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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hnf4a

Z-value: 7.61

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Transcription factors associated with Hnf4a

Gene Symbol Gene ID Gene Info
Hnf4a
ENSMUSG00000017950.10 hepatic nuclear factor 4, alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf4amm10_v2_chr2_+_163547148_1635471880.538.8e-04Click!

Activity profile of Hnf4a motif

Sorted Z-values of Hnf4a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39287074 95.78 ENSMUST00000003137.8
Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
chr17_-_46438471 84.62 ENSMUST00000087012.5
Slc22a7
solute carrier family 22 (organic anion transporter), member 7
chr4_-_62087261 81.03 ENSMUST00000107488.3
ENSMUST00000107472.1
ENSMUST00000084531.4
Mup3
major urinary protein 3
chr19_+_39007019 61.77 ENSMUST00000025966.4
Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
chr4_-_60501903 60.52 ENSMUST00000084548.4
ENSMUST00000103012.3
ENSMUST00000107499.3
Mup1
major urinary protein 1
chr19_-_8405060 58.81 ENSMUST00000064507.5
ENSMUST00000120540.1
ENSMUST00000096269.4
Slc22a30
solute carrier family 22, member 30
chr19_-_40073731 58.08 ENSMUST00000048959.3
Cyp2c54
cytochrome P450, family 2, subfamily c, polypeptide 54
chr4_-_62054112 57.75 ENSMUST00000074018.3
Mup20
major urinary protein 20
chr19_-_8131982 56.33 ENSMUST00000065651.4
Slc22a28
solute carrier family 22, member 28
chr4_-_60741275 55.97 ENSMUST00000117932.1
Mup12
major urinary protein 12
chr19_-_39463067 55.17 ENSMUST00000035488.2
Cyp2c38
cytochrome P450, family 2, subfamily c, polypeptide 38
chr15_-_82764176 55.09 ENSMUST00000055721.4
Cyp2d40
cytochrome P450, family 2, subfamily d, polypeptide 40
chr10_-_128960965 54.11 ENSMUST00000026398.3
Mettl7b
methyltransferase like 7B
chr9_-_46235631 42.69 ENSMUST00000118649.1
Apoc3
apolipoprotein C-III
chr19_+_12633507 41.42 ENSMUST00000119960.1
Glyat
glycine-N-acyltransferase
chr2_+_173153048 40.37 ENSMUST00000029017.5
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr7_-_99695628 40.03 ENSMUST00000145381.1
Slco2b1
solute carrier organic anion transporter family, member 2b1
chr19_+_12633303 39.97 ENSMUST00000044976.5
Glyat
glycine-N-acyltransferase
chr19_+_39510844 39.24 ENSMUST00000025968.4
Cyp2c39
cytochrome P450, family 2, subfamily c, polypeptide 39
chr3_+_122895072 38.90 ENSMUST00000023820.5
Fabp2
fatty acid binding protein 2, intestinal
chr9_-_22002599 37.36 ENSMUST00000115336.2
ENSMUST00000044926.5
Ccdc151
coiled-coil domain containing 151
chr7_-_99695572 37.33 ENSMUST00000137914.1
Slco2b1
solute carrier organic anion transporter family, member 2b1
chr17_-_34743849 33.51 ENSMUST00000069507.8
C4b
complement component 4B (Chido blood group)
chr19_+_39992424 32.48 ENSMUST00000049178.2
Cyp2c37
cytochrome P450, family 2. subfamily c, polypeptide 37
chr15_+_82452372 32.12 ENSMUST00000089129.5
Cyp2d9
cytochrome P450, family 2, subfamily d, polypeptide 9
chr11_+_101367542 30.78 ENSMUST00000019469.2
G6pc
glucose-6-phosphatase, catalytic
chr19_-_44407703 30.32 ENSMUST00000041331.2
Scd1
stearoyl-Coenzyme A desaturase 1
chr4_-_62150810 29.49 ENSMUST00000077719.3
Mup21
major urinary protein 21
chrX_+_10252305 28.03 ENSMUST00000049910.6
Otc
ornithine transcarbamylase
chrX_+_10252361 27.84 ENSMUST00000115528.2
Otc
ornithine transcarbamylase
chr11_+_70054334 23.71 ENSMUST00000018699.6
ENSMUST00000108585.2
Asgr1
asialoglycoprotein receptor 1
chr9_+_44673227 23.66 ENSMUST00000034609.4
ENSMUST00000071219.5
Treh
trehalase (brush-border membrane glycoprotein)
chr19_-_8218832 22.85 ENSMUST00000113298.2
Slc22a29
solute carrier family 22. member 29
chr17_-_73950172 22.65 ENSMUST00000024866.4
Xdh
xanthine dehydrogenase
chr9_+_46240696 22.58 ENSMUST00000034585.6
Apoa4
apolipoprotein A-IV
chr2_-_77170534 22.35 ENSMUST00000111833.2
Ccdc141
coiled-coil domain containing 141
chr3_-_121815212 21.93 ENSMUST00000029770.5
Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr19_-_39649046 20.98 ENSMUST00000067328.6
Cyp2c67
cytochrome P450, family 2, subfamily c, polypeptide 67
chr7_-_12998172 20.55 ENSMUST00000120903.1
Slc27a5
solute carrier family 27 (fatty acid transporter), member 5
chr15_-_82620907 20.37 ENSMUST00000109515.1
Cyp2d34
cytochrome P450, family 2, subfamily d, polypeptide 34
chr2_-_25500613 19.78 ENSMUST00000040042.4
C8g
complement component 8, gamma polypeptide
chr7_-_12998140 19.65 ENSMUST00000032539.7
Slc27a5
solute carrier family 27 (fatty acid transporter), member 5
chr6_-_125380793 19.47 ENSMUST00000042647.6
Plekhg6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr19_+_44203265 19.28 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr4_+_134397380 18.88 ENSMUST00000105870.1
Pafah2
platelet-activating factor acetylhydrolase 2
chr3_+_118562129 18.76 ENSMUST00000039177.7
Dpyd
dihydropyrimidine dehydrogenase
chr8_-_121944886 18.66 ENSMUST00000057653.7
Car5a
carbonic anhydrase 5a, mitochondrial
chr7_+_44465391 18.41 ENSMUST00000035929.4
ENSMUST00000146128.1
Aspdh
aspartate dehydrogenase domain containing
chr15_+_82555087 18.17 ENSMUST00000068861.6
Cyp2d12
cytochrome P450, family 2, subfamily d, polypeptide 12
chr7_+_27029074 17.92 ENSMUST00000075552.5
Cyp2a12
cytochrome P450, family 2, subfamily a, polypeptide 12
chr2_+_58755177 17.91 ENSMUST00000102755.3
Upp2
uridine phosphorylase 2
chr14_-_55758458 17.59 ENSMUST00000001497.7
Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr2_+_58754910 17.43 ENSMUST00000059102.6
Upp2
uridine phosphorylase 2
chr1_+_171214013 17.18 ENSMUST00000111328.1
Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr7_-_105600103 16.83 ENSMUST00000033185.8
Hpx
hemopexin
chr16_+_37580137 16.50 ENSMUST00000160847.1
Hgd
homogentisate 1, 2-dioxygenase
chr9_-_121916288 15.66 ENSMUST00000062474.4
Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
chr17_-_34862122 15.41 ENSMUST00000154526.1
Cfb
complement factor B
chr15_+_3270767 15.41 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1
selenoprotein P, plasma, 1
chr5_+_90561102 15.39 ENSMUST00000094615.4
5830473C10Rik
RIKEN cDNA 5830473C10 gene
chr19_-_11081088 14.78 ENSMUST00000025636.6
Ms4a8a
membrane-spanning 4-domains, subfamily A, member 8A
chr2_-_27248335 14.71 ENSMUST00000139312.1
Sardh
sarcosine dehydrogenase
chr7_+_143473736 14.64 ENSMUST00000052348.5
Slc22a18
solute carrier family 22 (organic cation transporter), member 18
chr17_-_34862473 14.33 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
Cfb
complement factor B
chr1_+_171213969 14.27 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr8_+_13026024 14.23 ENSMUST00000033820.3
F7
coagulation factor VII
chr2_-_134554348 14.00 ENSMUST00000028704.2
Hao1
hydroxyacid oxidase 1, liver
chr3_-_10335650 13.98 ENSMUST00000078748.3
Slc10a5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr1_+_74284930 13.89 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd
paroxysmal nonkinesiogenic dyskinesia
chr15_-_82407187 13.37 ENSMUST00000072776.3
Cyp2d10
cytochrome P450, family 2, subfamily d, polypeptide 10
chr17_-_34603675 13.22 ENSMUST00000015622.7
Rnf5
ring finger protein 5
chr5_+_114146525 13.17 ENSMUST00000102582.1
Acacb
acetyl-Coenzyme A carboxylase beta
chr10_+_127849917 12.97 ENSMUST00000077530.2
Rdh19
retinol dehydrogenase 19
chr3_+_60031754 12.22 ENSMUST00000029325.3
Aadac
arylacetamide deacetylase (esterase)
chr6_+_54429603 12.16 ENSMUST00000132855.1
ENSMUST00000126637.1
Wipf3
WAS/WASL interacting protein family, member 3
chr1_+_175631996 11.94 ENSMUST00000040250.8
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr12_-_103738158 11.93 ENSMUST00000095450.4
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr15_+_10358556 11.80 ENSMUST00000022858.7
Agxt2
alanine-glyoxylate aminotransferase 2
chr15_-_82394022 11.75 ENSMUST00000170255.1
Cyp2d11
cytochrome P450, family 2, subfamily d, polypeptide 11
chr1_+_175632169 11.74 ENSMUST00000097458.3
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr7_+_45896941 11.65 ENSMUST00000069772.7
ENSMUST00000107716.1
Tmem143
transmembrane protein 143
chr16_-_30267524 11.62 ENSMUST00000064856.7
Cpn2
carboxypeptidase N, polypeptide 2
chr15_+_10358525 11.49 ENSMUST00000110540.1
ENSMUST00000110541.1
ENSMUST00000110542.1
Agxt2
alanine-glyoxylate aminotransferase 2
chr17_-_34882004 11.48 ENSMUST00000152417.1
ENSMUST00000146299.1
C2
Gm20547
complement component 2 (within H-2S)
predicted gene 20547
chr4_+_141746672 11.38 ENSMUST00000038161.4
Agmat
agmatine ureohydrolase (agmatinase)
chr8_+_13037802 11.32 ENSMUST00000152034.1
ENSMUST00000128418.1
F10
coagulation factor X
chr6_+_71199827 11.25 ENSMUST00000067492.7
Fabp1
fatty acid binding protein 1, liver
chr16_+_8513429 11.23 ENSMUST00000065987.7
ENSMUST00000115838.1
ENSMUST00000115839.2
Abat
4-aminobutyrate aminotransferase
chr1_-_136960427 11.22 ENSMUST00000027649.7
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr11_-_77894096 11.10 ENSMUST00000017597.4
Pipox
pipecolic acid oxidase
chr6_-_128526703 10.75 ENSMUST00000143664.1
ENSMUST00000112132.1
ENSMUST00000032510.7
Pzp
pregnancy zone protein
chr17_-_36129425 10.60 ENSMUST00000046131.9
ENSMUST00000173322.1
ENSMUST00000172968.1
Gm7030
predicted gene 7030
chr10_+_18845071 10.51 ENSMUST00000019998.7
Perp
PERP, TP53 apoptosis effector
chr8_+_13037308 10.31 ENSMUST00000063820.5
ENSMUST00000033821.4
F10
coagulation factor X
chr1_+_157526127 10.19 ENSMUST00000111700.1
Sec16b
SEC16 homolog B (S. cerevisiae)
chr10_-_20724696 10.09 ENSMUST00000170265.1
Pde7b
phosphodiesterase 7B
chr1_+_139501692 10.06 ENSMUST00000027615.5
F13b
coagulation factor XIII, beta subunit
chr1_+_88055377 10.04 ENSMUST00000138182.1
ENSMUST00000113142.3
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr4_+_95579417 9.89 ENSMUST00000043335.4
Fggy
FGGY carbohydrate kinase domain containing
chr11_+_76904475 9.88 ENSMUST00000142166.1
Tmigd1
transmembrane and immunoglobulin domain containing 1
chr1_+_88055467 9.76 ENSMUST00000173325.1
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr8_-_13200576 9.75 ENSMUST00000165605.2
Grtp1
GH regulated TBC protein 1
chrX_-_162565514 9.48 ENSMUST00000154424.1
Reps2
RALBP1 associated Eps domain containing protein 2
chr5_-_103977326 9.43 ENSMUST00000120320.1
Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr4_+_95579463 9.24 ENSMUST00000150830.1
ENSMUST00000134012.2
Fggy
FGGY carbohydrate kinase domain containing
chr7_+_30232310 9.17 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr15_+_99099412 9.12 ENSMUST00000061295.6
Dnajc22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr6_+_83156401 8.99 ENSMUST00000032106.4
1700003E16Rik
RIKEN cDNA 1700003E16 gene
chr5_-_103977360 8.96 ENSMUST00000048118.8
Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr17_-_46645128 8.93 ENSMUST00000003642.6
Klc4
kinesin light chain 4
chr2_-_110305730 8.91 ENSMUST00000046233.2
Bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
chr11_-_12412136 8.89 ENSMUST00000174874.1
Cobl
cordon-bleu WH2 repeat
chr5_-_103977404 8.76 ENSMUST00000112803.2
Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr5_-_24447587 8.65 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
Tmub1
transmembrane and ubiquitin-like domain containing 1
chr11_+_104282371 8.64 ENSMUST00000106988.1
ENSMUST00000106989.1
Mapt
microtubule-associated protein tau
chr17_-_91088726 8.57 ENSMUST00000072671.7
ENSMUST00000174331.1
ENSMUST00000161402.3
ENSMUST00000054059.8
Nrxn1
neurexin I
chr11_+_78499087 8.56 ENSMUST00000017488.4
Vtn
vitronectin
chr4_-_83324239 8.55 ENSMUST00000048274.4
ENSMUST00000102823.3
Ttc39b
tetratricopeptide repeat domain 39B
chr1_+_171225054 8.51 ENSMUST00000111321.1
ENSMUST00000005824.5
ENSMUST00000111320.1
ENSMUST00000111319.1
Apoa2
apolipoprotein A-II
chr11_+_73199445 8.48 ENSMUST00000006105.6
Shpk
sedoheptulokinase
chr2_-_77170592 8.40 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141
coiled-coil domain containing 141
chr6_+_21986438 8.28 ENSMUST00000115382.1
Cped1
cadherin-like and PC-esterase domain containing 1
chr7_-_46030281 8.24 ENSMUST00000002850.5
Abcc6
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
chr13_+_67833235 8.22 ENSMUST00000060609.7
Gm10037
predicted gene 10037
chr17_-_35909626 8.22 ENSMUST00000141132.1
Atat1
alpha tubulin acetyltransferase 1
chr19_+_44992127 8.16 ENSMUST00000179305.1
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr11_+_70519183 8.15 ENSMUST00000057685.2
Gltpd2
glycolipid transfer protein domain containing 2
chr12_+_37241633 8.13 ENSMUST00000049874.7
Agmo
alkylglycerol monooxygenase
chr12_+_21316385 8.02 ENSMUST00000076813.6
Iah1
isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)
chr13_+_64248649 8.02 ENSMUST00000181403.1
1810034E14Rik
RIKEN cDNA 1810034E14 gene
chr6_+_21985903 7.85 ENSMUST00000137437.1
ENSMUST00000115383.2
Cped1
cadherin-like and PC-esterase domain containing 1
chr12_+_59130994 7.79 ENSMUST00000177460.1
Ctage5
CTAGE family, member 5
chr2_-_69342600 7.77 ENSMUST00000102709.1
ENSMUST00000102710.3
ENSMUST00000180142.1
Abcb11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr4_-_138326234 7.76 ENSMUST00000105817.3
ENSMUST00000030536.6
Pink1
PTEN induced putative kinase 1
chr12_+_37241729 7.73 ENSMUST00000160768.1
Agmo
alkylglycerol monooxygenase
chr7_-_31055594 7.72 ENSMUST00000039909.6
Fxyd1
FXYD domain-containing ion transport regulator 1
chr6_-_71322200 7.69 ENSMUST00000173297.1
ENSMUST00000114188.2
Smyd1
SET and MYND domain containing 1
chr11_-_61267177 7.67 ENSMUST00000066277.3
ENSMUST00000074127.7
ENSMUST00000108715.2
Aldh3a2
aldehyde dehydrogenase family 3, subfamily A2
chr12_+_59130767 7.64 ENSMUST00000175877.1
Ctage5
CTAGE family, member 5
chr12_+_37242030 7.47 ENSMUST00000160390.1
Agmo
alkylglycerol monooxygenase
chr2_+_92375306 7.43 ENSMUST00000028650.8
Pex16
peroxisomal biogenesis factor 16
chr11_-_3931789 7.26 ENSMUST00000109992.1
ENSMUST00000109988.1
Tcn2
transcobalamin 2
chr1_-_24005608 7.24 ENSMUST00000027338.3
1110058L19Rik
RIKEN cDNA 1110058L19 gene
chr4_+_118526986 7.21 ENSMUST00000106367.1
2610528J11Rik
RIKEN cDNA 2610528J11 gene
chr4_+_41762309 7.13 ENSMUST00000108042.2
Il11ra1
interleukin 11 receptor, alpha chain 1
chr4_+_126609818 6.87 ENSMUST00000097886.3
ENSMUST00000164362.1
5730409E04Rik
RIKEN cDNA 5730409E04Rik gene
chr12_+_7977640 6.87 ENSMUST00000171271.1
ENSMUST00000037811.6
ENSMUST00000037520.7
Apob
apolipoprotein B
chr19_+_39060998 6.77 ENSMUST00000087236.4
Cyp2c65
cytochrome P450, family 2, subfamily c, polypeptide 65
chr14_+_101840602 6.71 ENSMUST00000159314.1
Lmo7
LIM domain only 7
chr12_+_59131473 6.58 ENSMUST00000177162.1
Ctage5
CTAGE family, member 5
chr5_-_125294107 6.55 ENSMUST00000127148.1
Scarb1
scavenger receptor class B, member 1
chr11_-_3931960 6.45 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
Tcn2
transcobalamin 2
chr12_+_59131286 6.38 ENSMUST00000176464.1
ENSMUST00000170992.2
ENSMUST00000176322.1
Ctage5
CTAGE family, member 5
chr4_+_118527229 6.36 ENSMUST00000030261.5
2610528J11Rik
RIKEN cDNA 2610528J11 gene
chr1_-_155417283 6.35 ENSMUST00000027741.5
Xpr1
xenotropic and polytropic retrovirus receptor 1
chr6_-_85137743 6.35 ENSMUST00000174769.1
ENSMUST00000174286.1
ENSMUST00000045986.7
Spr
sepiapterin reductase
chr6_+_85154992 6.28 ENSMUST00000089584.5
Spr-ps1
sepiapterin reductase pseudogene 1
chrX_-_16817339 6.17 ENSMUST00000040820.6
Maob
monoamine oxidase B
chr5_+_30232581 6.16 ENSMUST00000145167.1
Ept1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr1_+_193301953 6.08 ENSMUST00000016315.9
Lamb3
laminin, beta 3
chr19_-_6921753 6.05 ENSMUST00000173635.1
Esrra
estrogen related receptor, alpha
chr4_-_119538769 6.04 ENSMUST00000079611.6
AA415398
expressed sequence AA415398
chr19_-_10604258 6.00 ENSMUST00000037678.6
Dak
dihydroxyacetone kinase 2 homolog (yeast)
chr4_-_83324135 5.93 ENSMUST00000030205.7
Ttc39b
tetratricopeptide repeat domain 39B
chr6_+_86195214 5.65 ENSMUST00000032066.9
Tgfa
transforming growth factor alpha
chr10_-_25536114 5.65 ENSMUST00000179685.1
Smlr1
small leucine-rich protein 1
chr9_-_57147034 5.57 ENSMUST00000034842.4
Neil1
nei endonuclease VIII-like 1 (E. coli)
chr7_+_120173847 5.57 ENSMUST00000033201.5
Anks4b
ankyrin repeat and sterile alpha motif domain containing 4B
chr7_-_66689474 5.54 ENSMUST00000068980.3
Asb7
