ISMARA results: Hnf1a

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hnf1a

Z-value: 2.69

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Transcription factors associated with Hnf1a

Gene Symbol	Gene ID	Gene Info
Hnf1a Ensembl NCBI MGI UniProt	ENSMUSG00000029556.6	HNF1 homeobox A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hnf1a	mm10_v2_chr5_-_114971056_114971079	0.47	3.5e-03	Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_10215955 Show fit	15.57	ENSMUST00000130720.1	Prlr Ensembl NCBI MGI UniProt Show fit	prolactin receptor
chr11_+_101367542 Show fit	13.92	ENSMUST00000019469.2	G6pc Ensembl NCBI MGI UniProt Show fit	glucose-6-phosphatase, catalytic
chr7_+_140763739 Show fit	13.68	ENSMUST00000026552.7	Cyp2e1 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily e, polypeptide 1
chr1_-_130661584 Show fit	13.38	ENSMUST00000137276.2	C4bp Ensembl NCBI MGI UniProt Show fit	complement component 4 binding protein
chr1_-_130661613 Show fit	12.99	ENSMUST00000027657.7	C4bp Ensembl NCBI MGI UniProt Show fit	complement component 4 binding protein
chr5_+_90518932 Show fit	12.66	ENSMUST00000113179.2 ENSMUST00000128740.1	Afm Ensembl NCBI MGI UniProt Show fit	afamin
chr11_-_84167466 Show fit	11.62	ENSMUST00000050771.7	Gm11437 Ensembl NCBI MGI UniProt Show fit	predicted gene 11437
chr5_-_89457763 Show fit	11.41	ENSMUST00000049209.8	Gc Ensembl NCBI MGI UniProt Show fit	group specific component
chr5_-_87337165 Show fit	10.70	ENSMUST00000031195.2	Ugt2a3 Ensembl NCBI MGI UniProt Show fit	UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_+_88211956 Show fit	10.61	ENSMUST00000073049.6	Ugt1a1 Ensembl NCBI MGI UniProt Show fit	UDP glucuronosyltransferase 1 family, polypeptide A1

Showing 1 to 10 of 126 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	37.8	GO:0006958	complement activation, classical pathway(GO:0006958)
1.6	23.6	GO:0052695	cellular glucuronidation(GO:0052695)
2.8	17.0	GO:1904075	regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
2.6	15.6	GO:0038161	prolactin signaling pathway(GO:0038161)
0.1	15.4	GO:0010466	negative regulation of peptidase activity(GO:0010466)
2.3	13.9	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.5	13.7	GO:0017144	drug metabolic process(GO:0017144)
0.1	13.2	GO:0006487	protein N-linked glycosylation(GO:0006487)
0.6	11.4	GO:0042359	vitamin D metabolic process(GO:0042359)
3.5	10.6	GO:0018879	biphenyl metabolic process(GO:0018879)

Showing 1 to 10 of 66 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	40.4	GO:0072562	blood microparticle(GO:0072562)
0.2	27.5	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0	24.7	GO:0005794	Golgi apparatus(GO:0005794)
0.1	20.1	GO:0016323	basolateral plasma membrane(GO:0016323)
1.9	17.0	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
0.8	10.6	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	10.1	GO:0008021	synaptic vesicle(GO:0008021)
0.0	9.6	GO:0005743	mitochondrial inner membrane(GO:0005743)
1.8	7.1	GO:0044279	other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0	6.5	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Showing 1 to 10 of 32 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	49.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.1	42.8	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.4	17.0	GO:0005159	insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
3.1	15.6	GO:0004925	prolactin receptor activity(GO:0004925)
4.6	13.9	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.4	13.7	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1	13.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
4.2	12.7	GO:0008431	vitamin E binding(GO:0008431)
3.8	11.4	GO:1902271	D3 vitamins binding(GO:1902271)
2.5	10.1	GO:0004058	aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)

Showing 1 to 10 of 51 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	22.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	22.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.2	15.6	PID ERBB4 PATHWAY	ErbB4 signaling events
0.2	13.9	PID FOXO PATHWAY	FoxO family signaling
0.2	9.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4	7.8	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	7.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	7.6	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	4.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	3.7	PID IL6 7 PATHWAY	IL6-mediated signaling events

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	18.4	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
1.2	16.0	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.8	15.6	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
4.6	13.7	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.3	11.4	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.5	10.1	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.6	9.7	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.6	7.9	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.6	7.8	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	7.1	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix

Showing 1 to 10 of 26 entries

Results for Hnf1a

Z-value: 2.69

Motif logo

Transcription factors associated with Hnf1a

Activity-expression correlation:

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: