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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Hdx
Z-value: 3.68
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Transcription factors associated with Hdx
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hdx | mm10_v2_chrX_-_111697069_111697127 | -0.56 | 4.0e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_62150810 Show fit | 43.62 |
ENSMUST00000077719.3
|
major urinary protein 21 |
|
| chr4_-_60662358 Show fit | 42.26 |
ENSMUST00000084544.4
ENSMUST00000098046.3 |
major urinary protein 11 |
|
| chr4_-_60139857 Show fit | 39.80 |
ENSMUST00000107490.4
ENSMUST00000074700.2 |
major urinary protein 2 |
|
| chr4_-_60582152 Show fit | 38.30 |
ENSMUST00000098047.2
|
major urinary protein 10 |
|
| chr4_-_61303998 Show fit | 37.20 |
ENSMUST00000071005.8
ENSMUST00000075206.5 |
major urinary protein 14 |
|
| chr4_-_60421933 Show fit | 36.68 |
ENSMUST00000107506.2
ENSMUST00000122381.1 ENSMUST00000118759.1 ENSMUST00000122177.1 |
major urinary protein 9 |
|
| chr4_-_61674094 Show fit | 36.67 |
ENSMUST00000098040.3
|
major urinary protein 18 |
|
| chr4_-_60222580 Show fit | 36.12 |
ENSMUST00000095058.4
ENSMUST00000163931.1 |
major urinary protein 8 |
|
| chr4_-_61303802 Show fit | 35.65 |
ENSMUST00000125461.1
|
major urinary protein 14 |
|
| chr15_+_4727175 Show fit | 16.12 |
ENSMUST00000162585.1
|
complement component 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hdx
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.0 | 45.1 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 3.8 | 42.3 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 2.3 | 13.6 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.1 | 13.0 | GO:0007586 | digestion(GO:0007586) |
| 0.5 | 9.2 | GO:0042448 | progesterone metabolic process(GO:0042448) |
| 1.0 | 8.7 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.0 | 8.1 | GO:0007596 | blood coagulation(GO:0007596) |
| 0.1 | 7.6 | GO:0006956 | complement activation(GO:0006956) |
| 0.5 | 7.5 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 1.1 | 6.4 | GO:0006068 | ethanol catabolic process(GO:0006068) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 45.1 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 8.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.3 | 7.6 | GO:0044215 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.0 | 7.6 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 6.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 4.8 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 4.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.7 | 4.1 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.0 | 4.0 | GO:0043204 | perikaryon(GO:0043204) |
| 0.3 | 3.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 21.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 2.7 | 13.6 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.1 | 10.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.6 | 9.2 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 1.3 | 9.0 | GO:0001851 | complement component C3b binding(GO:0001851) |
| 1.0 | 7.6 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.5 | 7.5 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 1.3 | 6.4 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 1.0 | 6.0 | GO:0047035 | alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.1 | 5.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.5 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 5.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 5.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 3.9 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 3.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 3.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 3.2 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 3.0 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 2.9 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 2.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 53.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.7 | 13.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.7 | 9.2 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.6 | 7.5 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.5 | 6.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.5 | 5.9 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 4.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.2 | 4.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 4.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 3.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |