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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hlx

Z-value: 0.26

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Transcription factors associated with Hlx

Gene Symbol Gene ID Gene Info
Hlx
ENSMUSG00000039377.6 H2.0-like homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hlxmm10_v2_chr1_-_184732616_184732627-0.344.4e-02Click!

Activity profile of Hlx motif

Sorted Z-values of Hlx motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_145032765 1.09 ENSMUST00000029919.5
Clca3
chloride channel calcium activated 3
chrX_-_143933089 0.75 ENSMUST00000087313.3
Dcx
doublecortin
chrX_-_143933204 0.40 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx
doublecortin
chr6_+_7555053 0.36 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1
tachykinin 1
chr7_-_45103747 0.23 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr11_+_99873389 0.22 ENSMUST00000093936.3
Krtap9-1
keratin associated protein 9-1
chr9_+_54980880 0.20 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr10_-_107486077 0.17 ENSMUST00000000445.1
Myf5
myogenic factor 5
chr9_+_7571396 0.16 ENSMUST00000120900.1
ENSMUST00000093896.3
ENSMUST00000151853.1
ENSMUST00000152878.1
Mmp27
matrix metallopeptidase 27
chr5_-_73632421 0.12 ENSMUST00000087177.2
Lrrc66
leucine rich repeat containing 66
chr19_+_53944870 0.12 ENSMUST00000025932.7
Shoc2
soc-2 (suppressor of clear) homolog (C. elegans)
chrM_+_2743 0.10 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr15_-_8710734 0.09 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_+_102158858 0.09 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr10_+_102159000 0.08 ENSMUST00000020039.6
Mgat4c
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr3_+_32436376 0.07 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr11_-_99244058 0.07 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr2_+_78051155 0.06 ENSMUST00000145972.1
4930440I19Rik
RIKEN cDNA 4930440I19 gene
chr19_-_53944621 0.06 ENSMUST00000135402.2
Bbip1
BBSome interacting protein 1
chr7_-_101837776 0.06 ENSMUST00000165052.1
Inppl1
inositol polyphosphate phosphatase-like 1
chr10_-_37138863 0.05 ENSMUST00000092584.5
Marcks
myristoylated alanine rich protein kinase C substrate
chr1_+_180109192 0.05 ENSMUST00000143176.1
ENSMUST00000135056.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr5_-_62766153 0.04 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_+_133850980 0.04 ENSMUST00000033602.8
Tnmd
tenomodulin
chr5_+_121749196 0.02 ENSMUST00000161064.1
Atxn2
ataxin 2
chr15_-_8710409 0.00 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Hlx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:2000851 positive regulation of glucocorticoid secretion(GO:2000851)
0.1 1.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.1 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0042166 acetylcholine binding(GO:0042166)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors