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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hes5_Hes7

Z-value: 3.44

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Transcription factors associated with Hes5_Hes7

Gene Symbol Gene ID Gene Info
Hes5
ENSMUSG00000048001.7 hes family bHLH transcription factor 5
Hes7
ENSMUSG00000023781.2 hes family bHLH transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hes5mm10_v2_chr4_+_154960915_1549609300.772.9e-08Click!
Hes7mm10_v2_chr11_+_69120404_691204040.582.0e-04Click!

Activity profile of Hes5_Hes7 motif

Sorted Z-values of Hes5_Hes7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_12026237 88.25 ENSMUST00000150972.1
Grb10
growth factor receptor bound protein 10
chr11_-_12026732 78.46 ENSMUST00000143915.1
Grb10
growth factor receptor bound protein 10
chr17_-_26199008 43.23 ENSMUST00000142410.1
ENSMUST00000120333.1
ENSMUST00000039113.7
Pdia2
protein disulfide isomerase associated 2
chrX_+_8271381 33.24 ENSMUST00000033512.4
Slc38a5
solute carrier family 38, member 5
chrX_+_8271133 33.16 ENSMUST00000127103.1
ENSMUST00000115591.1
Slc38a5
solute carrier family 38, member 5
chr12_+_109549157 26.66 ENSMUST00000128458.1
ENSMUST00000150851.1
Meg3
maternally expressed 3
chrX_+_8271642 24.55 ENSMUST00000115590.1
Slc38a5
solute carrier family 38, member 5
chr8_+_122269569 18.81 ENSMUST00000055537.2
Gm22
predicted gene 22
chr12_+_109459843 15.84 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr1_-_193035651 13.11 ENSMUST00000016344.7
Syt14
synaptotagmin XIV
chr6_+_4755327 11.77 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr13_+_108316395 10.66 ENSMUST00000171178.1
Depdc1b
DEP domain containing 1B
chr8_-_24948771 10.50 ENSMUST00000119720.1
ENSMUST00000121438.2
Adam32
a disintegrin and metallopeptidase domain 32
chr13_+_108316332 10.48 ENSMUST00000051594.5
Depdc1b
DEP domain containing 1B
chrX_-_9256899 10.14 ENSMUST00000115553.2
Gm14862
predicted gene 14862
chr6_-_52226165 10.11 ENSMUST00000114425.2
Hoxa9
homeobox A9
chr11_+_11684967 9.76 ENSMUST00000126058.1
ENSMUST00000141436.1
Ikzf1
IKAROS family zinc finger 1
chr4_-_138757578 9.70 ENSMUST00000030526.6
Pla2g2f
phospholipase A2, group IIF
chr19_-_5394385 8.95 ENSMUST00000044527.4
Tsga10ip
testis specific 10 interacting protein
chr3_-_95241598 7.52 ENSMUST00000090815.5
ENSMUST00000107197.1
Gm128
predicted gene 128
chr2_+_150570409 7.19 ENSMUST00000089200.2
Cst7
cystatin F (leukocystatin)
chr4_+_134468320 6.58 ENSMUST00000030636.4
ENSMUST00000127279.1
ENSMUST00000105867.1
Stmn1
stathmin 1
chr4_+_154869585 6.35 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
Mmel1
membrane metallo-endopeptidase-like 1
chr5_+_31251678 5.74 ENSMUST00000054829.7
ENSMUST00000114570.1
ENSMUST00000075611.7
Krtcap3
keratinocyte associated protein 3
chr2_-_92370999 5.30 ENSMUST00000176810.1
ENSMUST00000090582.4
Gyltl1b
glycosyltransferase-like 1B
chr9_-_121641526 5.22 ENSMUST00000125075.1
ENSMUST00000077706.3
Lyzl4
lysozyme-like 4
chr15_+_39076885 5.17 ENSMUST00000067072.3
Cthrc1
collagen triple helix repeat containing 1
chr2_-_92371039 4.81 ENSMUST00000068586.6
Gyltl1b
glycosyltransferase-like 1B
chr9_-_36726374 4.76 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1
checkpoint kinase 1
chr4_+_11191354 4.67 ENSMUST00000170901.1
Ccne2
cyclin E2
chr6_-_145076106 4.58 ENSMUST00000111742.1
ENSMUST00000048252.4
Bcat1
branched chain aminotransferase 1, cytosolic
chr2_-_92370968 4.15 ENSMUST00000176774.1
Gyltl1b
glycosyltransferase-like 1B
chr9_+_64121501 4.11 ENSMUST00000118215.1
Lctl
lactase-like
chr2_+_24345282 3.97 ENSMUST00000114485.2
Il1rn
interleukin 1 receptor antagonist
chr19_+_47178820 3.73 ENSMUST00000111808.3
Neurl1a
neuralized homolog 1A (Drosophila)
chr6_+_71707561 3.70 ENSMUST00000121469.1
Reep1
receptor accessory protein 1
chr11_-_120348513 3.70 ENSMUST00000071555.6
Actg1
actin, gamma, cytoplasmic 1
chr9_+_107587711 3.66 ENSMUST00000010192.5
Ifrd2
interferon-related developmental regulator 2
chr9_-_78443204 3.53 ENSMUST00000070742.7
ENSMUST00000034898.7
Mb21d1
Mab-21 domain containing 1
chr4_-_149126688 3.17 ENSMUST00000030815.2
Cort
cortistatin
chr10_-_87493651 3.16 ENSMUST00000020243.7
Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr3_-_95855860 3.11 ENSMUST00000015892.7
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr3_-_95855753 3.07 ENSMUST00000161476.1
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr6_+_35177610 2.86 ENSMUST00000170234.1
Nup205
nucleoporin 205
chr8_+_60632856 2.83 ENSMUST00000160719.1
Mfap3l
microfibrillar-associated protein 3-like
chr3_-_95315086 2.73 ENSMUST00000098867.3
Gm10691
predicted gene 10691
chr8_+_60632818 2.63 ENSMUST00000161421.1
Mfap3l
microfibrillar-associated protein 3-like
chr17_+_35861318 2.53 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm
nurim (nuclear envelope membrane protein)
chr1_+_63176818 2.47 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr10_+_36974536 2.42 ENSMUST00000019911.7
Hdac2
histone deacetylase 2
chr17_-_25273861 2.38 ENSMUST00000172868.1
ENSMUST00000172618.1
Ube2i
ubiquitin-conjugating enzyme E2I
chr11_-_120348091 2.38 ENSMUST00000106215.4
Actg1
actin, gamma, cytoplasmic 1
chr15_+_32244801 2.09 ENSMUST00000067458.6
Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr13_+_35741313 2.08 ENSMUST00000163595.2
Cdyl
chromodomain protein, Y chromosome-like
chr6_+_72097561 1.94 ENSMUST00000069994.4
ENSMUST00000114112.1
St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr2_+_91526756 1.93 ENSMUST00000111338.3
Ckap5
cytoskeleton associated protein 5
chr8_-_87804411 1.92 ENSMUST00000165770.2
Zfp423
zinc finger protein 423
chr7_-_131362687 1.89 ENSMUST00000059438.9
2310057M21Rik
RIKEN cDNA 2310057M21 gene
chr11_+_80477015 1.89 ENSMUST00000053413.10
ENSMUST00000147694.1
Cdk5r1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr16_+_45224315 1.76 ENSMUST00000102802.3
ENSMUST00000063654.4
Btla
B and T lymphocyte associated
chr17_-_28080567 1.74 ENSMUST00000114836.1
ENSMUST00000042692.5
Tcp11
t-complex protein 11
chr14_+_31019183 1.72 ENSMUST00000052239.5
Pbrm1
polybromo 1
chr6_+_49319274 1.72 ENSMUST00000055559.7
ENSMUST00000114491.1
Ccdc126
coiled-coil domain containing 126
chr4_-_43562397 1.68 ENSMUST00000030187.7
Tln1
talin 1
chr10_+_79822617 1.62 ENSMUST00000046833.4
Misp
mitotic spindle positioning
chr3_-_90052463 1.53 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l
ubiquitin associated protein 2-like
chr12_+_77239036 1.49 ENSMUST00000062804.7
Fut8
fucosyltransferase 8
chr11_+_3963970 1.43 ENSMUST00000020705.4
ENSMUST00000109985.1
Pes1
pescadillo homolog 1, containing BRCT domain (zebrafish)
chr15_-_32244632 1.36 ENSMUST00000181536.1
0610007N19Rik
RIKEN cDNA 0610007N19
chr4_-_117251879 1.27 ENSMUST00000165128.1
ENSMUST00000077500.4
Gm1661
predicted gene 1661
chr1_-_161876656 1.27 ENSMUST00000048377.5
Suco
SUN domain containing ossification factor
chr6_+_83165920 1.19 ENSMUST00000077407.5
ENSMUST00000113913.1
ENSMUST00000130212.1
Dctn1
dynactin 1
chr10_+_36974558 1.10 ENSMUST00000105510.1
Hdac2
histone deacetylase 2
chr3_+_104638658 0.84 ENSMUST00000046212.1
Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr9_+_20652107 0.77 ENSMUST00000034689.6
Pin1
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
chr4_-_133756769 0.77 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr18_-_46280820 0.73 ENSMUST00000025354.3
Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chrX_-_112406779 0.72 ENSMUST00000026601.2
Satl1
spermidine/spermine N1-acetyl transferase-like 1
chr2_+_163203072 0.72 ENSMUST00000109428.2
Tox2
TOX high mobility group box family member 2
chr18_+_37320374 0.64 ENSMUST00000078271.2
Pcdhb5
protocadherin beta 5
chr18_-_35722330 0.62 ENSMUST00000133064.1
Ecscr
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr17_-_25274299 0.61 ENSMUST00000172587.1
ENSMUST00000049911.9
ENSMUST00000173713.1
Ube2i
ubiquitin-conjugating enzyme E2I
chr8_+_124722139 0.59 ENSMUST00000034463.3
Arv1
ARV1 homolog (yeast)
chr14_+_31019159 0.49 ENSMUST00000112094.1
ENSMUST00000144009.1
Pbrm1
polybromo 1
chr5_+_141241490 0.46 ENSMUST00000085774.4
Sdk1
sidekick homolog 1 (chicken)
chr17_-_35979679 0.45 ENSMUST00000173724.1
ENSMUST00000172900.1
ENSMUST00000174849.1
Prr3
proline-rich polypeptide 3
chr3_+_10366903 0.45 ENSMUST00000029049.5
Chmp4c
charged multivesicular body protein 4C
chr2_-_65567465 0.35 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr11_-_59787636 0.32 ENSMUST00000125307.1
Pld6
phospholipase D family, member 6
chr2_-_150255591 0.31 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr10_+_39369750 0.29 ENSMUST00000063091.6
ENSMUST00000099967.3
ENSMUST00000126486.1
Fyn
Fyn proto-oncogene
chrX_-_8175890 0.28 ENSMUST00000143984.1
Tbc1d25
TBC1 domain family, member 25
chr12_+_69372112 0.27 ENSMUST00000050063.7
Arf6
ADP-ribosylation factor 6
chr4_-_123904826 0.25 ENSMUST00000181292.1
Gm26606
predicted gene, 26606
chr5_+_43515513 0.24 ENSMUST00000167522.1
ENSMUST00000144558.1
ENSMUST00000076939.6
C1qtnf7
C1q and tumor necrosis factor related protein 7
chr5_+_128601106 0.21 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chr2_-_150179679 0.20 ENSMUST00000099418.2
Gm10770
predicted gene 10770
chrX_-_44368329 0.17 ENSMUST00000056834.3
ENSMUST00000115057.1
Dcaf12l2
DDB1 and CUL4 associated factor 12-like 2
chr2_+_29060239 0.16 ENSMUST00000100237.3
Ttf1
transcription termination factor, RNA polymerase I
chr11_+_97315716 0.13 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45
mitochondrial ribosomal protein L45

Network of associatons between targets according to the STRING database.

First level regulatory network of Hes5_Hes7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.2 166.7 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
5.1 90.9 GO:0015816 glycine transport(GO:0015816)
3.3 9.8 GO:0045660 positive regulation of neutrophil differentiation(GO:0045660)
1.1 3.2 GO:0050883 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
1.0 39.8 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.9 6.6 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.9 26.7 GO:0008340 determination of adult lifespan(GO:0008340)
0.8 4.0 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.8 4.6 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.7 4.3 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.7 4.8 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.7 10.1 GO:0042118 endothelial cell activation(GO:0042118)
0.5 15.8 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.5 6.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.5 3.0 GO:1903182 regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755)
0.5 1.9 GO:0021586 pons maturation(GO:0021586)
0.4 5.2 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.4 1.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 5.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.4 1.5 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.4 2.9 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.3 3.7 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.3 1.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.3 9.7 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.3 2.1 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091)
0.2 1.2 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.2 1.7 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 3.7 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.2 3.5 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.2 0.7 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.2 1.5 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 1.8 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.2 1.4 GO:0007000 nucleolus organization(GO:0007000)
0.2 0.5 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.1 0.7 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 20.8 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.1 8.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 3.2 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 4.5 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.3 GO:0007309 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
0.1 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 0.6 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1 6.1 GO:0045214 sarcomere organization(GO:0045214)
0.1 1.7 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.1 1.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 6.3 GO:2000117 negative regulation of cysteine-type endopeptidase activity(GO:2000117)
0.0 0.3 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 1.3 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 2.5 GO:0045471 response to ethanol(GO:0045471)
0.0 1.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.2 GO:0038031 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 0.6 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.2 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0 1.7 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.3 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.3 GO:0097284 hepatocyte apoptotic process(GO:0097284)
0.0 3.2 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.5 GO:0048148 behavioral response to cocaine(GO:0048148)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.6 1.9 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.6 2.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.5 8.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.5 3.0 GO:1990356 sumoylated E2 ligase complex(GO:1990356)
0.4 2.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 3.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.2 6.2 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.2 4.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 2.5 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.4 GO:0070545 PeBoW complex(GO:0070545)
0.1 6.1 GO:0043034 costamere(GO:0043034)
0.1 1.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 3.7 GO:0097440 apical dendrite(GO:0097440)
0.1 1.2 GO:0005869 dynactin complex(GO:0005869)
0.1 1.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.7 GO:0097225 sperm midpiece(GO:0097225)
0.1 4.8 GO:0005657 replication fork(GO:0005657)
0.1 5.4 GO:0005581 collagen trimer(GO:0005581)
0.1 84.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.7 GO:0090543 Flemming body(GO:0090543)
0.1 1.9 GO:0090544 BAF-type complex(GO:0090544)
0.1 5.2 GO:0036126 sperm flagellum(GO:0036126)
0.0 4.1 GO:0005903 brush border(GO:0005903)
0.0 9.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 140.8 GO:0005829 cytosol(GO:0005829)
0.0 1.5 GO:0031519 PcG protein complex(GO:0031519)
0.0 9.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.7 GO:0001726 ruffle(GO:0001726)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 90.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
3.9 43.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
3.4 166.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.6 4.8 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.3 4.0 GO:0045353 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
0.9 3.7 GO:0031849 olfactory receptor binding(GO:0031849)
0.9 3.5 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.8 4.6 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.7 2.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.7 4.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.5 3.0 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.4 1.7 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.4 5.2 GO:0003796 lysozyme activity(GO:0003796)
0.3 9.8 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.2 9.7 GO:0004623 phospholipase A2 activity(GO:0004623)
0.2 0.7 GO:0019809 spermidine binding(GO:0019809)
0.2 5.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 0.8 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.7 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.1 1.7 GO:0030274 LIM domain binding(GO:0030274)
0.1 3.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 4.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.5 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 1.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 10.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.7 GO:0045182 translation regulator activity(GO:0045182)
0.1 7.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 3.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 1.9 GO:0008373 sialyltransferase activity(GO:0008373)
0.1 3.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.2 GO:0070840 dynein complex binding(GO:0070840)
0.0 1.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 15.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 3.5 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 0.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 6.6 GO:0015631 tubulin binding(GO:0015631)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 166.7 PID IGF1 PATHWAY IGF1 pathway
0.5 4.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 41.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.4 6.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 4.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 12.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 3.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 5.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.2 16.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 9.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 6.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 15.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.9 PID AURORA A PATHWAY Aurora A signaling
0.1 0.8 PID MYC PATHWAY C-MYC pathway
0.1 1.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 3.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 166.7 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
1.9 90.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 9.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.5 4.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 15.8 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 4.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 4.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.2 1.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 21.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.9 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 4.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.5 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 3.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.8 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.5 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.0 0.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)