ankyrin repeat and SOCS box-containing 7
chr2_-_130638094 5.47 ENSMUST00000089561.3
ENSMUST00000110260.1
Lzts3
leucine zipper, putative tumor suppressor family member 3
chr2_-_17460610 5.44 ENSMUST00000145492.1
Nebl
nebulette
chr11_+_105967938 5.36 ENSMUST00000001963.7
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr4_-_41697040 5.35 ENSMUST00000102962.3
ENSMUST00000084701.5
Cntfr
ciliary neurotrophic factor receptor
chr16_-_17928136 5.32 ENSMUST00000003622.8
Slc25a1
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
chr14_+_101840501 5.29 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr19_-_39812744 5.17 ENSMUST00000162507.1
ENSMUST00000160476.1
Cyp2c40
cytochrome P450, family 2, subfamily c, polypeptide 40
chr15_-_27630644 5.17 ENSMUST00000059662.7
Fam105b
family with sequence similarity 105, member B
chr7_+_45897429 5.00 ENSMUST00000140243.1
Tmem143
transmembrane protein 143
chr4_+_152199805 4.87 ENSMUST00000105652.2
Acot7
acyl-CoA thioesterase 7
chr6_-_113434529 4.86 ENSMUST00000133348.1
Cidec
cell death-inducing DFFA-like effector c
chr2_+_59160838 4.75 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
Pkp4
plakophilin 4
chr1_+_132008285 4.74 ENSMUST00000146432.1
Elk4
ELK4, member of ETS oncogene family
chr10_+_81559447 4.74 ENSMUST00000002518.8
Aes
amino-terminal enhancer of split
chr9_-_44417983 4.74 ENSMUST00000053286.7
Ccdc84
coiled-coil domain containing 84
chr12_-_80112998 4.73 ENSMUST00000165114.1
ENSMUST00000021552.1
Zfp36l1
zinc finger protein 36, C3H type-like 1
chrX_-_95166307 4.69 ENSMUST00000113873.2
ENSMUST00000113876.2
ENSMUST00000113885.1
ENSMUST00000113883.1
ENSMUST00000182001.1
ENSMUST00000113882.1
ENSMUST00000113878.1
ENSMUST00000182562.1
Arhgef9
CDC42 guanine nucleotide exchange factor (GEF) 9
chr3_-_7613427 4.67 ENSMUST00000168269.2
Il7
interleukin 7
chr7_+_30232032 4.65 ENSMUST00000149654.1
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr2_+_3704787 4.50 ENSMUST00000115054.2
Fam107b
family with sequence similarity 107, member B
chr16_-_34095983 4.49 ENSMUST00000114973.1
ENSMUST00000114964.1
Kalrn
kalirin, RhoGEF kinase
chr6_-_113434757 4.48 ENSMUST00000113091.1
Cidec
cell death-inducing DFFA-like effector c
chr11_+_76904513 4.41 ENSMUST00000072633.3
Tmigd1
transmembrane and immunoglobulin domain containing 1
chr19_+_42052228 4.40 ENSMUST00000164518.2
4933411K16Rik
RIKEN cDNA 4933411K16 gene
chr3_-_84304762 4.39 ENSMUST00000107692.1
Trim2
tripartite motif-containing 2
chr7_+_66689889 4.34 ENSMUST00000153007.1
ENSMUST00000177726.1
ENSMUST00000121777.2
ENSMUST00000150071.1
ENSMUST00000077967.6
Lins
lines homolog (Drosophila)
chrX_+_36328353 4.31 ENSMUST00000016383.3
Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr6_-_83775767 4.29 ENSMUST00000014892.6
Tex261
testis expressed gene 261
chr15_-_82794236 4.24 ENSMUST00000006094.4
Cyp2d26
cytochrome P450, family 2, subfamily d, polypeptide 26
chrX_+_48623737 4.20 ENSMUST00000114936.1
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr11_+_58199556 4.04 ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
ENSMUST00000058704.8
Igtp
Irgm2
interferon gamma induced GTPase
immunity-related GTPase family M member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf4a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
19.3 77.4 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
18.6 55.9 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
13.5 40.4 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
12.4 49.6 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
11.9 391.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
10.7 42.7 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
10.0 40.2 GO:0046951 ketone body biosynthetic process(GO:0046951)
9.7 135.1 GO:0015747 urate transport(GO:0015747)
9.6 57.8 GO:0008355 olfactory learning(GO:0008355)
9.6 248.7 GO:0035634 response to stilbenoid(GO:0035634)
7.8 23.3 GO:0019265 glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) L-alanine catabolic process(GO:0042853)
7.8 7.8 GO:1903383 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
7.3 21.9 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
6.3 18.8 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) thymidine metabolic process(GO:0046104)
5.1 30.8 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
4.9 14.7 GO:1901052 sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)
4.7 23.7 GO:0005984 disaccharide metabolic process(GO:0005984)
4.6 13.8 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
4.6 18.4 GO:0006742 NADP catabolic process(GO:0006742)
4.5 22.6 GO:0009115 xanthine catabolic process(GO:0009115)
4.4 13.2 GO:2001293 fatty-acyl-CoA biosynthetic process(GO:0046949) malonyl-CoA metabolic process(GO:2001293)
4.2 155.1 GO:0019369 arachidonic acid metabolic process(GO:0019369)
3.9 23.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
3.7 11.1 GO:0071929 alpha-tubulin acetylation(GO:0071929)
3.7 11.1 GO:0006553 lysine metabolic process(GO:0006553)
3.6 14.2 GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641)
3.5 14.0 GO:0009441 glycolate metabolic process(GO:0009441)
3.4 16.8 GO:0015886 heme transport(GO:0015886)
3.3 16.5 GO:0006572 tyrosine catabolic process(GO:0006572)
3.1 49.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
2.9 17.4 GO:0045964 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
2.8 8.5 GO:0046340 diacylglycerol catabolic process(GO:0046340)
2.8 8.5 GO:0035962 response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
2.6 7.7 GO:0006714 sesquiterpenoid metabolic process(GO:0006714)
2.4 4.7 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
2.3 37.4 GO:0036158 outer dynein arm assembly(GO:0036158)
2.3 11.4 GO:0009446 spermidine biosynthetic process(GO:0008295) putrescine biosynthetic process(GO:0009446)
2.2 8.9 GO:0045329 carnitine biosynthetic process(GO:0045329)
2.2 6.5 GO:0010899 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
2.1 8.6 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
1.9 7.8 GO:0046618 drug export(GO:0046618)
1.9 11.5 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
1.8 17.9 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
1.8 5.4 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
1.7 6.9 GO:0090365 regulation of mRNA modification(GO:0090365)
1.6 19.8 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
1.6 11.2 GO:0061113 pancreas morphogenesis(GO:0061113)
1.5 23.3 GO:0046485 ether lipid metabolic process(GO:0046485)
1.4 50.1 GO:0050892 intestinal absorption(GO:0050892)
1.4 8.3 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
1.3 5.3 GO:0003360 brainstem development(GO:0003360)
1.3 3.9 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
1.3 7.7 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
1.3 8.9 GO:0001757 somite specification(GO:0001757)
1.3 6.3 GO:1902221 L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221)
1.2 8.6 GO:0015862 uridine transport(GO:0015862)
1.2 4.9 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) fatty-acyl-CoA catabolic process(GO:0036115) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
1.1 6.9 GO:0006642 triglyceride mobilization(GO:0006642)
1.1 17.1 GO:0019321 pentose metabolic process(GO:0019321)
1.1 7.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
1.1 5.3 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
1.0 10.2 GO:0006901 vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
1.0 3.0 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
1.0 4.0 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
1.0 8.6 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.9 13.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.8 6.5 GO:0009249 protein lipoylation(GO:0009249)
0.8 3.2 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.8 4.7 GO:2000210 positive regulation of anoikis(GO:2000210)
0.8 3.1 GO:0061235 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.8 8.6 GO:0097421 liver regeneration(GO:0097421)
0.8 5.4 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.8 10.5 GO:0002934 desmosome organization(GO:0002934)
0.7 6.4 GO:0061366 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.7 3.5 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.6 1.9 GO:0003285 septum secundum development(GO:0003285) cardiac muscle tissue regeneration(GO:0061026) negative regulation of connective tissue replacement(GO:1905204)
0.6 5.6 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.6 7.3 GO:0006824 cobalt ion transport(GO:0006824)
0.6 6.0 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.6 24.0 GO:0051642 centrosome localization(GO:0051642)
0.5 2.7 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.5 21.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.5 17.6 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.5 25.3 GO:0006956 complement activation(GO:0006956)
0.5 1.4 GO:0060061 Spemann organizer formation(GO:0060061) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.5 5.6 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.4 3.1 GO:0007296 vitellogenesis(GO:0007296)
0.4 4.0 GO:0030035 microspike assembly(GO:0030035)
0.4 14.6 GO:0015893 drug transport(GO:0015893)
0.4 5.0 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.4 3.7 GO:0043691 reverse cholesterol transport(GO:0043691)
0.4 1.2 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.4 7.1 GO:0046697 decidualization(GO:0046697)
0.4 9.3 GO:0034389 lipid particle organization(GO:0034389)
0.4 1.1 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.4 5.7 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.3 4.7 GO:0070932 histone H3 deacetylation(GO:0070932)
0.3 5.1 GO:0030497 fatty acid elongation(GO:0030497)
0.3 2.0 GO:0015808 L-alanine transport(GO:0015808)
0.3 3.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.3 2.3 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.3 41.3 GO:0009636 response to toxic substance(GO:0009636)
0.3 35.3 GO:0009166 nucleotide catabolic process(GO:0009166)
0.3 3.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.2 1.2 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.2 10.6 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.2 1.4 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 0.9 GO:0061386 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 9.4 GO:0006953 acute-phase response(GO:0006953)
0.2 2.2 GO:0043649 dicarboxylic acid catabolic process(GO:0043649)
0.2 11.8 GO:0050919 negative chemotaxis(GO:0050919)
0.2 7.7 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.2 0.8 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)
0.2 38.1 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.2 18.3 GO:0046889 positive regulation of lipid biosynthetic process(GO:0046889)
0.2 4.7 GO:0002360 T cell lineage commitment(GO:0002360)
0.2 4.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.2 1.7 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.2 12.8 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.2 6.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 3.7 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.2 8.2 GO:0007566 embryo implantation(GO:0007566)
0.1 3.1 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 2.6 GO:0051205 protein insertion into membrane(GO:0051205)
0.1 1.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 1.7 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.1 8.7 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.1 0.5 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 9.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 3.0 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 20.8 GO:0031668 cellular response to extracellular stimulus(GO:0031668)
0.1 1.8 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 24.6 GO:0016042 lipid catabolic process(GO:0016042)
0.1 3.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.7 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 2.2 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.1 14.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 3.4 GO:0007588 excretion(GO:0007588)
0.1 2.6 GO:0035329 hippo signaling(GO:0035329)
0.1 6.2 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 0.5 GO:0015879 carnitine transport(GO:0015879)
0.1 2.1 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.4 GO:0015074 DNA integration(GO:0015074)
0.0 1.7 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.0 0.6 GO:0008272 sulfate transport(GO:0008272)
0.0 7.5 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 0.9 GO:0014037 Schwann cell differentiation(GO:0014037)
0.0 4.5 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 4.3 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 3.0 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 3.2 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)
0.0 2.4 GO:0034976 response to endoplasmic reticulum stress(GO:0034976)
0.0 6.4 GO:0032259 methylation(GO:0032259)
0.0 1.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 35.3 GO:0045098 type III intermediate filament(GO:0045098)
3.9 43.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
3.3 50.1 GO:0045179 apical cortex(GO:0045179)
2.8 31.1 GO:0042627 chylomicron(GO:0042627)
1.8 19.8 GO:0005579 membrane attack complex(GO:0005579)
1.5 6.1 GO:0005610 laminin-5 complex(GO:0005610)
1.4 8.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.4 123.8 GO:0009925 basal plasma membrane(GO:0009925)
1.3 5.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
1.3 37.6 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
1.2 11.1 GO:0097427 microtubule bundle(GO:0097427)
1.1 8.9 GO:1990357 terminal web(GO:1990357)
0.9 5.6 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.9 24.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.9 13.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.9 8.6 GO:0045298 tubulin complex(GO:0045298)
0.8 7.8 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.7 13.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.6 4.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.6 5.0 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.6 7.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.6 54.1 GO:0005811 lipid particle(GO:0005811)
0.5 8.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.5 70.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.3 61.1 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 47.5 GO:0072562 blood microparticle(GO:0072562)
0.3 7.1 GO:0031528 microvillus membrane(GO:0031528)
0.3 32.2 GO:0005814 centriole(GO:0005814)
0.3 465.8 GO:0005783 endoplasmic reticulum(GO:0005783)
0.2 25.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 4.8 GO:0030057 desmosome(GO:0030057)
0.2 3.7 GO:0045120 pronucleus(GO:0045120)
0.2 8.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 7.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 8.9 GO:0005871 kinesin complex(GO:0005871)
0.1 1.5 GO:0036038 MKS complex(GO:0036038)
0.1 199.6 GO:0005739 mitochondrion(GO:0005739)
0.1 1.5 GO:0031011 Ino80 complex(GO:0031011)
0.1 3.4 GO:0016592 mediator complex(GO:0016592)
0.1 8.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.1 GO:0001533 cornified envelope(GO:0001533)
0.1 2.2 GO:0048786 presynaptic active zone(GO:0048786)
0.1 2.7 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 4.0 GO:0030175 filopodium(GO:0030175)
0.1 3.2 GO:0001772 immunological synapse(GO:0001772)
0.1 15.0 GO:0014069 postsynaptic density(GO:0014069)
0.1 8.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.8 GO:0072686 mitotic spindle(GO:0072686)
0.0 14.2 GO:0005813 centrosome(GO:0005813)
0.0 37.9 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 2.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 3.0 GO:0001650 fibrillar center(GO:0001650)
0.0 0.2 GO:0070938 contractile ring(GO:0070938)
0.0 2.3 GO:0012506 vesicle membrane(GO:0012506)
0.0 8.8 GO:0005768 endosome(GO:0005768)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 4.9 GO:0044297 cell body(GO:0044297)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
39.4 118.3 GO:0005186 pheromone activity(GO:0005186)
32.2 193.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
30.0 119.9 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
20.3 81.4 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
14.0 55.9 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
12.8 51.2 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
12.4 49.6 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
10.3 72.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
10.3 30.8 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
9.0 135.1 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
7.8 23.3 GO:0050479 glyceryl-ether monooxygenase activity(GO:0050479)
7.1 35.3 GO:0004850 uridine phosphorylase activity(GO:0004850)
6.4 19.1 GO:0019150 D-ribulokinase activity(GO:0019150)
5.7 40.2 GO:0015245 fatty acid transporter activity(GO:0015245)
5.6 162.0 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
5.4 21.7 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
4.9 14.7 GO:0008480 sarcosine dehydrogenase activity(GO:0008480)
4.9 117.1 GO:0070330 aromatase activity(GO:0070330)
4.5 22.6 GO:0004854 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
4.2 16.8 GO:0015232 heme transporter activity(GO:0015232)
4.2 33.5 GO:0001849 complement component C1q binding(GO:0001849)
3.9 23.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
3.9 23.3 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
3.8 22.6 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
3.5 132.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
3.3 78.6 GO:0005550 pheromone binding(GO:0005550)
3.1 31.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
2.8 11.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
2.7 18.8 GO:0002054 nucleobase binding(GO:0002054)
2.6 13.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
2.5 10.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822) efflux transmembrane transporter activity(GO:0015562)
2.2 6.5 GO:0016979 lipoate-protein ligase activity(GO:0016979)
2.0 14.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
2.0 17.9 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
1.9 18.9 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
1.8 5.4 GO:0004743 pyruvate kinase activity(GO:0004743)
1.8 7.1 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
1.7 40.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
1.6 6.5 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
1.6 11.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.6 7.8 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
1.4 19.8 GO:0019841 retinol binding(GO:0019841)
1.3 5.4 GO:0008240 tripeptidyl-peptidase activity(GO:0008240) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573)
1.2 8.6 GO:0099609 microtubule lateral binding(GO:0099609)
1.2 10.8 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
1.1 6.9 GO:0004126 cytidine deaminase activity(GO:0004126)
1.1 18.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
1.1 5.3 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
1.1 5.3 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
1.1 3.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.0 11.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.0 7.8 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.9 24.6 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.9 6.9 GO:0035473 lipase binding(GO:0035473)
0.8 13.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.7 14.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.7 12.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.7 2.0 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
0.7 8.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.6 2.6 GO:0031849 olfactory receptor binding(GO:0031849)
0.6 16.5 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.6 14.6 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.5 11.2 GO:0008483 transaminase activity(GO:0008483)
0.5 19.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.5 3.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.4 5.0 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.4 4.0 GO:0051434 BH3 domain binding(GO:0051434)
0.4 77.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 5.6 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.4 32.3 GO:0038024 cargo receptor activity(GO:0038024)
0.4 4.9 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.3 4.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 13.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.3 5.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.3 10.6 GO:0042605 peptide antigen binding(GO:0042605)
0.3 10.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 0.8 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.2 2.7 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 53.7 GO:0008168 methyltransferase activity(GO:0008168)
0.2 1.9 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.2 0.9 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.2 3.6 GO:0038191 neuropilin binding(GO:0038191)
0.2 27.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 8.9 GO:0003785 actin monomer binding(GO:0003785)
0.2 23.7 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2 17.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.2 1.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 7.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 2.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 8.9 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 3.0 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 5.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.9 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.5 GO:0005124 scavenger receptor binding(GO:0005124)
0.1 3.5 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 2.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.2 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 4.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.4 GO:0048018 receptor agonist activity(GO:0048018)
0.1 8.9 GO:0003777 microtubule motor activity(GO:0003777)
0.1 6.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.7 GO:0005123 death receptor binding(GO:0005123)
0.1 3.7 GO:0001221 transcription cofactor binding(GO:0001221)
0.1 9.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.9 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 1.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 2.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 2.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.7 GO:0043531 ADP binding(GO:0043531)
0.0 0.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 1.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 2.2 GO:0042805 actinin binding(GO:0042805)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 4.7 GO:0008083 growth factor activity(GO:0008083)
0.0 9.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 7.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.4 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 2.8 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.8 GO:0030674 protein binding, bridging(GO:0030674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 29.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.9 62.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.6 21.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 6.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.5 8.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.5 8.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4 5.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 9.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.3 5.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 25.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 10.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 3.9 PID ARF 3PATHWAY Arf1 pathway
0.1 4.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.1 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 9.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 4.7 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 4.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 4.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 1.4 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.5 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.9 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 23.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
7.1 99.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
7.0 77.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
6.0 48.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
4.6 77.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
4.0 40.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
3.2 22.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
2.9 41.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
2.8 35.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
2.0 51.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.4 15.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.3 23.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
1.0 19.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
1.0 10.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.8 13.8 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.7 11.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.6 29.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.5 48.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.5 13.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.4 11.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.4 5.0 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.4 80.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.4 9.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.3 6.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.3 8.9 REACTOME KINESINS Genes involved in Kinesins
0.3 10.4 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.3 3.9 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.3 6.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3 8.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 4.7 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.3 4.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.3 4.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.3 3.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 2.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.2 3.1 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 3.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 3.1 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.2 3.0 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 3.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 6.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 2.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 14.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 10.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 2.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 10.1 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.1 6.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 3.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 2.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis