProt Show fit	trefoil factor 2 (spasmolytic protein 1)
chr2_-_62483637 Show fit	20.03	ENSMUST00000136686.1 ENSMUST00000102733.3	Gcg Ensembl NCBI MGI UniProt Show fit	glucagon
chr7_+_131032061 Show fit	17.42	ENSMUST00000084509.3	Dmbt1 Ensembl NCBI MGI UniProt Show fit	deleted in malignant brain tumors 1
chr6_+_142298419 Show fit	16.69	ENSMUST00000041993.2	Iapp Ensembl NCBI MGI UniProt Show fit	islet amyloid polypeptide
chr3_+_107230608 Show fit	13.08	ENSMUST00000179399.1	A630076J17Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA A630076J17 gene
chr9_+_46268601 Show fit	12.35	ENSMUST00000121598.1	Apoa5 Ensembl NCBI MGI UniProt Show fit	apolipoprotein A-V

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa2_Foxa1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	40.3	GO:0006508	proteolysis(GO:0006508)
3.6	25.5	GO:0060455	negative regulation of gastric acid secretion(GO:0060455)
2.9	20.0	GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.9	17.4	GO:0001833	inner cell mass cell proliferation(GO:0001833)
2.1	16.7	GO:0097646	calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
3.3	13.3	GO:0010901	regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.3	9.3	GO:0017144	drug metabolic process(GO:0017144)
0.1	8.4	GO:0009166	nucleotide catabolic process(GO:0009166)
0.3	7.9	GO:0046688	response to copper ion(GO:0046688)
1.2	7.1	GO:0038161	prolactin signaling pathway(GO:0038161)

Showing 1 to 10 of 155 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	167.3	GO:0005615	extracellular space(GO:0005615)
0.1	20.7	GO:0072562	blood microparticle(GO:0072562)
2.5	17.4	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.6	13.9	GO:0042627	chylomicron(GO:0042627)
0.0	13.9	GO:0016323	basolateral plasma membrane(GO:0016323)
1.1	8.9	GO:0045098	type III intermediate filament(GO:0045098)
0.0	5.5	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.2	5.3	GO:0005771	multivesicular body(GO:0005771)
0.0	4.8	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	4.3	GO:0000930	gamma-tubulin complex(GO:0000930)

Showing 1 to 10 of 54 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.3	71.8	GO:0004556	alpha-amylase activity(GO:0004556)
1.7	54.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.3	38.1	GO:0005179	hormone activity(GO:0005179)
1.9	24.7	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.4	19.8	GO:0005044	scavenger receptor activity(GO:0005044)
1.8	12.4	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.1	11.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.8	8.9	GO:0004850	uridine phosphorylase activity(GO:0004850)
0.2	7.7	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
2.5	7.5	GO:0005333	norepinephrine transmembrane transporter activity(GO:0005333)

Showing 1 to 10 of 101 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	30.9	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	23.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	7.4	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	6.9	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.1	4.6	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	4.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	3.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	3.0	PID IL27 PATHWAY	IL27-mediated signaling events
0.1	3.0	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	3.0	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	19.6	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.5	17.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.5	13.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.5	8.9	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.2	8.5	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
2.6	7.7	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.6	7.5	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.4	7.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.5	6.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.3	5.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Showing 1 to 10 of 48 entries

Results for Foxa2_Foxa1

Z-value: 2.63

Motif logo

Transcription factors associated with Foxa2_Foxa1

Activity-expression correlation:

Activity profile of Foxa2_Foxa1 motif

Sorted Z-values of Foxa2_Foxa1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa2_Foxa1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: