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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hmx3

Z-value: 0.34

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Transcription factors associated with Hmx3

Gene Symbol Gene ID Gene Info
Hmx3
ENSMUSG00000040148.5 H6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_131542867-0.202.5e-01Click!

Activity profile of Hmx3 motif

Sorted Z-values of Hmx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_20269162 0.87 ENSMUST00000024155.7
Kcnk16
potassium channel, subfamily K, member 16
chr13_+_23746734 0.56 ENSMUST00000099703.2
Hist1h2bb
histone cluster 1, H2bb
chr10_-_80421847 0.50 ENSMUST00000156244.1
Tcf3
transcription factor 3
chr15_+_66670749 0.45 ENSMUST00000065916.7
Tg
thyroglobulin
chr9_-_123678873 0.45 ENSMUST00000040960.6
Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr9_-_123678782 0.44 ENSMUST00000170591.1
ENSMUST00000171647.1
Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr7_+_24370255 0.39 ENSMUST00000171904.1
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr7_-_127208423 0.35 ENSMUST00000120705.1
Tbc1d10b
TBC1 domain family, member 10b
chr4_+_154960915 0.27 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr1_-_78968079 0.27 ENSMUST00000049117.5
Gm5830
predicted pseudogene 5830
chr7_-_30559828 0.26 ENSMUST00000108164.1
Lin37
lin-37 homolog (C. elegans)
chr6_+_86371489 0.25 ENSMUST00000089558.5
Snrpg
small nuclear ribonucleoprotein polypeptide G
chr5_-_53707532 0.23 ENSMUST00000031093.3
Cckar
cholecystokinin A receptor
chr7_-_30559600 0.20 ENSMUST00000043975.4
ENSMUST00000156241.1
Lin37
lin-37 homolog (C. elegans)
chr8_-_23237623 0.20 ENSMUST00000033950.5
Gins4
GINS complex subunit 4 (Sld5 homolog)
chr4_-_129261394 0.18 ENSMUST00000145261.1
C77080
expressed sequence C77080
chr11_+_69838514 0.16 ENSMUST00000133967.1
ENSMUST00000094065.4
Tmem256
transmembrane protein 256
chr2_+_3114220 0.16 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr11_+_114668524 0.16 ENSMUST00000106602.3
ENSMUST00000077915.3
ENSMUST00000106599.1
ENSMUST00000082092.4
Rpl38
ribosomal protein L38
chr2_+_27165233 0.16 ENSMUST00000000910.6
Dbh
dopamine beta hydroxylase
chrX_+_150594420 0.16 ENSMUST00000112713.2
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_+_25681158 0.15 ENSMUST00000108403.3
B9d2
B9 protein domain 2
chr19_+_41933464 0.15 ENSMUST00000026154.7
Zdhhc16
zinc finger, DHHC domain containing 16
chr4_+_19818722 0.14 ENSMUST00000035890.7
Slc7a13
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr3_-_155055341 0.13 ENSMUST00000064076.3
Tnni3k
TNNI3 interacting kinase
chr12_+_52699297 0.13 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr10_-_92375367 0.13 ENSMUST00000182870.1
Gm20757
predicted gene, 20757
chr7_+_25267669 0.12 ENSMUST00000169266.1
Cic
capicua homolog (Drosophila)
chr9_+_19712829 0.12 ENSMUST00000077023.3
Olfr857
olfactory receptor 857
chr2_-_153015331 0.11 ENSMUST00000028972.8
Pdrg1
p53 and DNA damage regulated 1
chr4_-_62470868 0.10 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
Wdr31
WD repeat domain 31
chr3_+_60006743 0.10 ENSMUST00000169794.1
Aadacl2
arylacetamide deacetylase-like 2
chr3_+_96629919 0.10 ENSMUST00000048915.6
Rbm8a
RNA binding motif protein 8a
chr12_+_108179738 0.10 ENSMUST00000101055.4
Ccnk
cyclin K
chr14_-_55560340 0.09 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr4_+_80834123 0.09 ENSMUST00000133655.1
ENSMUST00000006151.6
Tyrp1
tyrosinase-related protein 1
chr18_-_37638719 0.09 ENSMUST00000058635.2
Slc25a2
solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2
chr4_+_80834298 0.09 ENSMUST00000102831.1
Tyrp1
tyrosinase-related protein 1
chr11_+_103133333 0.08 ENSMUST00000124928.1
ENSMUST00000062530.4
Hexim2
hexamethylene bis-acetamide inducible 2
chr2_+_57997884 0.08 ENSMUST00000112616.1
ENSMUST00000166729.1
Galnt5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5
chr4_+_144893127 0.08 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_-_158814469 0.08 ENSMUST00000161589.2
Pappa2
pappalysin 2
chr7_-_45510400 0.08 ENSMUST00000033096.7
Nucb1
nucleobindin 1
chr12_-_104473236 0.07 ENSMUST00000021513.4
Gsc
goosecoid homeobox
chr11_+_103133303 0.07 ENSMUST00000107037.1
Hexim2
hexamethylene bis-acetamide inducible 2
chrM_+_9452 0.07 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr2_+_130424321 0.07 ENSMUST00000128994.1
ENSMUST00000028900.9
Vps16
vacuolar protein sorting 16 (yeast)
chr5_-_137684665 0.07 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
Agfg2
ArfGAP with FG repeats 2
chr15_+_9436028 0.07 ENSMUST00000042360.3
Capsl
calcyphosine-like
chrX_+_159708593 0.06 ENSMUST00000080394.6
Sh3kbp1
SH3-domain kinase binding protein 1
chr1_-_175979114 0.06 ENSMUST00000104983.1
B020018G12Rik
RIKEN cDNA B020018G12 gene
chr19_+_8802486 0.06 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr1_+_110099295 0.06 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr7_-_126897424 0.06 ENSMUST00000120007.1
Tmem219
transmembrane protein 219
chr11_-_99374895 0.06 ENSMUST00000006963.2
Krt28
keratin 28
chr17_-_57247632 0.05 ENSMUST00000005975.6
Gpr108
G protein-coupled receptor 108
chr7_+_3645267 0.05 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr14_+_54464141 0.04 ENSMUST00000022782.8
Lrp10
low-density lipoprotein receptor-related protein 10
chr14_+_52769753 0.04 ENSMUST00000178768.2
Trav7d-4
T cell receptor alpha variable 7D-4
chr4_+_65604984 0.04 ENSMUST00000050850.7
ENSMUST00000107366.1
Trim32
tripartite motif-containing 32
chr17_-_35697971 0.04 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr11_-_99337930 0.04 ENSMUST00000100482.2
Krt26
keratin 26
chr3_-_142169311 0.03 ENSMUST00000106230.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr2_-_84715160 0.03 ENSMUST00000035840.5
Zdhhc5
zinc finger, DHHC domain containing 5
chr5_+_121777929 0.03 ENSMUST00000160821.1
Atxn2
ataxin 2
chr15_+_101473472 0.03 ENSMUST00000088049.3
Krt86
keratin 86
chr7_-_121035096 0.03 ENSMUST00000065740.2
Gm9905
predicted gene 9905
chr2_-_72986716 0.03 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr17_-_35046539 0.03 ENSMUST00000007250.7
Msh5
mutS homolog 5 (E. coli)
chr12_-_83487708 0.02 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3
D4, zinc and double PHD fingers, family 3
chr4_-_45532470 0.02 ENSMUST00000147448.1
Shb
src homology 2 domain-containing transforming protein B

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0035524 proline transmembrane transport(GO:0035524)
0.1 0.3 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.2 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.1 0.5 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.2 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.1 0.2 GO:0006589 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.0 0.5 GO:0015705 iodide transport(GO:0015705)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:1902261 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.0 0.2 GO:0048318 axial mesoderm development(GO:0048318)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.1 0.2 GO:0060205 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.0 0.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.1 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.9 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.5 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.2 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.2 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA