ISMARA results: Hic2

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hic2

Z-value: 2.49

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Transcription factors associated with Hic2

Gene Symbol	Gene ID	Gene Info
Hic2 Ensembl NCBI MGI UniProt	ENSMUSG00000050240.8	hypermethylated in cancer 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hic2	mm10_v2_chr16_+_17233560_17233664	0.68	5.7e-06	Click!

Activity profile of Hic2 motif

Sorted Z-values of Hic2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_109459843 Show fit	18.92	ENSMUST00000173812.1	Dlk1 Ensembl NCBI MGI UniProt Show fit	delta-like 1 homolog (Drosophila)
chr12_+_109549157 Show fit	13.16	ENSMUST00000128458.1 ENSMUST00000150851.1	Meg3 Ensembl NCBI MGI UniProt Show fit	maternally expressed 3
chr11_+_7197780 Show fit	9.98	ENSMUST00000020704.7	Igfbp1 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor binding protein 1
chr7_+_19411086 Show fit	9.60	ENSMUST00000003643.1	Ckm Ensembl NCBI MGI UniProt Show fit	creatine kinase, muscle
chr11_+_87794206 Show fit	9.49	ENSMUST00000121303.1	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr10_+_127725392 Show fit	8.58	ENSMUST00000026466.3	Tac2 Ensembl NCBI MGI UniProt Show fit	tachykinin 2
chr11_+_115877497 Show fit	8.39	ENSMUST00000144032.1	Myo15b Ensembl NCBI MGI UniProt Show fit	myosin XVB
chr11_-_102365111 Show fit	8.35	ENSMUST00000006749.9	Slc4a1 Ensembl NCBI MGI UniProt Show fit	solute carrier family 4 (anion exchanger), member 1
chr6_+_34412334 Show fit	8.30	ENSMUST00000007449.8	Akr1b7 Ensembl NCBI MGI UniProt Show fit	aldo-keto reductase family 1, member B7
chr14_+_51853699 Show fit	8.15	ENSMUST00000169070.1 ENSMUST00000074477.6	Ear6 Ensembl NCBI MGI UniProt Show fit	eosinophil-associated, ribonuclease A family, member 6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hic2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	30.9	GO:0046852	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.8	24.5	GO:0008340	determination of adult lifespan(GO:0008340)
0.9	14.6	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
1.1	14.0	GO:2000653	regulation of genetic imprinting(GO:2000653)
0.9	12.8	GO:0060087	relaxation of vascular smooth muscle(GO:0060087)
4.0	11.9	GO:0035702	monocyte homeostasis(GO:0035702)
1.2	11.5	GO:0051133	regulation of NK T cell activation(GO:0051133)
1.3	11.3	GO:0032264	IMP salvage(GO:0032264)
1.7	10.2	GO:0032796	uropod organization(GO:0032796)
0.3	10.1	GO:0048821	erythrocyte development(GO:0048821)

Showing 1 to 10 of 411 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	37.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	27.2	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.6	15.8	GO:0005859	muscle myosin complex(GO:0005859)
0.2	14.7	GO:0005844	polysome(GO:0005844)
0.2	13.8	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.7	10.4	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.4	10.4	GO:0001891	phagocytic cup(GO:0001891)
0.1	10.4	GO:0030667	secretory granule membrane(GO:0030667)
0.1	10.4	GO:0005903	brush border(GO:0005903)
0.4	10.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)

Showing 1 to 10 of 161 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	39.8	GO:0005509	calcium ion binding(GO:0005509)
1.3	11.3	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.1	10.1	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.0	10.1	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.5	9.8	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
1.6	9.6	GO:0004111	creatine kinase activity(GO:0004111)
0.5	9.5	GO:0032036	myosin heavy chain binding(GO:0032036)
1.8	9.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.4	8.9	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.2	8.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)

Showing 1 to 10 of 282 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	39.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	11.1	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	10.9	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.2	9.7	PID IL23 PATHWAY	IL23-mediated signaling events
0.2	9.3	NABA COLLAGENS	Genes encoding collagen proteins
0.2	8.6	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.2	8.4	PID IGF1 PATHWAY	IGF1 pathway
0.1	8.1	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.2	7.5	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.1	7.0	PID PLK1 PATHWAY	PLK1 signaling events

Showing 1 to 10 of 81 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	33.5	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3	14.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	14.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.3	14.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	14.0	REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	Genes involved in NCAM signaling for neurite out-growth
0.5	11.8	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.2	11.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	9.3	REACTOME PLATELET AGGREGATION PLUG FORMATION	Genes involved in Platelet Aggregation (Plug Formation)
0.1	8.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3	8.6	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC

Showing 1 to 10 of 97 entries

Results for Hic2

Z-value: 2.49

Motif logo

Transcription factors associated with Hic2

Activity-expression correlation:

Activity profile of Hic2 motif

Sorted Z-values of Hic2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hic2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: